Development Level

Tchem 1 | 1,598
Tclin 1 | 613

Disease

Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Carcinoma 2 | 11,493
Cataract 2 | 297
DOID:2627 2 | 94
Endometrial cancer 2 | 311
Failure to gain weight 2 | 365
Fatigue 2 | 182
Frontal bossing 2 | 157
Hypoplastic mandible condyle 2 | 275
Joint laxity 2 | 54
Kidney cancer 2 | 2,613
Lens Opacities 2 | 231
Mandibular hypoplasia 2 | 275
Micrognathism 2 | 275
Myopia 2 | 176
Pediatric failure to thrive 2 | 365
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
glioblastoma 2 | 5,792
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
lung cancer 2 | 4,740
medulloblastoma, large-cell 2 | 6,241
ovarian cancer 2 | 8,520
psoriasis 2 | 6,694
AGAMMAGLOBULINEMIA 1, AUTOSOMAL RECESSIVE 1 | 8
Abnormality of the penis 1 | 7
Action Tremor 1 | 22
Adenocarcinoma Of Esophagus 1 | 14
Adenocarcinoma of lung (disorder) 1 | 60
Agammaglobulinemia, non-Bruton type 1 | 8
Angioid streaks 1 | 11
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 1 | 13
Birth length less than 3rd percentile 1 | 6
Bronchioloalveolar Adenocarcinoma 1 | 14
CLEFT CHIN 1 | 9
Cardiovascular Abnormalities 1 | 31
Congenital abnormality of vein 1 | 3
Conjunctival hamartoma 1 | 7
Cowden disease 1 | 18
Cutis marmorata 1 | 32
Epidermal Nevus 1 | 4
Facial asymmetry 1 | 32
Fetal alcohol syndrome 1 | 22
Fibrous skin tumor of tuberous sclerosis 1 | 18
Fissured tongue 1 | 25
Fleshy earlobes 1 | 8
Gastric Cancer, Hereditary Diffuse 1 | 12
Gastrointestinal Hemorrhage 1 | 52
Gastrointestinal hamartomatous polyps 1 | 10
Goiter 1 | 38
Hamartoma Syndrome, Multiple 1 | 10
Hamartomatous polyp 1 | 10
Hematologic Neoplasms 1 | 22
Hemimegalencephaly 1 | 5
Hereditary Nonpolyposis Colorectal Cancer 1 | 11
Hereditary nonpolyposis colorectal carcinoma 1 | 18
Hyperkeratosis, generalized 1 | 14
Hyperthyroidism 1 | 53
Increased gastric cancer 1 | 21
Infection of bone 1 | 19
Insulin resistant diabetes 1 | 13
Irritation - emotion 1 | 68
Leiomyosarcoma of uterus 1 | 13
Lipoatrophy 1 | 19
Lipodystrophy 1 | 40
Lymphoma, Large B-Cell, Diffuse 1 | 34
Macrocephaly 1 | 11
Macule 1 | 19
Malformations of Cortical Development 1 | 13
Malignant neoplasm of breast 1 | 15
Malignant neoplasm of ovary 1 | 4
Micronodular cirrhosis 1 | 12
Mucosal telangiectasiae 1 | 14
Multiple, subcutaneous nodules 1 | 53
NEVUS, EPIDERMAL (disorder) 1 | 5
Neoplasm of stomach 1 | 11
Nevus, Epidermal 1 | 5
Numerous nevi 1 | 5
Papule 1 | 43
Paranasal Sinus Diseases 1 | 34
Penile Neoplasms 1 | 4
Polyp of large intestine 1 | 8
Port-Wine Stain 1 | 8
Rectal Neoplasms 1 | 18
Recurrent skin infections 1 | 21
Rieger syndrome 1 | 8
Sinusitis 1 | 65
Stomach Carcinoma 1 | 11
Subacute progressive viral hepatitis 1 | 9
Subcutaneous lipomas 1 | 9
Subcutaneous nodule 1 | 53
Terminal tremor 1 | 20
Thin hypoplastic alae nasi 1 | 51
Thyroid Gland Follicular Adenoma 1 | 9
Thyroiditis 1 | 29
Transitional cell carcinoma of bladder 1 | 17

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678

Target Family

Kinase 2 | 634

GO Component

phosphatidylinositol 3-kinase ... 2 | 2
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

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