Development Level

Tbio 100 | 11,445
Tchem 14 | 1,598
Tdark 6 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 6 | 499
embryonic lethality prior to o... 4 | 239
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
embryonic lethality prior to t... 3 | 278
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased leukocyte cell numbe... 2 | 73
embryonic growth retardation 2 | 106
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
abnormal bone structure 1 | 187
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spine curvature 1 | 9
abnormal spleen morphology 1 | 55
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
hyperactivity 1 | 148
hypoactivity 1 | 132
increased NK cell number 1 | 3
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
prenatal lethality 1 | 28
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thick ventricular wall 1 | 7
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 79 | 11,493
ovarian cancer 71 | 8,520
medulloblastoma, large-cell 55 | 6,241
osteosarcoma 55 | 7,950
lung cancer 54 | 4,740
group 3 medulloblastoma 43 | 4,104
glioblastoma 41 | 5,792
atypical teratoid / rhabdoid tumor 40 | 5,112
psoriasis 38 | 6,694
Multiple myeloma 33 | 1,332
ependymoma 32 | 4,679
acute quadriplegic myopathy 30 | 1,158
oligodendroglioma 30 | 2,850
Cancer 29 | 2,499
primitive neuroectodermal tumor 29 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
Waldenstrons macroglobulinemia 27 | 765
Breast cancer 24 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Kidney cancer 22 | 2,613
lung adenocarcinoma 22 | 2,716
astrocytoma 21 | 1,146
non-small cell lung cancer 21 | 2,890
Pick disease 20 | 1,894
adult high grade glioma 19 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
malignant mesothelioma 19 | 3,232
dermatomyositis 18 | 966
astrocytic glioma 17 | 2,597
subependymal giant cell astrocytoma 17 | 2,287
diabetes mellitus 16 | 1,728
invasive ductal carcinoma 15 | 2,951
juvenile dermatomyositis 15 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Amyotrophic lateral sclerosis 11 | 451
Astrocytoma, Pilocytic 11 | 3,081
pancreatic cancer 11 | 2,398
Down syndrome 10 | 499
Rheumatoid arthritis 10 | 1,191
colon cancer 10 | 1,478
lung carcinoma 10 | 2,843
Intellectual disability 9 | 1,016
acute myeloid leukemia 9 | 783
breast carcinoma 9 | 1,638
group 4 medulloblastoma 9 | 1,855
pediatric high grade glioma 9 | 1,064
primary pancreatic ductal adenocarcinoma 9 | 1,109
tuberculosis 9 | 2,010
ulcerative colitis 9 | 1,819
Adenocarcinoma of lung 8 | 142
Disease Models, Animal 8 | 155
adrenocortical carcinoma 8 | 1,428
cystic fibrosis 8 | 1,696
progressive supranuclear palsy 8 | 676
Neurodegenerative disease 7 | 414
Schizophrenia 7 | 1,160
Autosomal recessive predisposition 6 | 1,442
Stomach Neoplasms 6 | 300
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
ductal carcinoma in situ 6 | 1,745
gastric carcinoma 6 | 807
medulloblastoma 6 | 720
mucosa-associated lymphoid tissue lymphoma 6 | 484
pituitary cancer 6 | 1,972
tuberculosis and treatment for 6 months 6 | 409
Acquired scoliosis 5 | 281
Alzheimer's disease 5 | 658
Cognitive delay 5 | 608
Curvature of spine 5 | 282
Depressive disorder 5 | 409
Diamond-Blackfan anemia 5 | 31
Disease Progression 5 | 136
Global developmental delay 5 | 608
Lupus erythematosus 5 | 57
Mammary Neoplasms, Experimental 5 | 154
Mental and motor retardation 5 | 608
Vascular disease 5 | 319
atypical teratoid/rhabdoid tumor 5 | 357
inflammatory breast cancer 5 | 286
nasopharyngeal carcinoma 5 | 1,058
non primary Sjogren syndrome sicca 5 | 891
primary Sjogren syndrome 5 | 735
spina bifida 5 | 1,074
Alcoholic Intoxication, Chronic 4 | 289
Anemia 4 | 365
Duchenne muscular dystrophy 4 | 601
Failure to gain weight 4 | 365
Leukemia 4 | 104
Lung Neoplasms 4 | 232
Multiple Sclerosis 4 | 540
Neoplasm Invasiveness 4 | 161
Pediatric failure to thrive 4 | 365
Prostatic Neoplasms 4 | 495
active Crohn's disease 4 | 922
aldosterone-producing adenoma 4 | 665
hepatocellular carcinoma 4 | 547
interstitial cystitis 4 | 2,312
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Endocrine System 119 | 18,159
Blood and immune system 117 | 16,909
Digestive Tract 117 | 17,369
Female tissues 117 | 17,400
Liver and Pancreas 117 | 16,750
Respiratory system 117 | 16,393
Urinary Tract 117 | 16,678
Male tissues 116 | 17,142
Skin and soft tissues 116 | 17,230
Nervous System 115 | 16,725
Cardiovascular System 113 | 15,192

Target Family

Non-IDG 93 | 12,091
Enzyme 19 | 4,145
Kinase 4 | 634
Transcription Factor 4 | 1,400
Epigenetic 1 | 242

GO Component

intracellular ribonucleoprotei... 121 | 121
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cleavage and polyadenylation specificity factor subunit 3 CPSF3 Tbio Non-IDG -1.47182 27.3 190
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
Poly [ADP-ribose] polymerase 4 PARP4 Tchem Enzyme -1.45503 26.0 123
Heterogeneous nuclear ribonucleoprotein U-like protein 1 HNRNPUL1 Tbio Non-IDG -0.99811 11.3 132
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Telomerase protein component 1 TEP1 Tbio Enzyme -1.74492 50.6 71
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120
Steroid receptor RNA activator 1 SRA1 Tbio Non-IDG -2.78991 595.4 160
RNA-binding protein 14 RBM14 Tbio Non-IDG -2.10043 124.7 168
La-related protein 6 LARP6 Tbio Non-IDG -1.42450 28.5 86