Development Level

Tbio 24 | 11,651
Tchem 12 | 1,388
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
abnormal bone structure 2 | 187
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
enlarged heart 1 | 210
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 29 | 11,493
Cancer 28 | 2,499
lung cancer 20 | 4,740
osteosarcoma 19 | 7,950
ovarian cancer 19 | 8,520
psoriasis 19 | 6,694
Breast cancer 18 | 3,578
invasive ductal carcinoma 17 | 2,951
medulloblastoma, large-cell 16 | 6,241
Kidney cancer 15 | 2,613
atypical teratoid / rhabdoid tumor 15 | 5,112
malignant mesothelioma 14 | 3,232
glioblastoma 12 | 5,792
non-small cell lung cancer 12 | 2,890
breast carcinoma 11 | 1,638
ependymoma 11 | 4,679
Cleft Palate 10 | 271
Schizophrenia 10 | 1,160
diabetes mellitus 10 | 1,728
ductal carcinoma in situ 10 | 1,745
group 3 medulloblastoma 10 | 4,104
lung adenocarcinoma 10 | 2,716
Autosomal recessive predisposition 9 | 1,442
Cleft Lip 9 | 141
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Orbital separation excessive 8 | 244
adult high grade glioma 8 | 3,801
oligodendroglioma 8 | 2,850
ulcerative colitis 8 | 1,819
Astrocytoma, Pilocytic 7 | 3,081
Breast Neoplasms 7 | 445
Carcinoma, Hepatocellular 7 | 228
Depressive disorder 7 | 409
Downward slant of palpebral fissure 7 | 158
Liver carcinoma 7 | 240
Mammary Neoplasms 7 | 425
Prostatic Neoplasms 7 | 495
Seizures 7 | 596
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
lung carcinoma 7 | 2,843
pancreatic cancer 7 | 2,398
pituitary cancer 7 | 1,972
Achondroplasia 6 | 21
Craniosynostosis 6 | 74
Cryptorchidism 6 | 296
Epilepsy 6 | 792
Frontal bossing 6 | 157
High forehead 6 | 102
Hypoplastic mandible condyle 6 | 275
LADD syndrome 6 | 9
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Short stature 6 | 531
Tall forehead 6 | 102
Telecanthus 6 | 62
colon cancer 6 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
Acrocephalosyndactylia 5 | 17
Bipolar Disorder 5 | 666
Blepharoptosis 5 | 231
Byzanthine arch palate 5 | 194
Cognitive delay 5 | 608
Concave bridge of nose 5 | 195
Delayed Puberty 5 | 97
Delayed bone age 5 | 136
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Down syndrome 5 | 499
Global developmental delay 5 | 608
Hydrocephalus 5 | 152
Hypodontia 5 | 81
Liver cancer 5 | 604
Mental and motor retardation 5 | 608
Obesity 5 | 678
Osteoporosis 5 | 363
Polycystic ovary syndrome 5 | 360
Sensorineural Hearing Loss (disorder) 5 | 284
Stomach Neoplasms 5 | 300
Strabismus 5 | 270
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
progressive supranuclear palsy 5 | 676
subependymal giant cell astrocytoma 5 | 2,287
Abnormality of cardiovascular system morphology 4 | 23
Adenoid Cystic Carcinoma 4 | 99
Broad flat nasal bridge 4 | 236
Endometrial cancer 4 | 311
Leukemia 4 | 104
Lung Neoplasms 4 | 232
Mental Depression 4 | 333
Nasal bridge wide 4 | 236
Parkinson's disease 4 | 392
Ventricular Septal Defects 4 | 119
active ulcerative colitis 4 | 764
medulloblastoma 4 | 720
tuberculosis 4 | 2,010

Tissue

Endocrine System 42 | 18,159
Digestive Tract 41 | 17,369
Nervous System 41 | 16,725
Female tissues 40 | 17,400
Male tissues 40 | 17,142
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Blood and immune system 39 | 16,909
Liver and Pancreas 39 | 16,750
Respiratory system 38 | 16,393
Cardiovascular System 34 | 15,192

Target Family

Non-IDG 23 | 12,091
Kinase 15 | 634
Enzyme 5 | 4,145

GO Function

1-phosphatidylinositol-3-kinas... 43 | 43
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.33238 204.8 739
Fibroblast growth factor receptor substrate 2 FRS2 Tbio Non-IDG -2.37203 224.0 344
Fibroblast growth factor 22 FGF22 Tbio Non-IDG -1.15836 16.5 186
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.55166 363.0 320
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -4.00542 10573.5 798
Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 Tbio Enzyme -1.57214 38.2 155