Development Level

Tbio 2,164 | 10,625
Tdark 904 | 7,003
Tchem 690 | 1,890
Tclin 360 | 602

Collection

Eligible non-olfactory GPCR Proteins 108 | 143
Eligible Ion Channel Proteins 87 | 117
Eligible Kinase Proteins 20 | 134

IMPC Term

preweaning lethality, complete... 121 | 633
preweaning lethality, incomple... 72 | 260
abnormal behavior 60 | 226
decreased lean body mass 55 | 195
decreased bone mineral content 46 | 157
embryonic lethality prior to t... 45 | 187
decreased total body fat amoun... 42 | 186
decreased bone mineral density 38 | 126
decreased body weight 36 | 174
hyperactivity 35 | 108
decreased grip strength 34 | 123
increased circulating alkaline... 33 | 119
abnormal bone structure 31 | 131
increased or absent threshold ... 28 | 128
embryonic lethality prior to o... 27 | 148
enlarged heart 27 | 111
increased lean body mass 25 | 107
abnormal embryo size 24 | 112
abnormal retina morphology 23 | 100
decreased circulating glucose ... 22 | 121
decreased circulating triglyce... 21 | 83
increased grip strength 21 | 83
decreased body length 20 | 108
decreased fasted circulating g... 20 | 49
decreased circulating choleste... 19 | 85
hypoactivity 19 | 89
increased bone mineral content 19 | 92
increased total body fat amoun... 19 | 57
increased circulating HDL chol... 18 | 63
decreased circulating insulin ... 17 | 75
impaired glucose tolerance 17 | 52
increased circulating sodium l... 17 | 71
increased mean corpuscular vol... 17 | 91
short tibia 17 | 82
decreased rib number 16 | 59
improved glucose tolerance 16 | 56
abnormal bone mineralization 15 | 55
abnormal retinal pigmentation 15 | 61
cardiovascular system phenotyp... 15 | 35
decreased circulating HDL chol... 15 | 77
increased blood urea nitrogen ... 15 | 44
increased circulating chloride... 15 | 43
increased circulating choleste... 15 | 53
increased fasted circulating g... 15 | 68
increased mean corpuscular hem... 15 | 93
abnormal gait 14 | 51
abnormal lens morphology 14 | 73
decreased lumbar vertebrae num... 14 | 62
increased body weight 14 | 42
increased hemoglobin content 14 | 45
tremors 14 | 34
abnormal seminal vesicle morph... 13 | 47
abnormal sleep behavior 13 | 63
decreased heart weight 13 | 44
decreased leukocyte cell numbe... 13 | 54
decreased mean corpuscular hem... 13 | 34
decreased mean corpuscular vol... 13 | 50
increased leukocyte cell numbe... 13 | 37
limb grasping 13 | 35
prenatal lethality prior to he... 13 | 64
thrombocytopenia 13 | 46
decreased circulating alanine ... 12 | 53
decreased circulating serum al... 12 | 79
decreased prepulse inhibition 12 | 52
increased circulating calcium ... 12 | 32
increased exploration in new e... 12 | 56
enlarged epididymis 11 | 27
increased hematocrit 11 | 36
male infertility 11 | 62
abnormal epididymis morphology 10 | 31
decreased circulating amylase ... 10 | 24
decreased startle reflex 10 | 48
increased bone mineral density 10 | 52
increased heart weight 10 | 37
abnormal neural tube closure 9 | 37
abnormal spleen morphology 9 | 36
decreased NK T cell number 9 | 28
decreased caudal vertebrae num... 9 | 49
decreased circulating chloride... 9 | 32
increased circulating creatini... 9 | 29
increased circulating phosphat... 9 | 24
increased circulating potassiu... 9 | 31
increased sacral vertebrae num... 9 | 62
increased startle reflex 9 | 38
abnormal coat/hair pigmentatio... 8 | 54
abnormal heart morphology 8 | 51
abnormal kidney morphology 8 | 30
abnormal midbrain development 8 | 22
decreased T cell number 8 | 31
decreased circulating creatini... 8 | 31
decreased eosinophil cell numb... 8 | 41
decreased hemoglobin content 8 | 53
decreased mature B cell number 8 | 25
decreased neutrophil cell numb... 8 | 37
decreased threshold for audito... 8 | 32
decreased vertical activity 8 | 22
increased circulating total pr... 8 | 20
increased rib number 8 | 41
small superior vagus ganglion 8 | 20
straub tail 8 | 26

Disease

osteosarcoma 1,663 | 7,933
ovarian cancer 1,642 | 8,484
psoriasis 1,549 | 6,685
medulloblastoma, large-cell 1,407 | 6,234
glioblastoma 1,325 | 5,572
lung cancer 1,045 | 4,466
atypical teratoid / rhabdoid tumor 997 | 4,369
lung carcinoma 935 | 2,844
pilocytic astrocytoma 896 | 3,086
Cancer 772 | 2,346
invasive ductal carcinoma 768 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 746 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 746 | 3,289
lung adenocarcinoma 741 | 2,713
non-small cell lung cancer 728 | 2,798
interstitial cystitis 723 | 2,299
malignant mesothelioma 719 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 706 | 2,988
pediatric high grade glioma 702 | 2,712
oligodendroglioma 693 | 2,849
primitive neuroectodermal tumor 691 | 3,031
Breast cancer 676 | 3,094
Carcinoma 668 | 2,147
ulcerative colitis 622 | 2,087
subependymal giant cell astrocytoma 610 | 2,287
ependymoma 604 | 2,514
pancreatic cancer 597 | 2,300
adult high grade glioma 514 | 2,148
pituitary cancer 511 | 1,972
astrocytic glioma 503 | 2,241
diabetes mellitus 502 | 1,663
ductal carcinoma in situ 471 | 1,745
Pick disease 433 | 1,893
tuberculosis 429 | 1,557
group 4 medulloblastoma 428 | 1,875
cystic fibrosis 425 | 1,665
group 3 medulloblastoma 403 | 2,254
posterior fossa group A ependymoma 403 | 1,511
breast carcinoma 396 | 1,614
astrocytoma 389 | 1,493
colon cancer 358 | 1,475
medulloblastoma 357 | 1,524
primary pancreatic ductal adenocarcinoma 345 | 1,271
Rheumatoid Arthritis 344 | 1,160
cutaneous lupus erythematosus 344 | 1,056
adrenocortical carcinoma 330 | 1,427
sonic hedgehog group medulloblastoma 330 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 323 | 1,795
posterior fossa group B ependymoma 294 | 1,530
atypical teratoid/rhabdoid tumor 276 | 1,095
juvenile dermatomyositis 255 | 1,189
active Crohn's disease 247 | 918
spina bifida 234 | 1,064
primary Sjogren syndrome 233 | 789
gastric carcinoma 230 | 832
acute quadriplegic myopathy 229 | 1,157
Multiple myeloma 224 | 1,327
nasopharyngeal carcinoma 221 | 1,056
Multiple Sclerosis 219 | 498
Alzheimer's disease 212 | 644
Atopic dermatitis 211 | 944
dermatomyositis 208 | 933
esophageal adenocarcinoma 207 | 737
Obesity 201 | 616
Down syndrome 186 | 548
Duchenne muscular dystrophy 183 | 602
Schizophrenia 182 | 501
Kidney disease 174 | 396
mucosa-associated lymphoid tissue lymphoma 172 | 480
non primary Sjogren syndrome sicca 159 | 840
Epilepsy 157 | 346
fibroadenoma 152 | 557
aldosterone-producing adenoma 150 | 664
acute myeloid leukemia 149 | 780
Hypersensitivity reaction type II disease 148 | 235
autosomal dominant Emery-Dreifuss muscular dystrophy 145 | 499
non-small cell lung carcinoma 144 | 413
Asthma 142 | 349
Waldenstrons macroglobulinemia 140 | 765
pancreatic carcinoma 139 | 567
Prostatic Neoplasms 138 | 471
active ulcerative colitis 138 | 477
Autistic Disorder 136 | 320
Parkinson's disease 135 | 364
Hypertension 131 | 287
Intellectual disability 131 | 573
Arthritis 124 | 248
Mammary Neoplasms 123 | 410
IGA Glomerulonephritis 120 | 454
progressive supranuclear palsy 120 | 674
Endometriosis 118 | 535
Atherosclerosis 117 | 275
tuberculosis and treatment for 6 months 116 | 686
Neurodegenerative disease 107 | 383
Vascular disease 107 | 281
Cerebrovascular disease 104 | 231
nephrosclerosis 104 | 329
Heart disease 102 | 279
Coronary artery disease 100 | 240
sarcoidosis 99 | 358

Tissue

Female tissues 3,821 | 18,647
Urinary Tract 3,782 | 18,444
Nervous System 3,741 | 18,561
Endocrine System 3,727 | 18,512
Digestive Tract 3,712 | 18,473
Skin and soft tissues 3,621 | 18,115
Liver and Pancreas 3,591 | 18,136
Blood and immune system 3,553 | 17,995
Cardiovascular System 3,528 | 17,958
Male tissues 3,509 | 17,969
Respiratory system 3,444 | 17,484

Target Family

Non-IDG 2,002 | 11,971
Enzyme 589 | 4,146
oGPCR 414 | 421
GPCR 353 | 406
Transporter 271 | 473
Ion Channel 270 | 341
Kinase 174 | 634
Transcription Factor 29 | 1,400
Epigenetic 12 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

GO Component

plasma membrane 4,118 | 4,118
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
T-cell receptor beta chain V region CTL-L17 TCRB Tdark Non-IDG 0.00000 0
T-cell receptor alpha chain V region HPB-MLT N/A Tdark Non-IDG 0.00000 0
T-cell receptor alpha chain V region CTL-L17 TCRA Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788