Development Level

Tbio 622 | 11,445
Tdark 119 | 6,588
Tchem 69 | 1,598
Tclin 14 | 613

Collection

RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Target... 4 | 125
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 81 | 979
embryonic lethality prior to o... 26 | 239
preweaning lethality, incomple... 24 | 499
embryonic lethality prior to t... 21 | 278
abnormal embryo size 17 | 220
abnormal behavior 15 | 298
decreased lean body mass 10 | 135
hyperactivity 10 | 148
abnormal heart morphology 9 | 162
decreased body weight 9 | 161
decreased vertical activity 9 | 208
enlarged heart 9 | 210
increased startle reflex 9 | 112
abnormal coat-hair pigmentatio... 8 | 64
short tibia 8 | 97
decreased circulating choleste... 7 | 93
decreased total body fat amoun... 7 | 207
increased lean body mass 7 | 172
male infertility 7 | 123
abnormal bone structure 6 | 187
abnormal spleen morphology 6 | 55
decreased body length 6 | 101
decreased bone mineral content 6 | 151
decreased circulating alanine ... 6 | 47
decreased circulating glucose ... 6 | 126
decreased mean corpuscular vol... 6 | 79
decreased prepulse inhibition 6 | 82
embryonic growth retardation 6 | 106
increased fasted circulating g... 6 | 76
increased or absent threshold ... 6 | 101
decreased circulating HDL chol... 5 | 68
decreased circulating serum al... 5 | 82
decreased circulating total pr... 5 | 49
decreased erythrocyte cell num... 5 | 62
decreased hemoglobin content 5 | 68
impaired glucose tolerance 5 | 75
increased bone mineral density 5 | 72
increased circulating HDL chol... 5 | 80
increased total body fat amoun... 5 | 134
small testis 5 | 58
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
abnormal seminal vesicle morph... 4 | 114
abnormal sleep behavior 4 | 70
decreased circulating iron lev... 4 | 32
decreased circulating triglyce... 4 | 79
decreased fasted circulating g... 4 | 65
edema 4 | 59
female infertility 4 | 60
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased circulating chloride... 4 | 41
increased circulating triglyce... 4 | 42
prenatal lethality prior to he... 4 | 87
prolonged ST segment 4 | 36
abnormal bone mineralization 3 | 38
abnormal gait 3 | 69
abnormal placenta size 3 | 20
abnormal testis morphology 3 | 43
abnormal vertebrae morphology 3 | 18
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating aspartat... 3 | 34
decreased circulating insulin ... 3 | 76
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased circulating sodium l... 3 | 71
increased heart weight 3 | 62
pale yolk sac 3 | 25
pallor 3 | 34
prolonged QT interval 3 | 38
vertebral transformation 3 | 12
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal limb bud morphology 2 | 17
abnormal liver morphology 2 | 17
abnormal optic disc morphology 2 | 10
abnormal retina morphology 2 | 71
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased lactate dehydrogenas... 2 | 16
decreased startle reflex 2 | 75
enlarged spleen 2 | 41
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
microphthalmia 2 | 26
tremors 2 | 39

Disease

Carcinoma 517 | 11,493
ovarian cancer 464 | 8,520
osteosarcoma 397 | 7,950
medulloblastoma, large-cell 319 | 6,241
lung cancer 288 | 4,740
psoriasis 283 | 6,694
glioblastoma 266 | 5,792
group 3 medulloblastoma 257 | 4,104
atypical teratoid / rhabdoid tumor 233 | 5,112
ependymoma 177 | 4,679
Breast cancer 174 | 3,578
malignant mesothelioma 171 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 162 | 3,291
Cancer 154 | 2,499
adult high grade glioma 148 | 3,801
primitive neuroectodermal tumor 136 | 3,035
non-small cell lung cancer 132 | 2,890
Multiple myeloma 127 | 1,332
invasive ductal carcinoma 126 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 125 | 2,989
lung adenocarcinoma 124 | 2,716
oligodendroglioma 122 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 113 | 2,955
Kidney cancer 112 | 2,613
Astrocytoma, Pilocytic 111 | 3,081
astrocytic glioma 108 | 2,597
colon cancer 103 | 1,478
subependymal giant cell astrocytoma 102 | 2,287
pancreatic cancer 100 | 2,398
acute quadriplegic myopathy 97 | 1,158
Pick disease 89 | 1,894
diabetes mellitus 85 | 1,728
Waldenstrons macroglobulinemia 84 | 765
lung carcinoma 82 | 2,843
Intellectual disability 74 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 71 | 1,962
group 4 medulloblastoma 70 | 1,855
juvenile dermatomyositis 69 | 1,187
tuberculosis 68 | 2,010
ductal carcinoma in situ 67 | 1,745
dermatomyositis 66 | 966
breast carcinoma 65 | 1,638
cystic fibrosis 65 | 1,696
adrenocortical carcinoma 64 | 1,428
astrocytoma 63 | 1,146
pituitary cancer 61 | 1,972
non primary Sjogren syndrome sicca 60 | 891
pediatric high grade glioma 60 | 1,064
Autosomal recessive predisposition 59 | 1,442
Rheumatoid arthritis 55 | 1,191
ulcerative colitis 55 | 1,819
acute myeloid leukemia 53 | 783
interstitial cystitis 47 | 2,312
nasopharyngeal carcinoma 47 | 1,058
spina bifida 47 | 1,074
Dull intelligence 45 | 645
Low intelligence 45 | 645
Mental Retardation 45 | 645
Mental deficiency 45 | 645
Poor school performance 45 | 645
Cognitive delay 44 | 608
Global developmental delay 44 | 608
Mental and motor retardation 44 | 608
primary pancreatic ductal adenocarcinoma 43 | 1,109
Schizophrenia 40 | 1,160
Small head 40 | 374
cutaneous lupus erythematosus 40 | 1,057
Short stature 38 | 531
Breast Neoplasms 37 | 445
Neurodegenerative disease 34 | 414
progressive supranuclear palsy 34 | 676
Mammary Neoplasms 33 | 425
Stomach Neoplasms 33 | 300
Prostatic Neoplasms 32 | 495
hepatocellular carcinoma 32 | 547
medulloblastoma 31 | 720
Epilepsy 30 | 792
Liver cancer 30 | 604
Amyotrophic lateral sclerosis 29 | 451
Liver Cirrhosis, Experimental 29 | 769
Muscle hypotonia 29 | 571
primary Sjogren syndrome 29 | 735
Alzheimer's disease 27 | 658
Atopic dermatitis 27 | 952
esophageal adenocarcinoma 27 | 737
gastric carcinoma 27 | 807
Endometriosis 26 | 540
Seizures 26 | 596
sonic hedgehog group medulloblastoma 26 | 467
Adenocarcinoma of lung 25 | 142
Anemia 25 | 365
Cryptorchidism 25 | 296
Down syndrome 25 | 499
Melanoma 25 | 711
Microcephaly 25 | 166
aldosterone-producing adenoma 25 | 665
Duchenne muscular dystrophy 24 | 601
Strabismus 24 | 270
autosomal dominant Emery-Dreifuss muscular dystrophy 24 | 510
pancreatic carcinoma 24 | 562

Tissue

Endocrine System 807 | 18,159
Digestive Tract 800 | 17,369
Female tissues 800 | 17,400
Male tissues 797 | 17,142
Blood and immune system 793 | 16,909
Skin and soft tissues 793 | 17,230
Nervous System 791 | 16,725
Liver and Pancreas 787 | 16,750
Respiratory system 787 | 16,393
Urinary Tract 787 | 16,678
Cardiovascular System 768 | 15,192

Target Family

Non-IDG 472 | 12,091
Enzyme 213 | 4,145
Transcription Factor 69 | 1,400
Epigenetic 28 | 242
Kinase 28 | 634
Ion Channel 4 | 344
TF/Epigenetic 4 | 38
Transporter 4 | 473
GPCR 2 | 408

GO Component

nucleolus 824 | 824
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Shadow of prion protein SPRN Tbio Non-IDG -2.49698 315.1 88
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
Protein yippee-like 2 YPEL2 Tdark Non-IDG 0.05 0.75 22
Succinate dehydrogenase assembly factor 2, mitochondrial SDHAF2 Tbio Enzyme -1.86465 69.5 34
A-kinase anchor protein 11 AKAP11 Tbio Enzyme -1.02415 11.7 38
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331
p21-activated protein kinase-interacting protein 1 PAK1IP1 Tbio Enzyme -1.02033 9.87 62
Putative methyltransferase NSUN5C NSUN5P2 Tdark Enzyme 0.00000 0