Development Level

Tbio 1,927 | 10,625
Tchem 409 | 1,890
Tdark 311 | 7,003
Tclin 70 | 602

Collection

Eligible Kinase Proteins 23 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 176 | 633
preweaning lethality, incomple... 58 | 260
embryonic lethality prior to o... 51 | 148
embryonic lethality prior to t... 51 | 187
abnormal behavior 42 | 226
decreased body weight 37 | 174
decreased total body fat amoun... 36 | 186
abnormal embryo size 33 | 112
decreased lean body mass 31 | 195
abnormal bone structure 28 | 131
increased or absent threshold ... 25 | 128
decreased body length 24 | 108
decreased bone mineral content 23 | 157
increased circulating alkaline... 21 | 119
abnormal retina morphology 20 | 100
increased grip strength 20 | 83
increased mean corpuscular hem... 20 | 93
increased mean corpuscular vol... 20 | 91
decreased circulating glucose ... 19 | 121
hyperactivity 19 | 108
increased bone mineral content 18 | 92
increased lean body mass 18 | 107
prenatal lethality prior to he... 18 | 64
decreased bone mineral density 17 | 126
enlarged heart 17 | 111
abnormal lens morphology 16 | 73
decreased circulating choleste... 16 | 85
increased sacral vertebrae num... 16 | 62
abnormal bone mineralization 15 | 55
decreased circulating HDL chol... 15 | 77
decreased grip strength 15 | 123
decreased rib number 15 | 59
decreased caudal vertebrae num... 13 | 49
decreased circulating triglyce... 13 | 83
decreased leukocyte cell numbe... 13 | 54
decreased lumbar vertebrae num... 13 | 62
increased circulating HDL chol... 13 | 63
abnormal retinal pigmentation 12 | 61
decreased hemoglobin content 12 | 53
male infertility 12 | 62
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating serum al... 11 | 79
hypoactivity 11 | 89
increased circulating sodium l... 11 | 71
short tibia 11 | 82
abnormal eye morphology 10 | 38
decreased circulating LDL chol... 10 | 37
decreased mean corpuscular vol... 10 | 50
decreased prepulse inhibition 10 | 52
embryonic growth retardation 10 | 28
increased bone mineral density 10 | 52
abnormal gait 9 | 51
decreased erythrocyte cell num... 9 | 43
increased circulating creatini... 9 | 29
abnormal heart morphology 8 | 51
abnormal neural tube closure 8 | 37
corneal opacity 8 | 25
decreased circulating insulin ... 8 | 75
decreased hematocrit 8 | 25
decreased mean corpuscular hem... 8 | 34
increased circulating chloride... 8 | 43
increased circulating choleste... 8 | 53
increased circulating triglyce... 8 | 24
increased exploration in new e... 8 | 56
increased fasted circulating g... 8 | 68
thrombocytopenia 8 | 46
abnormal behavioral response t... 7 | 52
abnormal locomotor activation 7 | 26
abnormal spleen morphology 7 | 36
anophthalmia 7 | 20
cataract 7 | 26
decreased T cell number 7 | 31
decreased circulating alanine ... 7 | 53
decreased circulating alkaline... 7 | 41
decreased circulating chloride... 7 | 32
decreased circulating total pr... 7 | 41
decreased startle reflex 7 | 48
female infertility 7 | 34
impaired glucose tolerance 7 | 52
increased hemoglobin content 7 | 45
pale yolk sac 7 | 12
tremors 7 | 34
abnormal cornea morphology 6 | 24
abnormal cranium morphology 6 | 32
abnormal rib morphology 6 | 28
abnormal sleep behavior 6 | 63
abnormal tooth morphology 6 | 24
decreased circulating free fat... 6 | 39
decreased circulating fructosa... 6 | 31
decreased eosinophil cell numb... 6 | 41
decreased fasted circulating g... 6 | 49
decreased threshold for audito... 6 | 32
hydrops fetalis 6 | 22
increased blood urea nitrogen ... 6 | 44
increased heart weight 6 | 37
increased mean corpuscular hem... 6 | 25
increased startle reflex 6 | 38
limb grasping 6 | 35
polydactyly 6 | 22
small testis 6 | 37

Disease

ovarian cancer 1,679 | 8,484
osteosarcoma 1,416 | 7,933
medulloblastoma, large-cell 1,078 | 6,234
psoriasis 1,058 | 6,685
glioblastoma 949 | 5,572
lung cancer 930 | 4,466
atypical teratoid / rhabdoid tumor 730 | 4,369
malignant mesothelioma 655 | 3,162
Cancer 641 | 2,346
primitive neuroectodermal tumor 577 | 3,031
Breast cancer 574 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 545 | 3,289
group 3 medulloblastoma 527 | 2,254
oligodendroglioma 499 | 2,849
pediatric high grade glioma 492 | 2,712
non-small cell lung cancer 475 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 470 | 2,988
invasive ductal carcinoma 453 | 2,950
ependymoma 445 | 2,514
lung adenocarcinoma 407 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 398 | 2,956
Multiple myeloma 386 | 1,327
Carcinoma 367 | 2,147
astrocytic glioma 358 | 2,241
Pick disease 348 | 1,893
pilocytic astrocytoma 344 | 3,086
subependymal giant cell astrocytoma 339 | 2,287
pancreatic cancer 335 | 2,300
astrocytoma 326 | 1,493
group 4 medulloblastoma 298 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 296 | 1,795
colon cancer 281 | 1,475
adult high grade glioma 278 | 2,148
adrenocortical carcinoma 275 | 1,427
acute quadriplegic myopathy 274 | 1,157
ductal carcinoma in situ 269 | 1,745
breast carcinoma 267 | 1,614
sonic hedgehog group medulloblastoma 267 | 1,482
pituitary cancer 264 | 1,972
ulcerative colitis 262 | 2,087
lung carcinoma 261 | 2,844
diabetes mellitus 259 | 1,663
juvenile dermatomyositis 257 | 1,189
Waldenstrons macroglobulinemia 251 | 765
medulloblastoma 240 | 1,524
Rheumatoid Arthritis 234 | 1,160
dermatomyositis 233 | 933
interstitial cystitis 228 | 2,299
tuberculosis 215 | 1,557
posterior fossa group A ependymoma 214 | 1,511
atypical teratoid/rhabdoid tumor 193 | 1,095
spina bifida 191 | 1,064
acute myeloid leukemia 186 | 780
nasopharyngeal carcinoma 185 | 1,056
primary pancreatic ductal adenocarcinoma 179 | 1,271
cystic fibrosis 174 | 1,665
posterior fossa group B ependymoma 154 | 1,530
tuberculosis and treatment for 6 months 144 | 686
Atopic dermatitis 141 | 944
Intellectual disability 140 | 573
non primary Sjogren syndrome sicca 140 | 840
Endometriosis 138 | 535
progressive supranuclear palsy 138 | 674
Mammary Neoplasms 135 | 410
cutaneous lupus erythematosus 129 | 1,056
primary Sjogren syndrome 121 | 789
aldosterone-producing adenoma 117 | 664
active Crohn's disease 116 | 918
hepatocellular carcinoma 113 | 532
Amyotrophic Lateral Sclerosis 111 | 431
Alzheimer's disease 108 | 644
gastric carcinoma 106 | 832
esophageal adenocarcinoma 98 | 737
Prostatic Neoplasms 94 | 471
pancreatic carcinoma 94 | 567
IGA Glomerulonephritis 90 | 454
Down syndrome 86 | 548
Obesity 85 | 616
Stomach Neoplasms 84 | 282
gastric cancer 82 | 430
autosomal dominant Emery-Dreifuss muscular dystrophy 75 | 499
inflammatory breast cancer 75 | 404
Neurodegenerative disease 66 | 383
Peripheral Neuropathy 65 | 303
Crohn's disease 64 | 304
chronic rhinosinusitis 64 | 512
Liver carcinoma 63 | 217
Polycystic Ovary Syndrome 60 | 332
Schizophrenia 60 | 501
non-small cell lung carcinoma 60 | 413
active ulcerative colitis 58 | 477
glioblastoma multiforme 58 | 347
Melanoma 57 | 261
Vascular disease 57 | 281
hereditary spastic paraplegia 55 | 313
Lung Neoplasms 54 | 171
Parkinson's disease 54 | 364
Multiple Sclerosis 52 | 498
Duchenne muscular dystrophy 50 | 602
mucosa-associated lymphoid tissue lymphoma 49 | 480

Tissue

Digestive Tract 2,715 | 18,473
Female tissues 2,714 | 18,647
Nervous System 2,714 | 18,561
Male tissues 2,711 | 17,969
Endocrine System 2,710 | 18,512
Liver and Pancreas 2,708 | 18,136
Blood and immune system 2,706 | 17,995
Urinary Tract 2,706 | 18,444
Cardiovascular System 2,704 | 17,958
Skin and soft tissues 2,691 | 18,115
Respiratory system 2,688 | 17,484

Target Family

Non-IDG 1,396 | 11,971
Enzyme 588 | 4,146
Transcription Factor 355 | 1,400
Epigenetic 147 | 242
Kinase 143 | 634
Nuclear Receptor 47 | 48
TF/Epigenetic 23 | 38
Transporter 10 | 473
GPCR 4 | 406
Ion Channel 4 | 341

GO Component

nucleoplasm 2,717 | 2,717
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178