Development Level

Tbio 3,494 | 11,651
Tdark 1,041 | 6,593
Tchem 456 | 1,388
Tclin 106 | 612

Collection

RFA-RM-18-021 62 | 328
Kinase: IDG Consortium (Target... 53 | 125
Kinase: IDG Consortium (Comple... 21 | 37
Ion Channel: IDG Consortium (T... 6 | 99
GPCR: IDG Consortium (Targets) 3 | 126

IMPC Phenotype

preweaning lethality, complete... 375 | 979
preweaning lethality, incomple... 154 | 499
embryonic lethality prior to t... 109 | 278
abnormal embryo size 88 | 220
embryonic lethality prior to o... 88 | 239
abnormal behavior 78 | 298
enlarged heart 62 | 210
decreased total body fat amoun... 61 | 207
abnormal bone structure 59 | 187
decreased vertical activity 54 | 208
increased lean body mass 52 | 172
decreased body weight 50 | 161
abnormal heart morphology 49 | 162
embryonic growth retardation 44 | 106
hypoactivity 44 | 132
decreased grip strength 40 | 116
increased total body fat amoun... 40 | 134
increased startle reflex 39 | 112
hyperactivity 38 | 148
male infertility 38 | 123
decreased circulating glucose ... 36 | 126
decreased lean body mass 36 | 135
abnormal seminal vesicle morph... 34 | 114
decreased circulating triglyce... 33 | 79
increased circulating alkaline... 33 | 122
decreased body length 32 | 101
prenatal lethality prior to he... 32 | 87
increased mean corpuscular vol... 31 | 92
decreased bone mineral content 30 | 151
decreased bone mineral density 30 | 126
decreased circulating choleste... 30 | 93
increased bone mineral content 30 | 108
increased mean corpuscular hem... 28 | 96
cataract 26 | 92
decreased prepulse inhibition 25 | 82
increased or absent threshold ... 25 | 101
abnormal lens morphology 24 | 81
decreased circulating insulin ... 24 | 76
impaired glucose tolerance 24 | 75
small superior vagus ganglion 24 | 74
abnormal gait 23 | 69
female infertility 23 | 60
decreased lymphocyte cell numb... 22 | 83
edema 22 | 59
increased circulating HDL chol... 22 | 80
abnormal behavioral response t... 21 | 66
abnormal retina morphology 21 | 71
decreased hemoglobin content 21 | 68
improved glucose tolerance 21 | 79
increased circulating choleste... 21 | 66
abnormal neural tube closure 20 | 46
decreased circulating serum al... 20 | 82
decreased mean corpuscular vol... 20 | 79
thrombocytopenia 20 | 56
tremors 20 | 39
abnormal skin morphology 19 | 50
decreased blood urea nitrogen ... 19 | 51
decreased circulating HDL chol... 19 | 68
increased fasted circulating g... 19 | 76
small testis 19 | 58
abnormal eye morphology 18 | 68
abnormal kidney morphology 18 | 65
decreased caudal vertebrae num... 18 | 53
decreased circulating alanine ... 18 | 47
decreased erythrocyte cell num... 18 | 62
decreased fasted circulating g... 18 | 65
decreased leukocyte cell numbe... 18 | 73
decreased startle reflex 18 | 75
hydrometra 18 | 53
increased bone mineral density 18 | 72
short tibia 18 | 97
abnormal coat-hair pigmentatio... 17 | 64
abnormal spleen morphology 17 | 55
increased monocyte cell number 17 | 63
abnormal embryo turning 16 | 31
decreased circulating alkaline... 16 | 46
increased body length 16 | 32
increased circulating chloride... 16 | 41
increased grip strength 16 | 41
increased heart weight 16 | 62
increased hemoglobin content 16 | 45
increased mean platelet volume 16 | 45
corneal opacity 15 | 32
decreased circulating total pr... 15 | 49
increased circulating sodium l... 15 | 71
increased mean corpuscular hem... 15 | 36
abnormal bone mineralization 14 | 38
abnormal retinal blood vessel ... 14 | 26
abnormal testis morphology 14 | 43
increased neutrophil cell numb... 14 | 46
decreased mean corpuscular hem... 13 | 50
increased circulating triglyce... 13 | 42
abnormal cornea morphology 12 | 31
abnormal sleep behavior 12 | 70
anophthalmia 12 | 33
decreased circulating LDL chol... 12 | 38
decreased hematocrit 12 | 46
enlarged spleen 12 | 41
increased body weight 12 | 25
increased hematocrit 12 | 46

Disease

Carcinoma 3,175 | 11,493
ovarian cancer 2,543 | 8,520
osteosarcoma 2,326 | 7,950
psoriasis 1,847 | 6,694
medulloblastoma, large-cell 1,774 | 6,241
glioblastoma 1,620 | 5,792
lung cancer 1,517 | 4,740
atypical teratoid / rhabdoid tumor 1,428 | 5,112
group 3 medulloblastoma 1,354 | 4,104
ependymoma 1,175 | 4,679
Breast cancer 1,089 | 3,578
Cancer 1,007 | 2,499
malignant mesothelioma 1,006 | 3,232
adult high grade glioma 942 | 3,801
primitive neuroectodermal tumor 927 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 884 | 3,291
oligodendroglioma 814 | 2,850
non-small cell lung cancer 795 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 790 | 2,989
invasive ductal carcinoma 768 | 2,951
Kidney cancer 733 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 712 | 2,955
lung adenocarcinoma 706 | 2,716
astrocytic glioma 705 | 2,597
Astrocytoma, Pilocytic 679 | 3,081
pancreatic cancer 644 | 2,398
subependymal giant cell astrocytoma 597 | 2,287
lung carcinoma 593 | 2,843
Pick disease 546 | 1,894
group 4 medulloblastoma 535 | 1,855
Multiple myeloma 522 | 1,332
tuberculosis 505 | 2,010
interstitial cystitis 495 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 493 | 1,962
pituitary cancer 477 | 1,972
breast carcinoma 475 | 1,638
ductal carcinoma in situ 460 | 1,745
colon cancer 444 | 1,478
adrenocortical carcinoma 441 | 1,428
diabetes mellitus 436 | 1,728
ulcerative colitis 431 | 1,819
cystic fibrosis 400 | 1,696
acute quadriplegic myopathy 395 | 1,158
Intellectual disability 380 | 1,016
Rheumatoid arthritis 378 | 1,191
astrocytoma 377 | 1,146
juvenile dermatomyositis 370 | 1,187
dermatomyositis 351 | 966
Autosomal recessive predisposition 331 | 1,442
pediatric high grade glioma 329 | 1,064
Waldenstrons macroglobulinemia 323 | 765
spina bifida 323 | 1,074
Schizophrenia 306 | 1,160
primary pancreatic ductal adenocarcinoma 298 | 1,109
nasopharyngeal carcinoma 293 | 1,058
acute myeloid leukemia 276 | 783
cutaneous lupus erythematosus 268 | 1,057
non primary Sjogren syndrome sicca 256 | 891
Atopic dermatitis 239 | 952
Dull intelligence 235 | 645
Low intelligence 235 | 645
Mental Retardation 235 | 645
Mental deficiency 235 | 645
Poor school performance 235 | 645
Epilepsy 217 | 792
progressive supranuclear palsy 216 | 676
primary Sjogren syndrome 215 | 735
medulloblastoma 214 | 720
Cognitive delay 206 | 608
Global developmental delay 206 | 608
Mental and motor retardation 206 | 608
active Crohn's disease 198 | 922
Alzheimer's disease 197 | 658
Breast Neoplasms 194 | 445
Obesity 193 | 678
Short stature 193 | 531
Mammary Neoplasms 187 | 425
Prostatic Neoplasms 187 | 495
esophageal adenocarcinoma 183 | 737
gastric carcinoma 183 | 807
aldosterone-producing adenoma 182 | 665
hepatocellular carcinoma 180 | 547
Melanoma 179 | 711
Muscle hypotonia 179 | 571
Seizures 179 | 596
Bipolar Disorder 178 | 666
Liver Cirrhosis, Experimental 178 | 769
Endometriosis 170 | 540
Amyotrophic lateral sclerosis 169 | 451
active ulcerative colitis 157 | 764
pancreatic carcinoma 157 | 562
Liver cancer 156 | 604
Down syndrome 155 | 499
gastric cancer 151 | 459
tuberculosis and treatment for 6 months 150 | 409
sonic hedgehog group medulloblastoma 148 | 467
Small head 147 | 374
autosomal dominant Emery-Dreifuss muscular dystrophy 145 | 510
Stomach Neoplasms 141 | 300
Cryptorchidism 135 | 296

Tissue

Endocrine System 4,909 | 18,159
Digestive Tract 4,744 | 17,369
Skin and soft tissues 4,739 | 17,230
Female tissues 4,731 | 17,400
Male tissues 4,710 | 17,142
Blood and immune system 4,658 | 16,909
Nervous System 4,642 | 16,725
Urinary Tract 4,616 | 16,678
Liver and Pancreas 4,610 | 16,750
Respiratory system 4,562 | 16,393
Cardiovascular System 4,382 | 15,192

Target Family

Non-IDG 2,414 | 12,091
Transcription Factor 1,241 | 1,400
Enzyme 896 | 4,145
Kinase 259 | 634
Epigenetic 166 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 29 | 38
Transporter 27 | 473
GPCR 15 | 408
Ion Channel 11 | 344
oGPCR 1 | 421

GO Component

nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408