Development Level

Tbio 16 | 11,651
Tdark 2 | 6,593
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
decreased bone mineral content 2 | 151
abnormal maxilla morphology 1 | 17
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased lactate dehydrogenas... 1 | 16
increased anti-nuclear antigen... 1 | 19
increased heart rate variabili... 1 | 7
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
small seminal vesicle 1 | 10

Disease

osteosarcoma 14 | 7,950
Carcinoma 13 | 11,493
ovarian cancer 10 | 8,520
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
glioblastoma 8 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
invasive ductal carcinoma 6 | 2,951
lung carcinoma 6 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
Astrocytoma, Pilocytic 5 | 3,081
Breast cancer 5 | 3,578
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
lung cancer 5 | 4,740
oligodendroglioma 5 | 2,850
Pick disease 4 | 1,894
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
non-small cell lung cancer 4 | 2,890
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Hepatomegaly 3 | 285
Intellectual disability 3 | 1,016
Rheumatoid arthritis 3 | 1,191
active Crohn's disease 3 | 922
gastric carcinoma 3 | 807
pancreatic cancer 3 | 2,398
ulcerative colitis 3 | 1,819
Autosomal recessive predisposition 2 | 1,442
Barth syndrome 2 | 23
Class III malocclusion 2 | 78
Dull intelligence 2 | 645
Hypertrophic Cardiomyopathy 2 | 117
Hypertrophy of lower jaw 2 | 78
Increased size of mandible 2 | 78
Lipodystrophy 2 | 40
Liver Cirrhosis 2 | 181
Low intelligence 2 | 645
Mandibular hyperplasia 2 | 78
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Myopathy 2 | 185
Neutral lipid storage disease 2 | 12
Newborn respiratory distress syndrome 2 | 10
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Steatohepatitis 2 | 44
active ulcerative colitis 2 | 764
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
malignant mesothelioma 2 | 3,232
mandibular excess (physical finding) 2 | 78
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
Abnormal pigmentation 1 | 25
Acanthosis Nigricans 1 | 27
Advanced bone age 1 | 35
Agranulocytosis 1 | 6
Alopecia 1 | 115
Brachydactyly 1 | 156
Broad feet 1 | 19
Cardiac conduction abnormalities 1 | 78
EKG abnormalities 1 | 78
Enophthalmos 1 | 75
Everted lower lip vermilion 1 | 54
Exfoliation Syndrome 1 | 12
Fatigue 1 | 182
Fatty liver disease 1 | 103
Generalized hirsutism 1 | 36
Glomerulonephritis 1 | 46
Hirsutism 1 | 47
Hyperhidrosis disorder 1 | 81
Hyperinsulinism 1 | 133
Hypertriglyceridemia result 1 | 37
Increased sweating 1 | 81
Insulin Resistance 1 | 72
Leigh disease 1 | 100
Muscle Weakness 1 | 170
Neurodegenerative Disorders 1 | 79
Neutropenia 1 | 72
Precocious Puberty 1 | 28
Protruding lower lip 1 | 54
Round face 1 | 45
Round, full face 1 | 45
Sclerocystic Ovaries 1 | 17
Skeletal muscle hypertrophy 1 | 16
Sunken eyes 1 | 63
Sweating 1 | 81
Systemic primary carnitine deficiency disease 1 | 15
Tall stature 1 | 34
Weight Gain 1 | 100
X- linked recessive 1 | 110
inflammatory breast cancer 1 | 286

Tissue

Blood and immune system 19 | 16,909
Cardiovascular System 19 | 15,192
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Liver and Pancreas 19 | 16,750
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678

Target Family

Enzyme 18 | 4,145
Non-IDG 1 | 12,091

GO Function

1-acylglycerol-3-phosphate O-a... 19 | 19
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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