Development Level

Tbio 2,199 | 11,178
Tchem 420 | 1,885
Tdark 300 | 6,569
Tclin 77 | 612

Collection

Kinase: IDG Consortium (Target... 24 | 125
Kinase: IDG Consortium (Comple... 9 | 37
GPCR: IDG Consortium (Targets) 3 | 126

IMPC Phenotype

preweaning lethality, complete... 326 | 979
preweaning lethality, incomple... 101 | 499
embryonic lethality prior to t... 92 | 278
embryonic lethality prior to o... 88 | 239
abnormal embryo size 64 | 220
abnormal behavior 60 | 298
decreased body weight 40 | 161
decreased total body fat amoun... 39 | 207
abnormal bone structure 38 | 187
enlarged heart 37 | 210
abnormal heart morphology 35 | 162
increased lean body mass 34 | 172
embryonic growth retardation 32 | 106
increased startle reflex 29 | 112
decreased lean body mass 27 | 135
male infertility 27 | 123
prenatal lethality prior to he... 27 | 87
decreased bone mineral density 26 | 126
hyperactivity 26 | 148
increased mean corpuscular vol... 26 | 92
increased bone mineral density 25 | 72
increased circulating alkaline... 25 | 122
decreased vertical activity 24 | 208
hypoactivity 24 | 132
decreased bone mineral content 23 | 151
decreased circulating glucose ... 23 | 126
increased mean corpuscular hem... 23 | 96
increased or absent threshold ... 23 | 101
cataract 22 | 92
decreased circulating choleste... 22 | 93
decreased prepulse inhibition 22 | 82
increased bone mineral content 22 | 108
decreased body length 21 | 101
increased total body fat amoun... 21 | 134
abnormal kidney morphology 20 | 65
decreased lymphocyte cell numb... 20 | 83
decreased circulating triglyce... 19 | 79
abnormal seminal vesicle morph... 18 | 114
decreased leukocyte cell numbe... 18 | 73
abnormal lens morphology 17 | 81
abnormal neural tube closure 17 | 46
decreased mean corpuscular vol... 17 | 79
decreased grip strength 16 | 116
increased circulating HDL chol... 16 | 80
abnormal coat-hair pigmentatio... 15 | 64
decreased hemoglobin content 15 | 68
abnormal retina morphology 14 | 71
corneal opacity 14 | 32
female infertility 14 | 60
increased circulating choleste... 14 | 66
short tibia 14 | 97
decreased circulating HDL chol... 13 | 68
decreased circulating LDL chol... 13 | 38
decreased circulating serum al... 13 | 82
edema 13 | 59
impaired glucose tolerance 13 | 75
increased mean platelet volume 13 | 45
abnormal embryo turning 12 | 31
abnormal eye morphology 12 | 68
abnormal gait 12 | 69
abnormal spleen morphology 12 | 55
decreased blood urea nitrogen ... 12 | 51
decreased erythrocyte cell num... 12 | 62
decreased startle reflex 12 | 75
hydrometra 12 | 53
increased grip strength 12 | 41
increased neutrophil cell numb... 12 | 46
small superior vagus ganglion 12 | 74
thrombocytopenia 12 | 56
abnormal bone mineralization 11 | 38
abnormal craniofacial morpholo... 11 | 33
decreased caudal vertebrae num... 11 | 53
decreased circulating alkaline... 11 | 46
decreased heart left ventricle... 11 | 28
decreased neutrophil cell numb... 11 | 42
increased circulating chloride... 11 | 41
increased monocyte cell number 11 | 63
tremors 11 | 39
abnormal forebrain development 10 | 20
decreased circulating alanine ... 10 | 47
decreased circulating insulin ... 10 | 76
decreased hematocrit 10 | 46
decreased mean corpuscular hem... 10 | 50
increased circulating sodium l... 10 | 71
increased hemoglobin content 10 | 45
long tibia 10 | 25
abnormal behavioral response t... 9 | 66
abnormal cornea morphology 9 | 31
abnormal skin morphology 9 | 50
decreased circulating total pr... 9 | 49
decreased mean platelet volume 9 | 25
increased body length 9 | 32
increased circulating creatini... 9 | 38
increased circulating triglyce... 9 | 42
increased mean corpuscular hem... 9 | 36
small testis 9 | 58
abnormal sleep behavior 8 | 70
anophthalmia 8 | 33
pale yolk sac 8 | 25
pallor 8 | 34

Disease

Carcinoma 1,919 | 11,192
ovarian cancer 1,758 | 8,297
osteosarcoma 1,503 | 7,766
medulloblastoma, large-cell 1,122 | 6,086
psoriasis 1,091 | 6,514
glioblastoma 1,017 | 5,635
lung cancer 991 | 4,607
group 3 medulloblastoma 894 | 4,002
atypical teratoid / rhabdoid tumor 860 | 4,971
ependymoma 693 | 4,559
Cancer 692 | 2,388
Breast cancer 681 | 3,469
malignant mesothelioma 674 | 3,135
primitive neuroectodermal tumor 585 | 2,957
adult high grade glioma 562 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 551 | 3,204
oligodendroglioma 501 | 2,768
non-small cell lung cancer 493 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 481 | 2,902
Kidney cancer 478 | 2,548
invasive ductal carcinoma 464 | 2,867
lung adenocarcinoma 423 | 2,627
astrocytic glioma 420 | 2,530
intraductal papillary-mucinous adenoma (IPMA) 410 | 2,872
Multiple myeloma 374 | 1,296
Pick disease 359 | 1,856
pancreatic cancer 353 | 2,322
Astrocytoma, Pilocytic 345 | 3,006
subependymal giant cell astrocytoma 345 | 2,230
pancreatic ductal adenocarcinoma liver metastasis 306 | 1,911
tuberculosis 295 | 1,963
group 4 medulloblastoma 293 | 1,806
adrenocortical carcinoma 286 | 1,385
acute quadriplegic myopathy 285 | 1,133
diabetes mellitus 280 | 1,683
colon cancer 278 | 1,428
breast carcinoma 277 | 1,589
ductal carcinoma in situ 275 | 1,686
pituitary cancer 275 | 1,915
lung carcinoma 274 | 2,755
astrocytoma 269 | 1,113
Rheumatoid arthritis 263 | 1,156
Intellectual disability 261 | 998
juvenile dermatomyositis 256 | 1,147
ulcerative colitis 249 | 1,765
Waldenstrons macroglobulinemia 243 | 742
interstitial cystitis 242 | 2,237
dermatomyositis 231 | 941
Autosomal recessive predisposition 213 | 1,407
pediatric high grade glioma 211 | 1,035
acute myeloid leukemia 201 | 760
Schizophrenia 186 | 1,136
spina bifida 183 | 1,053
cystic fibrosis 182 | 1,629
nasopharyngeal carcinoma 181 | 1,024
primary pancreatic ductal adenocarcinoma 170 | 1,071
Dull intelligence 167 | 634
Low intelligence 167 | 634
Mental Retardation 167 | 634
Mental deficiency 167 | 634
Poor school performance 167 | 634
Cognitive delay 155 | 596
Global developmental delay 155 | 596
Mental and motor retardation 155 | 596
Breast Neoplasms 152 | 423
Short stature 152 | 514
Atopic dermatitis 145 | 915
non primary Sjogren syndrome sicca 145 | 861
Mammary Neoplasms 144 | 403
medulloblastoma 141 | 702
progressive supranuclear palsy 139 | 656
cutaneous lupus erythematosus 137 | 1,016
Endometriosis 136 | 521
aldosterone-producing adenoma 132 | 646
primary Sjogren syndrome 129 | 710
Small head 128 | 366
Epilepsy 120 | 775
active Crohn's disease 120 | 882
Obesity 118 | 655
hepatocellular carcinoma 114 | 536
Alzheimer's disease 113 | 640
gastric carcinoma 113 | 781
Muscle hypotonia 111 | 562
Prostatic Neoplasms 105 | 472
Bipolar Disorder 104 | 646
esophageal adenocarcinoma 103 | 696
Liver Cirrhosis, Experimental 102 | 733
Seizures 102 | 584
Amyotrophic lateral sclerosis 101 | 437
tuberculosis and treatment for 6 months 100 | 399
pancreatic carcinoma 98 | 555
Cryptorchidism 97 | 287
Melanoma 97 | 689
active ulcerative colitis 96 | 736
Liver cancer 95 | 589
Stomach Neoplasms 93 | 287
Hypoplastic mandible condyle 89 | 273
Mandibular hypoplasia 89 | 273
Micrognathism 89 | 273
gastric cancer 86 | 445

Tissue

Endocrine System 2,982 | 18,159
Digestive Tract 2,974 | 17,369
Female tissues 2,966 | 17,400
Male tissues 2,963 | 17,142
Skin and soft tissues 2,962 | 17,230
Blood and immune system 2,947 | 16,909
Urinary Tract 2,943 | 16,678
Liver and Pancreas 2,940 | 16,750
Respiratory system 2,929 | 16,393
Nervous System 2,927 | 16,725
Cardiovascular System 2,867 | 15,192

Target Family

Non-IDG 1,511 | 12,091
Enzyme 644 | 4,145
Transcription Factor 424 | 1,400
Epigenetic 162 | 242
Kinase 153 | 634
Nuclear Receptor 47 | 48
TF/Epigenetic 24 | 38
Transporter 18 | 473
GPCR 8 | 408
Ion Channel 5 | 344

GO Component

nucleoplasm 2,996 | 2,996
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
GEM-interacting protein GMIP Tbio Non-IDG -1.02340 9.61 45
Zinc finger protein 500 ZNF500 Tdark Transcription Factor 0.95 0.10 240
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Chromodomain-helicase-DNA-binding protein 6 CHD6 Tbio Epigenetic -1.01113 11.4 31