Development Level

Tbio 26 | 11,445

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal skin condition 1 | 6
decreased circulating alkaline... 1 | 46
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased circulating alkaline... 1 | 122
increased monocyte cell number 1 | 63
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15

Disease

Carcinoma 22 | 11,493
psoriasis 13 | 6,694
Kidney cancer 9 | 2,613
Breast cancer 8 | 3,578
acute quadriplegic myopathy 8 | 1,158
medulloblastoma, large-cell 8 | 6,241
Myopathy 7 | 185
lung cancer 7 | 4,740
ovarian cancer 7 | 8,520
Autosomal recessive predisposition 6 | 1,442
Hypertrophic Cardiomyopathy 6 | 117
Liver cancer 6 | 604
glioblastoma 6 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung adenocarcinoma 6 | 2,716
Astrocytoma, Pilocytic 5 | 3,081
Cardiomyopathy 5 | 116
Skin cancer 5 | 469
atypical teratoid / rhabdoid tumor 5 | 5,112
colon cancer 5 | 1,478
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
osteosarcoma 5 | 7,950
primitive neuroectodermal tumor 5 | 3,035
Dilated cardiomyopathy 4 | 56
Distal arthrogryposis 4 | 42
Melanoma 4 | 711
Pick disease 4 | 1,894
adrenocortical carcinoma 4 | 1,428
interstitial cystitis 4 | 2,312
invasive ductal carcinoma 4 | 2,951
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Acquired scoliosis 3 | 281
Cancer 3 | 2,499
Cardiomyopathy, Hypertrophic 3 | 24
Cardiomyopathy, Hypertrophic, Familial 3 | 9
Curvature of spine 3 | 282
Endometrial cancer 3 | 311
Muscle hypotonia 3 | 571
Myocardial Infarction 3 | 151
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
Abnormality of metabolism/homeostasis 2 | 134
Acidosis, Lactic 2 | 97
Amyotrophic lateral sclerosis 2 | 451
Arthrogryposis 2 | 54
Atrial Septal Defects 2 | 85
Blepharoptosis 2 | 231
Byzanthine arch palate 2 | 194
Cardiac Arrhythmia 2 | 103
Cardiac conduction abnormalities 2 | 78
Cardiomyopathy, Dilated 2 | 83
Cardiovascular system disease 2 | 246
Conduction disorder of the heart 2 | 79
Congestive heart failure 2 | 113
Creatine phosphokinase serum increased 2 | 110
EKG abnormalities 2 | 78
Electrocardiogram abnormal 2 | 81
Electrocardiogram change 2 | 78
Elevated creatine kinase 2 | 110
Failure to gain weight 2 | 365
Flexion contracture of proximal interphalangeal joint 2 | 75
Generalized muscle weakness 2 | 57
Heart disease 2 | 306
Heart failure 2 | 162
Highly variable severity 2 | 157
Increased serum lactate 2 | 60
Lactic acidemia 2 | 95
Long philtrum 2 | 137
Neck muscle weakness 2 | 17
Ophthalmoplegia 2 | 106
Osteoporosis 2 | 363
Pediatric failure to thrive 2 | 365
Prenatal onset 2 | 139
Proximal muscle weakness 2 | 47
Proximal neurogenic muscle weakness 2 | 47
Respiratory Insufficiency 2 | 132
Respiratory distress 2 | 43
Respiratory function loss 2 | 121
Variable expressivity 2 | 157
fibroadenoma 2 | 559
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
juvenile dermatomyositis 2 | 1,187
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
posterior fossa group B ependymoma 2 | 416
tuberculosis 2 | 2,010

Tissue

Endocrine System 26 | 18,159
Skin and soft tissues 26 | 17,230
Digestive Tract 25 | 17,369
Cardiovascular System 24 | 15,192
Male tissues 24 | 17,142
Blood and immune system 23 | 16,909
Female tissues 23 | 17,400
Liver and Pancreas 22 | 16,750
Nervous System 21 | 16,725
Urinary Tract 21 | 16,678
Respiratory system 17 | 16,393

Target Family

Non-IDG 22 | 12,091
Enzyme 1 | 4,145
Ion Channel 1 | 344
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Component

myofibril 26 | 26
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Myosin-4 MYH4 Tbio Non-IDG -1.81214 51.8 52
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Myosin-15 MYH15 Tbio Non-IDG -0.95780 9.01 40
Myosin-6 MYH6 Tbio Non-IDG -2.95952 901.3 45
Leiomodin-2 LMOD2 Tbio Non-IDG -0.89671 9.37 55
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Rho guanine nucleotide exchange factor 25 ARHGEF25 Tbio Non-IDG -1.43926 31.5 50
Protein SCO2 homolog, mitochondrial SCO2 Tbio Non-IDG -2.19082 152.8 117