Development Level

Tbio 202 | 10,625
Tdark 41 | 7,003
Tchem 31 | 1,890
Tclin 4 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 16 | 633
abnormal behavior 9 | 226
embryonic lethality prior to t... 9 | 187
decreased total body fat amoun... 7 | 186
embryonic lethality prior to o... 7 | 148
decreased body weight 6 | 174
decreased mean corpuscular vol... 6 | 50
increased mean corpuscular hem... 6 | 93
preweaning lethality, incomple... 5 | 260
abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
abnormal sleep behavior 4 | 63
decreased mean corpuscular hem... 4 | 34
decreased prepulse inhibition 4 | 52
hypoactivity 4 | 89
increased bone mineral content 4 | 92
increased bone mineral density 4 | 52
increased circulating alkaline... 4 | 119
increased circulating sodium l... 4 | 71
short tibia 4 | 82
thrombocytosis 4 | 23
abnormal limb bud morphology 3 | 15
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
cardiovascular system phenotyp... 3 | 35
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased erythrocyte cell num... 3 | 43
decreased hemoglobin content 3 | 53
decreased lean body mass 3 | 195
decreased rib number 3 | 59
hemorrhage 3 | 12
improved glucose tolerance 3 | 56
increased circulating potassiu... 3 | 31
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
abnormal epididymis morphology 2 | 31
abnormal eye size 2 | 11
abnormal iris morphology 2 | 12
abnormal lung morphology 2 | 15
abnormal pericardium morpholog... 2 | 11
abnormal seminal vesicle morph... 2 | 47
absent pinna reflex 2 | 21
decreased B cell number 2 | 30
decreased CD4-positive, alpha ... 2 | 19
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased basophil cell number 2 | 11
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
decreased circulating phosphat... 2 | 15
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased heart rate 2 | 10
decreased hematocrit 2 | 25
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
edema 2 | 11
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
impaired glucose tolerance 2 | 52
increased B cell number 2 | 23
increased NK T cell number 2 | 11
increased blood urea nitrogen ... 2 | 44
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased fasted circulating g... 2 | 68
increased leukocyte cell numbe... 2 | 37
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
small adrenal glands 2 | 15
trunk curl 2 | 15
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased cervical vertebrae n... 1 | 12
decreased circulating sodium l... 1 | 18
decreased heart weight 1 | 44
decreased red blood cell distr... 1 | 11
enlarged spleen 1 | 26
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased eosinophil cell numb... 1 | 9
increased rib number 1 | 41
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
stereotypic behavior 1 | 3
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 163 | 8,484
osteosarcoma 128 | 7,933
medulloblastoma, large-cell 103 | 6,234
glioblastoma 99 | 5,572
atypical teratoid / rhabdoid tumor 74 | 4,369
psoriasis 73 | 6,685
lung cancer 62 | 4,466
lung carcinoma 55 | 2,844
invasive ductal carcinoma 52 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 51 | 2,956
ependymoma 50 | 2,514
pilocytic astrocytoma 50 | 3,086
pediatric high grade glioma 48 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,289
malignant mesothelioma 45 | 3,162
Breast cancer 43 | 3,094
pancreatic cancer 41 | 2,300
subependymal giant cell astrocytoma 41 | 2,287
astrocytoma 40 | 1,493
oligodendroglioma 40 | 2,849
tuberculosis 38 | 1,557
Pick disease 37 | 1,893
adult high grade glioma 37 | 2,148
ulcerative colitis 37 | 2,087
primitive neuroectodermal tumor 36 | 3,031
diabetes mellitus 35 | 1,663
non-small cell lung cancer 35 | 2,798
Multiple myeloma 34 | 1,327
astrocytic glioma 34 | 2,241
interstitial cystitis 34 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,795
Rheumatoid Arthritis 33 | 1,160
juvenile dermatomyositis 33 | 1,189
lung adenocarcinoma 33 | 2,713
primary pancreatic ductal adenocarcinoma 32 | 1,271
Carcinoma 30 | 2,147
group 4 medulloblastoma 30 | 1,875
Cancer 29 | 2,346
breast carcinoma 29 | 1,614
ductal carcinoma in situ 27 | 1,745
medulloblastoma 26 | 1,524
acute quadriplegic myopathy 25 | 1,157
dermatomyositis 25 | 933
pituitary cancer 25 | 1,972
adrenocortical carcinoma 24 | 1,427
cystic fibrosis 24 | 1,665
colon cancer 23 | 1,475
Alzheimer's disease 22 | 644
active Crohn's disease 22 | 918
posterior fossa group A ependymoma 21 | 1,511
Neurodegenerative disease 19 | 383
primary Sjogren syndrome 19 | 789
Down syndrome 18 | 548
Duchenne muscular dystrophy 18 | 602
Waldenstrons macroglobulinemia 18 | 765
cutaneous lupus erythematosus 17 | 1,056
esophageal adenocarcinoma 17 | 737
group 3 medulloblastoma 17 | 2,254
spina bifida 17 | 1,064
progressive supranuclear palsy 16 | 674
sonic hedgehog group medulloblastoma 16 | 1,482
Parkinson's disease 15 | 364
atypical teratoid/rhabdoid tumor 15 | 1,095
mucosa-associated lymphoid tissue lymphoma 15 | 480
posterior fossa group B ependymoma 15 | 1,530
Multiple Sclerosis 14 | 498
non primary Sjogren syndrome sicca 14 | 840
Hermansky-Pudlak syndrome 12 | 43
Hypersensitivity reaction type II disease 12 | 235
gastric carcinoma 12 | 832
sarcoidosis 12 | 358
Atopic dermatitis 11 | 944
IGA Glomerulonephritis 11 | 454
Schizophrenia 11 | 501
aldosterone-producing adenoma 11 | 664
pancreatic carcinoma 11 | 567
Parkinson Disease 10 | 102
active ulcerative colitis 10 | 477
Asthma 9 | 349
Becker muscular dystrophy 9 | 187
Kidney disease 9 | 396
Melanoma 9 | 261
acute myeloid leukemia 9 | 780
Amyotrophic Lateral Sclerosis 8 | 431
Intellectual disability 8 | 573
Obesity 8 | 616
Osteopetrosis 8 | 40
Type 1 diabetes mellitus 8 | 101
fibroadenoma 8 | 557
head and neck cancer and chronic obstructive pulmonary disease 8 | 237
tuberculosis and treatment for 3 months 8 | 327
Dementia 7 | 129
Epilepsy 7 | 346
Gaucher disease type 1 7 | 171
Neuropathy 7 | 210
hepatocellular carcinoma 7 | 532
hereditary spastic paraplegia 7 | 313
nephrosclerosis 7 | 329
tuberculosis and treatment for 6 months 7 | 686

Tissue

Digestive Tract 268 | 18,473
Endocrine System 268 | 18,512
Female tissues 268 | 18,647
Liver and Pancreas 268 | 18,136
Male tissues 268 | 17,969
Nervous System 268 | 18,561
Urinary Tract 268 | 18,444
Blood and immune system 267 | 17,995
Cardiovascular System 267 | 17,958
Respiratory system 266 | 17,484
Skin and soft tissues 263 | 18,115

Target Family

Non-IDG 181 | 11,971
Enzyme 59 | 4,146
Transporter 25 | 473
Ion Channel 8 | 341
Kinase 3 | 634
GPCR 1 | 406
Transcription Factor 1 | 1,400

GO Component

lysosomal membrane 278 | 278
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
Transmembrane 6 superfamily member 1 TM6SF1 Tdark Non-IDG -0.16400 2.15 54
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Equilibrative nucleoside transporter 3 SLC29A3 Tbio Transporter -2.36515 247.3 58
Neuroblast differentiation-associated protein AHNAK AHNAK Tbio Non-IDG -1.61845 51.3 82
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.91579 94.4 137
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
H(+)/Cl(-) exchange transporter 5 CLCN5 Tbio Ion Channel -2.29453 217.9 141
HLA class II histocompatibility antigen, DRB1-9 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 0