Development Level

Tbio 337 | 11,445
Tdark 114 | 6,588
Tchem 75 | 1,598
Tclin 40 | 613

Collection

RFA-RM-18-021 24 | 328
Kinase: IDG Consortium (Target... 14 | 125
GPCR: IDG Consortium (Targets) 7 | 126
GPCR: IDG Consortium (Complete... 4 | 25
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 19 | 499
decreased bone mineral content 12 | 151
abnormal behavior 10 | 298
enlarged heart 9 | 210
abnormal heart morphology 8 | 162
decreased bone mineral density 8 | 126
increased circulating alkaline... 8 | 122
abnormal embryo size 7 | 220
abnormal bone structure 6 | 187
decreased total body fat amoun... 6 | 207
decreased vertical activity 6 | 208
hyperactivity 6 | 148
increased mean corpuscular vol... 6 | 92
increased total body fat amoun... 6 | 134
decreased heart weight 5 | 27
hypoactivity 5 | 132
improved glucose tolerance 5 | 79
increased mean corpuscular hem... 5 | 96
abnormal coat-hair pigmentatio... 4 | 64
abnormal gait 4 | 69
abnormal retina morphology 4 | 71
abnormal sleep behavior 4 | 70
cardiovascular system phenotyp... 4 | 36
decreased body weight 4 | 161
decreased circulating glucose ... 4 | 126
decreased lean body mass 4 | 135
enlarged lymph nodes 4 | 37
increased circulating calcium ... 4 | 34
increased circulating choleste... 4 | 66
increased hematocrit 4 | 46
increased lean body mass 4 | 172
increased leukocyte cell numbe... 4 | 47
increased startle reflex 4 | 112
male infertility 4 | 123
small testis 4 | 58
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal testis morphology 3 | 43
absent startle reflex 3 | 24
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased circulating calcium ... 3 | 36
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased heart rate variabili... 3 | 13
decreased prepulse inhibition 3 | 82
embryonic growth retardation 3 | 106
embryonic lethality prior to t... 3 | 278
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating aspartat... 3 | 15
increased circulating free fat... 3 | 20
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
long tibia 3 | 25
prenatal lethality 3 | 28
thrombocytopenia 3 | 56
abnormal QT variability 2 | 10
abnormal neural tube closure 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased food intake 2 | 13
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased respiratory quotient 2 | 16
edema 2 | 59
enlarged spleen 2 | 41
enlarged testis 2 | 6
female infertility 2 | 60
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased circulating HDL chol... 2 | 80
increased circulating alanine ... 2 | 13
increased circulating creatini... 2 | 38
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased circulating magnesiu... 2 | 10
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased heart rate 2 | 23
increased or absent threshold ... 2 | 101
increased red blood cell distr... 2 | 34
microphthalmia 2 | 26
mydriasis 2 | 6
pallor 2 | 34
prolonged QT interval 2 | 38
short tibia 2 | 97
small seminal vesicle 2 | 10
vertebral transformation 2 | 12
decreased T cell number 1 | 15
decreased mean corpuscular hem... 1 | 31

Disease

Carcinoma 316 | 11,493
ovarian cancer 261 | 8,520
osteosarcoma 244 | 7,950
psoriasis 228 | 6,694
medulloblastoma, large-cell 204 | 6,241
glioblastoma 199 | 5,792
atypical teratoid / rhabdoid tumor 169 | 5,112
lung cancer 163 | 4,740
ependymoma 158 | 4,679
adult high grade glioma 135 | 3,801
Breast cancer 133 | 3,578
lung carcinoma 131 | 2,843
Astrocytoma, Pilocytic 124 | 3,081
group 3 medulloblastoma 124 | 4,104
malignant mesothelioma 112 | 3,232
oligodendroglioma 110 | 2,850
Cancer 107 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 105 | 2,989
lung adenocarcinoma 105 | 2,716
invasive ductal carcinoma 101 | 2,951
non-small cell lung cancer 101 | 2,890
primitive neuroectodermal tumor 98 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 97 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 95 | 2,955
astrocytic glioma 94 | 2,597
pancreatic cancer 89 | 2,398
Kidney cancer 85 | 2,613
tuberculosis 80 | 2,010
interstitial cystitis 75 | 2,312
pituitary cancer 73 | 1,972
colon cancer 72 | 1,478
cystic fibrosis 72 | 1,696
subependymal giant cell astrocytoma 71 | 2,287
ulcerative colitis 70 | 1,819
diabetes mellitus 69 | 1,728
ductal carcinoma in situ 63 | 1,745
Schizophrenia 60 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 59 | 1,962
Rheumatoid arthritis 56 | 1,191
Pick disease 55 | 1,894
group 4 medulloblastoma 55 | 1,855
breast carcinoma 54 | 1,638
juvenile dermatomyositis 49 | 1,187
adrenocortical carcinoma 48 | 1,428
astrocytoma 48 | 1,146
Autosomal recessive predisposition 47 | 1,442
cutaneous lupus erythematosus 43 | 1,057
spina bifida 42 | 1,074
acute quadriplegic myopathy 40 | 1,158
primary pancreatic ductal adenocarcinoma 38 | 1,109
Bipolar Disorder 36 | 666
Duchenne muscular dystrophy 36 | 601
pediatric high grade glioma 35 | 1,064
Epilepsy 34 | 792
Multiple Sclerosis 34 | 540
acute myeloid leukemia 34 | 783
Asthma 33 | 385
Atopic dermatitis 33 | 952
Liver Cirrhosis, Experimental 33 | 769
Obesity 33 | 678
Intellectual disability 32 | 1,016
Multiple myeloma 31 | 1,332
Parkinson's disease 31 | 392
active Crohn's disease 30 | 922
dermatomyositis 30 | 966
gastric carcinoma 30 | 807
Melanoma 29 | 711
Prostatic Neoplasms 29 | 495
non primary Sjogren syndrome sicca 29 | 891
Liver cancer 28 | 604
active ulcerative colitis 28 | 764
Hypertension 27 | 396
hepatocellular carcinoma 27 | 547
nasopharyngeal carcinoma 27 | 1,058
primary Sjogren syndrome 27 | 735
aldosterone-producing adenoma 26 | 665
pancreatic carcinoma 26 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 25 | 510
medulloblastoma 25 | 720
non-small cell lung carcinoma 25 | 317
Depressive disorder 24 | 409
Skin cancer 24 | 469
Seizures 23 | 596
Cognitive delay 22 | 608
Down syndrome 22 | 499
Global developmental delay 22 | 608
Major Depressive Disorder 22 | 301
Mental and motor retardation 22 | 608
fibroadenoma 22 | 559
Breast Neoplasms 21 | 445
Mammary Neoplasms 21 | 425
Mental Depression 21 | 333
Muscle hypotonia 21 | 571
Amyotrophic lateral sclerosis 20 | 451
Arthritis 20 | 290
chronic rhinosinusitis 20 | 512
esophageal adenocarcinoma 20 | 737
gastric cancer 20 | 459
Mental Retardation 19 | 645
Short stature 19 | 531

Tissue

Endocrine System 549 | 18,159
Digestive Tract 510 | 17,369
Female tissues 509 | 17,400
Skin and soft tissues 505 | 17,230
Male tissues 500 | 17,142
Blood and immune system 497 | 16,909
Liver and Pancreas 493 | 16,750
Nervous System 488 | 16,725
Urinary Tract 486 | 16,678
Respiratory system 481 | 16,393
Cardiovascular System 436 | 15,192

Target Family

Non-IDG 344 | 12,091
Enzyme 110 | 4,145
GPCR 43 | 408
Kinase 42 | 634
Ion Channel 14 | 344
Transcription Factor 8 | 1,400
Transporter 3 | 473
Epigenetic 1 | 242
oGPCR 1 | 421

GO Component

intracellular 566 | 566
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
TBC1 domain family member 3B TBC1D3B Tbio Non-IDG 0.00000 3
TBC1 domain family member 3L TBC1D3L Tdark Non-IDG 0.00000 2
Protocadherin gamma-A3 PCDHGA3 Tbio Non-IDG -0.38917 3.38 181
Telomere length regulation protein TEL2 homolog TELO2 Tbio Non-IDG -0.93554 9.48 94
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Tripartite motif-containing protein 60 TRIM60 Tdark Non-IDG -0.16386 2.39 38