Development Level

Tbio 102 | 10,625
Tchem 15 | 1,890
Tdark 6 | 7,003
Tclin 1 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 5 | 633
decreased lean body mass 4 | 195
abnormal bone structure 3 | 131
abnormal sleep behavior 3 | 63
decreased circulating HDL chol... 3 | 77
embryonic lethality prior to t... 3 | 187
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased total body fat amoun... 2 | 186
increased bone mineral content 2 | 92
increased grip strength 2 | 83
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal duodenum morphology 1 | 1
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal iris transilluminatio... 1 | 1
abnormal limb bud morphology 1 | 15
abnormal lung morphology 1 | 15
abnormal placenta size 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 17
absent heartbeat 1 | 6
anophthalmia 1 | 20
brachydactyly 1 | 2
decreased B cell number 1 | 30
decreased CD11b-low dendritic ... 1 | 3
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased NK T cell number 1 | 28
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased startle reflex 1 | 48
enlarged epididymis 1 | 27
enlarged heart 1 | 111
hydrometra 1 | 13
impaired righting response 1 | 19
increased CD11b-high dendritic... 1 | 5
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
male infertility 1 | 62
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13

Disease

ovarian cancer 75 | 8,492
osteosarcoma 70 | 7,933
psoriasis 64 | 6,685
medulloblastoma, large-cell 61 | 6,234
glioblastoma 52 | 5,572
atypical teratoid / rhabdoid tumor 40 | 4,369
lung cancer 33 | 4,473
malignant mesothelioma 33 | 3,163
lung carcinoma 32 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,988
pilocytic astrocytoma 28 | 3,086
subependymal giant cell astrocytoma 27 | 2,287
Pick disease 26 | 1,893
Carcinoma 24 | 2,147
Breast cancer 23 | 3,099
primitive neuroectodermal tumor 23 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
invasive ductal carcinoma 22 | 2,950
pediatric high grade glioma 22 | 2,712
non-small cell lung cancer 21 | 2,798
oligodendroglioma 21 | 2,849
adult high grade glioma 20 | 2,148
ependymoma 20 | 2,514
astrocytic glioma 19 | 2,241
astrocytoma 19 | 1,493
interstitial cystitis 19 | 2,299
cystic fibrosis 17 | 1,670
medulloblastoma 17 | 1,524
group 3 medulloblastoma 16 | 2,254
lung adenocarcinoma 16 | 2,714
Multiple myeloma 15 | 1,328
pancreatic cancer 15 | 2,300
Cancer 14 | 2,346
dermatomyositis 14 | 967
group 4 medulloblastoma 14 | 1,875
tuberculosis 14 | 1,563
Alzheimer's disease 13 | 644
Neurodegenerative disease 12 | 383
colon cancer 12 | 1,475
pituitary cancer 12 | 1,972
ulcerative colitis 12 | 2,087
ductal carcinoma in situ 11 | 1,745
primary pancreatic ductal adenocarcinoma 11 | 1,271
Waldenstrons macroglobulinemia 10 | 765
breast carcinoma 10 | 1,614
diabetes mellitus 10 | 1,663
juvenile dermatomyositis 10 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
tuberculosis and treatment for 6 months 10 | 686
posterior fossa group A ependymoma 9 | 1,511
posterior fossa group B ependymoma 9 | 1,530
active Crohn's disease 8 | 918
adrenocortical carcinoma 8 | 1,427
nasopharyngeal carcinoma 8 | 1,056
progressive supranuclear palsy 8 | 674
Intellectual disability 7 | 573
Parkinson's disease 7 | 364
Rheumatoid Arthritis 7 | 1,171
acute myeloid leukemia 7 | 785
acute quadriplegic myopathy 7 | 1,157
gastric carcinoma 7 | 832
hereditary spastic paraplegia 7 | 313
primary Sjogren syndrome 7 | 789
sonic hedgehog group medulloblastoma 7 | 1,482
spina bifida 7 | 1,064
IGA Glomerulonephritis 6 | 454
atypical teratoid/rhabdoid tumor 6 | 1,095
esophageal adenocarcinoma 6 | 737
interstitial lung disease 6 | 292
mucosa-associated lymphoid tissue lymphoma 6 | 480
Dementia 5 | 129
Microcephaly 5 | 149
Multiple Sclerosis 5 | 498
active ulcerative colitis 5 | 477
aldosterone-producing adenoma 5 | 664
cutaneous lupus erythematosus 5 | 1,056
non primary Sjogren syndrome sicca 5 | 840
pancreatic carcinoma 5 | 567
Amyloidosis 4 | 68
Amyotrophic Lateral Sclerosis 4 | 432
Bipolar Disorder 4 | 266
Disease Progression 4 | 125
Duchenne muscular dystrophy 4 | 602
Epilepsy 4 | 346
Gaucher disease type 1 4 | 171
Hermansky-Pudlak syndrome 4 | 43
Kidney disease 4 | 397
Oculocerebrorenal syndrome 4 | 24
Prostatic Neoplasms 4 | 471
Schizophrenia 4 | 503
Tetanus 4 | 66
Toxic encephalopathy 4 | 131
Vascular disease 4 | 281
chronic lymphocytic leukemia 4 | 244
chronic rhinosinusitis 4 | 512
fibroadenoma 4 | 557
limb girdle muscular dystrophy 2A 4 | 156
Becker muscular dystrophy 3 | 187
Endometriosis 3 | 535

Tissue

Nervous System 124 | 18,561
Urinary Tract 124 | 18,444
Cardiovascular System 123 | 17,958
Digestive Tract 123 | 18,473
Endocrine System 123 | 18,512
Female tissues 123 | 18,647
Blood and immune system 122 | 17,995
Liver and Pancreas 122 | 18,136
Male tissues 122 | 17,969
Respiratory system 122 | 17,484
Skin and soft tissues 122 | 18,115

Target Family

Non-IDG 76 | 11,969
Enzyme 36 | 4,146
Transporter 8 | 473
GPCR 2 | 408
Kinase 2 | 634

GO Component

trans-Golgi network 124 | 124
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein chibby homolog 1 CBY1 Tbio Non-IDG -2.28288 192.4 61
Nucleobindin-1 NUCB1 Tbio Non-IDG -2.69747 485.4 129
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 ARAP1 Tbio Non-IDG -0.97819 13.6 86
Phospholipid-transporting ATPase IA ATP8A1 Tbio Transporter -1.55308 34.3 33
ProSAAS PCSK1N Tbio Non-IDG -2.23680 169.4 66
Ataxin-2 ATXN2 Tbio Non-IDG -2.28893 208.6 178
Syntaxin-4 STX4 Tbio Non-IDG -1.93051 79.1 192
Golgin subfamily A member 4 GOLGA4 Tbio Non-IDG -1.67978 44.4 51
Kelch-like protein 20 KLHL20 Tbio Non-IDG -0.70425 7.77 71
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase GCNT1 Tchem Enzyme -1.96073 91.9 156