Development Level

Tbio 21 | 10,625
Tchem 16 | 1,890
Tclin 6 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 7 | 633
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased bone mineral content 3 | 157
decreased kidney weight 3 | 7
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
decreased body weight 2 | 174
decreased circulating creatini... 2 | 31
decreased grip strength 2 | 123
embryonic lethality prior to o... 2 | 148
enlarged lymph nodes 2 | 27
impaired pupillary reflex 2 | 14
abnormal behavior 1 | 226
abnormal body wall morphology 1 | 7
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal motor learning 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
abnormal spinal cord morpholog... 1 | 8
abnormal tail morphology 1 | 17
absent heartbeat 1 | 6
absent startle reflex 1 | 15
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
enlarged heart 1 | 111
immune system phenotype 1 | 17
impaired righting response 1 | 19
increased circulating HDL chol... 1 | 63
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased neutrophil cell numb... 1 | 15
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
mydriasis 1 | 9
narrow eye opening 1 | 15
no spontaneous movement 1 | 1

Disease

Cancer 26 | 2,346
osteosarcoma 19 | 7,933
psoriasis 19 | 6,685
lung cancer 18 | 4,466
ovarian cancer 18 | 8,484
invasive ductal carcinoma 17 | 2,950
medulloblastoma, large-cell 16 | 6,234
Breast cancer 15 | 3,094
Carcinoma 15 | 2,147
malignant mesothelioma 13 | 3,162
non-small cell lung cancer 12 | 2,798
atypical teratoid / rhabdoid tumor 11 | 4,369
glioblastoma 11 | 5,572
breast carcinoma 10 | 1,614
ductal carcinoma in situ 10 | 1,745
lung adenocarcinoma 10 | 2,713
Cleft Lip 9 | 91
Cleft palate 9 | 125
diabetes mellitus 9 | 1,663
ependymoma 9 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
ulcerative colitis 9 | 2,087
oligodendroglioma 8 | 2,849
Craniosynostosis 7 | 47
Liver carcinoma 7 | 217
Mammary Neoplasms 7 | 410
Prostatic Neoplasms 7 | 471
interstitial cystitis 7 | 2,299
lung carcinoma 7 | 2,844
pilocytic astrocytoma 7 | 3,086
pituitary cancer 7 | 1,972
Achondroplasia 6 | 20
LADD syndrome 6 | 9
colon cancer 6 | 1,475
group 3 medulloblastoma 6 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
juvenile dermatomyositis 6 | 1,189
pancreatic cancer 6 | 2,300
Acrocephalosyndactylia 5 | 15
Down syndrome 5 | 548
astrocytic glioma 5 | 2,241
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
medulloblastoma 5 | 1,524
pediatric high grade glioma 5 | 2,712
progressive supranuclear palsy 5 | 674
subependymal giant cell astrocytoma 5 | 2,287
Adenoid Cystic Carcinoma 4 | 99
Craniofacial Abnormalities 4 | 147
Diffuse large B-cell lymphoma 4 | 41
Hamman-Rich syndrome 4 | 35
Lung Neoplasms 4 | 171
Parkinson's disease 4 | 364
Pick disease 4 | 1,893
Polycystic Ovary Syndrome 4 | 332
Rheumatoid Arthritis 4 | 1,160
Schizophrenia 4 | 501
Stomach Neoplasms 4 | 282
Vascular disease 4 | 281
adult high grade glioma 4 | 2,148
astrocytoma 4 | 1,493
atypical teratoid/rhabdoid tumor 4 | 1,095
group 4 medulloblastoma 4 | 1,875
primitive neuroectodermal tumor 4 | 3,031
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis 4 | 1,557
Alzheimer's disease 3 | 644
Centronuclear myopathy 3 | 21
Endometrial cancer 3 | 25
Heart disease 3 | 279
Hypochondroplasia 3 | 11
Hypophosphatemia 3 | 31
Hypospadias 3 | 65
Kallmann Syndrome 3 | 33
Kidney cancer 3 | 118
Klinefelter's syndrome 3 | 59
Lacrimoauriculodentodigital syndrome 3 | 3
Liver Cirrhosis 3 | 101
Obesity 3 | 616
Peripheral Neuropathy 3 | 303
Polydactyly 3 | 93
Prostate cancer 3 | 172
Pulmonary Fibrosis 3 | 66
Renal Cell Carcinoma 3 | 199
Syndactyly 3 | 56
Synostosis 3 | 18
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 477
acute quadriplegic myopathy 3 | 1,157
adrenocortical carcinoma 3 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
dermatomyositis 3 | 933
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
Lung disease 2 | 132

Tissue

Female tissues 43 | 18,647
Nervous System 43 | 18,561
Digestive Tract 42 | 18,473
Endocrine System 42 | 18,512
Liver and Pancreas 42 | 18,136
Skin and soft tissues 42 | 18,115
Urinary Tract 42 | 18,444
Blood and immune system 41 | 17,995
Cardiovascular System 40 | 17,958
Male tissues 39 | 17,969
Respiratory system 36 | 17,484

Target Family

Non-IDG 23 | 11,971
Kinase 15 | 634
Enzyme 5 | 4,146

GO Function

1-phosphatidylinositol-3-kinas... 43 | 43
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.51373 345.1 271
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -3.97848 10115.4 658
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.26683 181.8 641
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.83412 76.6 133