Development Level

Tbio 312 | 10,625
Tdark 125 | 7,003
Tchem 78 | 1,890
Tclin 33 | 602

Collection

Eligible Kinase Proteins 9 | 134
Eligible Ion Channel Proteins 3 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 13 | 633
abnormal behavior 8 | 226
decreased lean body mass 8 | 195
increased circulating alkaline... 8 | 119
increased mean corpuscular vol... 8 | 91
preweaning lethality, incomple... 8 | 260
abnormal retina morphology 7 | 100
decreased bone mineral content 7 | 157
decreased bone mineral density 7 | 126
decreased circulating serum al... 6 | 79
hyperactivity 6 | 108
increased circulating HDL chol... 6 | 63
abnormal bone structure 5 | 131
abnormal embryo size 5 | 112
abnormal sleep behavior 5 | 63
cardiovascular system phenotyp... 5 | 35
enlarged heart 5 | 111
increased total body fat amoun... 5 | 57
abnormal gait 4 | 51
abnormal retinal pigmentation 4 | 61
decreased NK T cell number 4 | 28
decreased circulating glucose ... 4 | 121
decreased circulating triglyce... 4 | 83
enlarged lymph nodes 4 | 27
improved glucose tolerance 4 | 56
increased gamma-delta T cell n... 4 | 16
increased hematocrit 4 | 36
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
male infertility 4 | 62
abnormal bone mineralization 3 | 55
abnormal coat/hair pigmentatio... 3 | 54
abnormal heart morphology 3 | 51
decreased body length 3 | 108
decreased circulating HDL chol... 3 | 77
decreased eosinophil cell numb... 3 | 41
decreased gamma-delta T cell n... 3 | 18
decreased lumbar vertebrae num... 3 | 62
decreased monocyte cell number 3 | 28
decreased respiratory quotient 3 | 12
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
hypoactivity 3 | 89
increased fasted circulating g... 3 | 68
increased lean body mass 3 | 107
increased mature B cell number 3 | 12
increased rib number 3 | 41
increased sacral vertebrae num... 3 | 62
short tibia 3 | 82
abnormal neural tube closure 2 | 37
abnormal retinal blood vessel ... 2 | 18
abnormal testis morphology 2 | 30
corneal opacity 2 | 25
decreased CD8-positive, alpha-... 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased body weight 2 | 174
decreased circulating chloride... 2 | 32
decreased circulating choleste... 2 | 85
decreased circulating free fat... 2 | 39
decreased circulating insulin ... 2 | 75
decreased circulating sodium l... 2 | 18
decreased effector memory CD8-... 2 | 24
decreased food intake 2 | 6
decreased granulocyte number 2 | 8
decreased grip strength 2 | 123
decreased heart rate variabili... 2 | 11
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased mature B cell number 2 | 25
decreased pre-pro B cell numbe... 2 | 2
decreased red blood cell distr... 2 | 11
decreased threshold for audito... 2 | 32
embryonic lethality prior to o... 2 | 148
impaired pupillary reflex 2 | 14
increased B cell number 2 | 23
increased CD4-positive, CD25-p... 2 | 18
increased T cell number 2 | 15
increased circulating aspartat... 2 | 17
increased circulating choleste... 2 | 53
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 20
increased circulating triglyce... 2 | 24
increased effector memory CD4-... 2 | 15
increased effector memory CD8-... 2 | 14
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 37
increased red blood cell distr... 2 | 21
long tibia 2 | 13
microphthalmia 2 | 15
mydriasis 2 | 9
shortened RR interval 2 | 19
shortened ST segment 2 | 9
small testis 2 | 37
thrombocytopenia 2 | 46
vertebral transformation 2 | 12
impaired righting response 1 | 19
increased mean platelet volume 1 | 19
limb grasping 1 | 35

Disease

ovarian cancer 259 | 8,484
osteosarcoma 237 | 7,933
psoriasis 215 | 6,685
medulloblastoma, large-cell 203 | 6,234
glioblastoma 188 | 5,572
lung cancer 148 | 4,466
atypical teratoid / rhabdoid tumor 137 | 4,369
pilocytic astrocytoma 127 | 3,086
lung carcinoma 125 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 109 | 2,988
Breast cancer 107 | 3,094
malignant mesothelioma 107 | 3,162
invasive ductal carcinoma 105 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 102 | 2,956
Cancer 100 | 2,346
oligodendroglioma 100 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 98 | 3,289
lung adenocarcinoma 97 | 2,713
primitive neuroectodermal tumor 96 | 3,031
non-small cell lung cancer 94 | 2,798
pediatric high grade glioma 86 | 2,712
ependymoma 85 | 2,514
interstitial cystitis 84 | 2,299
adult high grade glioma 82 | 2,148
ulcerative colitis 79 | 2,087
astrocytic glioma 76 | 2,241
pancreatic cancer 75 | 2,300
subependymal giant cell astrocytoma 75 | 2,287
cystic fibrosis 72 | 1,665
pituitary cancer 71 | 1,972
Carcinoma 68 | 2,147
tuberculosis 68 | 1,557
group 4 medulloblastoma 65 | 1,875
colon cancer 64 | 1,475
ductal carcinoma in situ 64 | 1,745
diabetes mellitus 61 | 1,663
astrocytoma 60 | 1,493
medulloblastoma 60 | 1,524
Pick disease 54 | 1,893
breast carcinoma 53 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 52 | 1,795
group 3 medulloblastoma 51 | 2,254
juvenile dermatomyositis 50 | 1,189
cutaneous lupus erythematosus 47 | 1,056
Rheumatoid Arthritis 45 | 1,160
posterior fossa group B ependymoma 45 | 1,530
sonic hedgehog group medulloblastoma 44 | 1,482
spina bifida 44 | 1,064
posterior fossa group A ependymoma 42 | 1,511
adrenocortical carcinoma 40 | 1,427
primary pancreatic ductal adenocarcinoma 39 | 1,271
acute quadriplegic myopathy 37 | 1,157
Duchenne muscular dystrophy 36 | 602
atypical teratoid/rhabdoid tumor 36 | 1,095
acute myeloid leukemia 35 | 780
Atopic dermatitis 34 | 944
gastric carcinoma 34 | 832
Multiple Sclerosis 31 | 498
active Crohn's disease 31 | 918
primary Sjogren syndrome 30 | 789
Asthma 29 | 349
Multiple myeloma 29 | 1,327
dermatomyositis 29 | 933
nasopharyngeal carcinoma 29 | 1,056
non primary Sjogren syndrome sicca 27 | 840
non-small cell lung carcinoma 27 | 413
aldosterone-producing adenoma 26 | 664
Obesity 25 | 616
Parkinson's disease 24 | 364
Down syndrome 23 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 499
Mammary Neoplasms 22 | 410
Prostatic Neoplasms 22 | 471
Schizophrenia 22 | 501
fibroadenoma 22 | 557
esophageal adenocarcinoma 21 | 737
pancreatic carcinoma 21 | 567
hepatocellular carcinoma 20 | 532
Hypertension 19 | 287
Arthritis 18 | 248
Amyotrophic Lateral Sclerosis 17 | 431
Anemia 17 | 252
Epilepsy 17 | 346
Hypersensitivity reaction type II disease 17 | 235
active ulcerative colitis 17 | 477
facioscapulohumeral dystrophy 17 | 286
gastric cancer 17 | 430
mucosa-associated lymphoid tissue lymphoma 17 | 480
progressive supranuclear palsy 17 | 674
tuberculosis and treatment for 6 months 17 | 686
Alzheimer's disease 16 | 644
Autistic Disorder 16 | 320
Intellectual disability 16 | 573
Kidney disease 16 | 396
Vascular disease 16 | 281
chronic rhinosinusitis 16 | 512
Heart disease 15 | 279
IGA Glomerulonephritis 15 | 454
Pneumonia 15 | 133
sarcoidosis 15 | 358

Tissue

Nervous System 530 | 18,561
Endocrine System 529 | 18,512
Female tissues 528 | 18,647
Digestive Tract 526 | 18,473
Skin and soft tissues 523 | 18,115
Urinary Tract 522 | 18,444
Liver and Pancreas 517 | 18,136
Cardiovascular System 515 | 17,958
Blood and immune system 513 | 17,995
Male tissues 512 | 17,969
Respiratory system 498 | 17,484

Target Family

Non-IDG 337 | 11,971
Enzyme 124 | 4,146
Kinase 36 | 634
GPCR 25 | 406
Ion Channel 14 | 341
Transcription Factor 7 | 1,400
Transporter 3 | 473
Epigenetic 1 | 242
oGPCR 1 | 421

GO Component

intracellular 548 | 548
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
ADP-ribosylation factor-like protein 16 ARL16 Tdark Enzyme -0.13389 1.44 17
Interferon lambda-1 IFNL1 Tbio Non-IDG -1.90881 86.4 137
TBC1 domain family member 2B TBC1D2B Tdark Non-IDG 0.64 0.18 19
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
Tripartite motif-containing protein 42 TRIM42 Tdark Non-IDG 0.60 0.29 72