Development Level

Tbio 3,290 | 10,625
Tdark 1,154 | 7,003
Tchem 555 | 1,890
Tclin 108 | 602

Collection

Eligible Kinase Proteins 47 | 134
Eligible Ion Channel Proteins 5 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 249 | 633
preweaning lethality, incomple... 90 | 260
embryonic lethality prior to t... 79 | 187
abnormal behavior 74 | 226
decreased body weight 57 | 174
embryonic lethality prior to o... 57 | 148
decreased total body fat amoun... 55 | 186
decreased lean body mass 53 | 195
abnormal embryo size 42 | 112
decreased bone mineral content 41 | 157
decreased grip strength 41 | 123
increased circulating alkaline... 41 | 119
increased or absent threshold ... 38 | 128
abnormal bone structure 37 | 131
decreased body length 36 | 108
hyperactivity 32 | 108
increased grip strength 32 | 83
decreased bone mineral density 31 | 126
hypoactivity 31 | 89
decreased circulating triglyce... 30 | 83
increased lean body mass 30 | 107
abnormal retina morphology 29 | 100
decreased circulating choleste... 29 | 85
enlarged heart 29 | 111
increased bone mineral content 29 | 92
increased mean corpuscular vol... 29 | 91
abnormal lens morphology 28 | 73
decreased circulating glucose ... 27 | 121
decreased circulating HDL chol... 25 | 77
increased mean corpuscular hem... 23 | 93
prenatal lethality prior to he... 23 | 64
increased circulating HDL chol... 22 | 63
increased circulating choleste... 22 | 53
decreased circulating insulin ... 21 | 75
decreased circulating serum al... 21 | 79
decreased caudal vertebrae num... 20 | 49
abnormal bone mineralization 19 | 55
decreased rib number 19 | 59
increased total body fat amoun... 19 | 57
decreased lumbar vertebrae num... 18 | 62
increased fasted circulating g... 18 | 68
short tibia 18 | 82
abnormal coat/hair pigmentatio... 17 | 54
abnormal gait 17 | 51
abnormal neural tube closure 17 | 37
decreased circulating alanine ... 17 | 53
increased sacral vertebrae num... 17 | 62
male infertility 17 | 62
abnormal behavioral response t... 16 | 52
decreased circulating alkaline... 16 | 41
impaired glucose tolerance 16 | 52
increased circulating chloride... 16 | 43
increased hemoglobin content 16 | 45
thrombocytopenia 16 | 46
abnormal retinal pigmentation 15 | 61
decreased circulating LDL chol... 15 | 37
improved glucose tolerance 15 | 56
increased heart weight 15 | 37
tremors 15 | 34
abnormal heart morphology 14 | 51
decreased leukocyte cell numbe... 14 | 54
increased circulating sodium l... 14 | 71
increased exploration in new e... 14 | 56
increased startle reflex 14 | 38
abnormal eye morphology 13 | 38
abnormal hindbrain development 13 | 24
abnormal seminal vesicle morph... 13 | 47
decreased T cell number 13 | 31
decreased erythrocyte cell num... 13 | 43
decreased fasted circulating g... 13 | 49
decreased heart weight 13 | 44
decreased hemoglobin content 13 | 53
decreased mean corpuscular vol... 13 | 50
decreased startle reflex 13 | 48
increased body weight 13 | 42
increased bone mineral density 13 | 52
abnormal spleen morphology 12 | 36
cataract 12 | 26
corneal opacity 12 | 25
decreased blood urea nitrogen ... 12 | 31
decreased circulating aspartat... 12 | 27
decreased circulating free fat... 12 | 39
decreased eosinophil cell numb... 12 | 41
decreased prepulse inhibition 12 | 52
abnormal forebrain development 11 | 18
abnormal midbrain development 11 | 22
abnormal sleep behavior 11 | 63
decreased circulating fructosa... 11 | 31
decreased circulating total pr... 11 | 41
female infertility 11 | 34
hydrops fetalis 11 | 22
increased circulating triglyce... 11 | 24
increased mean corpuscular hem... 11 | 25
abnormal locomotor activation 10 | 26
abnormal tooth morphology 10 | 24
decreased circulating chloride... 10 | 32
decreased circulating creatini... 10 | 31
increased circulating creatini... 10 | 29
limb grasping 10 | 35
small testis 10 | 37

Disease

ovarian cancer 2,573 | 8,484
osteosarcoma 2,325 | 7,933
psoriasis 1,846 | 6,685
medulloblastoma, large-cell 1,796 | 6,234
glioblastoma 1,563 | 5,572
lung cancer 1,457 | 4,466
atypical teratoid / rhabdoid tumor 1,214 | 4,369
malignant mesothelioma 1,003 | 3,162
Breast cancer 965 | 3,094
Cancer 949 | 2,346
primitive neuroectodermal tumor 938 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 904 | 3,289
oligodendroglioma 828 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 806 | 2,988
group 3 medulloblastoma 792 | 2,254
invasive ductal carcinoma 787 | 2,950
non-small cell lung cancer 784 | 2,798
pediatric high grade glioma 757 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 724 | 2,956
ependymoma 713 | 2,514
lung adenocarcinoma 709 | 2,713
pilocytic astrocytoma 693 | 3,086
astrocytic glioma 625 | 2,241
pancreatic cancer 613 | 2,300
subependymal giant cell astrocytoma 607 | 2,287
lung carcinoma 599 | 2,844
Carcinoma 592 | 2,147
group 4 medulloblastoma 590 | 1,875
Pick disease 540 | 1,893
adult high grade glioma 525 | 2,148
Multiple myeloma 520 | 1,327
interstitial cystitis 511 | 2,299
ulcerative colitis 493 | 2,087
pituitary cancer 488 | 1,972
breast carcinoma 473 | 1,614
astrocytoma 471 | 1,493
ductal carcinoma in situ 465 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 455 | 1,795
medulloblastoma 452 | 1,524
adrenocortical carcinoma 449 | 1,427
colon cancer 449 | 1,475
sonic hedgehog group medulloblastoma 422 | 1,482
diabetes mellitus 412 | 1,663
cystic fibrosis 407 | 1,665
tuberculosis 399 | 1,557
acute quadriplegic myopathy 394 | 1,157
posterior fossa group A ependymoma 385 | 1,511
Rheumatoid Arthritis 381 | 1,160
juvenile dermatomyositis 373 | 1,189
dermatomyositis 356 | 933
primary pancreatic ductal adenocarcinoma 335 | 1,271
atypical teratoid/rhabdoid tumor 329 | 1,095
posterior fossa group B ependymoma 327 | 1,530
Waldenstrons macroglobulinemia 326 | 765
spina bifida 319 | 1,064
nasopharyngeal carcinoma 295 | 1,056
acute myeloid leukemia 278 | 780
cutaneous lupus erythematosus 275 | 1,056
non primary Sjogren syndrome sicca 245 | 840
Atopic dermatitis 240 | 944
primary Sjogren syndrome 240 | 789
progressive supranuclear palsy 228 | 674
tuberculosis and treatment for 6 months 227 | 686
Intellectual disability 209 | 573
Alzheimer's disease 196 | 644
gastric carcinoma 193 | 832
active Crohn's disease 192 | 918
esophageal adenocarcinoma 189 | 737
Mammary Neoplasms 182 | 410
aldosterone-producing adenoma 180 | 664
Endometriosis 176 | 535
Prostatic Neoplasms 175 | 471
hepatocellular carcinoma 175 | 532
Down syndrome 171 | 548
Obesity 162 | 616
pancreatic carcinoma 160 | 567
Amyotrophic Lateral Sclerosis 156 | 431
autosomal dominant Emery-Dreifuss muscular dystrophy 147 | 499
Duchenne muscular dystrophy 138 | 602
inflammatory breast cancer 137 | 404
gastric cancer 135 | 430
IGA Glomerulonephritis 134 | 454
Stomach Neoplasms 131 | 282
Schizophrenia 128 | 501
chronic rhinosinusitis 127 | 512
fibroadenoma 127 | 557
Neurodegenerative disease 117 | 383
Parkinson's disease 113 | 364
Multiple Sclerosis 111 | 498
glioblastoma multiforme 107 | 347
active ulcerative colitis 105 | 477
sarcoidosis 101 | 358
Melanoma 100 | 261
non-small cell lung carcinoma 99 | 413
Vascular disease 98 | 281
tuberculosis and treatment for 3 months 97 | 327
Crohn's disease 96 | 304
Peripheral Neuropathy 96 | 303
Kidney disease 95 | 396
Polycystic Ovary Syndrome 95 | 332

Tissue

Female tissues 4,988 | 18,647
Endocrine System 4,970 | 18,512
Nervous System 4,969 | 18,561
Digestive Tract 4,953 | 18,473
Urinary Tract 4,923 | 18,444
Male tissues 4,920 | 17,969
Blood and immune system 4,910 | 17,995
Liver and Pancreas 4,892 | 18,136
Cardiovascular System 4,869 | 17,958
Skin and soft tissues 4,868 | 18,115
Respiratory system 4,761 | 17,484

Target Family

Non-IDG 2,396 | 11,971
Transcription Factor 1,263 | 1,400
Enzyme 916 | 4,146
Kinase 250 | 634
Epigenetic 165 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 29 | 38
Transporter 29 | 473
GPCR 12 | 406
Ion Channel 9 | 341

GO Component

nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955