Development Level

Tbio 58 | 11,651
Tclin 12 | 612
Tdark 12 | 6,593
Tchem 9 | 1,388

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased total body fat amoun... 3 | 207
increased lean body mass 3 | 172
abnormal behavior 2 | 298
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating calcium ... 2 | 34
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal stomach morphology 1 | 10
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
hypoactivity 1 | 132
increased IgG2b level 1 | 1
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating phosphat... 1 | 26
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
thrombocytopenia 1 | 56

Disease

Carcinoma 45 | 11,493
ovarian cancer 41 | 8,520
osteosarcoma 39 | 7,950
psoriasis 33 | 6,694
medulloblastoma, large-cell 31 | 6,241
glioblastoma 26 | 5,792
lung cancer 25 | 4,740
ependymoma 24 | 4,679
atypical teratoid / rhabdoid tumor 22 | 5,112
adult high grade glioma 21 | 3,801
invasive ductal carcinoma 20 | 2,951
group 3 medulloblastoma 19 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
lung carcinoma 18 | 2,843
oligodendroglioma 17 | 2,850
Cancer 16 | 2,499
ductal carcinoma in situ 16 | 1,745
non-small cell lung cancer 16 | 2,890
astrocytic glioma 15 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
primitive neuroectodermal tumor 15 | 3,035
Multiple myeloma 14 | 1,332
lung adenocarcinoma 14 | 2,716
pancreatic cancer 14 | 2,398
ulcerative colitis 13 | 1,819
Autosomal recessive predisposition 12 | 1,442
Muscle hypotonia 12 | 571
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
Breast cancer 11 | 3,578
Schizophrenia 11 | 1,160
diabetes mellitus 11 | 1,728
malignant mesothelioma 11 | 3,232
Astrocytoma, Pilocytic 10 | 3,081
Cerebellar Ataxia 10 | 304
Diabetes mellitus type 2 10 | 69
Epilepsy 10 | 792
Treatment Refractory Type 2 Diabetes Mellitus 10 | 53
adrenocortical carcinoma 10 | 1,428
astrocytoma 10 | 1,146
breast carcinoma 10 | 1,638
subependymal giant cell astrocytoma 10 | 2,287
Leigh disease 9 | 100
Neurodegenerative disease 9 | 414
Pick disease 9 | 1,894
Seizures 9 | 596
Vomiting 9 | 116
Blepharoptosis 8 | 231
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Mitochondrial complex I deficiency 8 | 46
cystic fibrosis 8 | 1,696
group 4 medulloblastoma 8 | 1,855
tuberculosis 8 | 2,010
Acidosis, Lactic 7 | 97
Alzheimer's disease 7 | 658
Dystonia 7 | 164
Failure to gain weight 7 | 365
Hypertrophic Cardiomyopathy 7 | 117
Hypoglycemia 7 | 152
Intellectual disability 7 | 1,016
Kidney cancer 7 | 2,613
Lactic acidemia 7 | 95
Muscle Weakness 7 | 170
Optic Atrophy 7 | 242
Pediatric failure to thrive 7 | 365
active ulcerative colitis 7 | 764
colon cancer 7 | 1,478
interstitial cystitis 7 | 2,312
Sensorineural Hearing Loss (disorder) 6 | 284
cutaneous lupus erythematosus 6 | 1,057
nasopharyngeal carcinoma 6 | 1,058
pancreatic carcinoma 6 | 562
primary pancreatic ductal adenocarcinoma 6 | 1,109
Atopic dermatitis 5 | 952
Dementia 5 | 175
Developmental regression 5 | 95
Gliosis 5 | 56
Hyperreflexia 5 | 209
Impaired exercise tolerance 5 | 42
Loss of developmental milestones 5 | 95
Mental deterioration in childhood 5 | 95
Muscle Spasticity 5 | 195
Myopathy 5 | 185
Neurodevelopmental regression 5 | 95
Neuropathy 5 | 261
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Strabismus 5 | 270
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
aldosterone-producing adenoma 5 | 665
dermatomyositis 5 | 966
fibroadenoma 5 | 559
juvenile dermatomyositis 5 | 1,187
pituitary cancer 5 | 1,972
spina bifida 5 | 1,074

Tissue

Endocrine System 88 | 18,159
Female tissues 87 | 17,400
Male tissues 87 | 17,142
Nervous System 87 | 16,725
Skin and soft tissues 87 | 17,230
Digestive Tract 86 | 17,369
Blood and immune system 85 | 16,909
Liver and Pancreas 85 | 16,750
Respiratory system 85 | 16,393
Urinary Tract 85 | 16,678
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 41 | 12,091
Enzyme 37 | 4,145
Kinase 6 | 634
Transporter 5 | 473
GPCR 2 | 408

GO Component

mitochondrial membrane 91 | 91
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.20054 15.1 166
Long-chain specific acyl-CoA dehydrogenase, mitochondrial ACADL Tbio Enzyme -1.52646 31.4 231
StAR-related lipid transfer protein 13 STARD13 Tbio Non-IDG -2.03717 75.4 82
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 HSD3B2 Tclin Enzyme -2.06512 109.2 126
Bcl-2-like protein 13 BCL2L13 Tbio Non-IDG -1.56317 34.2 204
Sideroflexin-3 SFXN3 Tdark Non-IDG -0.50060 3.38 107
ATP-binding cassette sub-family G member 2 ABCG2 Tchem Transporter -3.41877 2731.1 246
Dynamin-2 DNM2 Tchem Non-IDG -2.43547 282.5 143
Dynamin-3 DNM3 Tbio Non-IDG -1.43916 22.6 146