Development Level

Tbio 74 | 11,651
Tchem 15 | 1,388
Tdark 9 | 6,593
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 4 | 161
decreased circulating choleste... 4 | 93
decreased caudal vertebrae num... 3 | 53
decreased circulating aspartat... 3 | 34
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased total body fat amoun... 3 | 134
abnormal behavior 2 | 298
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
female infertility 2 | 60
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased lean body mass 2 | 172
increased startle reflex 2 | 112
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal hair texture 1 | 4
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased NK T cell number 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased coping response 1 | 8
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased granulocyte number 1 | 1
increased heart rate 1 | 23
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
shortened RR interval 1 | 17
thin ventricular wall 1 | 24

Disease

Carcinoma 64 | 11,493
ovarian cancer 59 | 8,520
osteosarcoma 47 | 7,950
medulloblastoma, large-cell 39 | 6,241
psoriasis 37 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
Autosomal recessive predisposition 31 | 1,442
glioblastoma 29 | 5,792
atypical teratoid / rhabdoid tumor 28 | 5,112
Zellweger syndrome 27 | 37
lung cancer 27 | 4,740
ependymoma 25 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Muscle hypotonia 24 | 571
Epilepsy 21 | 792
Seizures 21 | 596
invasive ductal carcinoma 21 | 2,951
Failure to gain weight 20 | 365
Pediatric failure to thrive 20 | 365
Short stature 20 | 531
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
malignant mesothelioma 20 | 3,232
ulcerative colitis 20 | 1,819
Hepatomegaly 19 | 285
Infantile Refsum disease 19 | 23
Peroxisomal disease 19 | 22
Cataract 18 | 297
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
Muscle Spasticity 18 | 195
Concave bridge of nose 17 | 195
Depressed nasal bridge 17 | 195
Depressed nasal root/bridge 17 | 195
Nystagmus 17 | 317
Optic Atrophy 17 | 242
Retinitis Pigmentosa 17 | 226
Adrenoleukodystrophy 16 | 29
Cerebellar Ataxia 16 | 304
Chondrodysplasia punctata 16 | 41
Low Vision 16 | 174
Sensorineural Hearing Loss (disorder) 16 | 284
Visual Impairment 16 | 174
adult high grade glioma 16 | 3,801
interstitial cystitis 16 | 2,312
Abnormal skeletal development 15 | 60
Abnormality of metabolism/homeostasis 15 | 134
Abnormality of retinal pigmentation 15 | 111
Blepharoptosis 15 | 231
Broad flat nasal bridge 15 | 236
Developmental regression 15 | 95
High forehead 15 | 102
Hypoplastic mandible condyle 15 | 275
Lens Opacities 15 | 231
Liver diseases 15 | 87
Loss of developmental milestones 15 | 95
Mandibular hypoplasia 15 | 275
Mental deterioration in childhood 15 | 95
Micrognathism 15 | 275
Nasal bridge wide 15 | 236
Neurodevelopmental regression 15 | 95
Osteochondrodysplasias 15 | 72
Psychomotor regression 15 | 95
Psychomotor regression beginning in infancy 15 | 95
Psychomotor regression in infants 15 | 95
Psychomotor regression, progressive 15 | 95
Retinal pigment epithelial abnormality 15 | 111
Small head 15 | 374
Strabismus 15 | 270
Tall forehead 15 | 102
Addison Disease 14 | 18
Adrenal cortical hypofunction 14 | 23
Byzanthine arch palate 14 | 194
Congenital Epicanthus 14 | 177
Death in early childhood 14 | 82
Death in infancy 14 | 82
Difficulties with night vision 14 | 87
Electroencephalogram abnormal 14 | 101
Elevated levels of phytanic acid 14 | 15
Hydronephrosis 14 | 89
Hyperreflexia 14 | 209
Increased head circumference 14 | 147
Increased size of skull 14 | 147
Kidney cancer 14 | 2,613
Liver Failure 14 | 73
Long narrow head 14 | 75
Narrow skull shape 14 | 75
Night Blindness 14 | 101
Respiratory Insufficiency 14 | 132
Respiratory function loss 14 | 121
Stippled epiphyses 14 | 28
Turridolichocephaly 14 | 75
Upward slant of palpebral fissure 14 | 75
astrocytic glioma 14 | 2,597
ductal carcinoma in situ 14 | 1,745
group 3 medulloblastoma 14 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
lung adenocarcinoma 14 | 2,716
subependymal giant cell astrocytoma 14 | 2,287
tuberculosis 14 | 2,010

Tissue

Digestive Tract 99 | 17,369
Endocrine System 99 | 18,159
Blood and immune system 98 | 16,909
Liver and Pancreas 98 | 16,750
Skin and soft tissues 98 | 17,230
Urinary Tract 98 | 16,678
Female tissues 97 | 17,400
Male tissues 97 | 17,142
Nervous System 96 | 16,725
Respiratory system 95 | 16,393
Cardiovascular System 92 | 15,192

Target Family

Enzyme 60 | 4,145
Non-IDG 34 | 12,091
Transporter 5 | 473
Kinase 1 | 634

GO Component

peroxisome 100 | 100
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Mpv17 MPV17 Tbio Non-IDG -1.67807 47.6 134
Peroxisomal carnitine O-octanoyltransferase CROT Tbio Enzyme -1.33388 20.1 252
Stimulator of interferon genes protein TMEM173 Tbio Non-IDG -2.37722 230.3 450
Isopentenyl-diphosphate Delta-isomerase 1 IDI1 Tbio Enzyme -1.60998 38.3 124
Peroxisomal trans-2-enoyl-CoA reductase PECR Tbio Enzyme -1.66224 43.2 104
Isopentenyl-diphosphate delta-isomerase 2 IDI2 Tbio Enzyme -1.25123 20.8 84
HRAS-like suppressor 3 PLA2G16 Tbio Non-IDG -1.96915 96.3 230
Hydroxyacid oxidase 2 HAO2 Tchem Enzyme -1.22385 16.1 72
2-iminobutanoate/2-iminopropanoate deaminase RIDA Tbio Enzyme -1.74722 52.8 104
Peroxisomal leader peptide-processing protease TYSND1 Tbio Enzyme -0.45376 3.53 54