Development Level

Tbio 841 | 11,178
Tchem 195 | 1,885
Tdark 177 | 6,569
Tclin 68 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125

IMPC Phenotype

preweaning lethality, complete... 132 | 979
embryonic lethality prior to o... 33 | 239
embryonic lethality prior to t... 31 | 278
preweaning lethality, incomple... 30 | 499
abnormal embryo size 22 | 220
abnormal behavior 19 | 298
decreased total body fat amoun... 15 | 207
embryonic growth retardation 15 | 106
cataract 14 | 92
hypoactivity 14 | 132
abnormal bone structure 13 | 187
abnormal lens morphology 13 | 81
decreased lean body mass 13 | 135
enlarged heart 13 | 210
increased lean body mass 13 | 172
increased mean corpuscular hem... 13 | 96
decreased body weight 12 | 161
hyperactivity 12 | 148
decreased bone mineral content 11 | 151
decreased vertical activity 10 | 208
increased circulating choleste... 10 | 66
increased startle reflex 10 | 112
increased total body fat amoun... 10 | 134
abnormal heart morphology 9 | 162
decreased circulating glucose ... 9 | 126
increased circulating alkaline... 9 | 122
prenatal lethality prior to he... 9 | 87
abnormal gait 8 | 69
decreased circulating triglyce... 8 | 79
decreased grip strength 8 | 116
increased bone mineral density 8 | 72
increased fasted circulating g... 8 | 76
increased mean corpuscular vol... 8 | 92
small superior vagus ganglion 8 | 74
abnormal neural tube closure 7 | 46
abnormal skin morphology 7 | 50
decreased circulating choleste... 7 | 93
decreased erythrocyte cell num... 7 | 62
increased bone mineral content 7 | 108
increased circulating HDL chol... 7 | 80
pallor 7 | 34
persistence of hyaloid vascula... 7 | 33
thrombocytopenia 7 | 56
abnormal kidney morphology 6 | 65
abnormal seminal vesicle morph... 6 | 114
decreased bone mineral density 6 | 126
decreased fasted circulating g... 6 | 65
decreased prepulse inhibition 6 | 82
hydrometra 6 | 53
improved glucose tolerance 6 | 79
increased heart weight 6 | 62
increased or absent threshold ... 6 | 101
male infertility 6 | 123
small testis 6 | 58
abnormal coat appearance 5 | 31
abnormal craniofacial morpholo... 5 | 33
abnormal embryo turning 5 | 31
abnormal retina morphology 5 | 71
abnormal testis morphology 5 | 43
decreased blood urea nitrogen ... 5 | 51
decreased circulating alkaline... 5 | 46
decreased circulating phosphat... 5 | 27
decreased mean corpuscular vol... 5 | 79
increased blood urea nitrogen ... 5 | 48
increased circulating bilirubi... 5 | 16
increased circulating sodium l... 5 | 71
increased hemoglobin content 5 | 45
short tibia 5 | 97
thrombocytosis 5 | 27
abnormal behavioral response t... 4 | 66
abnormal epididymis morphology 4 | 42
abnormal eye morphology 4 | 68
abnormal retinal vasculature m... 4 | 27
abnormal vertebrae morphology 4 | 18
decreased circulating HDL chol... 4 | 68
decreased circulating alanine ... 4 | 47
decreased circulating insulin ... 4 | 76
decreased circulating total pr... 4 | 49
decreased mean platelet volume 4 | 25
decreased red blood cell distr... 4 | 41
decreased total retina thickne... 4 | 17
edema 4 | 59
enlarged lymph nodes 4 | 37
impaired glucose tolerance 4 | 75
increased circulating calcium ... 4 | 34
increased circulating phosphat... 4 | 26
increased circulating serum al... 4 | 22
increased grip strength 4 | 41
increased leukocyte cell numbe... 4 | 47
increased prepulse inhibition 4 | 32
long tibia 4 | 25
microphthalmia 4 | 26
small kidney 4 | 16
abnormal coat-hair pigmentatio... 3 | 64
abnormal limb bud morphology 3 | 17
abnormal locomotor behavior 3 | 24
abnormal placenta size 3 | 20
abnormal sleep behavior 3 | 70
decreased circulating creatini... 3 | 39
decreased hemoglobin content 3 | 68

Disease

ovarian cancer 721 | 8,297
Carcinoma 665 | 11,192
osteosarcoma 560 | 7,766
medulloblastoma, large-cell 459 | 6,086
psoriasis 425 | 6,514
lung cancer 408 | 4,607
glioblastoma 386 | 5,635
atypical teratoid / rhabdoid tumor 345 | 4,971
ependymoma 283 | 4,559
pancreatic ductal adenocarcinoma liver metastasis 277 | 1,911
group 3 medulloblastoma 265 | 4,002
Breast cancer 249 | 3,469
adult high grade glioma 246 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 235 | 3,204
Autosomal recessive predisposition 216 | 1,407
malignant mesothelioma 216 | 3,135
astrocytic glioma 210 | 2,530
Cancer 207 | 2,388
Multiple myeloma 205 | 1,296
oligodendroglioma 195 | 2,768
invasive ductal carcinoma 191 | 2,867
primitive neuroectodermal tumor 188 | 2,957
lung adenocarcinoma 181 | 2,627
non-small cell lung cancer 181 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 180 | 2,902
Astrocytoma, Pilocytic 171 | 3,006
tuberculosis 164 | 1,963
intraductal papillary-mucinous adenoma (IPMA) 162 | 2,872
subependymal giant cell astrocytoma 156 | 2,230
pancreatic cancer 148 | 2,322
Pick disease 145 | 1,856
diabetes mellitus 140 | 1,683
lung carcinoma 137 | 2,755
breast carcinoma 134 | 1,589
interstitial cystitis 134 | 2,237
group 4 medulloblastoma 127 | 1,806
Muscle hypotonia 125 | 562
Cognitive delay 123 | 596
Global developmental delay 123 | 596
Mental and motor retardation 123 | 596
Epilepsy 122 | 775
ulcerative colitis 120 | 1,765
ductal carcinoma in situ 118 | 1,686
Intellectual disability 113 | 998
Kidney cancer 113 | 2,548
Seizures 111 | 584
Schizophrenia 107 | 1,136
pituitary cancer 104 | 1,915
colon cancer 97 | 1,428
adrenocortical carcinoma 95 | 1,385
cystic fibrosis 95 | 1,629
Waldenstrons macroglobulinemia 94 | 742
Dull intelligence 93 | 634
Low intelligence 93 | 634
Mental Retardation 93 | 634
Mental deficiency 93 | 634
Poor school performance 93 | 634
acute quadriplegic myopathy 91 | 1,133
dermatomyositis 86 | 941
astrocytoma 85 | 1,113
Obesity 83 | 655
Failure to gain weight 80 | 359
Pediatric failure to thrive 80 | 359
non primary Sjogren syndrome sicca 79 | 861
Alzheimer's disease 77 | 640
Cerebellar Ataxia 76 | 302
Neurodegenerative disease 75 | 402
Rheumatoid arthritis 75 | 1,156
juvenile dermatomyositis 75 | 1,147
acute myeloid leukemia 73 | 760
Leigh disease 68 | 100
Liver Cirrhosis, Experimental 68 | 733
active ulcerative colitis 67 | 736
nasopharyngeal carcinoma 66 | 1,024
Acidosis, Lactic 65 | 97
primary pancreatic ductal adenocarcinoma 65 | 1,071
Lactic acidemia 64 | 95
Breast Neoplasms 63 | 423
active Crohn's disease 62 | 882
Bipolar Disorder 60 | 646
Parkinson's disease 60 | 378
cutaneous lupus erythematosus 60 | 1,016
primary Sjogren syndrome 60 | 710
Mammary Neoplasms 59 | 403
Atopic dermatitis 58 | 915
medulloblastoma 57 | 702
Nystagmus 56 | 309
Optic Atrophy 56 | 239
Prostatic Neoplasms 56 | 472
gastric carcinoma 56 | 781
Hypoglycemia 55 | 146
pediatric high grade glioma 55 | 1,035
spina bifida 54 | 1,053
Dystonia 53 | 163
Hyperreflexia 53 | 208
esophageal adenocarcinoma 53 | 696
Hepatomegaly 52 | 280
Small head 52 | 366
aldosterone-producing adenoma 52 | 646
Infantile onset 51 | 236

Tissue

Endocrine System 1,264 | 18,159
Digestive Tract 1,256 | 17,369
Skin and soft tissues 1,253 | 17,230
Female tissues 1,251 | 17,400
Nervous System 1,247 | 16,725
Urinary Tract 1,247 | 16,678
Liver and Pancreas 1,245 | 16,750
Blood and immune system 1,242 | 16,909
Male tissues 1,242 | 17,142
Respiratory system 1,228 | 16,393
Cardiovascular System 1,200 | 15,192

Target Family

Enzyme 599 | 4,145
Non-IDG 519 | 12,091
Kinase 68 | 634
Transporter 40 | 473
Transcription Factor 30 | 1,400
Epigenetic 13 | 242
Ion Channel 6 | 344
GPCR 3 | 408
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

GO Component

mitochondrion 1,281 | 1,281
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CDGSH iron-sulfur domain-containing protein 3, mitochondrial CISD3 Tdark Non-IDG -0.48090 2.02 6
Phytanoyl-CoA hydroxylase-interacting protein-like PHYHIPL Tdark Enzyme 0.18 0.53 29
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Age-related maculopathy susceptibility protein 2 ARMS2 Tbio Non-IDG -2.37487 234.4 45
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
Ankycorbin RAI14 Tdark Non-IDG -1.33275 19.5 49
Putative transferase CAF17, mitochondrial IBA57 Tbio Enzyme -0.95798 9.91 43
Protein FAM110B FAM110B Tdark Non-IDG -0.03110 1.29 47
DnaJ homolog subfamily A member 3, mitochondrial DNAJA3 Tbio Non-IDG -1.55298 43.3 192
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like BNIP3L Tbio Non-IDG -2.20837 153.7 355