Development Level

Tbio 157 | 10,625
Tchem 16 | 1,890
Tdark 7 | 7,003
Tclin 4 | 602

IMPC Phenotype

preweaning lethality, complete... 9 | 633
preweaning lethality, incomple... 8 | 260
abnormal behavior 3 | 226
abnormal heart morphology 3 | 51
corneal opacity 3 | 25
decreased bone mineral density 3 | 126
increased or absent threshold ... 3 | 128
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
abnormal retinal pigmentation 2 | 61
abnormal tooth morphology 2 | 24
absent vibrissae 2 | 14
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
female infertility 2 | 34
increased bone mineral density 2 | 52
male infertility 2 | 62
prenatal lethality 2 | 16
prenatal lethality prior to he... 2 | 64
abnormal allantois morphology 1 | 3
abnormal bone structure 1 | 131
abnormal coat-hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo development 1 | 2
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eyelid morphology 1 | 6
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart looping 1 | 2
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal optic disc morphology 1 | 10
abnormal ovary morphology 1 | 3
abnormal pericardium morpholog... 1 | 11
abnormal posture 1 | 5
abnormal response to new envir... 1 | 8
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal startle reflex 1 | 14
abnormal tail bud morphology 1 | 6
abnormal tail morphology 1 | 17
abnormal tail movements 1 | 12
absent ovary 1 | 2
cataract 1 | 26
corneal vascularization 1 | 5
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
eyelids fail to open 1 | 2
hydrops fetalis 1 | 22
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased Ly6C high monocyte n... 1 | 12
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
irregularly shaped pupil 1 | 7
microphthalmia 1 | 15
narrow eye opening 1 | 15
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
prolonged PR interval 1 | 4
shortened QT interval 1 | 4
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small superior vagus ganglion 1 | 20
small testis 1 | 37
tremors 1 | 34

Disease

ovarian cancer 97 | 8,491
osteosarcoma 89 | 7,933
medulloblastoma, large-cell 84 | 6,234
psoriasis 78 | 6,685
Cancer 74 | 2,346
glioblastoma 72 | 5,572
lung cancer 67 | 4,473
atypical teratoid / rhabdoid tumor 59 | 4,369
malignant mesothelioma 46 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,289
non-small cell lung cancer 42 | 2,798
pediatric high grade glioma 39 | 2,712
Breast cancer 37 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
invasive ductal carcinoma 37 | 2,950
primitive neuroectodermal tumor 37 | 3,031
lung adenocarcinoma 36 | 2,714
lung carcinoma 36 | 2,844
oligodendroglioma 34 | 2,849
pancreatic cancer 32 | 2,300
group 4 medulloblastoma 31 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
sonic hedgehog group medulloblastoma 31 | 1,482
pituitary cancer 29 | 1,972
interstitial cystitis 28 | 2,299
ulcerative colitis 28 | 2,087
colon cancer 27 | 1,475
astrocytoma 26 | 1,493
subependymal giant cell astrocytoma 25 | 2,287
Rheumatoid Arthritis 24 | 1,170
breast carcinoma 24 | 1,614
ductal carcinoma in situ 24 | 1,745
ependymoma 24 | 2,514
pilocytic astrocytoma 24 | 3,086
astrocytic glioma 23 | 2,241
Carcinoma 22 | 2,147
Pick disease 22 | 1,893
cystic fibrosis 21 | 1,670
primary pancreatic ductal adenocarcinoma 21 | 1,271
diabetes mellitus 20 | 1,663
group 3 medulloblastoma 20 | 2,254
acute quadriplegic myopathy 18 | 1,157
adult high grade glioma 18 | 2,148
medulloblastoma 18 | 1,524
tuberculosis 18 | 1,563
acute myeloid leukemia 17 | 785
adrenocortical carcinoma 17 | 1,427
Craniofacial Abnormalities 16 | 147
Multiple myeloma 16 | 1,327
juvenile dermatomyositis 16 | 1,189
posterior fossa group A ependymoma 16 | 1,511
active Crohn's disease 14 | 918
Amyotrophic Lateral Sclerosis 13 | 432
Atopic dermatitis 13 | 944
Mammary Neoplasms 13 | 410
cutaneous lupus erythematosus 13 | 1,056
dermatomyositis 13 | 966
posterior fossa group B ependymoma 13 | 1,530
Intellectual disability 12 | 573
Waldenstrons macroglobulinemia 12 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
gastric carcinoma 12 | 832
primary Sjogren syndrome 12 | 788
spina bifida 12 | 1,064
Endometriosis 11 | 535
Kidney disease 11 | 397
Prostatic Neoplasms 11 | 471
nasopharyngeal carcinoma 11 | 1,056
Melanoma 10 | 261
Obesity 10 | 616
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
chronic lymphosyte leukemia 9 | 232
esophageal adenocarcinoma 9 | 737
Colorectal Neoplasms 8 | 217
Congenital heart disease 8 | 63
Duchenne muscular dystrophy 8 | 602
Lung Neoplasms 8 | 171
Peripheral Neuropathy 8 | 303
inflammatory breast cancer 8 | 404
pancreatic carcinoma 8 | 567
Neoplasm Invasiveness 7 | 127
Polycystic Ovary Syndrome 7 | 334
X-linked cerebral adrenoleukodystrophy 7 | 115
aldosterone-producing adenoma 7 | 664
gastric cancer 7 | 436
tuberculosis and treatment for 6 months 7 | 686
Bipolar Disorder 6 | 266
Down syndrome 6 | 548
Infertility 6 | 163
Juvenile arthritis 6 | 124
Stomach Neoplasms 6 | 282
atypical teratoid/rhabdoid tumor 6 | 1,095
chronic lymphocytic leukemia 6 | 244
chronic rhinosinusitis 6 | 512
fibroadenoma 6 | 557
nephrosclerosis 6 | 329
non primary Sjogren syndrome sicca 6 | 840
progressive supranuclear palsy 6 | 674
hepatocellular carcinoma 5 | 550
pterygium 5 | 74

Tissue

Nervous System 182 | 18,560
Digestive Tract 181 | 18,472
Endocrine System 181 | 18,511
Female tissues 181 | 18,646
Skin and soft tissues 180 | 18,114
Urinary Tract 180 | 18,443
Male tissues 178 | 17,968
Liver and Pancreas 177 | 18,135
Cardiovascular System 176 | 17,957
Blood and immune system 175 | 17,994
Respiratory system 170 | 17,483

Target Family

Transcription Factor 125 | 1,400
Non-IDG 38 | 11,969
Enzyme 8 | 4,146
Epigenetic 5 | 242
Nuclear Receptor 4 | 48
Kinase 3 | 634
TF/Epigenetic 1 | 38

GO Component

transcription factor complex 184 | 184
nucleus 5,106 | 5,106
cytoplasm 4,984 | 4,984
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,264 | 3,264
extracellular exosome 2,757 | 2,757
nucleoplasm 2,716 | 2,716
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 536 | 536
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SKI family transcriptional corepressor 2 SKOR2 Tbio Non-IDG -0.51537 4.32 50
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.58936 5.14 132
Dachshund homolog 2 DACH2 Tbio Non-IDG -0.93745 8.59 121
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.04240 90.2 423
Mediator of RNA polymerase II transcription subunit 7 MED7 Tbio Enzyme -1.04585 10.2 155
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.89468 62.9 159
POU domain, class 5, transcription factor 1 POU5F1 Tbio Transcription Factor -3.28009 1980.8 817
Influenza virus NS1A-binding protein IVNS1ABP Tbio Non-IDG -0.94782 10.1 76
Mediator of RNA polymerase II transcription subunit 23 MED23 Tbio Enzyme -1.42178 30.0 128
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961