Development Level

Tchem 4 | 1,598
Tbio 3 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
absent vibrissae 1 | 12
decreased bone mineral content 1 | 151
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
small superior vagus ganglion 1 | 74

Disease

Cancer 6 | 2,499
Carcinoma 5 | 11,493
ovarian cancer 5 | 8,520
glioblastoma 4 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung cancer 4 | 4,740
Autoimmune lymphoproliferative syndrome 3 | 11
Autoimmune lymphoproliferative syndrome type 2B 3 | 9
cutaneous lupus erythematosus 3 | 1,057
lung carcinoma 3 | 2,843
osteosarcoma 3 | 7,950
psoriasis 3 | 6,694
Astrocytoma, Pilocytic 2 | 3,081
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Breast cancer 2 | 3,578
Melanoma 2 | 711
Reperfusion Injury 2 | 86
Skin Neoplasms 2 | 69
Somatic mutation 2 | 61
Splenomegaly 2 | 190
Stomach Neoplasms 2 | 300
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
interstitial cystitis 2 | 2,312
Adenocarcinoma 1 | 122
Anti-nuclear factor positive 1 | 18
Antiphospholipid antibody positivity 1 | 4
Autoimmune hemolytic anemia 1 | 31
Autoimmune thrombocytopenia 1 | 22
Breast Neoplasms 1 | 445
Calcinosis 1 | 70
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, squamous cell of head and neck 1 | 31
Caspase-8 deficiency 1 | 1
Cerebral Hemorrhage 1 | 42
Chemical and Drug Induced Liver Injury 1 | 195
Chronic diarrhea 1 | 29
Colorectal Neoplasms 1 | 243
Congenital atresia of pulmonary artery 1 | 5
Craniofacial Abnormalities 1 | 151
Decreased T cell activation 1 | 4
Defective B cell activation 1 | 1
Defective lymphocyte apoptosis 1 | 4
Degenerative brain disorder 1 | 100
Eczema 1 | 45
Edema 1 | 81
Elevated serum IgA 1 | 5
Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere 1 | 5
Encephalopathies 1 | 43
Eosinophilia 1 | 28
Esophageal Neoplasms 1 | 69
Fatty Liver 1 | 70
Follicular hyperplasia 1 | 4
Gastric Cancer, Hereditary Diffuse 1 | 12
Gaucher disease type 1 1 | 180
HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 1 | 5
Hearing Loss, Sensorineural 1 | 11
Heart Valve Diseases 1 | 25
Heart valve disease 1 | 39
Herpes encephalitis 1 | 6
Hodgkin Disease 1 | 15
Idiopathic thrombocytopenia 1 | 22
Immune thrombocytopenic purpura 1 | 24
Increased IgM levels 1 | 16
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Iron deficiency anemia 1 | 12
Lymphadenopathy 1 | 62
Lymphoma 1 | 81
Lymphoma, Extranodal NK-T-Cell 1 | 2
Lymphoma, Non-Hodgkin 1 | 24
MYELODYSPLASTIC SYNDROME 1 | 53
Mammary Neoplasms 1 | 425
Micronodular cirrhosis 1 | 12
Myelodysplastic Syndromes 1 | 26
Myocardial Reperfusion Injury 1 | 37
Neoplasm Metastasis 1 | 168
Neoplasm of stomach 1 | 11
Nephritis 1 | 51
Nephrotic Syndrome 1 | 78
Papillomavirus Infections 1 | 3
Platelet antibody positive 1 | 4
Pneumoconiosis 1 | 15
Reactive airway disease 1 | 21
Recurrent infections 1 | 48
Recurrent sinopulmonary infections 1 | 6
Respiratory Syncytial Virus Infections 1 | 5
Rift Valley fever 1 | 14
Squamous cell carcinoma of the head and neck 1 | 29
Stomach Carcinoma 1 | 11
Stomach cancer 1 | 30
Subacute progressive viral hepatitis 1 | 9
Supratentorial atrophy 1 | 94
Uterine Cervical Neoplasm 1 | 25
Uterine Cervical Neoplasms 1 | 26
Vitiligo 1 | 73
esophageal cancer 1 | 22
non-small cell lung carcinoma 1 | 317

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Non-IDG 3 | 12,091
Enzyme 2 | 4,145
Kinase 2 | 634

GO Component

ripoptosome 7 | 7
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.22748 161.7 603
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
TIR domain-containing adapter molecule 1 TICAM1 Tbio Non-IDG -1.50467 33.0 226
CASP8 and FADD-like apoptosis regulator CFLAR Tbio Non-IDG -2.89793 871.7 683
Caspase-10 CASP10 Tchem Enzyme -1.97653 89.1 457
FAS-associated death domain protein FADD Tbio Non-IDG -2.70083 469.8 708