Development Level

Tbio 45 | 11,445
Tchem 5 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavioral response t... 1 | 66
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
increased body length 1 | 32
increased circulating choleste... 1 | 66
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
shortened RR interval 1 | 17

Disease

ovarian cancer 46 | 8,520
Multiple myeloma 32 | 1,332
Carcinoma 25 | 11,493
psoriasis 25 | 6,694
lung cancer 24 | 4,740
osteosarcoma 24 | 7,950
glioblastoma 18 | 5,792
HIV Infections 15 | 102
Waldenstrons macroglobulinemia 13 | 765
dermatomyositis 12 | 966
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
Breast cancer 10 | 3,578
Cancer 10 | 2,499
medulloblastoma, large-cell 10 | 6,241
adult high grade glioma 9 | 3,801
diabetes mellitus 9 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
group 3 medulloblastoma 7 | 4,104
invasive ductal carcinoma 7 | 2,951
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
astrocytic glioma 6 | 2,597
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
lung adenocarcinoma 6 | 2,716
non primary Sjogren syndrome sicca 6 | 891
Astrocytoma, Pilocytic 5 | 3,081
Mantle cell lymphoma 5 | 23
Pick disease 5 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
primary Sjogren syndrome 5 | 735
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Liver Cirrhosis, Experimental 4 | 769
juvenile dermatomyositis 4 | 1,187
primitive neuroectodermal tumor 4 | 3,035
Neurodegenerative disease 3 | 414
Osteoporosis 3 | 363
Vascular disease 3 | 319
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
esophageal adenocarcinoma 3 | 737
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung carcinoma 3 | 2,843
tuberculosis 3 | 2,010
Acquired metabolic disease 2 | 336
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Animal Mammary Neoplasms 2 | 136
Arthralgia 2 | 90
Attention deficit hyperactivity disorder 2 | 278
Cerebral atrophy 2 | 178
Cockayne syndrome 2 | 60
Congenital pes cavus 2 | 88
Congestive heart failure 2 | 113
Contact Dermatitis 2 | 81
Craniofacial Abnormalities 2 | 151
Dementia 2 | 175
Depressive disorder 2 | 409
Dermatitis, Contact 2 | 71
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Distal amyotrophy 2 | 51
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Distal sensory impairment 2 | 52
Duchenne muscular dystrophy 2 | 601
Dysarthria 2 | 192
Epilepsy 2 | 792
Esophageal Squamous Cell Carcinoma 2 | 77
Glaucoma 2 | 239
Heart failure 2 | 162
Hypothyroidism 2 | 122
Machado-Joseph disease 2 | 18
Macroglossia 2 | 65
Muscle Weakness 2 | 170
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Neuropathy 2 | 261
Prostate cancer 2 | 175
Seizures 2 | 596
Sensorineural hearing loss 2 | 106
Skeletal muscle atrophy 2 | 139
Squamous cell carcinoma of esophagus 2 | 77
Stomach Neoplasms 2 | 300
Thrombocytopenia 2 | 197
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
muscle degeneration 2 | 139
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 56 | 16,909
Cardiovascular System 56 | 15,192
Digestive Tract 56 | 17,369
Endocrine System 56 | 18,159
Female tissues 56 | 17,400
Liver and Pancreas 56 | 16,750
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Respiratory system 56 | 16,393
Skin and soft tissues 56 | 17,230
Urinary Tract 56 | 16,678

Target Family

Enzyme 42 | 4,145
Non-IDG 14 | 12,091

GO Component

proteasome complex 56 | 56
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Proteasomal ATPase-associated factor 1 PAAF1 Tbio Enzyme -1.66158 45.6 80
E3 ubiquitin-protein ligase UBR1 UBR1 Tbio Enzyme -1.95732 91.8 136
Thioredoxin-like protein 1 TXNL1 Tbio Non-IDG -2.32888 224.7 143
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
Wolframin WFS1 Tbio Non-IDG -2.40006 260.2 118
26S proteasome regulatory subunit 10B PSMC6 Tbio Enzyme -2.65165 339.0 214
Ubiquilin-1 UBQLN1 Tbio Non-IDG -1.92650 87.0 256
Proteasome subunit alpha type-7 PSMA7 Tbio Enzyme -2.71627 496.7 288