Development Level

Tbio 4 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal retina morphology 1 | 71
decreased body weight 1 | 161
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
increased circulating creatini... 1 | 38
increased mean corpuscular hem... 1 | 96

Disease

lung cancer 4 | 4,740
Emery-Dreifuss muscular dystrophy 3 | 23
Lipodystrophy 3 | 40
Pelger-Huet anomaly 3 | 8
Progeria 3 | 25
atypical teratoid / rhabdoid tumor 3 | 5,112
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
ovarian cancer 3 | 8,520
primitive neuroectodermal tumor 3 | 3,035
psoriasis 3 | 6,694
Adenocarcinoma of lung 2 | 142
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Breast cancer 2 | 3,578
Endometriosis 2 | 540
Gait abnormality 2 | 135
Progressive disorder 2 | 142
adult-onset autosomal dominant demyelinating leukodystrophy 2 | 10
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
osteosarcoma 2 | 7,950
pediatric high grade glioma 2 | 1,064
Abnormal atrioventricular conduction 1 | 1
Abnormality of circulating leptin level 1 | 1
Abnormality of the Achilles tendon 1 | 3
Absence of subcutaneous fat 1 | 3
Acro-osteolysis of distal phalanges 1 | 4
Acroosteolysis of distal phalanges (feet) 1 | 2
Adipose tissue loss 1 | 3
Aplasia of the phalanges of the 3rd toe 1 | 1
Aplasia/Hypoplasia of the clavicles 1 | 2
Arteriosclerosis of small cerebral arteries 1 | 3
Atrial Flutter 1 | 4
Atypical Werner syndrome 1 | 1
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 1 | 1
Axial muscle weakness 1 | 6
Bilateral coxa valga 1 | 3
Bipartite clavicle 1 | 5
Calcification of mitral valve 1 | 2
Carcinoid tumor of lung 1 | 1
Cardiomyopathy, Familial Idiopathic 1 | 1
Charcot-Marie-Tooth disease, Type 2B1 1 | 1
Craniofacial disproportion 1 | 3
Emery-Dreifuss Muscular Dystrophy 3 1 | 1
Enlarged peripheral nerves 1 | 1
Epidermal hyperkeratosis 1 | 3
Familial Partial Lipodystrophy, Type 1 1 | 1
Familial Partial Lipodystrophy, Type 2 1 | 1
Flattening of facial bones 1 | 4
HIV-Associated Lipodystrophy Syndrome 1 | 2
Hardened artery wall in small cerebral arteries 1 | 3
Heart-hand syndrome, Slovenian type 1 | 1
Hydrops of placenta 1 | 2
Hypoplastic facial bones 1 | 4
Hypotrophic facial bones 1 | 4
Increased adipose tissue around the neck 1 | 2
Increased anterioposterior diameter of chest 1 | 2
Increased facial adipose tissue 1 | 1
Increased intraabdominal fat 1 | 3
Increased intramuscular fat 1 | 1
Labial pseudohypertrophy 1 | 1
Lethal restrictive dermopathy 1 | 5
Lethal tight skin contracture syndrome (disorder) 1 | 2
Lipodystrophy, Familial Partial 1 | 8
Localized scleroderma 1 | 9
Loss of subcutaneous adipose tissue in limbs 1 | 6
Loss of truncal adipose tissue 1 | 2
MUSCULAR DYSTROPHY, CONGENITAL, LMNA-RELATED (disorder) 1 | 1
MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1B (disorder) 1 | 1
Malouf syndrome 1 | 1
Missing middle phalanges 1 | 2
Muscular Dystrophies, Limb-Girdle 1 | 7
Najjar syndrome 1 | 1
Neoplasm of small intestine 1 | 1
Overtubulated long bones 1 | 2
Patchy hypo- and hyperpigmentation 1 | 1
Pelvic girdle amyotrophy 1 | 2
Pelvic girdle weakness 1 | 7
Pelvic muscle wasting 1 | 2
Peripheral Arterial Diseases 1 | 3
Peroneal muscle weakness 1 | 1
Pili Torti 1 | 6
Pinched nasal tip 1 | 2
Progressive acroosteolysis of the clavicle 1 | 3
Prominent scalp veins 1 | 3
Prominent superficial veins 1 | 3
Proximal lower limb muscle atrophy 1 | 3
Pseudoarthrosis of clavicle 1 | 5
Renal carcinoma 1 | 1
Sclerosis of hand bone 1 | 1
Sinoatrial Block 1 | 1
Small facial bones 1 | 4
Subcutaneous calcification 1 | 2
Underdevelopment of facial bones 1 | 4
Wizened face 1 | 9

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Non-IDG 4 | 12,091

GO Component

lamin filament 4 | 4
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear prelamin A recognition factor NARF Tbio Non-IDG -1.27665 18.1 132
Lamin-B1 LMNB1 Tbio Non-IDG -2.58749 373.5 496
Lamin-B2 LMNB2 Tbio Non-IDG -2.00661 99.1 208
Prelamin-A/C LMNA Tbio Non-IDG -3.03952 1089.9 1005