Development Level

Tbio 46 | 10,625
Tclin 11 | 602
Tdark 11 | 7,003
Tchem 9 | 1,890

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
embryonic lethality prior to t... 2 | 187
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
abnormal QRS complex 1 | 25
abnormal heart left ventricle ... 1 | 20
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased erythrocyte cell num... 1 | 43
decreased hematocrit 1 | 25
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular vol... 1 | 50
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
hypoactivity 1 | 89
increased aggression 1 | 2
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased heart weight 1 | 37
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
preweaning lethality, incomple... 1 | 260
shortened QT interval 1 | 4
straub tail 1 | 26

Disease

ovarian cancer 34 | 8,484
osteosarcoma 33 | 7,933
psoriasis 29 | 6,685
medulloblastoma, large-cell 27 | 6,234
glioblastoma 21 | 5,572
lung cancer 21 | 4,466
invasive ductal carcinoma 17 | 2,950
oligodendroglioma 16 | 2,849
non-small cell lung cancer 15 | 2,798
Cancer 14 | 2,346
atypical teratoid / rhabdoid tumor 14 | 4,369
ductal carcinoma in situ 14 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
pediatric high grade glioma 14 | 2,712
primitive neuroectodermal tumor 14 | 3,031
ependymoma 13 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
lung adenocarcinoma 13 | 2,713
lung carcinoma 13 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
Multiple myeloma 11 | 1,327
astrocytoma 11 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
pancreatic cancer 11 | 2,300
ulcerative colitis 11 | 2,087
Diabetes mellitus type 2 10 | 69
Treatment Refractory Type 2 Diabetes Mellitus 10 | 53
adrenocortical carcinoma 10 | 1,427
astrocytic glioma 10 | 2,241
diabetes mellitus 10 | 1,663
pilocytic astrocytoma 10 | 3,086
posterior fossa group B ependymoma 10 | 1,530
Neurodegenerative disease 9 | 383
malignant mesothelioma 8 | 3,162
subependymal giant cell astrocytoma 8 | 2,287
Alzheimer's disease 7 | 644
Breast cancer 7 | 3,094
Pick disease 7 | 1,893
adult high grade glioma 7 | 2,148
atypical teratoid/rhabdoid tumor 7 | 1,095
breast carcinoma 7 | 1,614
colon cancer 7 | 1,475
group 3 medulloblastoma 7 | 2,254
medulloblastoma 7 | 1,524
primary pancreatic ductal adenocarcinoma 7 | 1,271
Leigh disease 6 | 81
group 4 medulloblastoma 6 | 1,875
interstitial cystitis 6 | 2,299
nasopharyngeal carcinoma 6 | 1,056
pancreatic carcinoma 6 | 567
sonic hedgehog group medulloblastoma 6 | 1,482
fibroadenoma 5 | 557
spina bifida 5 | 1,064
tuberculosis 5 | 1,557
Atopic dermatitis 4 | 944
MITOCHONDRIAL COMPLEX I DEFICIENCY 4 | 37
Neuropathy 4 | 210
Parkinson's disease 4 | 364
Prostatic Neoplasms 4 | 471
Vascular disease 4 | 281
active ulcerative colitis 4 | 477
acute myeloid leukemia 4 | 780
acute quadriplegic myopathy 4 | 1,157
aldosterone-producing adenoma 4 | 664
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis 4 | 1,665
gastric carcinoma 4 | 832
hereditary spastic paraplegia 4 | 313
Carcinoma 3 | 2,147
Cardiomyopathy 3 | 110
Dementia 3 | 129
Dystonia 3 | 77
Epilepsy 3 | 346
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 3 | 14
Mammary Neoplasms 3 | 410
Multiple acyl-CoA dehydrogenase deficiency 3 | 26
Myocardial Infarction 3 | 126
Myopathy 3 | 128
NADH:Q(1) Oxidoreductase deficiency 3 | 20
Optic atrophy 3 | 43
Rheumatoid Arthritis 3 | 1,160
Schizophrenia 3 | 501
dermatomyositis 3 | 933
gastric cancer 3 | 430
hepatocellular carcinoma 3 | 532
juvenile dermatomyositis 3 | 1,189
limb girdle muscular dystrophy 2A 3 | 156
non primary Sjogren syndrome sicca 3 | 840
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
Becker muscular dystrophy 2 | 187
Heart disease 2 | 279
Polycystic Ovary Syndrome 2 | 332
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
esophageal adenocarcinoma 2 | 737
mucosa-associated lymphoid tissue lymphoma 2 | 480
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 74 | 17,995
Cardiovascular System 74 | 17,958
Digestive Tract 74 | 18,473
Female tissues 74 | 18,647
Liver and Pancreas 74 | 18,136
Male tissues 74 | 17,969
Nervous System 74 | 18,561
Urinary Tract 74 | 18,444
Endocrine System 73 | 18,512
Respiratory system 72 | 17,484
Skin and soft tissues 72 | 18,115

Target Family

Non-IDG 34 | 11,971
Enzyme 33 | 4,146
Kinase 6 | 634
Transporter 3 | 473
GPCR 1 | 406

GO Component

mitochondrial membrane 77 | 77
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Syntaphilin SNPH Tbio Non-IDG -1.68074 54.2 98
Sperm mitochondrial-associated cysteine-rich protein SMCP Tbio Non-IDG -1.94067 92.8 89
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 Tclin Enzyme -2.13591 109.9 147
C-Jun-amino-terminal kinase-interacting protein 1 MAPK8IP1 Tbio Enzyme -2.80392 652.2 146
Kinesin-like protein KIF28P KIF28P Tdark Non-IDG 0.00000 0
Dynamin-2 DNM2 Tchem Non-IDG -3.22299 1426.1 125
Serine/threonine-protein kinase VRK2 VRK2 Tbio Kinase -1.23773 17.9 112
NADH-ubiquinone oxidoreductase chain 1 MT-ND1 Tclin Enzyme -2.58092 376.4 123
Putative GED domain-containing protein DNM1P46 DNM1P46 Tdark Non-IDG 0.00000 0