Development Level

Tbio 163 | 11,651
Tchem 29 | 1,388
Tclin 18 | 612
Tdark 12 | 6,593

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 6 | 298
preweaning lethality, incomple... 6 | 499
short tibia 6 | 97
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
abnormal embryo size 3 | 220
abnormal seminal vesicle morph... 3 | 114
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
increased mean corpuscular hem... 3 | 96
abnormal bone structure 2 | 187
abnormal skin morphology 2 | 50
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating glucose ... 2 | 126
decreased circulating lactate ... 2 | 3
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
edema 2 | 59
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
prenatal lethality 2 | 28
prolonged ST segment 2 | 36
small adrenal glands 2 | 16
small superior vagus ganglion 2 | 74
thrombocytosis 2 | 27
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal skin coloration 1 | 25
abnormal thoracic cage shape 1 | 3
abnormal thymus morphology 1 | 7
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating unsatura... 1 | 2
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
premature death 1 | 5
prolonged QT interval 1 | 38
protruding tongue 1 | 3
small thymus 1 | 16
tremors 1 | 39

Disease

Carcinoma 144 | 11,493
ovarian cancer 133 | 8,520
osteosarcoma 97 | 7,950
glioblastoma 94 | 5,792
medulloblastoma, large-cell 85 | 6,241
psoriasis 74 | 6,694
lung cancer 67 | 4,740
atypical teratoid / rhabdoid tumor 62 | 5,112
malignant mesothelioma 57 | 3,232
ependymoma 55 | 4,679
Autosomal recessive predisposition 54 | 1,442
Astrocytoma, Pilocytic 53 | 3,081
tuberculosis 53 | 2,010
lung carcinoma 49 | 2,843
invasive ductal carcinoma 48 | 2,951
Cancer 46 | 2,499
lung adenocarcinoma 46 | 2,716
non-small cell lung cancer 46 | 2,890
group 3 medulloblastoma 45 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,291
diabetes mellitus 44 | 1,728
Breast cancer 42 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
subependymal giant cell astrocytoma 42 | 2,287
adult high grade glioma 39 | 3,801
oligodendroglioma 39 | 2,850
pancreatic cancer 34 | 2,398
interstitial cystitis 32 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
primitive neuroectodermal tumor 32 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
astrocytoma 30 | 1,146
Epilepsy 28 | 792
Kidney cancer 28 | 2,613
Seizures 28 | 596
ulcerative colitis 28 | 1,819
Multiple myeloma 26 | 1,332
Intellectual disability 25 | 1,016
Neurodegenerative disease 25 | 414
Pick disease 25 | 1,894
Rheumatoid arthritis 25 | 1,191
acute quadriplegic myopathy 25 | 1,158
dermatomyositis 25 | 966
pediatric high grade glioma 25 | 1,064
astrocytic glioma 24 | 2,597
breast carcinoma 24 | 1,638
group 4 medulloblastoma 24 | 1,855
Alzheimer's disease 23 | 658
cystic fibrosis 23 | 1,696
Dull intelligence 21 | 645
Low intelligence 21 | 645
Mental Retardation 21 | 645
Mental deficiency 21 | 645
Poor school performance 21 | 645
juvenile dermatomyositis 21 | 1,187
cutaneous lupus erythematosus 20 | 1,057
gastric carcinoma 20 | 807
Hepatomegaly 19 | 285
Schizophrenia 19 | 1,160
Waldenstrons macroglobulinemia 19 | 765
colon cancer 19 | 1,478
ductal carcinoma in situ 19 | 1,745
primary pancreatic ductal adenocarcinoma 19 | 1,109
Down syndrome 18 | 499
Liver Cirrhosis, Experimental 17 | 769
Muscle hypotonia 17 | 571
esophageal adenocarcinoma 16 | 737
Dementia 15 | 175
Obesity 15 | 678
pituitary cancer 15 | 1,972
Atopic dermatitis 14 | 952
Cognitive delay 14 | 608
Coronary artery disease 14 | 268
Duchenne muscular dystrophy 14 | 601
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Multiple Sclerosis 14 | 540
Muscle Spasticity 14 | 195
Splenomegaly 14 | 190
active Crohn's disease 14 | 922
active ulcerative colitis 14 | 764
adrenocortical carcinoma 14 | 1,428
mucosa-associated lymphoid tissue lymphoma 14 | 484
Bipolar Disorder 13 | 666
Cerebellar Ataxia 13 | 304
Heart disease 13 | 306
Hypertension 13 | 396
Kidney disease 13 | 430
Parkinson's disease 13 | 392
non primary Sjogren syndrome sicca 13 | 891
primary Sjogren syndrome 13 | 735
Asthma 12 | 385
Atherosclerosis 12 | 291
Coarse facial features 12 | 108
Major Depressive Disorder 12 | 301
Thickened facial skin with coarse facial features 12 | 108
pancreatic carcinoma 12 | 562
Anemia 11 | 365
Arthritis 11 | 290
Lung Neoplasms 11 | 232

Tissue

Endocrine System 220 | 18,159
Female tissues 220 | 17,400
Male tissues 219 | 17,142
Skin and soft tissues 219 | 17,230
Digestive Tract 218 | 17,369
Liver and Pancreas 218 | 16,750
Urinary Tract 218 | 16,678
Blood and immune system 217 | 16,909
Respiratory system 217 | 16,393
Nervous System 215 | 16,725
Cardiovascular System 210 | 15,192

Target Family

Non-IDG 109 | 12,091
Enzyme 90 | 4,145
Ion Channel 8 | 344
Transporter 7 | 473
Kinase 4 | 634
GPCR 3 | 408
Transcription Factor 1 | 1,400

GO Component

lysosome 222 | 222
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Aspartate aminotransferase, cytoplasmic GOT1 Tbio Enzyme -2.25904 173.1 355
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193
Arylsulfatase A ARSA Tbio Enzyme -2.50334 319.0 337
Synaptotagmin-11 SYT11 Tbio Non-IDG -1.00759 12.5 125
Vacuolar protein sorting-associated protein 35 VPS35 Tbio Non-IDG -2.02621 104.1 124
Sialidase-4 NEU4 Tchem Enzyme -1.39624 25.1 115
Calpain-2 catalytic subunit CAPN2 Tchem Non-IDG -1.69585 48.5 220