Development Level

Tbio 256 | 11,651
Tdark 100 | 6,593
Tclin 51 | 612
Tchem 25 | 1,388

IMPC Phenotype

preweaning lethality, complete... 52 | 979
embryonic lethality prior to o... 16 | 239
embryonic lethality prior to t... 14 | 278
abnormal embryo size 9 | 220
abnormal behavior 8 | 298
embryonic growth retardation 7 | 106
increased total body fat amoun... 7 | 134
enlarged heart 6 | 210
abnormal heart morphology 5 | 162
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
increased lean body mass 5 | 172
pallor 5 | 34
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
cataract 4 | 92
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
decreased vertical activity 4 | 208
increased heart weight 4 | 62
increased startle reflex 4 | 112
prenatal lethality prior to he... 4 | 87
abnormal spleen morphology 3 | 55
decreased circulating phosphat... 3 | 27
decreased mean corpuscular vol... 3 | 79
decreased prepulse inhibition 3 | 82
enlarged spleen 3 | 41
hyperactivity 3 | 148
hypoactivity 3 | 132
improved glucose tolerance 3 | 79
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
increased prepulse inhibition 3 | 32
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo turning 2 | 31
abnormal hindbrain development 2 | 16
abnormal kidney morphology 2 | 65
abnormal limb bud morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
abnormal skin coloration 2 | 25
abnormal tail bud morphology 2 | 8
abnormal tail morphology 2 | 25
decreased circulating LDL chol... 2 | 38
decreased circulating chloride... 2 | 30
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean platelet volume 2 | 25
decreased red blood cell distr... 2 | 41
impaired righting response 2 | 26
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
long tibia 2 | 25
male infertility 2 | 123
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
small testis 2 | 58
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal neural tube morpholog... 1 | 12
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
decreased body length 1 | 101
decreased circulating creatine... 1 | 4
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged urinary bladder 1 | 8
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased red blood cell distr... 1 | 34
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

ovarian cancer 245 | 8,520
Carcinoma 171 | 11,493
osteosarcoma 169 | 7,950
psoriasis 121 | 6,694
medulloblastoma, large-cell 120 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 117 | 1,962
lung cancer 107 | 4,740
glioblastoma 104 | 5,792
atypical teratoid / rhabdoid tumor 99 | 5,112
Multiple myeloma 88 | 1,332
ependymoma 81 | 4,679
Autosomal recessive predisposition 76 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 70 | 3,291
Breast cancer 69 | 3,578
adult high grade glioma 69 | 3,801
astrocytic glioma 61 | 2,597
group 3 medulloblastoma 57 | 4,104
invasive ductal carcinoma 55 | 2,951
oligodendroglioma 51 | 2,850
Epilepsy 50 | 792
lung adenocarcinoma 49 | 2,716
non-small cell lung cancer 49 | 2,890
malignant mesothelioma 48 | 3,232
Cerebellar Ataxia 47 | 304
Cognitive delay 46 | 608
Global developmental delay 46 | 608
Mental and motor retardation 46 | 608
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
Muscle hypotonia 45 | 571
Leigh disease 43 | 100
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,989
non primary Sjogren syndrome sicca 43 | 891
Diabetes mellitus type 2 42 | 69
Seizures 42 | 596
Treatment Refractory Type 2 Diabetes Mellitus 42 | 53
Acidosis, Lactic 40 | 97
Failure to gain weight 40 | 365
Lactic acidemia 40 | 95
Pediatric failure to thrive 40 | 365
Pick disease 39 | 1,894
breast carcinoma 39 | 1,638
Astrocytoma, Pilocytic 37 | 3,081
diabetes mellitus 37 | 1,728
lung carcinoma 37 | 2,843
group 4 medulloblastoma 35 | 1,855
subependymal giant cell astrocytoma 35 | 2,287
Waldenstrons macroglobulinemia 34 | 765
primitive neuroectodermal tumor 34 | 3,035
ulcerative colitis 33 | 1,819
Intellectual disability 32 | 1,016
Mitochondrial complex I deficiency 32 | 46
acute myeloid leukemia 32 | 783
tuberculosis 32 | 2,010
Blepharoptosis 31 | 231
Nystagmus 30 | 317
Dull intelligence 29 | 645
Hypertrophic Cardiomyopathy 29 | 117
Low intelligence 29 | 645
Mental Retardation 29 | 645
Mental deficiency 29 | 645
Poor school performance 29 | 645
ductal carcinoma in situ 29 | 1,745
pancreatic cancer 29 | 2,398
Dystonia 28 | 164
Muscle Weakness 28 | 170
Optic Atrophy 28 | 242
Sensorineural Hearing Loss (disorder) 28 | 284
colon cancer 28 | 1,478
Increased serum lactate 27 | 60
Hyperreflexia 26 | 209
Hypoglycemia 26 | 152
Highly variable clinical phenotype 25 | 150
Highly variable phenotype and severity 25 | 150
Highly variable phenotype, even within families 25 | 150
Phenotypic variability 25 | 150
pituitary cancer 25 | 1,972
Cancer 24 | 2,499
Muscle Spasticity 24 | 195
Strabismus 24 | 270
Developmental regression 23 | 95
Dystonic disease 23 | 106
Loss of developmental milestones 23 | 95
Mental deterioration in childhood 23 | 95
Neurodevelopmental regression 23 | 95
Psychomotor regression 23 | 95
Psychomotor regression beginning in infancy 23 | 95
Psychomotor regression in infants 23 | 95
Psychomotor regression, progressive 23 | 95
Schizophrenia 23 | 1,160
adrenocortical carcinoma 23 | 1,428
astrocytoma 23 | 1,146
pediatric high grade glioma 23 | 1,064
Mitochondrial Complex 1 Deficiency 22 | 28
Rheumatoid arthritis 22 | 1,191
Vomiting 22 | 116
Liver Cirrhosis, Experimental 21 | 769
Respiratory Failure 21 | 104
interstitial cystitis 21 | 2,312
medulloblastoma 21 | 720
Obesity 20 | 678

Tissue

Endocrine System 428 | 18,159
Digestive Tract 426 | 17,369
Male tissues 423 | 17,142
Female tissues 421 | 17,400
Liver and Pancreas 421 | 16,750
Skin and soft tissues 421 | 17,230
Urinary Tract 421 | 16,678
Blood and immune system 419 | 16,909
Nervous System 419 | 16,725
Respiratory system 417 | 16,393
Cardiovascular System 414 | 15,192

Target Family

Enzyme 191 | 4,145
Non-IDG 172 | 12,091
Transporter 56 | 473
Kinase 9 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344

GO Component

mitochondrial inner membrane 432 | 432
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
39S ribosomal protein L40, mitochondrial MRPL40 Tbio Non-IDG -0.92179 8.33 105
Hydroxyproline dehydrogenase PRODH2 Tbio Enzyme -0.72861 5.94 76
Enoyl-CoA delta isomerase 1, mitochondrial ECI1 Tbio Enzyme -2.67168 459.1 229
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
39S ribosomal protein L42, mitochondrial MRPL42 Tdark Non-IDG 0.02 0.40 139
Transmembrane protein 70, mitochondrial TMEM70 Tbio Non-IDG -1.36229 24.6 93
Protein Mpv17 MPV17 Tbio Non-IDG -1.67807 47.6 134
Radical S-adenosyl methionine domain-containing protein 2 RSAD2 Tbio Non-IDG -1.99883 103.3 117