Development Level

Tbio 701 | 10,625
Tchem 315 | 1,890
Tclin 215 | 602
Tdark 175 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 54 | 143
Eligible Ion Channel Proteins 40 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 34 | 633
preweaning lethality, incomple... 26 | 260
abnormal behavior 14 | 226
increased circulating alkaline... 14 | 119
decreased grip strength 13 | 123
decreased lean body mass 13 | 195
decreased bone mineral content 12 | 157
decreased bone mineral density 12 | 126
enlarged heart 12 | 111
embryonic lethality prior to t... 11 | 187
decreased total body fat amoun... 10 | 186
abnormal bone structure 9 | 131
decreased body weight 9 | 174
increased grip strength 9 | 83
hypoactivity 8 | 89
cardiovascular system phenotyp... 7 | 35
decreased circulating alanine ... 7 | 53
decreased fasted circulating g... 7 | 49
enlarged epididymis 7 | 27
increased body weight 7 | 42
abnormal embryo size 6 | 112
abnormal epididymis morphology 6 | 31
abnormal heart morphology 6 | 51
decreased circulating triglyce... 6 | 83
decreased rib number 6 | 59
embryonic lethality prior to o... 6 | 148
hyperactivity 6 | 108
impaired glucose tolerance 6 | 52
improved glucose tolerance 6 | 56
increased circulating sodium l... 6 | 71
increased lean body mass 6 | 107
increased mean corpuscular hem... 6 | 93
increased or absent threshold ... 6 | 128
tremors 6 | 34
abnormal gait 5 | 51
abnormal retina morphology 5 | 100
abnormal retinal pigmentation 5 | 61
abnormal seminal vesicle morph... 5 | 47
abnormal sleep behavior 5 | 63
decreased circulating alkaline... 5 | 41
decreased circulating insulin ... 5 | 75
decreased prepulse inhibition 5 | 52
enlarged spleen 5 | 26
increased blood urea nitrogen ... 5 | 44
increased bone mineral density 5 | 52
increased circulating HDL chol... 5 | 63
increased fasted circulating g... 5 | 68
increased mean corpuscular vol... 5 | 91
short tibia 5 | 82
small superior vagus ganglion 5 | 20
thrombocytopenia 5 | 46
abnormal kidney morphology 4 | 30
abnormal skin morphology 4 | 23
abnormal vibrissa morphology 4 | 17
absent vibrissae 4 | 14
decreased T cell number 4 | 31
decreased body length 4 | 108
decreased circulating choleste... 4 | 85
decreased circulating creatini... 4 | 31
decreased circulating glycerol... 4 | 19
decreased heart weight 4 | 44
decreased lumbar vertebrae num... 4 | 62
decreased monocyte cell number 4 | 28
increased circulating choleste... 4 | 53
increased circulating creatini... 4 | 29
increased circulating potassiu... 4 | 31
increased heart weight 4 | 37
increased sacral vertebrae num... 4 | 62
limb grasping 4 | 35
abnormal eye morphology 3 | 38
abnormal lens morphology 3 | 73
abnormal limb bud morphology 3 | 15
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased basophil cell number 3 | 11
decreased caudal vertebrae num... 3 | 49
decreased circulating HDL chol... 3 | 77
decreased circulating amylase ... 3 | 24
decreased circulating calcium ... 3 | 33
decreased circulating chloride... 3 | 32
decreased circulating free fat... 3 | 39
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
hydrops fetalis 3 | 22
increased bone mineral content 3 | 92
increased circulating iron lev... 3 | 25
increased circulating serum al... 3 | 25
increased circulating total pr... 3 | 20
increased leukocyte cell numbe... 3 | 37
small testis 3 | 37
abnormal coat appearance 2 | 25
abnormal lung morphology 2 | 15
abnormal spleen morphology 2 | 36
decreased Ly6C high monocyte n... 2 | 18
decreased mean corpuscular vol... 2 | 50
decreased vertical activity 2 | 22
increased body length 2 | 20
increased total body fat amoun... 2 | 57
persistence of hyaloid vascula... 2 | 22
vertebral fusion 2 | 23

Disease

psoriasis 600 | 6,685
osteosarcoma 598 | 7,933
ovarian cancer 568 | 8,484
medulloblastoma, large-cell 487 | 6,234
glioblastoma 460 | 5,572
lung cancer 410 | 4,466
lung carcinoma 371 | 2,844
atypical teratoid / rhabdoid tumor 345 | 4,369
pilocytic astrocytoma 319 | 3,086
Cancer 311 | 2,346
non-small cell lung cancer 305 | 2,798
malignant mesothelioma 293 | 3,162
interstitial cystitis 292 | 2,299
lung adenocarcinoma 291 | 2,713
invasive ductal carcinoma 289 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 284 | 3,289
Carcinoma 280 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 279 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 275 | 2,956
pancreatic cancer 257 | 2,300
Breast cancer 251 | 3,094
oligodendroglioma 248 | 2,849
pediatric high grade glioma 245 | 2,712
ulcerative colitis 245 | 2,087
primitive neuroectodermal tumor 227 | 3,031
pituitary cancer 216 | 1,972
subependymal giant cell astrocytoma 204 | 2,287
ependymoma 200 | 2,514
adult high grade glioma 182 | 2,148
cystic fibrosis 181 | 1,665
ductal carcinoma in situ 180 | 1,745
astrocytic glioma 177 | 2,241
cutaneous lupus erythematosus 174 | 1,056
colon cancer 172 | 1,475
tuberculosis 171 | 1,557
diabetes mellitus 165 | 1,663
group 4 medulloblastoma 161 | 1,875
breast carcinoma 152 | 1,614
group 3 medulloblastoma 146 | 2,254
posterior fossa group A ependymoma 145 | 1,511
pancreatic ductal adenocarcinoma liver metastasis 134 | 1,795
Pick disease 124 | 1,893
medulloblastoma 121 | 1,524
primary pancreatic ductal adenocarcinoma 121 | 1,271
adrenocortical carcinoma 118 | 1,427
astrocytoma 116 | 1,493
Rheumatoid Arthritis 113 | 1,160
posterior fossa group B ependymoma 108 | 1,530
sonic hedgehog group medulloblastoma 106 | 1,482
active Crohn's disease 104 | 918
Schizophrenia 98 | 501
primary Sjogren syndrome 93 | 789
gastric carcinoma 92 | 832
nasopharyngeal carcinoma 92 | 1,056
atypical teratoid/rhabdoid tumor 90 | 1,095
Obesity 89 | 616
Multiple Sclerosis 85 | 498
mucosa-associated lymphoid tissue lymphoma 84 | 480
Epilepsy 81 | 346
esophageal adenocarcinoma 79 | 737
Alzheimer's disease 76 | 644
Asthma 76 | 349
Kidney disease 76 | 396
Down syndrome 74 | 548
juvenile dermatomyositis 74 | 1,189
spina bifida 73 | 1,064
Atopic dermatitis 72 | 944
dermatomyositis 72 | 933
Hypertension 68 | 287
Duchenne muscular dystrophy 67 | 602
aldosterone-producing adenoma 64 | 664
nephrosclerosis 64 | 329
acute quadriplegic myopathy 63 | 1,157
pancreatic carcinoma 59 | 567
Endometriosis 57 | 535
IGA Glomerulonephritis 55 | 454
Autistic Disorder 54 | 320
Prostatic Neoplasms 54 | 471
Hypersensitivity reaction type II disease 53 | 235
Multiple myeloma 53 | 1,327
non primary Sjogren syndrome sicca 53 | 840
Parkinson's disease 52 | 364
Mammary Neoplasms 51 | 410
Atherosclerosis 49 | 275
fibroadenoma 49 | 557
Anemia 48 | 252
Bipolar Disorder 48 | 266
active ulcerative colitis 48 | 477
acute myeloid leukemia 48 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 48 | 499
Liver disease 45 | 219
non-small cell lung carcinoma 45 | 413
Hypertensive disease 44 | 193
progressive supranuclear palsy 44 | 674
Cerebrovascular disease 43 | 231
head and neck cancer and chronic obstructive pulmonary disease 43 | 237
hepatocellular carcinoma 43 | 532
Peripheral Neuropathy 42 | 303
Intellectual disability 40 | 573
Waldenstrons macroglobulinemia 40 | 765

Tissue

Female tissues 1,352 | 18,647
Nervous System 1,350 | 18,561
Urinary Tract 1,350 | 18,444
Digestive Tract 1,344 | 18,473
Endocrine System 1,343 | 18,512
Skin and soft tissues 1,324 | 18,115
Liver and Pancreas 1,320 | 18,136
Cardiovascular System 1,304 | 17,958
Blood and immune system 1,293 | 17,995
Male tissues 1,284 | 17,969
Respiratory system 1,270 | 17,484

Target Family

Non-IDG 539 | 11,971
GPCR 260 | 406
Transporter 238 | 473
Ion Channel 150 | 341
Enzyme 119 | 4,146
Kinase 64 | 634
oGPCR 36 | 421

GO Component

integral component of plasma m... 1,406 | 1,406
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-cell receptor alpha chain V region HPB-MLT N/A Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.40437 1.87 71
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
Monocarboxylate transporter 8 SLC16A2 Tbio Transporter -2.32240 230.6 103