Development Level

Tbio 238 | 11,651
Tdark 34 | 6,593
Tchem 24 | 1,388
Tclin 5 | 612

Collection

RFA-RM-18-021 3 | 328
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 26 | 979
embryonic lethality prior to t... 14 | 278
embryonic lethality prior to o... 12 | 239
abnormal behavior 11 | 298
decreased total body fat amoun... 9 | 207
decreased body weight 8 | 161
increased circulating alkaline... 8 | 122
preweaning lethality, incomple... 8 | 499
increased lean body mass 7 | 172
hypoactivity 6 | 132
short tibia 6 | 97
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
abnormal heart morphology 5 | 162
decreased mean corpuscular hem... 5 | 50
decreased mean corpuscular vol... 5 | 79
edema 5 | 59
enlarged heart 5 | 210
increased bone mineral density 5 | 72
increased mean corpuscular hem... 5 | 96
increased startle reflex 5 | 112
abnormal pericardium morpholog... 4 | 26
abnormal seminal vesicle morph... 4 | 114
abnormal sleep behavior 4 | 70
cardiovascular system phenotyp... 4 | 36
decreased prepulse inhibition 4 | 82
decreased vertical activity 4 | 208
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased circulating sodium l... 4 | 71
increased total body fat amoun... 4 | 134
prolonged QT interval 4 | 38
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal craniofacial morpholo... 3 | 33
abnormal iris morphology 3 | 13
abnormal response to new envir... 3 | 10
abnormal retina morphology 3 | 71
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased hemoglobin content 3 | 68
hemorrhage 3 | 23
increased circulating potassiu... 3 | 29
increased circulating serum al... 3 | 22
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
prolonged ST segment 3 | 36
thrombocytosis 3 | 27
tremors 3 | 39
trunk curl 3 | 16
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal eye size 2 | 7
abnormal head size 2 | 6
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal limb bud morphology 2 | 17
abnormal lung morphology 2 | 26
abnormal response to tactile s... 2 | 17
abnormal skin coloration 2 | 25
absent pinna reflex 2 | 23
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased circulating lactate ... 2 | 3
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased red blood cell distr... 2 | 41
embryonic growth retardation 2 | 106
enlarged kidney 2 | 14
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating fructosa... 2 | 13
increased circulating total pr... 2 | 28
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
mammalian phenotype 2 | 17
narrow eye opening 2 | 12
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small adrenal glands 2 | 16
abnormal vocalization 1 | 21
decreased T cell number 1 | 15
vertebral fusion 1 | 23

Disease

Carcinoma 177 | 11,493
ovarian cancer 173 | 8,520
osteosarcoma 139 | 7,950
medulloblastoma, large-cell 112 | 6,241
glioblastoma 108 | 5,792
atypical teratoid / rhabdoid tumor 84 | 5,112
psoriasis 84 | 6,694
ependymoma 82 | 4,679
lung cancer 71 | 4,740
lung carcinoma 61 | 2,843
adult high grade glioma 60 | 3,801
invasive ductal carcinoma 57 | 2,951
Breast cancer 55 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
Astrocytoma, Pilocytic 52 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 50 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,291
malignant mesothelioma 49 | 3,232
tuberculosis 48 | 2,010
pancreatic cancer 47 | 2,398
astrocytic glioma 45 | 2,597
Rheumatoid arthritis 44 | 1,191
subependymal giant cell astrocytoma 44 | 2,287
oligodendroglioma 43 | 2,850
Kidney cancer 42 | 2,613
Pick disease 42 | 1,894
group 3 medulloblastoma 41 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,962
Autosomal recessive predisposition 40 | 1,442
diabetes mellitus 39 | 1,728
non-small cell lung cancer 39 | 2,890
lung adenocarcinoma 38 | 2,716
interstitial cystitis 37 | 2,312
primitive neuroectodermal tumor 37 | 3,035
Multiple myeloma 36 | 1,332
astrocytoma 35 | 1,146
juvenile dermatomyositis 34 | 1,187
breast carcinoma 32 | 1,638
group 4 medulloblastoma 32 | 1,855
ulcerative colitis 32 | 1,819
Cancer 31 | 2,499
primary pancreatic ductal adenocarcinoma 31 | 1,109
pediatric high grade glioma 30 | 1,064
acute quadriplegic myopathy 29 | 1,158
ductal carcinoma in situ 29 | 1,745
adrenocortical carcinoma 27 | 1,428
pituitary cancer 26 | 1,972
cystic fibrosis 25 | 1,696
dermatomyositis 25 | 966
Schizophrenia 24 | 1,160
active Crohn's disease 24 | 922
colon cancer 23 | 1,478
Alzheimer's disease 22 | 658
sarcoidosis 22 | 370
Intellectual disability 21 | 1,016
Neurodegenerative disease 21 | 414
Epilepsy 20 | 792
Liver Cirrhosis, Experimental 20 | 769
Duchenne muscular dystrophy 19 | 601
Systemic lupus erythematosus 19 | 194
Waldenstrons macroglobulinemia 19 | 765
cutaneous lupus erythematosus 19 | 1,057
esophageal adenocarcinoma 19 | 737
Down syndrome 18 | 499
primary Sjogren syndrome 18 | 735
Multiple Sclerosis 17 | 540
Narcolepsy 17 | 72
active ulcerative colitis 17 | 764
non primary Sjogren syndrome sicca 17 | 891
spina bifida 17 | 1,074
Melanoma 16 | 711
mucosa-associated lymphoid tissue lymphoma 16 | 484
progressive supranuclear palsy 16 | 676
Berylliosis 15 | 28
Muscle hypotonia 15 | 571
Parkinson's disease 15 | 392
Anemia 14 | 365
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Multiple Sclerosis, Susceptibility to 14 | 15
Narcolepsy-cataplexy 14 | 21
Poor school performance 14 | 645
Splenomegaly 14 | 190
Cognitive delay 13 | 608
Diffuse cutaneous systemic sclerosis 13 | 17
Global developmental delay 13 | 608
Hermansky-Pudlak syndrome 13 | 42
Mental and motor retardation 13 | 608
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
Seizures 13 | 596
follicular lymphoma 13 | 20
gastric carcinoma 13 | 807
limited scleroderma 13 | 19
medulloblastoma 13 | 720
Atopic dermatitis 12 | 952
Hepatomegaly 12 | 285
pancreatic carcinoma 12 | 562

Tissue

Endocrine System 285 | 18,159
Skin and soft tissues 285 | 17,230
Blood and immune system 284 | 16,909
Digestive Tract 284 | 17,369
Female tissues 284 | 17,400
Male tissues 283 | 17,142
Respiratory system 283 | 16,393
Urinary Tract 282 | 16,678
Liver and Pancreas 281 | 16,750
Nervous System 280 | 16,725
Cardiovascular System 274 | 15,192

Target Family

Non-IDG 192 | 12,091
Enzyme 67 | 4,145
Transporter 25 | 473
Ion Channel 12 | 344
Kinase 3 | 634
GPCR 1 | 408
Transcription Factor 1 | 1,400

GO Component

lysosomal membrane 301 | 301
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137
Sialin SLC17A5 Tbio Transporter -2.93541 845.6 63
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
AP-1 complex subunit mu-2 AP1M2 Tbio Non-IDG -2.54240 341.5 68
KICSTOR complex protein kaptin KPTN Tbio Non-IDG -1.45875 26.8 153
Phosphatidylinositol 4-kinase type 2-alpha PI4K2A Tbio Kinase -2.88003 745.1 146
V-type proton ATPase subunit D ATP6V1D Tbio Enzyme -1.48812 30.2 69
Vacuolar protein sorting-associated protein 35 VPS35 Tbio Non-IDG -2.02621 104.1 124