Development Level

Tbio 271 | 11,651
Tchem 34 | 1,388
Tdark 28 | 6,593
Tclin 21 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 52 | 979
embryonic lethality prior to o... 12 | 239
embryonic lethality prior to t... 10 | 278
decreased fasted circulating g... 5 | 65
decreased total body fat amoun... 5 | 207
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
cataract 4 | 92
decreased circulating alkaline... 4 | 46
embryonic growth retardation 4 | 106
increased circulating choleste... 4 | 66
preweaning lethality, incomple... 4 | 499
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
abnormal testis morphology 3 | 43
decreased bone mineral density 3 | 126
decreased grip strength 3 | 116
enlarged heart 3 | 210
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
prenatal lethality prior to he... 3 | 87
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal tail movements 2 | 12
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased erythrocyte cell num... 2 | 62
decreased mean platelet volume 2 | 25
enlarged epididymis 2 | 31
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal locomotor behavior 1 | 24
abnormal neural tube morpholog... 1 | 12
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased urine magnesium leve... 1 | 3
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
long tibia 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
tremors 1 | 39
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

ovarian cancer 202 | 8,520
Carcinoma 201 | 11,493
osteosarcoma 160 | 7,950
psoriasis 116 | 6,694
lung cancer 115 | 4,740
medulloblastoma, large-cell 113 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 101 | 1,962
Autosomal recessive predisposition 99 | 1,442
glioblastoma 85 | 5,792
group 3 medulloblastoma 80 | 4,104
atypical teratoid / rhabdoid tumor 79 | 5,112
Muscle hypotonia 61 | 571
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,291
Epilepsy 59 | 792
Multiple myeloma 59 | 1,332
ependymoma 59 | 4,679
Cognitive delay 54 | 608
Global developmental delay 54 | 608
Mental and motor retardation 54 | 608
adult high grade glioma 53 | 3,801
Seizures 52 | 596
non-small cell lung cancer 52 | 2,890
Breast cancer 50 | 3,578
invasive ductal carcinoma 49 | 2,951
malignant mesothelioma 48 | 3,232
lung adenocarcinoma 46 | 2,716
Cancer 45 | 2,499
primitive neuroectodermal tumor 44 | 3,035
astrocytic glioma 41 | 2,597
Intellectual disability 40 | 1,016
interstitial cystitis 40 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,955
ulcerative colitis 40 | 1,819
diabetes mellitus 39 | 1,728
Dull intelligence 38 | 645
Low intelligence 38 | 645
Mental Retardation 38 | 645
Mental deficiency 38 | 645
Pick disease 38 | 1,894
Poor school performance 38 | 645
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
oligodendroglioma 37 | 2,850
Acidosis, Lactic 35 | 97
Leigh disease 35 | 100
Lactic acidemia 34 | 95
pancreatic cancer 34 | 2,398
Hypoglycemia 33 | 152
lung carcinoma 32 | 2,843
tuberculosis 32 | 2,010
Astrocytoma, Pilocytic 31 | 3,081
Cerebellar Ataxia 31 | 304
ductal carcinoma in situ 31 | 1,745
subependymal giant cell astrocytoma 31 | 2,287
breast carcinoma 30 | 1,638
Neurodegenerative disease 27 | 414
Obesity 27 | 678
Schizophrenia 26 | 1,160
Waldenstrons macroglobulinemia 26 | 765
adrenocortical carcinoma 26 | 1,428
Failure to gain weight 25 | 365
Pediatric failure to thrive 25 | 365
Vomiting 25 | 116
colon cancer 25 | 1,478
non primary Sjogren syndrome sicca 25 | 891
Lethargy 24 | 77
Liver Cirrhosis, Experimental 24 | 769
group 4 medulloblastoma 24 | 1,855
Kidney cancer 23 | 2,613
pituitary cancer 23 | 1,972
Nystagmus 22 | 317
Infantile onset 21 | 238
cystic fibrosis 21 | 1,696
Dystonia 20 | 164
Hyperreflexia 20 | 209
acute myeloid leukemia 20 | 783
aldosterone-producing adenoma 19 | 665
Dystonic disease 18 | 106
Increased serum lactate 18 | 60
Small head 18 | 374
Feeding difficulties in infancy 17 | 175
Highly variable clinical phenotype 17 | 150
Highly variable phenotype and severity 17 | 150
Highly variable phenotype, even within families 17 | 150
Metabolic acidosis 17 | 90
Optic Atrophy 17 | 242
Phenotypic variability 17 | 150
acute quadriplegic myopathy 17 | 1,158
nephrosclerosis 17 | 333
Anemia 16 | 365
Lactic acidosis 16 | 51
Maple syrup urine disease 16 | 24
Stomach Neoplasms 16 | 300
dermatomyositis 16 | 966
Hepatomegaly 15 | 285
Methylmalonic acidemia 15 | 37
Muscle Spasticity 15 | 195
Neuropathy 15 | 261
astrocytoma 15 | 1,146
gastric carcinoma 15 | 807
nasopharyngeal carcinoma 15 | 1,058

Tissue

Endocrine System 352 | 18,159
Digestive Tract 351 | 17,369
Female tissues 350 | 17,400
Skin and soft tissues 350 | 17,230
Urinary Tract 350 | 16,678
Liver and Pancreas 349 | 16,750
Blood and immune system 348 | 16,909
Male tissues 345 | 17,142
Nervous System 345 | 16,725
Respiratory system 342 | 16,393
Cardiovascular System 337 | 15,192

Target Family

Enzyme 265 | 4,145
Non-IDG 62 | 12,091
Kinase 18 | 634
Epigenetic 4 | 242
Transcription Factor 3 | 1,400
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Component

mitochondrial matrix 354 | 354
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

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