Development Level

Tbio 58 | 11,651
Tclin 34 | 612
Tchem 32 | 1,388
Tdark 8 | 6,593

Collection

RFA-RM-18-021 10 | 328
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 2 | 25
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 7 | 220
preweaning lethality, incomple... 7 | 499
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
abnormal behavior 4 | 298
decreased heart weight 4 | 27
decreased prepulse inhibition 4 | 82
abnormal bone structure 3 | 187
decreased bone mineral content 3 | 151
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
increased circulating HDL chol... 3 | 80
abnormal kidney morphology 2 | 65
abnormal pericardium morpholog... 2 | 26
abnormal sleep behavior 2 | 70
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased eosinophil cell numb... 2 | 11
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
pallor 2 | 34
small superior vagus ganglion 2 | 74
abnormal brain morphology 1 | 13
abnormal cecum morphology 1 | 7
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal limb bud morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal vertebrae morphology 1 | 18
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged uterus 1 | 11
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased vertical activity 1 | 24
microphthalmia 1 | 26
pale yolk sac 1 | 25
premature death 1 | 5
scaly skin 1 | 4
short tibia 1 | 97
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
small testis 1 | 58
thick skin 1 | 4
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 116 | 11,493
ovarian cancer 69 | 8,520
osteosarcoma 66 | 7,950
psoriasis 63 | 6,694
medulloblastoma, large-cell 62 | 6,241
glioblastoma 61 | 5,792
lung cancer 60 | 4,740
Breast cancer 50 | 3,578
atypical teratoid / rhabdoid tumor 49 | 5,112
Cancer 48 | 2,499
Kidney cancer 48 | 2,613
ependymoma 46 | 4,679
invasive ductal carcinoma 41 | 2,951
lung carcinoma 41 | 2,843
lung adenocarcinoma 40 | 2,716
non-small cell lung cancer 40 | 2,890
malignant mesothelioma 39 | 3,232
adult high grade glioma 38 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
Astrocytoma, Pilocytic 37 | 3,081
group 3 medulloblastoma 37 | 4,104
pancreatic cancer 35 | 2,398
interstitial cystitis 34 | 2,312
Autosomal recessive predisposition 29 | 1,442
ductal carcinoma in situ 29 | 1,745
primitive neuroectodermal tumor 28 | 3,035
breast carcinoma 27 | 1,638
Schizophrenia 26 | 1,160
astrocytic glioma 26 | 2,597
pituitary cancer 26 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
oligodendroglioma 25 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
ulcerative colitis 24 | 1,819
cystic fibrosis 23 | 1,696
diabetes mellitus 22 | 1,728
Obesity 21 | 678
Pick disease 19 | 1,894
adrenocortical carcinoma 19 | 1,428
tuberculosis 19 | 2,010
Hypertension 18 | 396
Liver cancer 18 | 604
Prostatic Neoplasms 18 | 495
group 4 medulloblastoma 18 | 1,855
subependymal giant cell astrocytoma 18 | 2,287
Alzheimer's disease 16 | 658
Melanoma 16 | 711
astrocytoma 16 | 1,146
primary pancreatic ductal adenocarcinoma 16 | 1,109
Liver Cirrhosis, Experimental 15 | 769
colon cancer 15 | 1,478
cutaneous lupus erythematosus 15 | 1,057
Breast Neoplasms 14 | 445
Epilepsy 14 | 792
Hypertensive disease 14 | 292
Major Depressive Disorder 14 | 301
Orbital separation excessive 14 | 244
Short stature 14 | 531
Skin cancer 14 | 469
Bipolar Disorder 13 | 666
Mammary Neoplasms 13 | 425
Coronary artery disease 12 | 268
Depressive disorder 12 | 409
Hypoplastic mandible condyle 12 | 275
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Unipolar Depression 12 | 250
fibroadenoma 12 | 559
gastric carcinoma 12 | 807
mucosa-associated lymphoid tissue lymphoma 12 | 484
pediatric high grade glioma 12 | 1,064
Lung Neoplasms 11 | 232
Mental Depression 11 | 333
Muscle hypotonia 11 | 571
pancreatic carcinoma 11 | 562
Down syndrome 10 | 499
Dull intelligence 10 | 645
Intellectual disability 10 | 1,016
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
nasopharyngeal carcinoma 10 | 1,058
spina bifida 10 | 1,074
Asthma 9 | 385
Atherosclerosis 9 | 291
Autistic Disorder 9 | 364
Diarrhea 9 | 253
Endometriosis 9 | 540
Neoplasm Metastasis 9 | 168
Osteoporosis 9 | 363
active ulcerative colitis 9 | 764
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
dermatomyositis 8 | 966
primary Sjogren syndrome 8 | 735

Tissue

Digestive Tract 129 | 17,369
Endocrine System 129 | 18,159
Female tissues 129 | 17,400
Skin and soft tissues 127 | 17,230
Liver and Pancreas 124 | 16,750
Male tissues 124 | 17,142
Nervous System 124 | 16,725
Blood and immune system 122 | 16,909
Urinary Tract 120 | 16,678
Respiratory system 117 | 16,393
Cardiovascular System 110 | 15,192

Target Family

Non-IDG 57 | 12,091
Kinase 26 | 634
GPCR 22 | 408
Ion Channel 11 | 344
Enzyme 8 | 4,145
Nuclear Receptor 4 | 48
Transporter 3 | 473
Transcription Factor 1 | 1,400

GO Component

receptor complex 132 | 132
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fc receptor-like protein 5 FCRL5 Tbio Non-IDG -1.23637 21.0 145
Intelectin-1 ITLN1 Tbio Non-IDG -2.49500 337.0 194
Integrin beta-7 ITGB7 Tclin Non-IDG -1.63572 38.4 374
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
Platelet glycoprotein 4 CD36 Tbio Non-IDG -2.63884 376.0 1155
Pituitary adenylate cyclase-activating polypeptide type I receptor ADCYAP1R1 Tchem GPCR -1.98111 94.8 184
5'-nucleotidase domain-containing protein 3 NT5DC3 Tdark Enzyme -1.73540 54.1 21
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Neurogenic locus notch homolog protein 3 NOTCH3 Tchem Non-IDG -2.67185 458.4 499