Development Level

Tbio 230 | 10,625
Tdark 109 | 7,003
Tclin 50 | 602
Tchem 36 | 1,890

IMPC Term

preweaning lethality, complete... 31 | 633
embryonic lethality prior to o... 15 | 148
embryonic lethality prior to t... 12 | 187
abnormal behavior 8 | 226
decreased body weight 7 | 174
abnormal embryo size 6 | 112
decreased bone mineral content 4 | 157
embryonic growth retardation 4 | 28
increased heart weight 4 | 37
prenatal lethality prior to he... 4 | 64
abnormal limb bud morphology 3 | 15
abnormal neural tube closure 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased leukocyte cell numbe... 3 | 54
decreased rib number 3 | 59
decreased total body fat amoun... 3 | 186
hyperactivity 3 | 108
increased circulating phosphat... 3 | 24
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 68
increased mean corpuscular vol... 3 | 91
pallor 3 | 13
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal skin coloration 2 | 18
abnormal tail bud morphology 2 | 6
decreased circulating HDL chol... 2 | 77
decreased circulating alkaline... 2 | 41
decreased circulating chloride... 2 | 32
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
decreased mean platelet volume 2 | 12
decreased red blood cell distr... 2 | 11
decreased startle reflex 2 | 48
enlarged heart 2 | 111
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased grip strength 2 | 83
increased lean body mass 2 | 107
persistence of hyaloid vascula... 2 | 22
abnormal QRS complex 1 | 25
abnormal allantois morphology 1 | 3
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal neural tube morpholog... 1 | 8
abnormal placenta morphology 1 | 4
abnormal retina morphology 1 | 100
abnormal skin appearance 1 | 8
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
absent vibrissae 1 | 14
corneal opacity 1 | 25
cyanosis 1 | 6
decreased CD11b-low dendritic ... 1 | 3
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased follicular B cell nu... 1 | 4
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased total retina thickne... 1 | 20
edema 1 | 11
enlarged heart atrium 1 | 2
female infertility 1 | 34
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
prenatal lethality 1 | 16
respiratory system phenotype 1 | 2
thrombocytopenia 1 | 46

Disease

ovarian cancer 235 | 8,484
osteosarcoma 168 | 7,933
psoriasis 122 | 6,685
medulloblastoma, large-cell 120 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 111 | 1,795
lung cancer 107 | 4,466
glioblastoma 101 | 5,572
Multiple myeloma 88 | 1,327
atypical teratoid / rhabdoid tumor 84 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,289
Breast cancer 67 | 3,094
astrocytic glioma 59 | 2,241
ependymoma 59 | 2,514
invasive ductal carcinoma 52 | 2,950
lung adenocarcinoma 51 | 2,713
oligodendroglioma 51 | 2,849
pediatric high grade glioma 50 | 2,712
malignant mesothelioma 47 | 3,162
non-small cell lung cancer 47 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,956
Diabetes mellitus type 2 42 | 69
Treatment Refractory Type 2 Diabetes Mellitus 42 | 53
non primary Sjogren syndrome sicca 42 | 840
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
medulloblastoma 41 | 1,524
ulcerative colitis 41 | 2,087
adult high grade glioma 40 | 2,148
Pick disease 38 | 1,893
pilocytic astrocytoma 37 | 3,086
Leigh disease 36 | 81
lung carcinoma 36 | 2,844
primitive neuroectodermal tumor 35 | 3,031
breast carcinoma 34 | 1,614
subependymal giant cell astrocytoma 34 | 2,287
diabetes mellitus 33 | 1,663
Waldenstrons macroglobulinemia 32 | 765
group 3 medulloblastoma 32 | 2,254
acute myeloid leukemia 30 | 780
pancreatic cancer 30 | 2,300
Cancer 28 | 2,346
colon cancer 28 | 1,475
ductal carcinoma in situ 28 | 1,745
pituitary cancer 27 | 1,972
MITOCHONDRIAL COMPLEX I DEFICIENCY 26 | 37
astrocytoma 26 | 1,493
group 4 medulloblastoma 26 | 1,875
tuberculosis 25 | 1,557
adrenocortical carcinoma 22 | 1,427
interstitial cystitis 22 | 2,299
Obesity 21 | 616
Rheumatoid Arthritis 21 | 1,160
atypical teratoid/rhabdoid tumor 20 | 1,095
acute quadriplegic myopathy 19 | 1,157
posterior fossa group A ependymoma 19 | 1,511
sonic hedgehog group medulloblastoma 19 | 1,482
Alzheimer's disease 18 | 644
cystic fibrosis 18 | 1,665
posterior fossa group B ependymoma 17 | 1,530
tuberculosis and treatment for 6 months 17 | 686
Cardiomyopathy 15 | 110
Mammary Neoplasms 15 | 410
hereditary spastic paraplegia 15 | 313
Down syndrome 14 | 548
Leber hereditary optic neuropathy 14 | 17
NADH:Q(1) Oxidoreductase deficiency 14 | 20
Neurodegenerative disease 14 | 383
aldosterone-producing adenoma 14 | 664
dermatomyositis 14 | 933
gastric carcinoma 14 | 832
Stomach Neoplasms 13 | 282
primary pancreatic ductal adenocarcinoma 13 | 1,271
Mitochondrial myopathy 12 | 23
Parkinson's disease 12 | 364
Schizophrenia 12 | 501
3-methylglutaconic aciduria 11 | 29
Atopic dermatitis 11 | 944
Lactic acidosis 11 | 42
Multiple Sclerosis 11 | 498
juvenile dermatomyositis 11 | 1,189
nasopharyngeal carcinoma 11 | 1,056
Degenerative polyarthritis 10 | 93
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 10 | 14
active Crohn's disease 10 | 918
hepatocellular carcinoma 10 | 532
inflammatory breast cancer 10 | 404
Diabetes Mellitus, Experimental 9 | 106
Intellectual disability 9 | 573
Optic Atrophy, Hereditary, Leber 9 | 14
Optic atrophy 9 | 43
Polycystic Ovary Syndrome 9 | 332
cutaneous lupus erythematosus 9 | 1,056
progressive supranuclear palsy 9 | 674
spina bifida 9 | 1,064
Carcinoma 8 | 2,147
Duchenne muscular dystrophy 8 | 602
IGA Glomerulonephritis 8 | 454
Prostatic Neoplasms 8 | 471
Vascular disease 8 | 281
fibroadenoma 8 | 557
pancreatic carcinoma 8 | 567

Tissue

Blood and immune system 424 | 17,995
Cardiovascular System 423 | 17,958
Digestive Tract 423 | 18,473
Endocrine System 423 | 18,512
Female tissues 423 | 18,647
Nervous System 423 | 18,561
Urinary Tract 423 | 18,444
Liver and Pancreas 422 | 18,136
Male tissues 422 | 17,969
Respiratory system 420 | 17,484
Skin and soft tissues 419 | 18,115

Target Family

Enzyme 188 | 4,146
Non-IDG 166 | 11,971
Transporter 56 | 473
Kinase 9 | 634
Epigenetic 3 | 242
Transcription Factor 2 | 1,400
Ion Channel 1 | 341

GO Component

mitochondrial inner membrane 425 | 425
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
39S ribosomal protein L37, mitochondrial MRPL37 Tdark Non-IDG -0.30103 2.00 47
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132