Development Level

Tbio 35 | 11,178
Tchem 6 | 1,885
Tdark 5 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal vocalization 2 | 21
decreased vertical activity 2 | 208
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased fluid intake 1 | 3
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased heart rate 1 | 23
increased total retina thickne... 1 | 4

Disease

Carcinoma 34 | 11,192
ovarian cancer 27 | 8,297
osteosarcoma 22 | 7,766
psoriasis 20 | 6,514
atypical teratoid / rhabdoid tumor 16 | 4,971
glioblastoma 16 | 5,635
Breast cancer 15 | 3,469
medulloblastoma, large-cell 15 | 6,086
Kidney cancer 14 | 2,548
ependymoma 13 | 4,559
astrocytic glioma 12 | 2,530
lung cancer 12 | 4,607
Cancer 11 | 2,388
adult high grade glioma 11 | 3,701
non-small cell lung cancer 11 | 2,799
oligodendroglioma 11 | 2,768
group 3 medulloblastoma 10 | 4,002
lung adenocarcinoma 10 | 2,627
Astrocytoma, Pilocytic 9 | 3,006
Liver cancer 9 | 589
malignant mesothelioma 9 | 3,135
pancreatic cancer 9 | 2,322
primitive neuroectodermal tumor 9 | 2,957
colon cancer 8 | 1,428
cystic fibrosis 8 | 1,629
esophageal adenocarcinoma 8 | 696
breast carcinoma 7 | 1,589
diabetes mellitus 7 | 1,683
interstitial cystitis 7 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,872
invasive ductal carcinoma 7 | 2,867
subependymal giant cell astrocytoma 7 | 2,230
Amyotrophic lateral sclerosis 6 | 437
Pick disease 6 | 1,856
cutaneous lupus erythematosus 6 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,204
lung carcinoma 6 | 2,755
nasopharyngeal carcinoma 6 | 1,024
Multiple myeloma 5 | 1,296
acute quadriplegic myopathy 5 | 1,133
pituitary cancer 5 | 1,915
spina bifida 5 | 1,053
ulcerative colitis 5 | 1,765
Autosomal recessive predisposition 4 | 1,407
Myopathy 4 | 185
Parkinson's disease 4 | 378
Schizophrenia 4 | 1,136
acute myeloid leukemia 4 | 760
dermatomyositis 4 | 941
ductal carcinoma in situ 4 | 1,686
juvenile dermatomyositis 4 | 1,147
non primary Sjogren syndrome sicca 4 | 861
primary pancreatic ductal adenocarcinoma 4 | 1,071
tuberculosis 4 | 1,963
Animal Mammary Neoplasms 3 | 130
Atopic dermatitis 3 | 915
Breast Neoplasms 3 | 423
Bullous pemphigoid 3 | 18
Crohn's disease 3 | 311
Dental caries 3 | 157
Epilepsy 3 | 775
Failure to gain weight 3 | 359
Large intestine cancer 3 | 123
Major Depressive Disorder 3 | 293
Mammary Neoplasms 3 | 403
Mammary Neoplasms, Animal 3 | 130
Melanoma 3 | 689
Muscle biopsy shows dystrophic changes 3 | 39
Muscular dystrophy 3 | 75
Pediatric failure to thrive 3 | 359
Unipolar Depression 3 | 244
Waldenstrons macroglobulinemia 3 | 742
active Crohn's disease 3 | 882
group 4 medulloblastoma 3 | 1,806
hereditary spastic paraplegia 3 | 313
primary Sjogren syndrome 3 | 710
Alcoholic Intoxication, Chronic 2 | 283
Cholesteatoma 2 | 16
Congenital clubfoot 2 | 108
Contracture 2 | 95
Contracture of joint 2 | 92
Creatine phosphokinase serum increased 2 | 110
Elevated creatine kinase 2 | 110
Flexion contracture 2 | 92
Flexion contractures of joints 2 | 92
Highly variable clinical phenotype 2 | 147
Highly variable phenotype and severity 2 | 147
Highly variable phenotype, even within families 2 | 147
Kidney Failure 2 | 108
Phenotypic variability 2 | 147
Renal Insufficiency 2 | 87
Renal failure in adulthood 2 | 75
Skin cancer 2 | 451
Stomach Neoplasms 2 | 287
active ulcerative colitis 2 | 736
atypical teratoid/rhabdoid tumor 2 | 349
limb-girdle muscular dystrophy 2 | 37
muscle degeneration 2 | 136
posterior fossa group A ependymoma 2 | 456

Tissue

Digestive Tract 45 | 17,369
Female tissues 45 | 17,400
Male tissues 45 | 17,142
Skin and soft tissues 45 | 17,230
Blood and immune system 44 | 16,909
Endocrine System 44 | 18,159
Liver and Pancreas 44 | 16,750
Respiratory system 44 | 16,393
Urinary Tract 44 | 16,678
Nervous System 43 | 16,725
Cardiovascular System 42 | 15,192

Target Family

Non-IDG 28 | 12,091
Enzyme 10 | 4,145
Transcription Factor 3 | 1,400
Kinase 2 | 634
Epigenetic 1 | 242
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Component

intermediate filament cytoskel... 46 | 46
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Keratin, type I cytoskeletal 17 KRT17 Tbio Non-IDG -2.43909 265.8 711
Plectin PLEC Tbio Non-IDG -2.50749 337.2 130
Pleckstrin homology-like domain family B member 2 PHLDB2 Tbio Non-IDG -0.95699 9.41 19
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
Homeobox protein Hox-A13 HOXA13 Tbio Transcription Factor -2.00063 103.6 114
E3 ubiquitin-protein ligase Praja-2 PJA2 Tbio Enzyme -0.64427 3.70 175
Cystinosin CTNS Tbio Non-IDG -2.31471 205.6 165
Midasin MDN1 Tdark Non-IDG -1.23175 16.3 10
Keratin, type II cytoskeletal 8 KRT8 Tbio Non-IDG -2.87670 710.7 1827
SAP30-binding protein SAP30BP Tbio Non-IDG -1.46067 27.4 189