Development Level

Tbio 294 | 11,445
Tchem 40 | 1,598
Tdark 31 | 6,588
Tclin 6 | 613

Collection

Kinase: IDG Consortium (Target... 6 | 125
RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Comple... 4 | 37

IMPC Phenotype

preweaning lethality, complete... 47 | 979
embryonic lethality prior to o... 12 | 239
embryonic lethality prior to t... 12 | 278
preweaning lethality, incomple... 12 | 499
abnormal embryo size 10 | 220
decreased total body fat amoun... 7 | 207
abnormal behavior 5 | 298
decreased hemoglobin content 5 | 68
enlarged heart 5 | 210
abnormal heart morphology 4 | 162
decreased bone mineral density 4 | 126
decreased circulating alanine ... 4 | 47
decreased leukocyte cell numbe... 4 | 73
decreased vertical activity 4 | 208
increased fasted circulating g... 4 | 76
increased lean body mass 4 | 172
increased startle reflex 4 | 112
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating aspartat... 3 | 34
decreased circulating iron lev... 3 | 32
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
increased bone mineral density 3 | 72
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
pallor 3 | 34
prenatal lethality prior to he... 3 | 87
abnormal neural tube morpholog... 2 | 12
abnormal seminal vesicle morph... 2 | 114
absent startle reflex 2 | 24
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
edema 2 | 59
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating serum al... 2 | 22
increased heart weight 2 | 62
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
persistence of hyaloid vascula... 2 | 33
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased IgE level 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased circulating chloride... 1 | 30
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
hemorrhage 1 | 23
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
prenatal lethality 1 | 28
small thymus 1 | 16
syndactyly 1 | 23
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 262 | 11,493
ovarian cancer 246 | 8,520
osteosarcoma 214 | 7,950
psoriasis 154 | 6,694
medulloblastoma, large-cell 141 | 6,241
glioblastoma 137 | 5,792
lung cancer 122 | 4,740
group 3 medulloblastoma 119 | 4,104
atypical teratoid / rhabdoid tumor 116 | 5,112
ependymoma 103 | 4,679
Breast cancer 88 | 3,578
malignant mesothelioma 88 | 3,232
oligodendroglioma 88 | 2,850
adult high grade glioma 82 | 3,801
Kidney cancer 73 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,989
primitive neuroectodermal tumor 67 | 3,035
astrocytic glioma 66 | 2,597
Multiple myeloma 65 | 1,332
Cancer 63 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,291
invasive ductal carcinoma 58 | 2,951
Pick disease 54 | 1,894
non-small cell lung cancer 54 | 2,890
pancreatic cancer 50 | 2,398
Waldenstrons macroglobulinemia 48 | 765
subependymal giant cell astrocytoma 47 | 2,287
Astrocytoma, Pilocytic 46 | 3,081
acute quadriplegic myopathy 46 | 1,158
dermatomyositis 46 | 966
lung adenocarcinoma 44 | 2,716
astrocytoma 43 | 1,146
juvenile dermatomyositis 42 | 1,187
tuberculosis 42 | 2,010
group 4 medulloblastoma 40 | 1,855
diabetes mellitus 39 | 1,728
pituitary cancer 39 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,962
Rheumatoid arthritis 37 | 1,191
lung carcinoma 36 | 2,843
progressive supranuclear palsy 34 | 676
ductal carcinoma in situ 33 | 1,745
interstitial cystitis 31 | 2,312
primary pancreatic ductal adenocarcinoma 30 | 1,109
Intellectual disability 29 | 1,016
acute myeloid leukemia 29 | 783
ulcerative colitis 29 | 1,819
adrenocortical carcinoma 28 | 1,428
pediatric high grade glioma 25 | 1,064
spina bifida 25 | 1,074
breast carcinoma 24 | 1,638
primary Sjogren syndrome 23 | 735
colon cancer 21 | 1,478
hepatocellular carcinoma 21 | 547
Amyotrophic lateral sclerosis 20 | 451
non primary Sjogren syndrome sicca 20 | 891
Schizophrenia 19 | 1,160
Autosomal recessive predisposition 18 | 1,442
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Short stature 18 | 531
cutaneous lupus erythematosus 17 | 1,057
nasopharyngeal carcinoma 17 | 1,058
tuberculosis and treatment for 6 months 17 | 409
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
gastric cancer 16 | 459
sonic hedgehog group medulloblastoma 16 | 467
Alzheimer's disease 15 | 658
Atopic dermatitis 15 | 952
Cognitive delay 15 | 608
Global developmental delay 15 | 608
Mental and motor retardation 15 | 608
cystic fibrosis 15 | 1,696
Anteverted nostril 14 | 191
Bipolar Disorder 14 | 666
Obesity 14 | 678
active Crohn's disease 14 | 922
aldosterone-producing adenoma 14 | 665
Broad flat nasal bridge 13 | 236
Depressive disorder 13 | 409
Epilepsy 13 | 792
Nasal bridge wide 13 | 236
posterior fossa group B ependymoma 13 | 416
Cataract 12 | 297
Down syndrome 12 | 499
Gaucher disease type 1 12 | 180
Hypogonadism 12 | 173
Hypoplastic mandible condyle 12 | 275
Liver cancer 12 | 604
Mammary Neoplasms 12 | 425
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Muscle hypotonia 12 | 571
Osteoporosis 12 | 363
Prostatic Neoplasms 12 | 495
pancreatic carcinoma 12 | 562

Tissue

Endocrine System 370 | 18,159
Digestive Tract 367 | 17,369
Female tissues 366 | 17,400
Liver and Pancreas 366 | 16,750
Male tissues 366 | 17,142
Nervous System 365 | 16,725
Skin and soft tissues 365 | 17,230
Blood and immune system 364 | 16,909
Respiratory system 363 | 16,393
Urinary Tract 363 | 16,678
Cardiovascular System 358 | 15,192

Target Family

Non-IDG 216 | 12,091
Enzyme 68 | 4,145
Transcription Factor 38 | 1,400
Kinase 25 | 634
Epigenetic 17 | 242
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38
GPCR 1 | 408
Transporter 1 | 473

GO Component

nuclear speck 371 | 371
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger CCHC domain-containing protein 18 ZCCHC18 Tdark Non-IDG 0.00000 12
Zinc finger protein PLAG1 PLAG1 Tbio Transcription Factor -1.99951 109.1 200
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Methyl-CpG-binding domain protein 1 MBD1 Tbio Transcription Factor -2.23809 171.1 297
Integrator complex subunit 7 INTS7 Tdark Non-IDG -0.82823 6.83 37
N6-adenosine-methyltransferase catalytic subunit METTL3 Tbio Enzyme -1.76174 60.5 94
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120
Pre-mRNA-splicing factor 18 PRPF18 Tbio Non-IDG -1.36183 19.8 84
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
THO complex subunit 6 homolog THOC6 Tbio Non-IDG -1.77416 57.9 131