Development Level

Tbio 75 | 11,445
Tchem 6 | 1,598
Tclin 3 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 5 | 187
abnormal coat-hair pigmentatio... 3 | 64
abnormal retina morphology 3 | 71
decreased bone mineral content 3 | 151
edema 3 | 59
hyperactivity 3 | 148
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal sleep behavior 2 | 70
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating triglyce... 2 | 79
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
impaired pupillary reflex 2 | 26
increased circulating calcium ... 2 | 34
increased vertical activity 2 | 24
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal digit morphology 1 | 10
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal retinal inner nuclear... 1 | 8
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 12
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
fused cornea and lens 1 | 5
fused phalanges 1 | 1
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 66 | 11,493
osteosarcoma 51 | 7,950
ovarian cancer 51 | 8,520
glioblastoma 44 | 5,792
psoriasis 41 | 6,694
atypical teratoid / rhabdoid tumor 36 | 5,112
medulloblastoma, large-cell 36 | 6,241
ependymoma 33 | 4,679
Astrocytoma, Pilocytic 31 | 3,081
Cancer 31 | 2,499
lung cancer 31 | 4,740
Breast cancer 30 | 3,578
adult high grade glioma 29 | 3,801
invasive ductal carcinoma 28 | 2,951
pancreatic cancer 28 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
Kidney cancer 24 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
lung adenocarcinoma 24 | 2,716
group 3 medulloblastoma 21 | 4,104
malignant mesothelioma 20 | 3,232
subependymal giant cell astrocytoma 20 | 2,287
astrocytic glioma 19 | 2,597
ductal carcinoma in situ 19 | 1,745
lung carcinoma 19 | 2,843
non-small cell lung cancer 19 | 2,890
oligodendroglioma 19 | 2,850
primitive neuroectodermal tumor 19 | 3,035
interstitial cystitis 17 | 2,312
ulcerative colitis 17 | 1,819
colon cancer 16 | 1,478
group 4 medulloblastoma 16 | 1,855
primary pancreatic ductal adenocarcinoma 16 | 1,109
tuberculosis 16 | 2,010
Pick disease 15 | 1,894
pituitary cancer 15 | 1,972
Liver Cirrhosis, Experimental 13 | 769
gastric carcinoma 13 | 807
cystic fibrosis 12 | 1,696
juvenile dermatomyositis 11 | 1,187
Duchenne muscular dystrophy 10 | 601
acute quadriplegic myopathy 10 | 1,158
diabetes mellitus 10 | 1,728
Down syndrome 9 | 499
astrocytoma 9 | 1,146
esophageal adenocarcinoma 9 | 737
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
spina bifida 9 | 1,074
Intellectual disability 8 | 1,016
Rheumatoid arthritis 8 | 1,191
active Crohn's disease 8 | 922
adrenocortical carcinoma 8 | 1,428
aldosterone-producing adenoma 8 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
breast carcinoma 8 | 1,638
mucosa-associated lymphoid tissue lymphoma 8 | 484
sonic hedgehog group medulloblastoma 8 | 467
Atopic dermatitis 7 | 952
Autosomal recessive predisposition 7 | 1,442
Liver cancer 7 | 604
Neoplasm Invasiveness 7 | 161
cutaneous lupus erythematosus 7 | 1,057
dermatomyositis 7 | 966
pediatric high grade glioma 7 | 1,064
Aarskog syndrome 6 | 12
Alzheimer's disease 6 | 658
Becker muscular dystrophy 6 | 191
Osteoporosis 6 | 363
Schizophrenia 6 | 1,160
active ulcerative colitis 6 | 764
pancreatic carcinoma 6 | 562
Amyotrophic lateral sclerosis 5 | 451
Bipolar Disorder 5 | 666
Carcinoma, Squamous Cell 5 | 110
Kidney disease 5 | 430
Mental Depression 5 | 333
Multiple myeloma 5 | 1,332
Oculocerebrorenal syndrome 5 | 29
Squamous cell carcinoma 5 | 129
Weight Gain 5 | 100
limb girdle muscular dystrophy 2A 5 | 213
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
primary Sjogren syndrome 5 | 735
progressive supranuclear palsy 5 | 676
Dull intelligence 4 | 645
Endometriosis 4 | 540
Epilepsy 4 | 792
Mental deficiency 4 | 645
Mesothelioma, Malignant 4 | 105
Neurodegenerative disease 4 | 414
Polycystic ovary syndrome 4 | 360
Poor school performance 4 | 645
Proteinuria 4 | 144
Seizures 4 | 596
acute myeloid leukemia 4 | 783
chronic lymphosyte leukemia 4 | 204
chronic rhinosinusitis 4 | 512
hepatocellular carcinoma 4 | 547

Tissue

Blood and immune system 87 | 16,909
Endocrine System 87 | 18,159
Female tissues 87 | 17,400
Liver and Pancreas 87 | 16,750
Male tissues 87 | 17,142
Respiratory system 87 | 16,393
Skin and soft tissues 87 | 17,230
Digestive Tract 86 | 17,369
Nervous System 86 | 16,725
Urinary Tract 86 | 16,678
Cardiovascular System 85 | 15,192

Target Family

Non-IDG 68 | 12,091
Enzyme 12 | 4,145
Kinase 5 | 634
Ion Channel 1 | 344
Transporter 1 | 473

GO Component

ruffle 87 | 87
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
Palladin PALLD Tbio Non-IDG -2.73002 528.8 164
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 ARAP3 Tbio Non-IDG -0.96067 13.8 85
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Transient receptor potential cation channel subfamily M member 7 TRPM7 Tchem Ion Channel -2.53154 365.5 317
Talin-2 TLN2 Tbio Non-IDG -1.36153 20.0 101
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
FERM domain-containing protein 4B FRMD4B Tdark Non-IDG -0.63178 4.93 32
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47