Development Level

Tclin 42 | 602
Tbio 26 | 10,625
Tchem 12 | 1,890
Tdark 1 | 7,003

Collection

Eligible Ion Channel Proteins 20 | 117

IMPC Term

abnormal behavior 3 | 226
decreased body weight 3 | 174
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased lean body mass 2 | 195
hyperactivity 2 | 108
increased circulating magnesiu... 2 | 10
increased mean corpuscular vol... 2 | 91
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal response to tactile s... 1 | 16
abnormal startle reflex 1 | 14
decreased B cell number 1 | 30
decreased NK T cell number 1 | 28
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased circulating fructosa... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased total body fat amoun... 1 | 186
enlarged epididymis 1 | 27
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased caudal vertebrae num... 1 | 8
increased circulating fructosa... 1 | 11
increased exploration in new e... 1 | 56
increased vertical activity 1 | 18
kyphosis 1 | 5
limb grasping 1 | 35
tremors 1 | 34

Disease

medulloblastoma, large-cell 44 | 6,234
glioblastoma 39 | 5,572
Multiple Sclerosis 36 | 498
Eaton-Lambert syndrome 35 | 40
atypical teratoid / rhabdoid tumor 34 | 4,369
oligodendroglioma 34 | 2,849
primitive neuroectodermal tumor 34 | 3,031
pilocytic astrocytoma 31 | 3,086
pediatric high grade glioma 27 | 2,712
astrocytic glioma 26 | 2,241
ependymoma 26 | 2,514
psoriasis 26 | 6,685
Carcinoma 23 | 2,147
Long QT syndrome 23 | 52
osteosarcoma 23 | 7,933
ovarian cancer 22 | 8,484
Epilepsy 21 | 346
pituitary cancer 21 | 1,972
subependymal giant cell astrocytoma 21 | 2,287
lung cancer 19 | 4,466
malignant mesothelioma 19 | 3,162
medulloblastoma 19 | 1,524
adult high grade glioma 17 | 2,148
Pick disease 16 | 1,893
lung carcinoma 16 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
Atrial Fibrillation 13 | 110
cystic fibrosis 13 | 1,665
Breast cancer 12 | 3,094
group 3 medulloblastoma 12 | 2,254
posterior fossa group A ependymoma 12 | 1,511
sonic hedgehog group medulloblastoma 12 | 1,482
colon cancer 11 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
invasive ductal carcinoma 11 | 2,950
posterior fossa group B ependymoma 11 | 1,530
atypical teratoid/rhabdoid tumor 10 | 1,095
lung adenocarcinoma 10 | 2,713
pancreatic cancer 10 | 2,300
Intellectual disability 9 | 573
adrenocortical carcinoma 9 | 1,427
ductal carcinoma in situ 9 | 1,745
non-small cell lung cancer 9 | 2,798
Episodic ataxia 8 | 17
group 4 medulloblastoma 8 | 1,875
interstitial cystitis 8 | 2,299
Heart disease 7 | 279
Amyotrophic Lateral Sclerosis 6 | 431
Brugada syndrome 6 | 26
Hypokalemia 6 | 40
Romano-Ward Syndrome 6 | 12
breast carcinoma 6 | 1,614
gastric carcinoma 6 | 832
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
primary pancreatic ductal adenocarcinoma 6 | 1,271
ulcerative colitis 6 | 2,087
Cancer 5 | 2,346
Congenital long QT syndrome 5 | 8
Down syndrome 5 | 548
Familial atrial fibrillation 5 | 16
Hypertension 5 | 287
Short QT syndrome 5 | 12
active Crohn's disease 5 | 918
active ulcerative colitis 5 | 477
astrocytoma 5 | 1,493
diabetes mellitus 5 | 1,663
fibroadenoma 5 | 557
Alzheimer's disease 4 | 644
Bipolar Disorder 4 | 266
Cerebellar Ataxia 4 | 72
Endometriosis 4 | 535
Neurodegenerative disease 4 | 383
Partial Epilepsy Treatment Adjunct 4 | 16
Timothy syndrome 4 | 12
Type 2 diabetes mellitus 4 | 189
Vascular disease 4 | 281
aldosterone-producing adenoma 4 | 664
chronic rhinosinusitis 4 | 512
nasopharyngeal carcinoma 4 | 1,056
non-inflammatory breast cancer 4 | 208
Autistic Disorder 3 | 320
Brugada Syndrome (disorder) 3 | 15
Cognitive disorder 3 | 44
Diabetes Mellitus, Non-Insulin-Dependent 3 | 157
Encephalitis 3 | 54
Heart conduction disease 3 | 65
Muscle Weakness 3 | 92
Osteoporosis 3 | 257
Parkinson's disease 3 | 364
Rheumatoid Arthritis 3 | 1,160
Schizophrenia 3 | 501
Schnyder corneal dystrophy 3 | 23
Ventricular Fibrillation 3 | 10
acute quadriplegic myopathy 3 | 1,157
hepatocellular carcinoma 3 | 532
pancreatic carcinoma 3 | 567
progressive supranuclear palsy 3 | 674
sarcoidosis 3 | 358
substance-related disorder 3 | 105

Tissue

Nervous System 81 | 18,561
Endocrine System 80 | 18,512
Blood and immune system 79 | 17,995
Cardiovascular System 79 | 17,958
Digestive Tract 79 | 18,473
Female tissues 79 | 18,647
Liver and Pancreas 79 | 18,136
Skin and soft tissues 79 | 18,115
Urinary Tract 79 | 18,444
Male tissues 78 | 17,969
Respiratory system 77 | 17,484

Target Family

Ion Channel 69 | 341
Non-IDG 8 | 11,971
Enzyme 2 | 4,146
Transporter 2 | 473

GO Component

voltage-gated potassium channe... 81 | 81
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

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