Development Level

Tbio 400 | 11,651
Tchem 84 | 1,388
Tclin 34 | 612
Tdark 34 | 6,593

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 54 | 979
embryonic lethality prior to t... 18 | 278
preweaning lethality, incomple... 18 | 499
embryonic lethality prior to o... 17 | 239
abnormal behavior 13 | 298
abnormal embryo size 12 | 220
abnormal bone structure 11 | 187
decreased body weight 11 | 161
decreased total body fat amoun... 10 | 207
increased lean body mass 9 | 172
increased total body fat amoun... 8 | 134
increased circulating alkaline... 7 | 122
decreased bone mineral content 6 | 151
decreased circulating alanine ... 6 | 47
decreased circulating choleste... 6 | 93
decreased circulating glucose ... 6 | 126
decreased circulating serum al... 6 | 82
decreased lean body mass 6 | 135
decreased lymphocyte cell numb... 6 | 83
hypoactivity 6 | 132
increased startle reflex 6 | 112
abnormal heart morphology 5 | 162
abnormal neural tube closure 5 | 46
decreased circulating HDL chol... 5 | 68
decreased circulating alkaline... 5 | 46
decreased leukocyte cell numbe... 5 | 73
decreased mean corpuscular vol... 5 | 79
decreased vertical activity 5 | 208
embryonic growth retardation 5 | 106
hyperactivity 5 | 148
increased neutrophil cell numb... 5 | 46
increased red blood cell distr... 5 | 34
male infertility 5 | 123
short tibia 5 | 97
abnormal embryo turning 4 | 31
abnormal eye morphology 4 | 68
abnormal lens morphology 4 | 81
abnormal retina morphology 4 | 71
cataract 4 | 92
decreased circulating LDL chol... 4 | 38
decreased circulating aspartat... 4 | 34
decreased circulating fructosa... 4 | 30
decreased circulating total pr... 4 | 49
decreased grip strength 4 | 116
decreased hemoglobin content 4 | 68
increased blood urea nitrogen ... 4 | 48
increased circulating bilirubi... 4 | 16
increased circulating sodium l... 4 | 71
increased mean platelet volume 4 | 45
tremors 4 | 39
abnormal gait 3 | 69
abnormal kidney morphology 3 | 65
abnormal spleen morphology 3 | 55
abnormal tooth morphology 3 | 24
decreased body length 3 | 101
decreased eosinophil cell numb... 3 | 24
decreased erythrocyte cell num... 3 | 62
edema 3 | 59
enlarged lymph nodes 3 | 37
enlarged spleen 3 | 41
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased circulating chloride... 3 | 41
increased circulating choleste... 3 | 66
increased circulating glucose ... 3 | 24
increased circulating phosphat... 3 | 26
increased grip strength 3 | 41
increased or absent threshold ... 3 | 101
increased spleen weight 3 | 10
persistence of hyaloid vascula... 3 | 33
thrombocytosis 3 | 27
abnormal locomotor behavior 2 | 24
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating free fat... 2 | 31
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased lactate dehydrogenas... 2 | 16
decreased neutrophil cell numb... 2 | 42
decreased startle reflex 2 | 75
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating calcium ... 2 | 34
increased circulating potassiu... 2 | 29
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
pale yolk sac 2 | 25
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
small testis 2 | 58

Disease

Carcinoma 356 | 11,493
ovarian cancer 338 | 8,520
osteosarcoma 283 | 7,950
psoriasis 247 | 6,694
medulloblastoma, large-cell 227 | 6,241
glioblastoma 209 | 5,792
lung cancer 203 | 4,740
atypical teratoid / rhabdoid tumor 185 | 5,112
Cancer 163 | 2,499
group 3 medulloblastoma 157 | 4,104
ependymoma 151 | 4,679
Breast cancer 149 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 130 | 3,291
malignant mesothelioma 130 | 3,232
adult high grade glioma 123 | 3,801
primitive neuroectodermal tumor 117 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 114 | 2,989
oligodendroglioma 109 | 2,850
non-small cell lung cancer 107 | 2,890
invasive ductal carcinoma 101 | 2,951
pancreatic cancer 101 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 100 | 2,955
subependymal giant cell astrocytoma 100 | 2,287
Astrocytoma, Pilocytic 96 | 3,081
Kidney cancer 95 | 2,613
astrocytic glioma 94 | 2,597
lung adenocarcinoma 94 | 2,716
diabetes mellitus 86 | 1,728
lung carcinoma 85 | 2,843
tuberculosis 80 | 2,010
Multiple myeloma 79 | 1,332
breast carcinoma 75 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 71 | 1,962
ductal carcinoma in situ 70 | 1,745
interstitial cystitis 68 | 2,312
Pick disease 66 | 1,894
astrocytoma 66 | 1,146
Autosomal recessive predisposition 65 | 1,442
Schizophrenia 65 | 1,160
colon cancer 65 | 1,478
ulcerative colitis 65 | 1,819
juvenile dermatomyositis 62 | 1,187
Intellectual disability 60 | 1,016
pituitary cancer 60 | 1,972
Waldenstrons macroglobulinemia 56 | 765
Rheumatoid arthritis 55 | 1,191
acute quadriplegic myopathy 52 | 1,158
cystic fibrosis 52 | 1,696
group 4 medulloblastoma 52 | 1,855
Epilepsy 50 | 792
Alzheimer's disease 49 | 658
primary pancreatic ductal adenocarcinoma 48 | 1,109
Prostatic Neoplasms 45 | 495
adrenocortical carcinoma 44 | 1,428
dermatomyositis 44 | 966
Seizures 42 | 596
Breast Neoplasms 41 | 445
pediatric high grade glioma 41 | 1,064
spina bifida 41 | 1,074
Bipolar Disorder 40 | 666
Dull intelligence 40 | 645
Low intelligence 40 | 645
Mental Retardation 40 | 645
Mental deficiency 40 | 645
Poor school performance 40 | 645
Cognitive delay 39 | 608
Global developmental delay 39 | 608
Mental and motor retardation 39 | 608
cutaneous lupus erythematosus 39 | 1,057
Mammary Neoplasms 38 | 425
Muscle hypotonia 38 | 571
nasopharyngeal carcinoma 38 | 1,058
Kidney disease 36 | 430
Duchenne muscular dystrophy 35 | 601
Melanoma 35 | 711
Obesity 35 | 678
Neurodegenerative disease 34 | 414
primary Sjogren syndrome 33 | 735
Atopic dermatitis 32 | 952
Down syndrome 32 | 499
Liver cancer 32 | 604
Short stature 32 | 531
Liver Cirrhosis, Experimental 31 | 769
active Crohn's disease 30 | 922
progressive supranuclear palsy 30 | 676
Depressive disorder 29 | 409
Parkinson's disease 29 | 392
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 510
Hypertension 28 | 396
Vascular disease 28 | 319
active ulcerative colitis 28 | 764
acute myeloid leukemia 28 | 783
non primary Sjogren syndrome sicca 28 | 891
pancreatic carcinoma 28 | 562
Mental Depression 27 | 333
medulloblastoma 27 | 720
Amyotrophic lateral sclerosis 26 | 451
Cryptorchidism 26 | 296
Endometriosis 26 | 540
esophageal adenocarcinoma 26 | 737

Tissue

Endocrine System 543 | 18,159
Digestive Tract 539 | 17,369
Female tissues 533 | 17,400
Skin and soft tissues 533 | 17,230
Male tissues 529 | 17,142
Urinary Tract 528 | 16,678
Blood and immune system 527 | 16,909
Liver and Pancreas 522 | 16,750
Nervous System 519 | 16,725
Respiratory system 519 | 16,393
Cardiovascular System 505 | 15,192

Target Family

Non-IDG 322 | 12,091
Enzyme 115 | 4,145
Transcription Factor 42 | 1,400
Kinase 33 | 634
Epigenetic 16 | 242
Transporter 8 | 473
Ion Channel 6 | 344
Nuclear Receptor 6 | 48
GPCR 2 | 408
TF/Epigenetic 2 | 38

GO Component

protein complex 552 | 552
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Peptidoglycan recognition protein 4 PGLYRP4 Tbio Non-IDG -0.77368 3.75 126
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Zinc finger and BTB domain-containing protein 17 ZBTB17 Tbio Transcription Factor -1.57508 40.4 92
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
Chromatin assembly factor 1 subunit B CHAF1B Tbio Non-IDG -1.02167 9.99 181
RNA-binding protein 39 RBM39 Tbio Non-IDG -0.95639 9.80 199
Nuclear factor erythroid 2-related factor 1 NFE2L1 Tbio Transcription Factor -1.57346 40.9 157
Deleted in azoospermia protein 1 DAZ1 Tbio Non-IDG -2.24914 176.6 159
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136