Development Level

Tbio 70 | 10,625
Tdark 23 | 7,003
Tchem 6 | 1,890

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 6 | 633
decreased lean body mass 3 | 195
decreased leukocyte cell numbe... 3 | 54
enlarged spleen 3 | 26
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
abnormal vocalization 2 | 21
decreased body weight 2 | 174
decreased circulating amylase ... 2 | 24
decreased circulating glucose ... 2 | 121
decreased erythrocyte cell num... 2 | 43
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased lymphocyte cell numb... 2 | 9
decreased prepulse inhibition 2 | 52
decreased threshold for audito... 2 | 32
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
increased fasted circulating g... 2 | 68
male infertility 2 | 62
thrombocytopenia 2 | 46
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal defecation 1 | 1
abnormal eye morphology 1 | 38
abnormal eyelid morphology 1 | 6
abnormal forebrain development 1 | 18
abnormal heart left ventricle ... 1 | 20
abnormal hindbrain development 1 | 24
abnormal iris morphology 1 | 12
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal skin coloration 1 | 18
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal tail bud morphology 1 | 6
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 5
decreased circulating alanine ... 1 | 53
decreased circulating calcium ... 1 | 33
decreased circulating fructosa... 1 | 31
decreased circulating iron lev... 1 | 25
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
hypoactivity 1 | 89
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased monocyte cell number 1 | 27
increased neutrophil cell numb... 1 | 15
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
limb grasping 1 | 35
microcephaly 1 | 3
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
shortened QT interval 1 | 4
small adrenal glands 1 | 15
straub tail 1 | 26
thrombocytosis 1 | 23

Disease

ovarian cancer 59 | 8,484
osteosarcoma 55 | 7,933
medulloblastoma, large-cell 34 | 6,234
glioblastoma 27 | 5,572
psoriasis 25 | 6,685
atypical teratoid / rhabdoid tumor 22 | 4,369
lung cancer 22 | 4,466
malignant mesothelioma 17 | 3,162
group 3 medulloblastoma 16 | 2,254
non-small cell lung cancer 15 | 2,798
Breast cancer 13 | 3,094
ependymoma 13 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
oligodendroglioma 13 | 2,849
primitive neuroectodermal tumor 13 | 3,031
Carcinoma 12 | 2,147
Multiple myeloma 12 | 1,327
Pick disease 12 | 1,893
astrocytic glioma 12 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
subependymal giant cell astrocytoma 11 | 2,287
Cancer 10 | 2,346
Rheumatoid Arthritis 10 | 1,160
adult high grade glioma 10 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
pilocytic astrocytoma 10 | 3,086
group 4 medulloblastoma 9 | 1,875
acute quadriplegic myopathy 8 | 1,157
invasive ductal carcinoma 8 | 2,950
medulloblastoma 8 | 1,524
pediatric high grade glioma 8 | 2,712
tuberculosis and treatment for 6 months 8 | 686
adrenocortical carcinoma 7 | 1,427
aldosterone-producing adenoma 7 | 664
astrocytoma 7 | 1,493
lung adenocarcinoma 7 | 2,713
lung carcinoma 7 | 2,844
spina bifida 7 | 1,064
dermatomyositis 6 | 933
pancreatic cancer 6 | 2,300
tuberculosis 6 | 1,557
ulcerative colitis 6 | 2,087
Amyotrophic Lateral Sclerosis 5 | 431
Parkinson's disease 5 | 364
hepatocellular carcinoma 5 | 532
juvenile dermatomyositis 5 | 1,189
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 918
acute myeloid leukemia 4 | 780
breast carcinoma 4 | 1,614
cystic fibrosis 4 | 1,665
diabetes mellitus 4 | 1,663
ductal carcinoma in situ 4 | 1,745
non primary Sjogren syndrome sicca 4 | 840
pituitary cancer 4 | 1,972
Endometriosis 3 | 535
Mammary Neoplasms 3 | 410
Neurodegenerative disease 3 | 383
Prostate cancer 3 | 172
cutaneous lupus erythematosus 3 | 1,056
gastric cancer 3 | 430
hereditary spastic paraplegia 3 | 313
interstitial cystitis 3 | 2,299
nasopharyngeal carcinoma 3 | 1,056
posterior fossa group B ependymoma 3 | 1,530
sarcoidosis 3 | 358
Aggressive systemic mastocytosis 2 | 6
Alzheimer's disease 2 | 644
Ataxia telangiectasia 2 | 31
Attention deficit hyperactivity disorder 2 | 156
Autistic Disorder 2 | 320
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 2 | 7
Breast Cancer, Familial 2 | 12
Celiac disease 2 | 112
Crohn's disease 2 | 304
Down syndrome 2 | 548
Hereditary Breast and Ovarian Cancer Syndrome 2 | 14
Hypertension 2 | 287
IGA Glomerulonephritis 2 | 454
Intellectual disability 2 | 573
Junctional epidermolysis bullosa 2 | 9
Liddle syndrome 2 | 14
Lung Neoplasms 2 | 171
Neoplastic Syndromes, Hereditary 2 | 48
Nijmegen breakage syndrome 2 | 23
Peripheral vascular disease 2 | 90
Prostatic Neoplasms 2 | 471
Rapadilino syndrome 2 | 7
Skin disease 2 | 65
atypical teratoid/rhabdoid tumor 2 | 1,095
chronic kidney disease 2 | 90
chronic rhinosinusitis 2 | 512
colon cancer 2 | 1,475
ovarian neoplasm 2 | 97
posterior fossa group A ependymoma 2 | 1,511
progressive supranuclear palsy 2 | 674
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis and treatment for 3 months 2 | 327
urothelial carcinoma 2 | 318

Tissue

Female tissues 98 | 18,647
Liver and Pancreas 98 | 18,136
Nervous System 98 | 18,561
Urinary Tract 98 | 18,444
Blood and immune system 97 | 17,995
Digestive Tract 97 | 18,473
Endocrine System 97 | 18,512
Male tissues 97 | 17,969
Cardiovascular System 96 | 17,958
Skin and soft tissues 96 | 18,115
Respiratory system 94 | 17,484

Target Family

Non-IDG 54 | 11,971
Enzyme 41 | 4,146
Kinase 2 | 634
Epigenetic 1 | 242
GPCR 1 | 406

GO Component

ubiquitin ligase complex 99 | 99
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
DCN1-like protein 3 DCUN1D3 Tdark Non-IDG -0.34242 2.58 44
NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 Tbio Enzyme -1.57709 42.8 121
E3 ubiquitin-protein ligase RNF168 RNF168 Tbio Enzyme -1.46566 28.7 150
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.18305 12.0 72
Ankyrin repeat and SOCS box protein 18 ASB18 Tdark Non-IDG 0.90 0.04 4
Polycomb complex protein BMI-1 BMI1 Tbio Non-IDG -2.80895 691.3 553
E3 ubiquitin-protein ligase BRE1B RNF40 Tbio Enzyme -0.78876 5.67 173
Ubiquitin-conjugating enzyme E2 D2 UBE2D2 Tbio Non-IDG -2.06903 107.6 211
E3 ubiquitin-protein ligase RNF144A RNF144A Tbio Enzyme -0.50601 3.76 142