Development Level

Tbio 4 | 11,445

IMPC Phenotype

decreased body weight 1 | 161
increased startle reflex 1 | 112

Disease

Carcinoma 4 | 11,493
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
Breast cancer 3 | 3,578
Cardiomyopathy, Dilated 3 | 83
Liver Cirrhosis, Experimental 3 | 769
ovarian cancer 3 | 8,520
Acquired scoliosis 2 | 281
Autosomal recessive predisposition 2 | 1,442
Bell Palsy 2 | 58
Blepharoptosis 2 | 231
Bulbar palsy 2 | 19
Bulbar weakness 2 | 19
Byzanthine arch palate 2 | 194
Cap Myopathy 2 | 2
Centrally nucleated skeletal muscle fibers 2 | 10
Congenital Fiber Type Disproportion 2 | 7
Congenital fiber-type disproportion 2 | 8
Congenital myopathy with fiber type disproportion 2 | 9
Contracture 2 | 96
Contracture of joint 2 | 93
Curvature of spine 2 | 282
Decreased to absent deep tendon reflexes 2 | 42
Deglutition Disorders 2 | 132
Distal arthrogryposis 2 | 42
Esophageal Neoplasms 2 | 69
Esophageal Squamous Cell Carcinoma 2 | 77
Facial Paresis 2 | 59
Facial diplegia 2 | 10
Facial muscle weakness of muscles innervated by CN VII 2 | 58
Failure to gain weight 2 | 365
Feeding difficulties 2 | 127
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Generalized muscle weakness 2 | 57
Highly variable severity 2 | 157
Inflammatory myofibroblastic tumor 2 | 8
Long face 2 | 71
Lumbar lordosis 2 | 35
Motor delay 2 | 147
Muscle hypotonia 2 | 571
Myopathies, Structural, Congenital 2 | 15
Myopathy 2 | 185
Narrow face 2 | 54
Neck muscle weakness 2 | 17
Nemaline Myopathy, Childhood Onset 2 | 6
Nemaline myopathy 2 | 17
Nemaline myopathy 1 2 | 2
Nemaline myopathy 4 2 | 2
Nemaline rods 2 | 7
Neonatal Hypotonia 2 | 64
No development of motor milestones 2 | 147
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Prenatal onset 2 | 139
Proximal muscle weakness 2 | 47
Proximal neurogenic muscle weakness 2 | 47
Recurrent respiratory infections 2 | 141
Reduced fetal movement 2 | 51
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Respiratory insufficiency due to muscle weakness 2 | 37
Squamous cell carcinoma of esophagus 2 | 77
Thin face 2 | 54
Type 1 fibers relatively smaller than type 2 fibers 2 | 5
Variable expressivity 2 | 157
Weak cry 2 | 17
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
group 3 medulloblastoma 2 | 4,104
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
invasive ductal carcinoma 2 | 2,951
medulloblastoma, large-cell 2 | 6,241
osteosarcoma 2 | 7,950
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
psoriasis 2 | 6,694
tuberculosis and treatment for 6 months 2 | 409
Animal Mammary Neoplasms 1 | 136
Cardiomyopathy 1 | 116
Class III malocclusion 1 | 78
Clubfoot 1 | 39
Congestive heart failure 1 | 113
Downward slant of palpebral fissure 1 | 158
Heart failure 1 | 162
Hemolytic anemia 1 | 77
Hypertrophic Cardiomyopathy 1 | 117
Hypertrophy of lower jaw 1 | 78
Increased size of mandible 1 | 78
Lower limb atrophy 1 | 8
Lower limb muscle hypotrophy 1 | 8
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Mandibular hyperplasia 1 | 78
Muscle atrophy, lower limb, distal 1 | 8
Neoplasm Metastasis 1 | 168
Overlapping fingers 1 | 10
Weight Gain 1 | 100
mandibular excess (physical finding) 1 | 78

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Non-IDG 4 | 12,091

GO Component

muscle thin filament tropomyos... 4 | 4
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Tropomyosin alpha-1 chain TPM1 Tbio Non-IDG -2.19537 154.3 227
Tropomyosin beta chain TPM2 Tbio Non-IDG -2.36824 225.4 193
Tropomyosin alpha-3 chain TPM3 Tbio Non-IDG -2.29065 184.1 140