Development Level

Tbio 433 | 10,625
Tchem 110 | 1,890
Tclin 34 | 602
Tdark 34 | 7,003

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 32 | 633
preweaning lethality, incomple... 17 | 260
decreased body weight 11 | 174
abnormal behavior 10 | 226
decreased grip strength 9 | 123
decreased total body fat amoun... 9 | 186
decreased bone mineral density 8 | 126
embryonic lethality prior to t... 8 | 187
decreased bone mineral content 7 | 157
decreased lean body mass 7 | 195
increased mean corpuscular hem... 7 | 93
increased or absent threshold ... 7 | 128
abnormal embryo size 6 | 112
decreased rib number 6 | 59
increased circulating alkaline... 6 | 119
increased lean body mass 6 | 107
abnormal bone mineralization 5 | 55
abnormal bone structure 5 | 131
abnormal lens morphology 5 | 73
abnormal retina morphology 5 | 100
hypoactivity 5 | 89
increased hematocrit 5 | 36
abnormal retinal pigmentation 4 | 61
abnormal sleep behavior 4 | 63
decreased T cell number 4 | 31
decreased circulating triglyce... 4 | 83
decreased lumbar vertebrae num... 4 | 62
decreased startle reflex 4 | 48
improved glucose tolerance 4 | 56
increased circulating sodium l... 4 | 71
increased grip strength 4 | 83
increased mean corpuscular vol... 4 | 91
increased sacral vertebrae num... 4 | 62
increased total body fat amoun... 4 | 57
abnormal femur morphology 3 | 14
abnormal gait 3 | 51
abnormal heart morphology 3 | 51
decreased blood urea nitrogen ... 3 | 31
decreased body length 3 | 108
decreased circulating HDL chol... 3 | 77
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating alkaline... 3 | 41
decreased circulating choleste... 3 | 85
decreased circulating free fat... 3 | 39
decreased circulating insulin ... 3 | 75
decreased fasted circulating g... 3 | 49
decreased heart weight 3 | 44
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular hem... 3 | 34
decreased mean corpuscular vol... 3 | 50
decreased vertical activity 3 | 22
enlarged spleen 3 | 26
hyperactivity 3 | 108
impaired glucose tolerance 3 | 52
increased bone mineral density 3 | 52
increased circulating calcium ... 3 | 32
increased heart weight 3 | 37
increased hemoglobin content 3 | 45
increased leukocyte cell numbe... 3 | 37
increased vertical activity 3 | 18
limb grasping 3 | 35
male infertility 3 | 62
abnormal behavioral response t... 2 | 52
abnormal body wall morphology 2 | 7
abnormal coping response 2 | 12
abnormal epididymis morphology 2 | 31
abnormal head morphology 2 | 10
abnormal retinal blood vessel ... 2 | 18
abnormal seminal vesicle morph... 2 | 47
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
abnormal testis morphology 2 | 30
cardiovascular system phenotyp... 2 | 35
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating potassiu... 2 | 17
decreased circulating total pr... 2 | 41
decreased prepulse inhibition 2 | 52
decreased threshold for audito... 2 | 32
embryonic lethality prior to o... 2 | 148
enlarged epididymis 2 | 27
enlarged heart 2 | 111
female infertility 2 | 34
hydrometra 2 | 13
increased blood urea nitrogen ... 2 | 44
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased circulating glucose ... 2 | 16
increased circulating potassiu... 2 | 31
increased circulating serum al... 2 | 25
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased respiratory quotient 2 | 12
increased startle reflex 2 | 38
pallor 2 | 13
polydactyly 2 | 22
short tibia 2 | 82
thrombocytosis 2 | 23

Disease

ovarian cancer 359 | 8,492
osteosarcoma 317 | 7,933
medulloblastoma, large-cell 289 | 6,234
glioblastoma 272 | 5,572
psoriasis 264 | 6,685
lung cancer 228 | 4,473
atypical teratoid / rhabdoid tumor 212 | 4,369
pilocytic astrocytoma 162 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 160 | 3,289
Cancer 158 | 2,346
primitive neuroectodermal tumor 155 | 3,031
pediatric high grade glioma 154 | 2,712
oligodendroglioma 148 | 2,849
invasive ductal carcinoma 146 | 2,950
lung adenocarcinoma 139 | 2,714
intraductal papillary-mucinous carcinoma (IPMC) 137 | 2,988
Breast cancer 135 | 3,099
non-small cell lung cancer 131 | 2,798
malignant mesothelioma 130 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 128 | 2,956
lung carcinoma 122 | 2,844
pancreatic cancer 122 | 2,300
subependymal giant cell astrocytoma 119 | 2,287
ependymoma 114 | 2,514
ulcerative colitis 108 | 2,087
interstitial cystitis 99 | 2,299
astrocytic glioma 98 | 2,241
astrocytoma 95 | 1,493
Carcinoma 92 | 2,147
breast carcinoma 92 | 1,614
group 3 medulloblastoma 92 | 2,254
Pick disease 91 | 1,893
group 4 medulloblastoma 90 | 1,875
ductal carcinoma in situ 89 | 1,745
adult high grade glioma 88 | 2,148
pituitary cancer 86 | 1,972
Multiple myeloma 85 | 1,328
tuberculosis 84 | 1,563
colon cancer 79 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 78 | 1,795
cystic fibrosis 77 | 1,670
diabetes mellitus 76 | 1,663
posterior fossa group A ependymoma 73 | 1,511
sonic hedgehog group medulloblastoma 71 | 1,482
adrenocortical carcinoma 70 | 1,427
juvenile dermatomyositis 69 | 1,189
acute quadriplegic myopathy 68 | 1,157
atypical teratoid/rhabdoid tumor 64 | 1,095
Alzheimer's disease 62 | 644
dermatomyositis 61 | 967
medulloblastoma 61 | 1,524
primary pancreatic ductal adenocarcinoma 59 | 1,271
cutaneous lupus erythematosus 56 | 1,056
spina bifida 50 | 1,064
Rheumatoid Arthritis 47 | 1,171
posterior fossa group B ependymoma 47 | 1,530
Waldenstrons macroglobulinemia 46 | 765
Prostatic Neoplasms 44 | 471
gastric carcinoma 43 | 832
Down syndrome 42 | 548
Duchenne muscular dystrophy 42 | 602
Neurodegenerative disease 42 | 383
active Crohn's disease 42 | 918
primary Sjogren syndrome 42 | 789
Atopic dermatitis 41 | 944
Endometriosis 40 | 535
esophageal adenocarcinoma 40 | 737
nasopharyngeal carcinoma 39 | 1,056
Kidney disease 38 | 397
Multiple Sclerosis 37 | 498
Mammary Neoplasms 36 | 410
fibroadenoma 36 | 557
Obesity 35 | 616
Schizophrenia 35 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 34 | 499
Parkinson's disease 33 | 364
progressive supranuclear palsy 32 | 674
Amyotrophic Lateral Sclerosis 31 | 432
IGA Glomerulonephritis 31 | 454
acute myeloid leukemia 30 | 785
non primary Sjogren syndrome sicca 29 | 840
Atherosclerosis 28 | 275
pancreatic carcinoma 28 | 567
Heart disease 27 | 279
Hypertension 27 | 293
Intellectual disability 27 | 573
Vascular disease 26 | 281
Liver carcinoma 25 | 217
tuberculosis and treatment for 6 months 25 | 686
Melanoma 22 | 261
aldosterone-producing adenoma 22 | 664
hepatocellular carcinoma 22 | 550
sarcoidosis 22 | 368
Arthritis 21 | 248
Stomach Neoplasms 21 | 282
Cerebrovascular disease 20 | 231
Colorectal Neoplasms 20 | 217
non-small cell lung carcinoma 20 | 413
Coronary artery disease 19 | 240
gastric cancer 19 | 436

Tissue

Endocrine System 608 | 18,512
Female tissues 608 | 18,647
Digestive Tract 607 | 18,473
Nervous System 607 | 18,561
Urinary Tract 607 | 18,444
Cardiovascular System 606 | 17,958
Liver and Pancreas 605 | 18,136
Male tissues 603 | 17,969
Skin and soft tissues 602 | 18,115
Blood and immune system 601 | 17,995
Respiratory system 599 | 17,484

Target Family

Non-IDG 377 | 11,969
Enzyme 134 | 4,146
Kinase 47 | 634
Transporter 18 | 473
Ion Channel 13 | 341
GPCR 7 | 408
Transcription Factor 7 | 1,400
Epigenetic 6 | 242
Nuclear Receptor 2 | 48

GO Component

perinuclear region of cytoplas... 611 | 611
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.46304 29.4 8
E3 ISG15--protein ligase HERC5 HERC5 Tbio Enzyme -1.59626 41.3 53
Zinc transporter ZIP12 SLC39A12 Tbio Transporter -0.81790 6.76 42
Calcium and integrin-binding protein 1 CIB1 Tbio Non-IDG -2.05927 116.0 218
NEDD4 family-interacting protein 2 NDFIP2 Tbio Non-IDG -0.60179 4.85 31
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.46222 253.3 121
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.34433 25.0 58
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.67984 438.1 349
Protein S100-A14 S100A14 Tbio Non-IDG -1.19891 20.4 43
Short transient receptor potential channel 7 TRPC7 Tbio Ion Channel -2.43795 198.9 193