Development Level

Tbio 186 | 11,651
Tdark 26 | 6,593
Tchem 17 | 1,388
Tclin 10 | 612

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 5 | 298
increased lean body mass 5 | 172
abnormal bone structure 4 | 187
decreased body weight 4 | 161
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
enlarged heart 4 | 210
impaired glucose tolerance 4 | 75
male infertility 4 | 123
tremors 4 | 39
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased basophil cell number 3 | 16
decreased circulating HDL chol... 3 | 68
decreased circulating alkaline... 3 | 46
decreased grip strength 3 | 116
decreased vertical activity 3 | 208
edema 3 | 59
hyperactivity 3 | 148
hypoactivity 3 | 132
increased circulating alkaline... 3 | 122
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
small thymus 3 | 16
abnormal lens morphology 2 | 81
abnormal locomotor behavior 2 | 24
abnormal seminal vesicle morph... 2 | 114
abnormal snout morphology 2 | 23
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased pulmonary respirator... 2 | 5
embryonic lethality prior to o... 2 | 239
enlarged stomach 2 | 2
female infertility 2 | 60
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating amylase ... 2 | 25
increased circulating chloride... 2 | 41
increased mean corpuscular hem... 2 | 96
increased red blood cell distr... 2 | 34
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal posture 1 | 2
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
abnormal tail morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
corneal opacity 1 | 32
cyanosis 1 | 7
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased vertical activity 1 | 24
microphthalmia 1 | 26
prolonged PQ interval 1 | 5
respiratory system phenotype 1 | 2
small testis 1 | 58

Disease

Carcinoma 166 | 11,493
ovarian cancer 147 | 8,520
osteosarcoma 134 | 7,950
medulloblastoma, large-cell 112 | 6,241
lung cancer 95 | 4,740
glioblastoma 94 | 5,792
psoriasis 90 | 6,694
group 3 medulloblastoma 85 | 4,104
atypical teratoid / rhabdoid tumor 83 | 5,112
ependymoma 65 | 4,679
adult high grade glioma 59 | 3,801
Breast cancer 57 | 3,578
malignant mesothelioma 57 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 51 | 2,989
invasive ductal carcinoma 49 | 2,951
non-small cell lung cancer 47 | 2,890
oligodendroglioma 45 | 2,850
primitive neuroectodermal tumor 44 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
Kidney cancer 41 | 2,613
Cancer 40 | 2,499
Astrocytoma, Pilocytic 38 | 3,081
Multiple myeloma 38 | 1,332
lung adenocarcinoma 38 | 2,716
lung carcinoma 35 | 2,843
pancreatic cancer 35 | 2,398
tuberculosis 35 | 2,010
subependymal giant cell astrocytoma 34 | 2,287
astrocytic glioma 33 | 2,597
Pick disease 32 | 1,894
acute quadriplegic myopathy 32 | 1,158
dermatomyositis 31 | 966
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
breast carcinoma 29 | 1,638
juvenile dermatomyositis 29 | 1,187
ulcerative colitis 29 | 1,819
colon cancer 28 | 1,478
group 4 medulloblastoma 27 | 1,855
Rheumatoid arthritis 26 | 1,191
ductal carcinoma in situ 26 | 1,745
adrenocortical carcinoma 25 | 1,428
interstitial cystitis 23 | 2,312
cystic fibrosis 22 | 1,696
pituitary cancer 22 | 1,972
primary pancreatic ductal adenocarcinoma 22 | 1,109
diabetes mellitus 20 | 1,728
nasopharyngeal carcinoma 20 | 1,058
pediatric high grade glioma 20 | 1,064
Amyotrophic lateral sclerosis 18 | 451
Autosomal recessive predisposition 18 | 1,442
astrocytoma 18 | 1,146
primary Sjogren syndrome 18 | 735
Schizophrenia 17 | 1,160
Waldenstrons macroglobulinemia 17 | 765
cutaneous lupus erythematosus 17 | 1,057
Atopic dermatitis 16 | 952
Down syndrome 16 | 499
non primary Sjogren syndrome sicca 15 | 891
Alzheimer's disease 14 | 658
Mammary Neoplasms 14 | 425
Breast Neoplasms 13 | 445
Duchenne muscular dystrophy 13 | 601
Bipolar Disorder 12 | 666
Epilepsy 12 | 792
active ulcerative colitis 12 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 807
Asthma 11 | 385
Emery-Dreifuss muscular dystrophy 11 | 23
Intellectual disability 11 | 1,016
aldosterone-producing adenoma 11 | 665
sarcoidosis 11 | 370
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Liver cancer 10 | 604
Mental and motor retardation 10 | 608
Prostatic Neoplasms 10 | 495
hereditary spastic paraplegia 10 | 318
pancreatic carcinoma 10 | 562
progressive supranuclear palsy 10 | 676
sonic hedgehog group medulloblastoma 10 | 467
spina bifida 10 | 1,074
Coronary artery disease 9 | 268
Diabetes Mellitus, Type 2 9 | 142
Liver Cirrhosis, Experimental 9 | 769
Neurodegenerative disease 9 | 414
Seizures 9 | 596
hepatocellular carcinoma 9 | 547
Depressive disorder 8 | 409
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Orbital separation excessive 8 | 244
Poor school performance 8 | 645
acute myeloid leukemia 8 | 783
gastric cancer 8 | 459
mucosa-associated lymphoid tissue lymphoma 8 | 484

Tissue

Endocrine System 236 | 18,159
Female tissues 236 | 17,400
Digestive Tract 235 | 17,369
Blood and immune system 234 | 16,909
Male tissues 234 | 17,142
Nervous System 234 | 16,725
Skin and soft tissues 234 | 17,230
Liver and Pancreas 233 | 16,750
Respiratory system 232 | 16,393
Urinary Tract 232 | 16,678
Cardiovascular System 227 | 15,192

Target Family

Non-IDG 148 | 12,091
Enzyme 44 | 4,145
Transcription Factor 19 | 1,400
Kinase 8 | 634
Epigenetic 5 | 242
GPCR 5 | 408
Ion Channel 5 | 344
Transporter 4 | 473
Nuclear Receptor 1 | 48

GO Component

nuclear membrane 239 | 239
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Lamina-associated polypeptide 2, isoforms beta/gamma TMPO Tbio Non-IDG -2.11834 246.0 283
Zinc finger protein 354C ZNF354C Tdark Transcription Factor -0.70660 4.42 43
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171
Choline/ethanolaminephosphotransferase 1 CEPT1 Tbio Enzyme -1.65915 46.8 82
Spindlin-1 SPIN1 Tbio Non-IDG -2.02987 109.3 128
General transcription factor 3C polypeptide 3 GTF3C3 Tdark Non-IDG 0.10 0.58 197
Nuclear pore complex protein Nup50 NUP50 Tbio Non-IDG -1.18445 15.9 270
Spermine oxidase SMOX Tbio Enzyme -3.09513 1199.4 58