Development Level

Tbio 31 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal locomotor activation 1 | 16
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased coping response 1 | 8
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
long tibia 1 | 25
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
small testis 1 | 58
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

Carcinoma 26 | 11,493
Retinitis Pigmentosa 17 | 226
ovarian cancer 16 | 8,520
osteosarcoma 12 | 7,950
Ciliopathy 11 | 71
Nephronophthisis 11 | 80
ependymoma 11 | 4,679
medulloblastoma, large-cell 10 | 6,241
Fundus dystrophy 9 | 83
Intellectual disability 9 | 1,016
Nystagmus 9 | 317
psoriasis 9 | 6,694
Autosomal recessive predisposition 8 | 1,442
Dull intelligence 8 | 645
Electroretinogram abnormal 8 | 95
Kidney cancer 8 | 2,613
Leber congenital amaurosis 8 | 69
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
lung cancer 8 | 4,740
Blindness 7 | 88
Cataract 7 | 297
Lens Opacities 7 | 231
Obesity 7 | 678
Polydactyly 7 | 107
chronic rhinosinusitis 7 | 512
group 3 medulloblastoma 7 | 4,104
Abnormality of retinal pigmentation 6 | 111
Anteverted nostril 6 | 191
Bardet-Biedl syndrome 6 | 51
Congenital hypoplasia of penis 6 | 176
Hypogonadism 6 | 173
Retinal Degeneration 6 | 106
Retinal pigment epithelial abnormality 6 | 111
Senior-Loken syndrome 6 | 22
cone-rod dystrophy 6 | 59
Asphyxiating thoracic dystrophy 5 | 44
Breast cancer 5 | 3,578
Cerebellar Ataxia 5 | 304
Cognitive delay 5 | 608
Difficulties with night vision 5 | 87
Glaucoma 5 | 239
Global developmental delay 5 | 608
Joubert syndrome 5 | 66
Keratoconus 5 | 113
Mental and motor retardation 5 | 608
Night Blindness 5 | 101
Optic Atrophy 5 | 242
Renal dysplasia and retinal aplasia (disorder) 5 | 10
Sensorineural Hearing Loss (disorder) 5 | 284
adult high grade glioma 5 | 3,801
glioblastoma 5 | 5,792
malignant mesothelioma 5 | 3,232
Abnormality of the retinal vasculature 4 | 59
Atypical scarring of skin 4 | 62
Blind Vision 4 | 111
Blindness, Legal 4 | 110
Broad flat nasal bridge 4 | 236
Conductive hearing loss 4 | 123
Congenital anomaly of testis 4 | 52
Cystic kidney disease 4 | 26
Hyperinsulinism 4 | 133
Kidney Diseases 4 | 114
Low Vision 4 | 174
Meckel syndrome 4 | 46
Muscle hypotonia 4 | 571
Nasal bridge wide 4 | 236
Night blindness, progressive 4 | 51
Ophthalmoplegia 4 | 106
Photodysphoria 4 | 121
Photophobia 4 | 121
Sensenbrenner syndrome 4 | 17
Short stature 4 | 531
Visual Impairment 4 | 174
lung carcinoma 4 | 2,843
Brachydactyly 3 | 156
Cone dystrophy 3 | 71
Congenital cerebral hernia 3 | 21
Ellis-Van Creveld syndrome 3 | 19
Hypertensive disease 3 | 292
Increase in blood pressure 3 | 119
Kidney damage 3 | 25
Meckel-Gruber syndrome 3 | 13
Melanoma 3 | 711
Multicystic Dysplastic Kidney 3 | 52
Multiple myeloma 3 | 1,332
Myopia 3 | 176
Nonsyndromic deafness 3 | 142
Retinal Dystrophies 3 | 33
Schizophrenia 3 | 1,160
Sensorineural hearing loss 3 | 106
Ulnar polydactyly of fingers 3 | 47
Usher Syndrome, Type 1 3 | 7
Usher syndrome 3 | 32
active Crohn's disease 3 | 922
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
lung adenocarcinoma 3 | 2,716

Tissue

Endocrine System 30 | 18,159
Digestive Tract 28 | 17,369
Male tissues 28 | 17,142
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Female tissues 27 | 17,400
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Blood and immune system 26 | 16,909
Liver and Pancreas 26 | 16,750
Cardiovascular System 25 | 15,192

Target Family

Non-IDG 28 | 12,091
Enzyme 3 | 4,145

GO Component

photoreceptor connecting ciliu... 31 | 31
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Septin-2 SEPT2 Tbio Non-IDG -2.29347 192.0 321
ADP-ribosylation factor-like protein 3 ARL3 Tbio Enzyme -1.52854 37.7 311
Tubulin-specific chaperone C TBCC Tbio Non-IDG -1.44496 27.9 210
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Intraflagellar transport protein 57 homolog IFT57 Tbio Non-IDG -1.31031 23.8 197
E3 ubiquitin-protein ligase Topors TOPORS Tbio Enzyme -1.94964 92.8 174
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -2.03755 107.9 152
Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 Tbio Non-IDG -1.41254 22.0 137
Centrin-1 CETN1 Tbio Non-IDG -1.86026 65.5 131
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129