Development Level

Tbio 238 | 10,625
Tchem 41 | 1,890
Tdark 23 | 7,003
Tclin 20 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 27 | 633
embryonic lethality prior to o... 9 | 148
abnormal retina morphology 5 | 100
embryonic lethality prior to t... 5 | 187
abnormal lens morphology 4 | 73
prenatal lethality prior to he... 4 | 64
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
abnormal retinal pigmentation 3 | 61
abnormal testis morphology 3 | 30
decreased body weight 3 | 174
decreased fasted circulating g... 3 | 49
embryonic growth retardation 3 | 28
increased circulating choleste... 3 | 53
increased startle reflex 3 | 38
small testis 3 | 37
abnormal behavioral response t... 2 | 52
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal tail movements 2 | 12
decreased CD4-positive, alpha ... 2 | 19
decreased Ly6C low monocyte nu... 2 | 23
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased total body fat amoun... 2 | 186
enlarged epididymis 2 | 27
hyperactivity 2 | 108
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating total pr... 2 | 20
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
male infertility 2 | 62
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased IgM level 1 | 1
decreased NK T cell number 1 | 28
decreased alpha-beta T cell nu... 1 | 12
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased exploration in new e... 1 | 9
decreased follicular B cell nu... 1 | 4
decreased gamma-delta T cell n... 1 | 18
decreased heart rate 1 | 10
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean platelet volume 1 | 12
decreased prepulse inhibition 1 | 52
decreased red blood cell distr... 1 | 11
decreased rib number 1 | 59
decreased vertical activity 1 | 22
female infertility 1 | 34
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased Ly6C high monocyte n... 1 | 12
increased Ly6C low monocyte nu... 1 | 8
increased NK cell number 1 | 19
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
short tibia 1 | 82
thrombocytopenia 1 | 46
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 188 | 8,484
osteosarcoma 150 | 7,933
psoriasis 110 | 6,685
lung cancer 108 | 4,466
medulloblastoma, large-cell 108 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 89 | 1,795
glioblastoma 75 | 5,572
atypical teratoid / rhabdoid tumor 60 | 4,369
Multiple myeloma 57 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,289
non-small cell lung cancer 48 | 2,798
Breast cancer 47 | 3,094
ulcerative colitis 46 | 2,087
malignant mesothelioma 44 | 3,162
group 3 medulloblastoma 43 | 2,254
invasive ductal carcinoma 43 | 2,950
lung adenocarcinoma 39 | 2,713
primitive neuroectodermal tumor 39 | 3,031
Cancer 38 | 2,346
Pick disease 38 | 1,893
interstitial cystitis 37 | 2,299
diabetes mellitus 36 | 1,663
pediatric high grade glioma 36 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,956
oligodendroglioma 35 | 2,849
astrocytic glioma 34 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
ependymoma 33 | 2,514
lung carcinoma 32 | 2,844
group 4 medulloblastoma 30 | 1,875
pancreatic cancer 30 | 2,300
subependymal giant cell astrocytoma 28 | 2,287
Leigh disease 27 | 81
pilocytic astrocytoma 27 | 3,086
tuberculosis 27 | 1,557
breast carcinoma 26 | 1,614
Neurodegenerative disease 25 | 383
ductal carcinoma in situ 25 | 1,745
non primary Sjogren syndrome sicca 25 | 840
posterior fossa group B ependymoma 25 | 1,530
Obesity 24 | 616
Waldenstrons macroglobulinemia 24 | 765
adrenocortical carcinoma 24 | 1,427
medulloblastoma 23 | 1,524
adult high grade glioma 22 | 2,148
colon cancer 22 | 1,475
pituitary cancer 21 | 1,972
acute myeloid leukemia 18 | 780
atypical teratoid/rhabdoid tumor 18 | 1,095
sonic hedgehog group medulloblastoma 18 | 1,482
Maple syrup urine disease 17 | 25
Methylmalonic acidemia 17 | 39
acute quadriplegic myopathy 17 | 1,157
aldosterone-producing adenoma 17 | 664
astrocytoma 17 | 1,493
cystic fibrosis 17 | 1,665
Stomach Neoplasms 16 | 282
dermatomyositis 16 | 933
gastric carcinoma 16 | 832
nephrosclerosis 16 | 329
primary pancreatic ductal adenocarcinoma 16 | 1,271
Lactic acidosis 15 | 42
pancreatic carcinoma 15 | 567
juvenile dermatomyositis 14 | 1,189
tuberculosis and treatment for 6 months 14 | 686
Prostatic Neoplasms 13 | 471
active Crohn's disease 13 | 918
nasopharyngeal carcinoma 13 | 1,056
Disease Progression 12 | 125
Epilepsy 12 | 346
Glycine encephalopathy 12 | 28
Multiple acyl-CoA dehydrogenase deficiency 12 | 26
Propionic acidemia 12 | 20
posterior fossa group A ependymoma 12 | 1,511
Alzheimer's disease 11 | 644
Degenerative polyarthritis 11 | 93
Hypoglycemia 11 | 81
Parkinson's disease 11 | 364
Rheumatoid Arthritis 11 | 1,160
hereditary spastic paraplegia 11 | 313
Atopic dermatitis 10 | 944
Mammary Neoplasms 10 | 410
Neuropathy 10 | 210
Osteoporosis 10 | 257
Polycystic Ovary Syndrome 10 | 332
Vascular disease 10 | 281
cutaneous lupus erythematosus 10 | 1,056
fibroadenoma 10 | 557
hepatocellular carcinoma 10 | 532
primary Sjogren syndrome 10 | 789
Anemia 9 | 252
Isovaleric acidemia 9 | 14
Liver carcinoma 9 | 217
Pyruvate decarboxylase deficiency 9 | 15
Sideroblastic anemia 9 | 18
gastric cancer 9 | 430
inflammatory breast cancer 9 | 404
Crohn's disease 8 | 304
Endometriosis 8 | 535
Schizophrenia 8 | 501

Tissue

Blood and immune system 322 | 17,995
Digestive Tract 322 | 18,473
Endocrine System 322 | 18,512
Urinary Tract 322 | 18,444
Female tissues 321 | 18,647
Liver and Pancreas 321 | 18,136
Nervous System 321 | 18,561
Cardiovascular System 320 | 17,958
Skin and soft tissues 320 | 18,115
Male tissues 319 | 17,969
Respiratory system 319 | 17,484

Target Family

Enzyme 243 | 4,146
Non-IDG 54 | 11,971
Kinase 16 | 634
Epigenetic 4 | 242
Transcription Factor 3 | 1,400
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Component

mitochondrial matrix 322 | 322
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Heat shock protein 75 kDa, mitochondrial TRAP1 Tchem Non-IDG -1.12188 14.9 328
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Protein SCO2 homolog, mitochondrial SCO2 Tbio Non-IDG -2.16453 144.3 98
Mitochondrial ribonuclease P protein 3 KIAA0391 Tbio Enzyme 66.3 56
Glycine N-acyltransferase GLYAT Tbio Enzyme -1.86227 71.5 87
Complement component 1 Q subcomponent-binding protein, mitochondrial C1QBP Tbio Non-IDG -2.51978 332.6 298
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 Tbio Enzyme -3.11277 1238.0 122
Endoribonuclease LACTB2 LACTB2 Tbio Enzyme -0.15635 1.90 96
ATP synthase F(0) complex subunit B1, mitochondrial ATP5F1 Tbio Enzyme -0.80065 5.85 92