Development Level

Tbio 63 | 10,625
Tclin 10 | 602
Tchem 9 | 1,890
Tdark 3 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 2 | 37

IMPC Phenotype

abnormal behavior 5 | 226
decreased bone mineral content 4 | 157
decreased grip strength 4 | 123
preweaning lethality, complete... 4 | 633
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
hypoactivity 3 | 89
short tibia 3 | 82
decreased circulating insulin ... 2 | 75
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
increased bone mineral content 2 | 92
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
increased total body fat amoun... 2 | 57
preweaning lethality, incomple... 2 | 260
thrombocytopenia 2 | 46
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal kidney morphology 1 | 30
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased vertical activity 1 | 22
enlarged epididymis 1 | 27
hemorrhage 1 | 12
immune system phenotype 1 | 17
improved glucose tolerance 1 | 56
increased body weight 1 | 42
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
limb grasping 1 | 35
long tibia 1 | 13
shortened RR interval 1 | 19
small spleen 1 | 11
tremors 1 | 34

Disease

medulloblastoma, large-cell 46 | 6,234
pilocytic astrocytoma 42 | 3,086
glioblastoma 41 | 5,572
ovarian cancer 41 | 8,491
osteosarcoma 39 | 7,933
oligodendroglioma 37 | 2,849
lung carcinoma 33 | 2,844
atypical teratoid / rhabdoid tumor 31 | 4,369
psoriasis 31 | 6,685
primitive neuroectodermal tumor 30 | 3,031
pediatric high grade glioma 29 | 2,712
Pick disease 26 | 1,893
astrocytoma 26 | 1,493
subependymal giant cell astrocytoma 25 | 2,287
ependymoma 19 | 2,514
Alzheimer's disease 18 | 644
lung cancer 18 | 4,473
malignant mesothelioma 17 | 3,163
Schizophrenia 16 | 503
posterior fossa group B ependymoma 16 | 1,530
Breast cancer 15 | 3,098
astrocytic glioma 15 | 2,241
sonic hedgehog group medulloblastoma 14 | 1,482
Carcinoma 13 | 2,147
Epilepsy 13 | 346
Parkinson's disease 13 | 364
group 3 medulloblastoma 13 | 2,254
lung adenocarcinoma 13 | 2,714
posterior fossa group A ependymoma 13 | 1,511
adult high grade glioma 12 | 2,148
atypical teratoid/rhabdoid tumor 12 | 1,095
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
invasive ductal carcinoma 12 | 2,950
group 4 medulloblastoma 11 | 1,875
medulloblastoma 11 | 1,524
Intellectual disability 10 | 573
Multiple myeloma 10 | 1,327
cystic fibrosis 10 | 1,670
interstitial cystitis 10 | 2,299
tuberculosis 10 | 1,563
Cancer 9 | 2,346
Neurodegenerative disease 9 | 383
Toxic encephalopathy 9 | 131
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
pituitary cancer 9 | 1,972
ulcerative colitis 9 | 2,087
Autistic Disorder 8 | 320
aldosterone-producing adenoma 8 | 664
colon cancer 8 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
pancreatic cancer 8 | 2,300
Bipolar Disorder 7 | 266
Tetanus 7 | 66
Waldenstrons macroglobulinemia 7 | 764
diabetes mellitus 7 | 1,663
ductal carcinoma in situ 7 | 1,745
non-small cell lung cancer 7 | 2,798
Botulism 6 | 20
acute myeloid leukemia 6 | 785
adrenocortical carcinoma 6 | 1,427
cutaneous lupus erythematosus 6 | 1,056
non-small cell lung carcinoma 6 | 413
pancreatic carcinoma 6 | 567
Brain disease 5 | 84
Diarrhea 5 | 155
Huntington's disease 5 | 72
Parkinson Disease 5 | 105
Rheumatoid Arthritis 5 | 1,170
gastric cancer 5 | 436
glioblastoma multiforme 5 | 347
Amyotrophic Lateral Sclerosis 4 | 432
Anemia 4 | 252
Cocaine-Related Disorders 4 | 88
Dementia 4 | 129
General anesthesia 4 | 53
Nerve Degeneration 4 | 73
Neuropathy 4 | 210
Parkinsonian Disorders 4 | 23
breast carcinoma 4 | 1,614
non primary Sjogren syndrome sicca 4 | 840
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
spina bifida 4 | 1,064
Attention deficit hyperactivity disorder 3 | 156
Cerebrovascular disease 3 | 231
Down syndrome 3 | 548
Duchenne muscular dystrophy 3 | 602
Endometriosis 3 | 535
Lennox-Gastaut syndrome 3 | 34
Local anesthesia 3 | 40
Morphine dependence 3 | 19
Myocardial Ischemia 3 | 169
Parkinsonism 3 | 19
Simple partial seizure 3 | 26
active Crohn's disease 3 | 918
acute quadriplegic myopathy 3 | 1,157
dermatomyositis 3 | 966
head and neck cancer 3 | 270
head and neck cancer and chronic obstructive pulmonary disease 3 | 237
juvenile dermatomyositis 3 | 1,189
progressive supranuclear palsy 3 | 674

Tissue

Blood and immune system 85 | 17,994
Cardiovascular System 85 | 17,957
Digestive Tract 85 | 18,472
Endocrine System 85 | 18,511
Female tissues 85 | 18,646
Liver and Pancreas 85 | 18,135
Male tissues 85 | 17,968
Nervous System 85 | 18,560
Skin and soft tissues 85 | 18,114
Urinary Tract 85 | 18,443
Respiratory system 84 | 17,483

Target Family

Non-IDG 57 | 11,969
Enzyme 15 | 4,146
Ion Channel 5 | 341
Transporter 5 | 473
Kinase 2 | 634
Epigenetic 1 | 242

GO Component

synaptic vesicle 85 | 85
nucleus 5,106 | 5,106
cytoplasm 4,984 | 4,984
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,264 | 3,264
extracellular exosome 2,757 | 2,757
nucleoplasm 2,716 | 2,716
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 536 | 536
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 16 CDK16 Tchem Kinase -1.43415 32.3 122
Synaptotagmin-7 SYT7 Tbio Non-IDG -1.72363 48.4 144
H(+)/Cl(-) exchange transporter 3 CLCN3 Tchem Ion Channel -2.25773 194.9 155
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.50812 310.3 171
Cortactin-binding protein 2 CTTNBP2 Tbio Non-IDG -2.42021 262.8 51
Orexin HCRT Tbio Non-IDG -3.24848 2104.5 162
Glutamate receptor 1 GRIA1 Tclin Ion Channel -3.15085 1376.5 691
Synaptic vesicle 2-related protein SVOP Tdark Non-IDG -0.56848 4.29 80
Disrupted in schizophrenia 1 protein DISC1 Tbio Non-IDG -2.38042 270.6 428
Vesicle transport through interaction with t-SNAREs homolog 1B VTI1B Tbio Non-IDG -1.83815 59.8 152