Development Level

Tbio 254 | 10,625
Tchem 61 | 1,890
Tclin 20 | 602
Tdark 20 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 28 | 633
embryonic lethality prior to t... 10 | 187
embryonic lethality prior to o... 9 | 148
decreased body weight 8 | 174
decreased lean body mass 7 | 195
abnormal bone structure 6 | 131
decreased circulating alanine ... 6 | 53
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
abnormal embryo size 5 | 112
decreased bone mineral content 5 | 157
decreased circulating HDL chol... 5 | 77
decreased circulating aspartat... 5 | 27
decreased circulating choleste... 5 | 85
decreased circulating total pr... 4 | 41
decreased grip strength 4 | 123
decreased leukocyte cell numbe... 4 | 54
decreased total body fat amoun... 4 | 186
abnormal bone mineralization 3 | 55
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
abnormal spleen morphology 3 | 36
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 49
decreased circulating LDL chol... 3 | 37
decreased circulating alkaline... 3 | 41
decreased circulating fructosa... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
hemorrhage 3 | 12
hypoactivity 3 | 89
increased circulating alkaline... 3 | 119
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
increased or absent threshold ... 3 | 128
abnormal embryo turning 2 | 15
abnormal eye morphology 2 | 38
abnormal limb bud morphology 2 | 15
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal neural tube morpholog... 2 | 8
abnormal snout morphology 2 | 18
decreased body length 2 | 108
decreased circulating chloride... 2 | 32
decreased circulating insulin ... 2 | 75
decreased circulating iron lev... 2 | 25
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
edema 2 | 11
embryonic growth retardation 2 | 28
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating aspartat... 2 | 17
increased circulating bilirubi... 2 | 16
increased circulating glucose ... 2 | 16
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased total body fat amoun... 2 | 57
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
small spleen 2 | 11
small thymus 2 | 11
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal cranium morphology 1 | 32
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal retinal inner nuclear... 1 | 5
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 21
decreased CD4-positive, alpha ... 1 | 19
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased pulmonary respirator... 1 | 4
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
enlarged stomach 1 | 2
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased effector memory CD4-... 1 | 15
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
lethargy 1 | 5
persistence of hyaloid vascula... 1 | 22
vertebral fusion 1 | 23

Disease

ovarian cancer 221 | 8,484
osteosarcoma 180 | 7,933
psoriasis 153 | 6,685
medulloblastoma, large-cell 151 | 6,234
glioblastoma 136 | 5,572
lung cancer 130 | 4,466
atypical teratoid / rhabdoid tumor 104 | 4,369
Cancer 96 | 2,346
Breast cancer 93 | 3,094
malignant mesothelioma 90 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 84 | 3,289
primitive neuroectodermal tumor 80 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 75 | 2,988
subependymal giant cell astrocytoma 71 | 2,287
non-small cell lung cancer 70 | 2,798
pediatric high grade glioma 70 | 2,712
pilocytic astrocytoma 70 | 3,086
oligodendroglioma 68 | 2,849
pancreatic cancer 68 | 2,300
invasive ductal carcinoma 65 | 2,950
lung adenocarcinoma 65 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 64 | 2,956
ependymoma 63 | 2,514
Carcinoma 62 | 2,147
lung carcinoma 60 | 2,844
astrocytoma 54 | 1,493
diabetes mellitus 54 | 1,663
astrocytic glioma 49 | 2,241
ductal carcinoma in situ 48 | 1,745
Multiple myeloma 46 | 1,327
group 3 medulloblastoma 46 | 2,254
interstitial cystitis 46 | 2,299
ulcerative colitis 46 | 2,087
Pick disease 45 | 1,893
medulloblastoma 45 | 1,524
colon cancer 43 | 1,475
pituitary cancer 43 | 1,972
group 4 medulloblastoma 42 | 1,875
adult high grade glioma 41 | 2,148
breast carcinoma 41 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,795
primary pancreatic ductal adenocarcinoma 40 | 1,271
juvenile dermatomyositis 39 | 1,189
tuberculosis 39 | 1,557
posterior fossa group A ependymoma 35 | 1,511
sonic hedgehog group medulloblastoma 35 | 1,482
Waldenstrons macroglobulinemia 34 | 765
cystic fibrosis 34 | 1,665
Alzheimer's disease 32 | 644
atypical teratoid/rhabdoid tumor 32 | 1,095
acute quadriplegic myopathy 30 | 1,157
Rheumatoid Arthritis 29 | 1,160
adrenocortical carcinoma 29 | 1,427
nasopharyngeal carcinoma 29 | 1,056
Duchenne muscular dystrophy 28 | 602
dermatomyositis 26 | 933
Kidney disease 25 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 25 | 499
cutaneous lupus erythematosus 25 | 1,056
spina bifida 25 | 1,064
Intellectual disability 24 | 573
Down syndrome 22 | 548
Obesity 22 | 616
Prostatic Neoplasms 22 | 471
progressive supranuclear palsy 22 | 674
primary Sjogren syndrome 21 | 789
posterior fossa group B ependymoma 20 | 1,530
Atopic dermatitis 19 | 944
Endometriosis 19 | 535
Neurodegenerative disease 19 | 383
active Crohn's disease 19 | 918
Melanoma 18 | 261
Schizophrenia 18 | 501
pancreatic carcinoma 18 | 567
Mammary Neoplasms 17 | 410
Parkinson's disease 17 | 364
acute myeloid leukemia 17 | 780
gastric cancer 17 | 430
gastric carcinoma 17 | 832
non primary Sjogren syndrome sicca 17 | 840
Amyotrophic Lateral Sclerosis 16 | 431
Lung Neoplasms 15 | 171
Polycystic Ovary Syndrome 15 | 332
Renal Cell Carcinoma 15 | 199
Vascular disease 15 | 281
fibroadenoma 15 | 557
hepatocellular carcinoma 15 | 532
hereditary spastic paraplegia 15 | 313
Liver carcinoma 14 | 217
aldosterone-producing adenoma 14 | 664
Adenoma 13 | 165
Asthma 13 | 349
Epilepsy 13 | 346
Hypertensive disease 13 | 193
esophageal adenocarcinoma 13 | 737
IGA Glomerulonephritis 12 | 454
Osteoporosis 12 | 257
active ulcerative colitis 12 | 477
Arthritis 11 | 248
chronic rhinosinusitis 11 | 512

Tissue

Nervous System 353 | 18,561
Digestive Tract 352 | 18,473
Male tissues 352 | 17,969
Urinary Tract 352 | 18,444
Endocrine System 351 | 18,512
Female tissues 351 | 18,647
Liver and Pancreas 351 | 18,136
Cardiovascular System 350 | 17,958
Skin and soft tissues 350 | 18,115
Blood and immune system 349 | 17,995
Respiratory system 347 | 17,484

Target Family

Non-IDG 216 | 11,971
Enzyme 59 | 4,146
Transcription Factor 28 | 1,400
Kinase 25 | 634
Epigenetic 10 | 242
Transporter 8 | 473
Ion Channel 4 | 341
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38

GO Component

protein complex 355 | 355
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Nuclear autoantigenic sperm protein NASP Tbio Non-IDG -1.72078 58.3 103
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Protein KIBRA WWC1 Tbio Non-IDG -1.88892 84.4 96
Collagen alpha-2(VI) chain COL6A2 Tbio Non-IDG -1.77264 56.4 133
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -1.97186 101.3 125
Transthyretin TTR Tclin Non-IDG -3.74965 5822.8 617
Sialic acid-binding Ig-like lectin 15 SIGLEC15 Tbio Non-IDG -0.52504 6.12 82