Development Level

Tbio 26 | 10,625
Tdark 5 | 7,003
Tchem 2 | 1,890

IMPC Phenotype

preweaning lethality, complete... 6 | 633
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to t... 2 | 187
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal placenta size 1 | 10
abnormal tail bud morphology 1 | 6
absent heartbeat 1 | 6
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
increased fasted circulating g... 1 | 68
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
pale liver 1 | 5
pale yolk sac 1 | 12

Disease

osteosarcoma 23 | 7,933
ovarian cancer 18 | 8,491
psoriasis 11 | 6,685
medulloblastoma, large-cell 10 | 6,234
atypical teratoid / rhabdoid tumor 8 | 4,369
glioblastoma 8 | 5,572
group 3 medulloblastoma 7 | 2,254
Carcinoma 6 | 2,147
lung cancer 6 | 4,473
malignant mesothelioma 6 | 3,163
oligodendroglioma 6 | 2,849
Endometriosis 5 | 535
Rheumatoid Arthritis 5 | 1,170
astrocytic glioma 5 | 2,241
astrocytoma 5 | 1,493
primitive neuroectodermal tumor 5 | 3,031
tuberculosis and treatment for 6 months 5 | 686
Pick disease 4 | 1,893
ependymoma 4 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
medulloblastoma 4 | 1,524
Breast cancer 3 | 3,098
Mammary Neoplasms 3 | 410
Multiple myeloma 3 | 1,327
acute quadriplegic myopathy 3 | 1,157
group 4 medulloblastoma 3 | 1,875
lung adenocarcinoma 3 | 2,714
pituitary cancer 3 | 1,972
spina bifida 3 | 1,064
tuberculosis 3 | 1,563
Cancer 2 | 2,346
FG syndrome 2 | 17
Intellectual disability 2 | 573
Ohdo syndrome 2 | 6
Waldenstrons macroglobulinemia 2 | 764
acute myeloid leukemia 2 | 785
adrenocortical carcinoma 2 | 1,427
adult high grade glioma 2 | 2,148
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,663
hepatocellular carcinoma 2 | 550
hereditary spastic paraplegia 2 | 313
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 2,087
Acquired metabolic disease 1 | 267
Atypical autism 1 | 25
Blepharophimosis 1 | 17
Bulimia nervosa 1 | 15
COPD 1 | 116
Cellulitis 1 | 13
Chromosome 22q11.2 microduplication syndrome 1 | 9
Chronic intestinal vascular insufficiency 1 | 12
Congenital diaphragmatic hernia 1 | 44
Congenital heart disease 1 | 63
Connective tissue cancer 1 | 9
Cornelia de Lange syndrome 1 | 21
Drug-Induced Liver Injury 1 | 118
Echinococcosis 1 | 28
Epicondylitis 1 | 19
Farber lipogranulomatosis 1 | 9
Gingivitis 1 | 19
Guillain-Barre syndrome 1 | 15
Hyperlipidemia 1 | 25
IGA Glomerulonephritis 1 | 454
Junctional epidermolysis bullosa 1 | 9
Kaposi's sarcoma 1 | 20
Kennedy's disease 1 | 13
Leiomyoma 1 | 25
Leiomyosarcoma 1 | 19
Liver carcinoma 1 | 217
Lujan Fryns syndrome 1 | 3
Mental depression 1 | 58
Microcephaly, postnatal progressive, with seizures and brain atrophy 1 | 1
Neonatal abstinence syndrome 1 | 9
Neoplasm Metastasis 1 | 138
Opitz-GBBB syndrome 1 | 19
Pericardial effusion 1 | 10
Philadelphia chromosome-positive acute lymphoblastic leukemia 1 | 47
Prostate cancer 1 | 172
Pulmonary Embolism 1 | 45
Seborrheic keratosis 1 | 6
Tetralogy of Fallot 1 | 38
Trichorhinophalangeal syndrome type II 1 | 14
Type 2 diabetes mellitus 1 | 192
Uterine fibroid 1 | 29
Velocardiofacial syndrome 1 | 45
Vestibular nystagmus 1 | 7
Vulvitis 1 | 5
X-linked intellectual disability with marfanoid habitus 1 | 3
aldosterone-producing adenoma 1 | 664
cystic fibrosis 1 | 1,670
fibroadenoma 1 | 557
pancreatic cancer 1 | 2,300
pancreatic carcinoma 1 | 567
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,795
pediatric high grade glioma 1 | 2,712
pilocytic astrocytoma 1 | 3,086
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 33 | 17,994
Cardiovascular System 33 | 17,957
Digestive Tract 33 | 18,472
Endocrine System 33 | 18,511
Female tissues 33 | 18,646
Liver and Pancreas 33 | 18,135
Male tissues 33 | 17,968
Nervous System 33 | 18,560
Respiratory system 33 | 17,483
Skin and soft tissues 33 | 18,114
Urinary Tract 33 | 18,443

Target Family

Enzyme 28 | 4,146
Non-IDG 4 | 11,969
Kinase 1 | 634

GO Component

mediator complex 33 | 33
nucleus 5,106 | 5,106
cytoplasm 4,984 | 4,984
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,264 | 3,264
extracellular exosome 2,757 | 2,757
nucleoplasm 2,716 | 2,716
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 536 | 536
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

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