Development Level

Tbio 783 | 10,625
Tdark 199 | 7,003
Tchem 190 | 1,890
Tclin 59 | 602

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 77 | 633
embryonic lethality prior to o... 24 | 148
embryonic lethality prior to t... 20 | 187
abnormal behavior 15 | 226
decreased lean body mass 15 | 195
decreased body weight 14 | 174
preweaning lethality, incomple... 14 | 260
abnormal embryo size 13 | 112
decreased total body fat amoun... 13 | 186
abnormal bone structure 11 | 131
increased circulating alkaline... 11 | 119
decreased bone mineral content 10 | 157
increased grip strength 10 | 83
increased mean corpuscular vol... 10 | 91
prenatal lethality prior to he... 10 | 64
abnormal lens morphology 9 | 73
abnormal retina morphology 9 | 100
decreased grip strength 9 | 123
hypoactivity 9 | 89
increased lean body mass 9 | 107
decreased circulating glucose ... 8 | 121
hyperactivity 8 | 108
increased mean corpuscular hem... 8 | 93
increased fasted circulating g... 7 | 68
increased heart weight 7 | 37
abnormal gait 6 | 51
abnormal testis morphology 6 | 30
decreased bone mineral density 6 | 126
decreased circulating triglyce... 6 | 83
embryonic growth retardation 6 | 28
enlarged heart 6 | 111
increased circulating HDL chol... 6 | 63
increased circulating choleste... 6 | 53
increased circulating sodium l... 6 | 71
abnormal retinal pigmentation 5 | 61
decreased circulating insulin ... 5 | 75
decreased rib number 5 | 59
increased bone mineral content 5 | 92
increased exploration in new e... 5 | 56
increased leukocyte cell numbe... 5 | 37
increased or absent threshold ... 5 | 128
small testis 5 | 37
abnormal behavioral response t... 4 | 52
abnormal limb bud morphology 4 | 15
abnormal locomotor activation 4 | 26
abnormal maxilla morphology 4 | 16
abnormal neural tube closure 4 | 37
abnormal rib morphology 4 | 28
abnormal skin coloration 4 | 18
abnormal skin morphology 4 | 23
decreased B cell number 4 | 30
decreased blood urea nitrogen ... 4 | 31
decreased body length 4 | 108
decreased caudal vertebrae num... 4 | 49
decreased circulating choleste... 4 | 85
decreased circulating fructosa... 4 | 31
decreased circulating serum al... 4 | 79
decreased leukocyte cell numbe... 4 | 54
decreased lumbar vertebrae num... 4 | 62
decreased prepulse inhibition 4 | 52
hemorrhage 4 | 12
improved glucose tolerance 4 | 56
increased NK cell number 4 | 19
increased bone mineral density 4 | 52
increased circulating bilirubi... 4 | 16
increased circulating chloride... 4 | 43
increased circulating creatini... 4 | 29
increased circulating phosphat... 4 | 24
increased erythrocyte cell num... 4 | 26
increased sacral vertebrae num... 4 | 62
increased startle reflex 4 | 38
pallor 4 | 13
persistence of hyaloid vascula... 4 | 22
short tibia 4 | 82
thrombocytopenia 4 | 46
thrombocytosis 4 | 23
abnormal craniofacial morpholo... 3 | 12
abnormal cranium morphology 3 | 32
abnormal epididymis morphology 3 | 31
abnormal heart left ventricle ... 3 | 20
abnormal kidney morphology 3 | 30
abnormal skin appearance 3 | 8
abnormal sleep behavior 3 | 63
abnormal vertebrae morphology 3 | 14
decreased circulating HDL chol... 3 | 77
decreased circulating creatini... 3 | 31
decreased circulating total pr... 3 | 41
decreased effector memory CD8-... 3 | 24
decreased startle reflex 3 | 48
decreased total retina thickne... 3 | 20
enlarged lymph nodes 3 | 27
hydrops fetalis 3 | 22
impaired glucose tolerance 3 | 52
increased blood urea nitrogen ... 3 | 44
increased circulating free fat... 3 | 17
increased circulating glucose ... 3 | 16
increased total body fat amoun... 3 | 57
male infertility 3 | 62
microphthalmia 3 | 15
small kidney 3 | 10

Disease

ovarian cancer 703 | 8,492
osteosarcoma 544 | 7,933
medulloblastoma, large-cell 446 | 6,234
psoriasis 412 | 6,685
lung cancer 398 | 4,473
glioblastoma 367 | 5,572
atypical teratoid / rhabdoid tumor 283 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 262 | 1,795
intraductal papillary-mucinous neoplasm (IPMN) 231 | 3,289
Breast cancer 218 | 3,099
malignant mesothelioma 218 | 3,163
Multiple myeloma 202 | 1,328
Cancer 194 | 2,346
invasive ductal carcinoma 190 | 2,950
ependymoma 187 | 2,514
oligodendroglioma 186 | 2,849
primitive neuroectodermal tumor 186 | 3,031
lung adenocarcinoma 182 | 2,714
astrocytic glioma 179 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 178 | 2,988
non-small cell lung cancer 176 | 2,798
pilocytic astrocytoma 171 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 169 | 2,956
ulcerative colitis 160 | 2,087
pediatric high grade glioma 158 | 2,712
subependymal giant cell astrocytoma 149 | 2,287
pancreatic cancer 146 | 2,300
group 3 medulloblastoma 144 | 2,254
lung carcinoma 144 | 2,844
adult high grade glioma 140 | 2,148
Pick disease 138 | 1,893
interstitial cystitis 136 | 2,299
tuberculosis 126 | 1,563
medulloblastoma 125 | 1,524
diabetes mellitus 124 | 1,663
group 4 medulloblastoma 123 | 1,875
breast carcinoma 122 | 1,614
ductal carcinoma in situ 119 | 1,745
astrocytoma 104 | 1,493
cystic fibrosis 103 | 1,670
pituitary cancer 99 | 1,972
Waldenstrons macroglobulinemia 98 | 765
adrenocortical carcinoma 95 | 1,427
colon cancer 92 | 1,475
dermatomyositis 87 | 967
acute quadriplegic myopathy 86 | 1,157
primary pancreatic ductal adenocarcinoma 85 | 1,271
sonic hedgehog group medulloblastoma 80 | 1,482
Obesity 76 | 616
juvenile dermatomyositis 76 | 1,189
Rheumatoid Arthritis 75 | 1,171
non primary Sjogren syndrome sicca 75 | 840
posterior fossa group B ependymoma 75 | 1,530
atypical teratoid/rhabdoid tumor 74 | 1,095
acute myeloid leukemia 73 | 785
Carcinoma 72 | 2,147
posterior fossa group A ependymoma 70 | 1,511
Neurodegenerative disease 68 | 383
Alzheimer's disease 67 | 644
nasopharyngeal carcinoma 64 | 1,056
cutaneous lupus erythematosus 60 | 1,056
Atopic dermatitis 59 | 944
active Crohn's disease 59 | 918
gastric carcinoma 58 | 832
primary Sjogren syndrome 57 | 789
Mammary Neoplasms 55 | 410
Parkinson's disease 55 | 364
Prostatic Neoplasms 52 | 471
tuberculosis and treatment for 6 months 52 | 686
spina bifida 51 | 1,064
Leigh disease 50 | 81
aldosterone-producing adenoma 50 | 664
esophageal adenocarcinoma 50 | 737
Down syndrome 47 | 548
hereditary spastic paraplegia 44 | 313
Intellectual disability 42 | 573
Stomach Neoplasms 42 | 282
progressive supranuclear palsy 42 | 674
Vascular disease 41 | 281
hepatocellular carcinoma 41 | 550
Liver carcinoma 40 | 217
fibroadenoma 40 | 557
Duchenne muscular dystrophy 38 | 602
Schizophrenia 38 | 503
Multiple Sclerosis 36 | 498
nephrosclerosis 36 | 329
pancreatic carcinoma 35 | 567
Amyotrophic Lateral Sclerosis 34 | 432
Epilepsy 33 | 346
IGA Glomerulonephritis 33 | 454
active ulcerative colitis 32 | 477
Cardiomyopathy 30 | 110
Diabetes Mellitus, Experimental 30 | 106
Toxic encephalopathy 30 | 131
Peripheral Neuropathy 29 | 303
Polycystic Ovary Syndrome 29 | 335
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 499
non-small cell lung carcinoma 29 | 413
tuberculosis and treatment for 3 months 29 | 327
gastric cancer 28 | 436

Tissue

Nervous System 1,220 | 18,561
Endocrine System 1,219 | 18,512
Liver and Pancreas 1,219 | 18,136
Digestive Tract 1,218 | 18,473
Female tissues 1,218 | 18,647
Urinary Tract 1,218 | 18,444
Blood and immune system 1,216 | 17,995
Cardiovascular System 1,213 | 17,958
Male tissues 1,212 | 17,969
Skin and soft tissues 1,210 | 18,115
Respiratory system 1,204 | 17,484

Target Family

Enzyme 574 | 4,146
Non-IDG 514 | 11,969
Kinase 67 | 634
Transporter 35 | 473
Transcription Factor 21 | 1,400
Epigenetic 9 | 242
Ion Channel 6 | 341
GPCR 3 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GO Component

mitochondrion 1,231 | 1,231
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Vasorin VASN Tbio Non-IDG -1.19472 15.7 108
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15
Adenine DNA glycosylase MUTYH Tbio Enzyme -2.83418 699.9 239
Lactation elevated protein 1 LACE1 Tbio Non-IDG -2.03200 109.3 113
5'-nucleotidase domain-containing protein 3 NT5DC3 Tdark Enzyme -1.72530 52.1 19