Development Level

Tbio 1,834 | 11,651
Tdark 1,523 | 6,593
Tchem 174 | 1,388
Tclin 134 | 612

Collection

RFA-RM-18-021 104 | 328
GPCR: IDG Consortium (Targets) 86 | 126
Ion Channel: IDG Consortium (T... 32 | 99
GPCR: IDG Consortium (Complete... 10 | 25
Kinase: IDG Consortium (Target... 8 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 109 | 979
preweaning lethality, incomple... 78 | 499
abnormal behavior 54 | 298
decreased vertical activity 45 | 208
embryonic lethality prior to t... 42 | 278
enlarged heart 39 | 210
decreased bone mineral content 38 | 151
abnormal bone structure 36 | 187
increased lean body mass 35 | 172
decreased total body fat amoun... 34 | 207
increased total body fat amoun... 32 | 134
embryonic lethality prior to o... 29 | 239
abnormal heart morphology 28 | 162
decreased lean body mass 28 | 135
decreased body weight 27 | 161
abnormal embryo size 26 | 220
decreased bone mineral density 26 | 126
hyperactivity 26 | 148
hypoactivity 24 | 132
decreased circulating glucose ... 23 | 126
increased bone mineral content 23 | 108
increased or absent threshold ... 23 | 101
abnormal seminal vesicle morph... 22 | 114
decreased body length 19 | 101
improved glucose tolerance 19 | 79
increased mean corpuscular vol... 19 | 92
decreased hemoglobin content 18 | 68
increased circulating alkaline... 17 | 122
abnormal sleep behavior 15 | 70
decreased circulating serum al... 15 | 82
decreased lymphocyte cell numb... 15 | 83
decreased prepulse inhibition 15 | 82
decreased startle reflex 15 | 75
embryonic growth retardation 15 | 106
increased mean corpuscular hem... 15 | 96
abnormal eye morphology 14 | 68
decreased erythrocyte cell num... 14 | 62
decreased leukocyte cell numbe... 14 | 73
increased circulating sodium l... 14 | 71
increased monocyte cell number 14 | 63
abnormal gait 13 | 69
decreased fasted circulating g... 13 | 65
decreased grip strength 13 | 116
increased circulating HDL chol... 13 | 80
increased startle reflex 13 | 112
abnormal epididymis morphology 12 | 42
abnormal kidney morphology 12 | 65
decreased circulating triglyce... 12 | 79
decreased mean corpuscular vol... 12 | 79
increased circulating calcium ... 12 | 34
increased fasted circulating g... 12 | 76
short tibia 12 | 97
abnormal behavioral response t... 11 | 66
abnormal coat-hair pigmentatio... 11 | 64
cataract 11 | 92
decreased circulating choleste... 11 | 93
decreased circulating insulin ... 11 | 76
decreased heart weight 11 | 27
limb grasping 11 | 41
male infertility 11 | 123
decreased circulating total pr... 10 | 49
decreased red blood cell distr... 10 | 41
increased bone mineral density 10 | 72
prenatal lethality prior to he... 10 | 87
abnormal lens morphology 9 | 81
abnormal spleen morphology 9 | 55
absent startle reflex 9 | 24
enlarged epididymis 9 | 31
hydrometra 9 | 53
increased circulating triglyce... 9 | 42
increased heart weight 9 | 62
increased red blood cell distr... 9 | 34
small superior vagus ganglion 9 | 74
thrombocytopenia 9 | 56
abnormal locomotor behavior 8 | 24
abnormal testis morphology 8 | 43
decreased circulating HDL chol... 8 | 68
decreased circulating alkaline... 8 | 46
decreased circulating chloride... 8 | 30
decreased hematocrit 8 | 46
decreased mean corpuscular hem... 8 | 50
increased blood urea nitrogen ... 8 | 48
increased circulating creatini... 8 | 38
increased circulating potassiu... 8 | 29
increased hemoglobin content 8 | 45
increased mean platelet volume 8 | 45
small testis 8 | 58
abnormal neural tube closure 7 | 46
abnormal retina morphology 7 | 71
abnormal vocalization 7 | 21
decreased circulating calcium ... 7 | 36
decreased circulating creatini... 7 | 39
edema 7 | 59
impaired glucose tolerance 7 | 75
increased circulating amylase ... 7 | 25
increased circulating choleste... 7 | 66
increased circulating serum al... 7 | 22
increased heart rate 7 | 23
increased leukocyte cell numbe... 7 | 47
increased mean corpuscular hem... 7 | 36

Disease

Carcinoma 2,152 | 11,493
ovarian cancer 1,365 | 8,520
osteosarcoma 1,334 | 7,950
psoriasis 1,135 | 6,694
medulloblastoma, large-cell 1,110 | 6,241
glioblastoma 1,024 | 5,792
atypical teratoid / rhabdoid tumor 963 | 5,112
ependymoma 844 | 4,679
lung cancer 706 | 4,740
adult high grade glioma 699 | 3,801
Astrocytoma, Pilocytic 644 | 3,081
group 3 medulloblastoma 634 | 4,104
Breast cancer 614 | 3,578
lung carcinoma 614 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 581 | 3,291
invasive ductal carcinoma 556 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 550 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 528 | 2,989
interstitial cystitis 520 | 2,312
primitive neuroectodermal tumor 517 | 3,035
non-small cell lung cancer 516 | 2,890
lung adenocarcinoma 493 | 2,716
malignant mesothelioma 471 | 3,232
oligodendroglioma 469 | 2,850
pancreatic cancer 455 | 2,398
Kidney cancer 442 | 2,613
astrocytic glioma 419 | 2,597
subependymal giant cell astrocytoma 416 | 2,287
pituitary cancer 385 | 1,972
tuberculosis 384 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 354 | 1,962
ulcerative colitis 354 | 1,819
ductal carcinoma in situ 349 | 1,745
group 4 medulloblastoma 331 | 1,855
Pick disease 328 | 1,894
cystic fibrosis 322 | 1,696
breast carcinoma 298 | 1,638
diabetes mellitus 286 | 1,728
Cancer 254 | 2,499
adrenocortical carcinoma 240 | 1,428
Autosomal recessive predisposition 225 | 1,442
active Crohn's disease 218 | 922
primary pancreatic ductal adenocarcinoma 212 | 1,109
cutaneous lupus erythematosus 204 | 1,057
pediatric high grade glioma 203 | 1,064
colon cancer 201 | 1,478
active ulcerative colitis 195 | 764
astrocytoma 194 | 1,146
Multiple myeloma 187 | 1,332
Rheumatoid arthritis 187 | 1,191
Schizophrenia 179 | 1,160
juvenile dermatomyositis 170 | 1,187
acute quadriplegic myopathy 168 | 1,158
spina bifida 167 | 1,074
non primary Sjogren syndrome sicca 165 | 891
nasopharyngeal carcinoma 162 | 1,058
Atopic dermatitis 160 | 952
gastric carcinoma 149 | 807
primary Sjogren syndrome 138 | 735
esophageal adenocarcinoma 137 | 737
Epilepsy 136 | 792
Melanoma 132 | 711
Intellectual disability 131 | 1,016
medulloblastoma 130 | 720
Alzheimer's disease 127 | 658
Liver Cirrhosis, Experimental 125 | 769
aldosterone-producing adenoma 121 | 665
Liver cancer 120 | 604
acute myeloid leukemia 117 | 783
Multiple Sclerosis 116 | 540
fibroadenoma 116 | 559
dermatomyositis 114 | 966
Obesity 113 | 678
Skin cancer 110 | 469
posterior fossa group A ependymoma 107 | 468
mucosa-associated lymphoid tissue lymphoma 106 | 484
Bipolar Disorder 105 | 666
Duchenne muscular dystrophy 103 | 601
pancreatic carcinoma 103 | 562
progressive supranuclear palsy 103 | 676
Seizures 96 | 596
Down syndrome 93 | 499
Endometriosis 85 | 540
Dull intelligence 82 | 645
Low intelligence 82 | 645
Mental Retardation 82 | 645
Mental deficiency 82 | 645
Muscle hypotonia 82 | 571
Poor school performance 82 | 645
Neurodegenerative disease 78 | 414
Cognitive delay 77 | 608
Global developmental delay 77 | 608
Mental and motor retardation 77 | 608
sonic hedgehog group medulloblastoma 77 | 467
autosomal dominant Emery-Dreifuss muscular dystrophy 76 | 510
Waldenstrons macroglobulinemia 74 | 765
Prostatic Neoplasms 72 | 495
Short stature 72 | 531
hepatocellular carcinoma 72 | 547
gastric cancer 69 | 459

Tissue

Endocrine System 3,150 | 18,159
Female tissues 2,977 | 17,400
Digestive Tract 2,959 | 17,369
Male tissues 2,914 | 17,142
Skin and soft tissues 2,905 | 17,230
Blood and immune system 2,847 | 16,909
Urinary Tract 2,837 | 16,678
Liver and Pancreas 2,836 | 16,750
Nervous System 2,836 | 16,725
Respiratory system 2,745 | 16,393
Cardiovascular System 2,501 | 15,192

Target Family

Non-IDG 1,929 | 12,091
Enzyme 739 | 4,145
oGPCR 410 | 421
Transporter 249 | 473
GPCR 186 | 408
Ion Channel 100 | 344
Kinase 28 | 634
Transcription Factor 19 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 2 | 48

GO Component

integral component of membrane 3,665 | 3,665
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Protein HIDE1 C19orf38 Tdark Non-IDG 0.00000 57
Olfactory receptor 7D2 OR7D2 Tdark oGPCR 0.00000 2