Development Level

Tbio 489 | 11,651
Tchem 93 | 1,388
Tclin 31 | 612
Tdark 31 | 6,593

Collection

RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 3 | 37
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 43 | 979
preweaning lethality, incomple... 28 | 499
abnormal embryo size 16 | 220
abnormal behavior 14 | 298
embryonic lethality prior to t... 14 | 278
decreased total body fat amoun... 12 | 207
embryonic lethality prior to o... 12 | 239
abnormal bone structure 10 | 187
decreased body weight 10 | 161
decreased vertical activity 8 | 208
hypoactivity 8 | 132
abnormal gait 7 | 69
abnormal lens morphology 7 | 81
decreased bone mineral density 7 | 126
decreased grip strength 7 | 116
increased mean corpuscular hem... 7 | 96
increased startle reflex 7 | 112
increased total body fat amoun... 7 | 134
cataract 6 | 92
decreased bone mineral content 6 | 151
decreased lean body mass 6 | 135
decreased lymphocyte cell numb... 6 | 83
female infertility 6 | 60
hyperactivity 6 | 148
increased circulating alkaline... 6 | 122
increased neutrophil cell numb... 6 | 46
male infertility 6 | 123
tremors 6 | 39
abnormal retina morphology 5 | 71
abnormal seminal vesicle morph... 5 | 114
abnormal sleep behavior 5 | 70
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased circulating triglyce... 5 | 79
decreased leukocyte cell numbe... 5 | 73
decreased startle reflex 5 | 75
edema 5 | 59
embryonic growth retardation 5 | 106
increased bone mineral density 5 | 72
increased heart weight 5 | 62
increased lean body mass 5 | 172
abnormal heart morphology 4 | 162
decreased body length 4 | 101
decreased circulating alkaline... 4 | 46
decreased circulating creatini... 4 | 39
decreased circulating insulin ... 4 | 76
decreased fasted circulating g... 4 | 65
decreased mean platelet volume 4 | 25
hydrometra 4 | 53
impaired glucose tolerance 4 | 75
increased bone mineral content 4 | 108
increased circulating sodium l... 4 | 71
increased hematocrit 4 | 46
increased mean corpuscular vol... 4 | 92
mammalian phenotype 4 | 17
small superior vagus ganglion 4 | 74
abnormal bone mineralization 3 | 38
abnormal femur morphology 3 | 14
convulsive seizures 3 | 13
decreased T cell number 3 | 15
decreased circulating alanine ... 3 | 47
decreased heart left ventricle... 3 | 28
decreased heart weight 3 | 27
decreased mean corpuscular vol... 3 | 79
decreased prepulse inhibition 3 | 82
enlarged heart 3 | 210
enlarged spleen 3 | 41
improved glucose tolerance 3 | 79
increased blood urea nitrogen ... 3 | 48
increased body weight 3 | 25
increased circulating chloride... 3 | 41
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
increased monocyte cell number 3 | 63
increased spleen weight 3 | 10
limb grasping 3 | 41
pallor 3 | 34
persistence of hyaloid vascula... 3 | 33
prenatal lethality 3 | 28
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal body wall morphology 2 | 9
abnormal epididymis morphology 2 | 42
abnormal head morphology 2 | 10
abnormal lung morphology 2 | 26
abnormal spleen morphology 2 | 55
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased neutrophil cell numb... 2 | 42
increased circulating iron lev... 2 | 30
increased circulating potassiu... 2 | 29
increased circulating serum al... 2 | 22
increased circulating triglyce... 2 | 42
increased prepulse inhibition 2 | 32
short tibia 2 | 97
thin ventricular wall 2 | 24
thrombocytosis 2 | 27

Disease

Carcinoma 419 | 11,493
ovarian cancer 378 | 8,520
osteosarcoma 328 | 7,950
medulloblastoma, large-cell 305 | 6,241
glioblastoma 298 | 5,792
psoriasis 282 | 6,694
atypical teratoid / rhabdoid tumor 275 | 5,112
lung cancer 250 | 4,740
ependymoma 225 | 4,679
adult high grade glioma 195 | 3,801
group 3 medulloblastoma 193 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 171 | 3,291
Astrocytoma, Pilocytic 169 | 3,081
Cancer 165 | 2,499
primitive neuroectodermal tumor 165 | 3,035
oligodendroglioma 157 | 2,850
Breast cancer 156 | 3,578
invasive ductal carcinoma 152 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 149 | 2,989
lung adenocarcinoma 146 | 2,716
malignant mesothelioma 146 | 3,232
non-small cell lung cancer 140 | 2,890
astrocytic glioma 135 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 135 | 2,955
pancreatic cancer 129 | 2,398
lung carcinoma 127 | 2,843
subependymal giant cell astrocytoma 127 | 2,287
Kidney cancer 125 | 2,613
interstitial cystitis 105 | 2,312
ulcerative colitis 103 | 1,819
tuberculosis 102 | 2,010
breast carcinoma 100 | 1,638
Pick disease 96 | 1,894
ductal carcinoma in situ 94 | 1,745
Multiple myeloma 89 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 89 | 1,962
pituitary cancer 87 | 1,972
colon cancer 86 | 1,478
cystic fibrosis 84 | 1,696
group 4 medulloblastoma 84 | 1,855
diabetes mellitus 82 | 1,728
Schizophrenia 79 | 1,160
adrenocortical carcinoma 76 | 1,428
astrocytoma 72 | 1,146
juvenile dermatomyositis 72 | 1,187
acute quadriplegic myopathy 71 | 1,158
Alzheimer's disease 64 | 658
dermatomyositis 63 | 966
pediatric high grade glioma 60 | 1,064
cutaneous lupus erythematosus 59 | 1,057
Autosomal recessive predisposition 56 | 1,442
primary pancreatic ductal adenocarcinoma 56 | 1,109
Intellectual disability 54 | 1,016
spina bifida 54 | 1,074
Neurodegenerative disease 49 | 414
Liver Cirrhosis, Experimental 48 | 769
Down syndrome 47 | 499
Prostatic Neoplasms 47 | 495
Rheumatoid arthritis 47 | 1,191
Waldenstrons macroglobulinemia 47 | 765
Atopic dermatitis 46 | 952
esophageal adenocarcinoma 46 | 737
nasopharyngeal carcinoma 44 | 1,058
Duchenne muscular dystrophy 43 | 601
Obesity 43 | 678
active Crohn's disease 43 | 922
gastric carcinoma 43 | 807
Bipolar Disorder 41 | 666
Endometriosis 40 | 540
fibroadenoma 39 | 559
medulloblastoma 39 | 720
primary Sjogren syndrome 39 | 735
Kidney disease 38 | 430
Seizures 38 | 596
Multiple Sclerosis 37 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 37 | 510
Breast Neoplasms 36 | 445
Depressive disorder 36 | 409
Dull intelligence 36 | 645
Low intelligence 36 | 645
Melanoma 36 | 711
Mental Retardation 36 | 645
Mental deficiency 36 | 645
Parkinson's disease 36 | 392
Poor school performance 36 | 645
Amyotrophic lateral sclerosis 35 | 451
Mammary Neoplasms 35 | 425
Epilepsy 34 | 792
progressive supranuclear palsy 34 | 676
Heart disease 33 | 306
Hypertension 32 | 396
Osteoporosis 32 | 363
Short stature 32 | 531
Atherosclerosis 31 | 291
Cognitive delay 31 | 608
Global developmental delay 31 | 608
Mental and motor retardation 31 | 608
Liver carcinoma 30 | 240
acute myeloid leukemia 30 | 783
non primary Sjogren syndrome sicca 30 | 891

Tissue

Endocrine System 634 | 18,159
Digestive Tract 627 | 17,369
Skin and soft tissues 623 | 17,230
Female tissues 622 | 17,400
Liver and Pancreas 620 | 16,750
Male tissues 620 | 17,142
Nervous System 618 | 16,725
Respiratory system 615 | 16,393
Urinary Tract 614 | 16,678
Blood and immune system 613 | 16,909
Cardiovascular System 587 | 15,192

Target Family

Non-IDG 399 | 12,091
Enzyme 144 | 4,145
Kinase 47 | 634
Transporter 18 | 473
Ion Channel 13 | 344
GPCR 8 | 408
Transcription Factor 8 | 1,400
Epigenetic 5 | 242
Nuclear Receptor 2 | 48

GO Component

perinuclear region of cytoplas... 644 | 644
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Polypeptide N-acetylgalactosaminyltransferase 3 GALNT3 Tbio Enzyme -2.80894 644.1 124
Protein MRVI1 MRVI1 Tbio Non-IDG -1.40400 26.2 22
Nocturnin NOCT Tbio Non-IDG -1.84562 69.3 92
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895