Development Level

Tbio 380 | 10,625
Tchem 81 | 1,890
Tdark 54 | 7,003
Tclin 22 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 23 | 633
decreased body weight 11 | 174
preweaning lethality, incomple... 11 | 260
decreased total body fat amoun... 9 | 186
decreased lean body mass 8 | 195
increased or absent threshold ... 8 | 128
embryonic lethality prior to t... 7 | 187
increased circulating alkaline... 7 | 119
abnormal behavior 6 | 226
abnormal epididymis morphology 6 | 31
abnormal seminal vesicle morph... 6 | 47
decreased hemoglobin content 6 | 53
decreased mean corpuscular vol... 6 | 50
decreased body length 5 | 108
decreased circulating choleste... 5 | 85
decreased lumbar vertebrae num... 5 | 62
embryonic lethality prior to o... 5 | 148
enlarged epididymis 5 | 27
abnormal bone structure 4 | 131
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased circulating calcium ... 4 | 33
decreased circulating serum al... 4 | 79
decreased erythrocyte cell num... 4 | 43
decreased grip strength 4 | 123
decreased leukocyte cell numbe... 4 | 54
decreased mean corpuscular hem... 4 | 34
hypoactivity 4 | 89
improved glucose tolerance 4 | 56
increased blood urea nitrogen ... 4 | 44
increased grip strength 4 | 83
increased mean corpuscular vol... 4 | 91
increased sacral vertebrae num... 4 | 62
abnormal coat/hair pigmentatio... 3 | 54
abnormal kidney morphology 3 | 30
abnormal retina morphology 3 | 100
abnormal testis morphology 3 | 30
cardiovascular system phenotyp... 3 | 35
decreased bone mineral content 3 | 157
decreased circulating fructosa... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased monocyte cell number 3 | 28
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
enlarged heart 3 | 111
increased bone mineral content 3 | 92
increased bone mineral density 3 | 52
increased circulating fructosa... 3 | 11
increased circulating serum al... 3 | 25
short tibia 3 | 82
abnormal QRS complex 2 | 25
abnormal bone mineralization 2 | 55
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal eye morphology 2 | 38
abnormal heart morphology 2 | 51
abnormal locomotor activation 2 | 26
abnormal retinal pigmentation 2 | 61
abnormal tail morphology 2 | 17
decreased Ly6C low monocyte nu... 2 | 23
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating bilirubi... 2 | 14
decreased circulating glucose ... 2 | 121
decreased circulating phosphat... 2 | 15
decreased heart weight 2 | 44
decreased hematocrit 2 | 25
decreased mean corpuscular hem... 2 | 19
decreased threshold for audito... 2 | 32
enlarged lymph nodes 2 | 27
female infertility 2 | 34
immune system phenotype 2 | 17
increased B cell number 2 | 23
increased T cell number 2 | 15
increased body weight 2 | 42
increased circulating total pr... 2 | 20
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased heart rate variabili... 2 | 4
increased mature B cell number 2 | 12
increased mean corpuscular hem... 2 | 93
increased rib number 2 | 41
increased total body fat amoun... 2 | 57
male infertility 2 | 62
polydactyly 2 | 22
small adrenal glands 2 | 15
small superior vagus ganglion 2 | 20
small testis 2 | 37
straub tail 2 | 26
vertebral fusion 2 | 23
abnormal rib morphology 1 | 28
decreased eosinophil cell numb... 1 | 41
decreased thoracic vertebrae n... 1 | 7
increased CD4-positive, CD25-p... 1 | 18
increased eosinophil cell numb... 1 | 9
limb grasping 1 | 35
prenatal lethality prior to he... 1 | 64
trunk curl 1 | 15

Disease

ovarian cancer 332 | 8,484
osteosarcoma 286 | 7,933
psoriasis 222 | 6,685
medulloblastoma, large-cell 202 | 6,234
glioblastoma 199 | 5,572
lung cancer 160 | 4,466
atypical teratoid / rhabdoid tumor 143 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 131 | 3,289
Breast cancer 130 | 3,094
malignant mesothelioma 130 | 3,162
invasive ductal carcinoma 120 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 101 | 2,956
oligodendroglioma 100 | 2,849
non-small cell lung cancer 98 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 95 | 2,988
pediatric high grade glioma 95 | 2,712
Cancer 94 | 2,346
pilocytic astrocytoma 94 | 3,086
pancreatic cancer 92 | 2,300
primitive neuroectodermal tumor 86 | 3,031
subependymal giant cell astrocytoma 85 | 2,287
lung adenocarcinoma 83 | 2,713
ependymoma 80 | 2,514
lung carcinoma 80 | 2,844
astrocytic glioma 78 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 77 | 1,795
Carcinoma 76 | 2,147
interstitial cystitis 76 | 2,299
ulcerative colitis 76 | 2,087
astrocytoma 73 | 1,493
group 3 medulloblastoma 73 | 2,254
posterior fossa group A ependymoma 63 | 1,511
tuberculosis 63 | 1,557
Pick disease 62 | 1,893
Multiple myeloma 60 | 1,327
adult high grade glioma 60 | 2,148
adrenocortical carcinoma 59 | 1,427
group 4 medulloblastoma 58 | 1,875
ductal carcinoma in situ 57 | 1,745
juvenile dermatomyositis 57 | 1,189
pituitary cancer 57 | 1,972
diabetes mellitus 55 | 1,663
cystic fibrosis 54 | 1,665
sonic hedgehog group medulloblastoma 53 | 1,482
dermatomyositis 52 | 933
acute quadriplegic myopathy 50 | 1,157
Rheumatoid Arthritis 47 | 1,160
breast carcinoma 46 | 1,614
colon cancer 45 | 1,475
medulloblastoma 42 | 1,524
posterior fossa group B ependymoma 41 | 1,530
spina bifida 40 | 1,064
Atopic dermatitis 39 | 944
cutaneous lupus erythematosus 39 | 1,056
primary pancreatic ductal adenocarcinoma 39 | 1,271
atypical teratoid/rhabdoid tumor 38 | 1,095
Waldenstrons macroglobulinemia 36 | 765
nasopharyngeal carcinoma 36 | 1,056
non primary Sjogren syndrome sicca 34 | 840
Alzheimer's disease 33 | 644
esophageal adenocarcinoma 33 | 737
progressive supranuclear palsy 32 | 674
active Crohn's disease 31 | 918
gastric carcinoma 31 | 832
primary Sjogren syndrome 31 | 789
aldosterone-producing adenoma 29 | 664
Obesity 27 | 616
pancreatic carcinoma 26 | 567
Neurodegenerative disease 24 | 383
mucosa-associated lymphoid tissue lymphoma 23 | 480
acute myeloid leukemia 22 | 780
IGA Glomerulonephritis 21 | 454
Hypertension 20 | 287
gastric cancer 20 | 430
Amyotrophic Lateral Sclerosis 19 | 431
Colorectal Neoplasms 19 | 217
Mammary Neoplasms 19 | 410
Prostatic Neoplasms 19 | 471
tuberculosis and treatment for 6 months 19 | 686
Down syndrome 18 | 548
Intellectual disability 18 | 573
Kidney disease 18 | 396
Parkinson's disease 18 | 364
hepatocellular carcinoma 18 | 532
Duchenne muscular dystrophy 17 | 602
active ulcerative colitis 17 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 499
Coronary artery disease 16 | 240
Endometriosis 16 | 535
Polycystic Ovary Syndrome 16 | 332
inflammatory breast cancer 16 | 404
Multiple Sclerosis 15 | 498
glioblastoma multiforme 15 | 347
hereditary spastic paraplegia 15 | 313
tuberculosis and treatment for 3 months 15 | 327
Atherosclerosis 14 | 275
Cerebrovascular disease 14 | 231
Epilepsy 14 | 346
Hypertensive disease 14 | 193
Peripheral Neuropathy 14 | 303

Tissue

Digestive Tract 536 | 18,473
Liver and Pancreas 536 | 18,136
Urinary Tract 536 | 18,444
Endocrine System 535 | 18,512
Female tissues 535 | 18,647
Nervous System 534 | 18,561
Cardiovascular System 533 | 17,958
Skin and soft tissues 533 | 18,115
Blood and immune system 532 | 17,995
Male tissues 530 | 17,969
Respiratory system 528 | 17,484

Target Family

Non-IDG 288 | 11,971
Enzyme 147 | 4,146
Transporter 34 | 473
Transcription Factor 28 | 1,400
Kinase 15 | 634
Epigenetic 9 | 242
GPCR 7 | 406
Ion Channel 4 | 341
TF/Epigenetic 3 | 38
Nuclear Receptor 2 | 48

GO Component

intracellular membrane-bounded... 537 | 537
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sialidase-3 NEU3 Tbio Enzyme -1.97558 109.4 23
Tether containing UBX domain for GLUT4 ASPSCR1 Tbio Non-IDG -3.18322 1605.1 195
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.95411 6.43 97
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
Zinc finger protein 540 ZNF540 Tbio Transcription Factor -0.07979 1.20 70
Protein DENND6A DENND6A Tbio Non-IDG 0.95 0.09 26
Polyhomeotic-like protein 3 PHC3 Tbio Non-IDG -2.68637 475.4 59
Cytochrome b5 CYB5A Tchem Non-IDG -3.24788 1711.2 249