Development Level

Tbio 108 | 11,651
Tchem 12 | 1,388
Tdark 10 | 6,593
Tclin 1 | 612

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased total body fat amoun... 3 | 207
preweaning lethality, incomple... 3 | 499
abnormal eye morphology 2 | 68
abnormal response to new envir... 2 | 10
abnormal sleep behavior 2 | 70
abnormal tail movements 2 | 12
decreased body weight 2 | 161
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased grip strength 2 | 116
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased startle reflex 2 | 112
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal duodenum morphology 1 | 4
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal iris transilluminatio... 1 | 2
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
alopecia 1 | 1
brachydactyly 1 | 19
decreased B cell number 1 | 5
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
hydrometra 1 | 53
hyperactivity 1 | 148
impaired righting response 1 | 26
increased IgG2b level 1 | 1
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
mammalian phenotype 1 | 17
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 85 | 11,493
ovarian cancer 80 | 8,520
osteosarcoma 70 | 7,950
psoriasis 65 | 6,694
medulloblastoma, large-cell 59 | 6,241
glioblastoma 53 | 5,792
atypical teratoid / rhabdoid tumor 42 | 5,112
adult high grade glioma 36 | 3,801
lung cancer 36 | 4,740
malignant mesothelioma 36 | 3,232
ependymoma 32 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
lung carcinoma 30 | 2,843
Astrocytoma, Pilocytic 29 | 3,081
Kidney cancer 29 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
Pick disease 28 | 1,894
subependymal giant cell astrocytoma 27 | 2,287
group 3 medulloblastoma 26 | 4,104
astrocytic glioma 25 | 2,597
Breast cancer 23 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
invasive ductal carcinoma 21 | 2,951
primitive neuroectodermal tumor 21 | 3,035
tuberculosis 21 | 2,010
interstitial cystitis 19 | 2,312
non-small cell lung cancer 19 | 2,890
oligodendroglioma 19 | 2,850
Multiple myeloma 17 | 1,332
group 4 medulloblastoma 16 | 1,855
cystic fibrosis 15 | 1,696
pancreatic cancer 15 | 2,398
Alzheimer's disease 14 | 658
Intellectual disability 13 | 1,016
colon cancer 13 | 1,478
dermatomyositis 13 | 966
lung adenocarcinoma 13 | 2,716
pituitary cancer 13 | 1,972
ulcerative colitis 13 | 1,819
Cancer 12 | 2,499
Neurodegenerative disease 12 | 414
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Schizophrenia 11 | 1,160
Waldenstrons macroglobulinemia 11 | 765
breast carcinoma 11 | 1,638
diabetes mellitus 11 | 1,728
ductal carcinoma in situ 11 | 1,745
juvenile dermatomyositis 11 | 1,187
Epilepsy 10 | 792
astrocytoma 10 | 1,146
primary pancreatic ductal adenocarcinoma 10 | 1,109
Autosomal recessive predisposition 8 | 1,442
Parkinson's disease 8 | 392
Seizures 8 | 596
active Crohn's disease 8 | 922
acute myeloid leukemia 8 | 783
acute quadriplegic myopathy 8 | 1,158
adrenocortical carcinoma 8 | 1,428
nasopharyngeal carcinoma 8 | 1,058
pediatric high grade glioma 8 | 1,064
progressive supranuclear palsy 8 | 676
Bipolar Disorder 7 | 666
Cataract 7 | 297
Cataract 8 multiple types 7 | 33
Cognitive delay 7 | 608
Dementia 7 | 175
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Oculocerebrorenal syndrome 7 | 29
Rheumatoid arthritis 7 | 1,191
cutaneous lupus erythematosus 7 | 1,057
hereditary spastic paraplegia 7 | 318
spina bifida 7 | 1,074
Depressive disorder 6 | 409
Liver Cirrhosis, Experimental 6 | 769
Liver cancer 6 | 604
Melanoma 6 | 711
Microcephaly 6 | 166
Multiple Sclerosis 6 | 540
Skin cancer 6 | 469
Toxic encephalopathy 6 | 141
esophageal adenocarcinoma 6 | 737
mucosa-associated lymphoid tissue lymphoma 6 | 484
non primary Sjogren syndrome sicca 6 | 891
tuberculosis and treatment for 6 months 6 | 409
Chronic Lymphocytic Leukemia 5 | 262
Down syndrome 5 | 499
Dull intelligence 5 | 645
Lens Opacities 5 | 231
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
aldosterone-producing adenoma 5 | 665
gastric cancer 5 | 459
gastric carcinoma 5 | 807
hepatocellular carcinoma 5 | 547
limb girdle muscular dystrophy 2A 5 | 213
pancreatic carcinoma 5 | 562
sonic hedgehog group medulloblastoma 5 | 467

Tissue

Endocrine System 130 | 18,159
Female tissues 130 | 17,400
Digestive Tract 129 | 17,369
Skin and soft tissues 129 | 17,230
Nervous System 128 | 16,725
Liver and Pancreas 127 | 16,750
Male tissues 127 | 17,142
Respiratory system 127 | 16,393
Blood and immune system 126 | 16,909
Urinary Tract 126 | 16,678
Cardiovascular System 124 | 15,192

Target Family

Non-IDG 83 | 12,091
Enzyme 36 | 4,145
Transporter 7 | 473
Kinase 3 | 634
GPCR 2 | 408

GO Component

trans-Golgi network 131 | 131
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
RNA binding protein fox-1 homolog 1 RBFOX1 Tbio Non-IDG -2.00815 99.2 207
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
AP-4 complex subunit beta-1 AP4B1 Tbio Non-IDG -0.79214 6.23 124
Phosphatidylinositol 4-kinase type 2-alpha PI4K2A Tbio Kinase -2.88003 745.1 146
Synaptotagmin-17 SYT17 Tbio Non-IDG -0.77330 6.07 106
Pleckstrin homology domain-containing family J member 1 PLEKHJ1 Tbio Non-IDG 0.70 0.18 107
ADP-ribosylation factor-binding protein GGA2 GGA2 Tbio Non-IDG -1.43055 25.6 142