Development Level

Tbio 175 | 10,625
Tchem 69 | 1,890
Tclin 42 | 602
Tdark 17 | 7,003

Collection

Eligible Ion Channel Proteins 4 | 117

IMPC Term

preweaning lethality, complete... 16 | 633
abnormal behavior 13 | 226
preweaning lethality, incomple... 8 | 260
decreased grip strength 7 | 123
embryonic lethality prior to o... 7 | 148
decreased lean body mass 6 | 195
hyperactivity 6 | 108
impaired glucose tolerance 6 | 52
increased circulating alkaline... 6 | 119
decreased circulating choleste... 5 | 85
decreased fasted circulating g... 5 | 49
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
increased lean body mass 5 | 107
prenatal lethality prior to he... 5 | 64
abnormal bone structure 4 | 131
abnormal lens morphology 4 | 73
decreased circulating HDL chol... 4 | 77
decreased circulating alkaline... 4 | 41
improved glucose tolerance 4 | 56
short tibia 4 | 82
abnormal embryo size 3 | 112
abnormal sleep behavior 3 | 63
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral content 3 | 157
decreased circulating glucose ... 3 | 121
decreased circulating insulin ... 3 | 75
decreased circulating serum al... 3 | 79
decreased lumbar vertebrae num... 3 | 62
edema 3 | 11
hemorrhage 3 | 12
hypoactivity 3 | 89
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 68
increased or absent threshold ... 3 | 128
abnormal QRS complex 2 | 25
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal limb bud morphology 2 | 15
abnormal locomotor activation 2 | 26
abnormal tooth morphology 2 | 24
decreased basophil cell number 2 | 11
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating amylase ... 2 | 24
decreased circulating chloride... 2 | 32
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased heart weight 2 | 44
decreased pulmonary respirator... 2 | 4
decreased respiratory quotient 2 | 12
decreased startle reflex 2 | 48
enlarged stomach 2 | 2
hydrops fetalis 2 | 22
increased blood urea nitrogen ... 2 | 44
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
increased circulating serum al... 2 | 25
increased grip strength 2 | 83
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
lethargy 2 | 5
male infertility 2 | 62
prenatal lethality 2 | 16
small thymus 2 | 11
straub tail 2 | 26
tremors 2 | 34
trunk curl 2 | 15
abnormal behavioral response t... 1 | 52
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal retina morphology 1 | 100
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased vertical activity 1 | 22
embryonic growth retardation 1 | 28
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased circulating creatini... 1 | 29
increased circulating magnesiu... 1 | 10
increased eosinophil cell numb... 1 | 9
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
stereotypic behavior 1 | 3
thrombocytopenia 1 | 46

Disease

glioblastoma 154 | 5,572
medulloblastoma, large-cell 153 | 6,234
ovarian cancer 145 | 8,484
psoriasis 137 | 6,685
osteosarcoma 131 | 7,933
pilocytic astrocytoma 111 | 3,086
atypical teratoid / rhabdoid tumor 109 | 4,369
oligodendroglioma 99 | 2,849
lung cancer 97 | 4,466
pediatric high grade glioma 90 | 2,712
primitive neuroectodermal tumor 86 | 3,031
subependymal giant cell astrocytoma 80 | 2,287
Cancer 78 | 2,346
malignant mesothelioma 71 | 3,162
Carcinoma 70 | 2,147
ependymoma 68 | 2,514
lung carcinoma 68 | 2,844
Breast cancer 64 | 3,094
Pick disease 62 | 1,893
invasive ductal carcinoma 61 | 2,950
astrocytoma 59 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,988
astrocytic glioma 57 | 2,241
pituitary cancer 55 | 1,972
adult high grade glioma 54 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,289
group 3 medulloblastoma 49 | 2,254
non-small cell lung cancer 48 | 2,798
pancreatic cancer 48 | 2,300
interstitial cystitis 47 | 2,299
lung adenocarcinoma 47 | 2,713
group 4 medulloblastoma 46 | 1,875
medulloblastoma 44 | 1,524
ulcerative colitis 44 | 2,087
Alzheimer's disease 42 | 644
atypical teratoid/rhabdoid tumor 42 | 1,095
colon cancer 42 | 1,475
posterior fossa group A ependymoma 42 | 1,511
Schizophrenia 41 | 501
diabetes mellitus 41 | 1,663
cystic fibrosis 39 | 1,665
sonic hedgehog group medulloblastoma 38 | 1,482
Epilepsy 35 | 346
tuberculosis 35 | 1,557
posterior fossa group B ependymoma 33 | 1,530
Parkinson's disease 32 | 364
Intellectual disability 31 | 573
Neurodegenerative disease 29 | 383
Obesity 29 | 616
ductal carcinoma in situ 29 | 1,745
Down syndrome 27 | 548
cutaneous lupus erythematosus 26 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
Multiple myeloma 25 | 1,327
acute quadriplegic myopathy 25 | 1,157
adrenocortical carcinoma 25 | 1,427
Autistic Disorder 24 | 320
Vascular disease 22 | 281
breast carcinoma 22 | 1,614
primary pancreatic ductal adenocarcinoma 22 | 1,271
Rheumatoid Arthritis 21 | 1,160
nasopharyngeal carcinoma 21 | 1,056
Bipolar Disorder 20 | 266
juvenile dermatomyositis 20 | 1,189
Prostatic Neoplasms 19 | 471
active Crohn's disease 19 | 918
aldosterone-producing adenoma 19 | 664
gastric carcinoma 19 | 832
Dementia 18 | 129
Duchenne muscular dystrophy 18 | 602
Endometriosis 18 | 535
spina bifida 18 | 1,064
Toxic encephalopathy 17 | 131
esophageal adenocarcinoma 17 | 737
Amyotrophic Lateral Sclerosis 16 | 431
non primary Sjogren syndrome sicca 16 | 840
pancreatic carcinoma 16 | 567
tuberculosis and treatment for 6 months 16 | 686
Kidney disease 15 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
progressive supranuclear palsy 15 | 674
Atopic dermatitis 14 | 944
Hypertension 14 | 287
Multiple Sclerosis 14 | 498
Peripheral Neuropathy 14 | 303
Waldenstrons macroglobulinemia 14 | 765
dermatomyositis 14 | 933
acute myeloid leukemia 13 | 780
gastric cancer 13 | 430
Cerebrovascular disease 12 | 231
Diabetes Mellitus, Experimental 12 | 106
Mammary Neoplasms 12 | 410
Polycystic Ovary Syndrome 12 | 332
mucosa-associated lymphoid tissue lymphoma 12 | 480
non-small cell lung carcinoma 12 | 413
Atherosclerosis 11 | 275
Hyperglycemia 11 | 120
Migraine 11 | 79
Pain agnosia 11 | 99

Tissue

Nervous System 302 | 18,561
Digestive Tract 301 | 18,473
Female tissues 301 | 18,647
Liver and Pancreas 301 | 18,136
Endocrine System 300 | 18,512
Male tissues 300 | 17,969
Urinary Tract 299 | 18,444
Cardiovascular System 298 | 17,958
Skin and soft tissues 297 | 18,115
Blood and immune system 295 | 17,995
Respiratory system 295 | 17,484

Target Family

Non-IDG 161 | 11,971
Enzyme 61 | 4,146
Ion Channel 33 | 341
Kinase 22 | 634
Transporter 11 | 473
GPCR 8 | 406
Transcription Factor 6 | 1,400
Nuclear Receptor 1 | 48

GO Component

neuronal cell body 303 | 303
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Seizure protein 6 homolog SEZ6 Tdark Non-IDG -0.87986 8.64 27
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Myelin basic protein MBP Tbio Non-IDG -3.69577 5257.0 715
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Striatin STRN Tbio Non-IDG -1.63637 51.0 118
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154