Development Level

Tbio 151 | 11,651
Tchem 11 | 1,388
Tdark 6 | 6,593
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 11 | 499
abnormal embryo size 5 | 220
abnormal heart morphology 5 | 162
decreased vertical activity 4 | 208
embryonic lethality prior to t... 4 | 278
enlarged heart 4 | 210
abnormal behavior 3 | 298
corneal opacity 3 | 32
increased bone mineral density 3 | 72
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal ovary morphology 2 | 7
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal tooth morphology 2 | 24
absent epididymis 2 | 3
absent ovary 2 | 3
absent vibrissae 2 | 12
decreased IgG1 level 2 | 8
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
female infertility 2 | 60
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased startle reflex 2 | 112
male infertility 2 | 123
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal eyelid morphology 1 | 7
abnormal forebrain development 1 | 20
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart looping 1 | 5
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal optic vesicle formati... 1 | 4
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal response to new envir... 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal somite shape 1 | 5
abnormal startle reflex 1 | 15
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased anti-nuclear antigen... 1 | 19
increased body temperature 1 | 9
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
long tibia 1 | 25
mammalian phenotype 1 | 17
microphthalmia 1 | 26
small kidney 1 | 16
small spleen 1 | 19
small testis 1 | 58
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 113 | 11,493
ovarian cancer 87 | 8,520
osteosarcoma 81 | 7,950
medulloblastoma, large-cell 79 | 6,241
psoriasis 70 | 6,694
Cancer 67 | 2,499
glioblastoma 65 | 5,792
lung cancer 65 | 4,740
atypical teratoid / rhabdoid tumor 58 | 5,112
group 3 medulloblastoma 44 | 4,104
malignant mesothelioma 43 | 3,232
ependymoma 42 | 4,679
Breast cancer 40 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
non-small cell lung cancer 36 | 2,890
adult high grade glioma 34 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
invasive ductal carcinoma 34 | 2,951
primitive neuroectodermal tumor 34 | 3,035
oligodendroglioma 33 | 2,850
lung adenocarcinoma 32 | 2,716
Kidney cancer 30 | 2,613
lung carcinoma 29 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
astrocytic glioma 27 | 2,597
group 4 medulloblastoma 27 | 1,855
interstitial cystitis 27 | 2,312
pancreatic cancer 27 | 2,398
Intellectual disability 26 | 1,016
ulcerative colitis 25 | 1,819
Astrocytoma, Pilocytic 24 | 3,081
pituitary cancer 23 | 1,972
Rheumatoid arthritis 22 | 1,191
ductal carcinoma in situ 22 | 1,745
colon cancer 21 | 1,478
diabetes mellitus 21 | 1,728
subependymal giant cell astrocytoma 21 | 2,287
cystic fibrosis 20 | 1,696
tuberculosis 20 | 2,010
breast carcinoma 19 | 1,638
pediatric high grade glioma 19 | 1,064
Craniofacial Abnormalities 18 | 151
Pick disease 18 | 1,894
Short stature 18 | 531
astrocytoma 18 | 1,146
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Autosomal recessive predisposition 16 | 1,442
Bipolar Disorder 16 | 666
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Multiple myeloma 16 | 1,332
acute quadriplegic myopathy 16 | 1,158
juvenile dermatomyositis 16 | 1,187
Muscle hypotonia 15 | 571
Cleft Palate 14 | 271
adrenocortical carcinoma 14 | 1,428
Breast Neoplasms 13 | 445
Melanoma 13 | 711
Small head 13 | 374
Strabismus 13 | 270
active Crohn's disease 13 | 922
acute myeloid leukemia 13 | 783
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
primary pancreatic ductal adenocarcinoma 13 | 1,109
Cryptorchidism 12 | 296
Prostatic Neoplasms 12 | 495
Schizophrenia 12 | 1,160
Amyotrophic lateral sclerosis 11 | 451
Mammary Neoplasms 11 | 425
Obesity 11 | 678
Waldenstrons macroglobulinemia 11 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
cutaneous lupus erythematosus 11 | 1,057
dermatomyositis 11 | 966
primary Sjogren syndrome 11 | 735
spina bifida 11 | 1,074
Endometriosis 10 | 540
Epilepsy 10 | 792
Seizures 10 | 596
Uranostaphyloschisis 10 | 167
gastric carcinoma 10 | 807
nasopharyngeal carcinoma 10 | 1,058
sonic hedgehog group medulloblastoma 10 | 467
Atopic dermatitis 9 | 952
Brachydactyly 9 | 156
Broad flat nasal bridge 9 | 236
Colorectal Neoplasms 9 | 243
Constipation 9 | 181
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Nasal bridge wide 9 | 236
medulloblastoma 9 | 720
Arthritis, Rheumatoid 8 | 174
Intrauterine retardation 8 | 176

Tissue

Endocrine System 165 | 18,159
Skin and soft tissues 162 | 17,230
Digestive Tract 158 | 17,369
Female tissues 158 | 17,400
Male tissues 157 | 17,142
Nervous System 153 | 16,725
Blood and immune system 150 | 16,909
Liver and Pancreas 150 | 16,750
Urinary Tract 150 | 16,678
Respiratory system 146 | 16,393
Cardiovascular System 134 | 15,192

Target Family

Transcription Factor 114 | 1,400
Non-IDG 36 | 12,091
Enzyme 8 | 4,145
Epigenetic 5 | 242
Kinase 4 | 634
Nuclear Receptor 4 | 48
TF/Epigenetic 1 | 38

GO Component

transcription factor complex 172 | 172
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
REST corepressor 1 RCOR1 Tbio Transcription Factor -1.96775 81.2 0
Neuronal PAS domain-containing protein 2 NPAS2 Tbio Transcription Factor -1.91320 81.4 182
Endothelial PAS domain-containing protein 1 EPAS1 Tchem Non-IDG -2.29071 180.5 477
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.93639 70.1 171
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
POU domain, class 5, transcription factor 1 POU5F1 Tbio Transcription Factor -3.31332 2140.4 983
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.80737 619.7 475
N-alpha-acetyltransferase 15, NatA auxiliary subunit NAA15 Tbio Enzyme -2.09909 118.0 157
Polyamine-modulated factor 1 PMF1 Tbio Non-IDG -0.62754 4.93 133
Zinc finger protein ZFPM1 ZFPM1 Tbio Transcription Factor -2.52665 326.6 82