Development Level

Tbio 1,656 | 10,625
Tdark 1,633 | 7,003
Tchem 267 | 1,890
Tclin 123 | 602

Collection

Eligible non-olfactory GPCR Proteins 98 | 143
Eligible Ion Channel Proteins 35 | 117
Eligible Kinase Proteins 7 | 134

IMPC Term

preweaning lethality, complete... 77 | 633
abnormal behavior 44 | 226
decreased total body fat amoun... 39 | 186
decreased bone mineral content 38 | 157
decreased lean body mass 37 | 195
preweaning lethality, incomple... 37 | 260
embryonic lethality prior to t... 28 | 187
decreased body weight 27 | 174
abnormal bone structure 26 | 131
decreased bone mineral density 24 | 126
decreased circulating glucose ... 22 | 121
hyperactivity 21 | 108
increased lean body mass 21 | 107
increased or absent threshold ... 21 | 128
enlarged heart 19 | 111
increased mean corpuscular vol... 19 | 91
embryonic lethality prior to o... 18 | 148
increased bone mineral content 18 | 92
increased circulating alkaline... 18 | 119
increased mean corpuscular hem... 18 | 93
decreased grip strength 17 | 123
abnormal sleep behavior 16 | 63
decreased body length 16 | 108
decreased circulating triglyce... 16 | 83
increased circulating sodium l... 16 | 71
abnormal retina morphology 15 | 100
hypoactivity 15 | 89
increased circulating calcium ... 15 | 32
decreased circulating insulin ... 14 | 75
decreased circulating serum al... 14 | 79
decreased rib number 14 | 59
increased total body fat amoun... 14 | 57
improved glucose tolerance 13 | 56
short tibia 13 | 82
abnormal gait 12 | 51
decreased circulating choleste... 12 | 85
decreased hemoglobin content 12 | 53
decreased leukocyte cell numbe... 12 | 54
increased exploration in new e... 12 | 56
increased grip strength 12 | 83
abnormal bone mineralization 11 | 55
abnormal embryo size 11 | 112
abnormal eye morphology 11 | 38
abnormal seminal vesicle morph... 11 | 47
decreased circulating HDL chol... 11 | 77
decreased prepulse inhibition 11 | 52
increased circulating potassiu... 11 | 31
increased fasted circulating g... 11 | 68
decreased eosinophil cell numb... 10 | 41
decreased fasted circulating g... 10 | 49
decreased heart weight 10 | 44
decreased lumbar vertebrae num... 10 | 62
decreased startle reflex 10 | 48
increased rib number 10 | 41
abnormal epididymis morphology 9 | 31
abnormal lens morphology 9 | 73
decreased mean corpuscular vol... 9 | 50
enlarged epididymis 9 | 27
increased blood urea nitrogen ... 9 | 44
increased sacral vertebrae num... 9 | 62
straub tail 9 | 26
abnormal coat/hair pigmentatio... 8 | 54
abnormal neural tube closure 8 | 37
abnormal retinal pigmentation 8 | 61
cardiovascular system phenotyp... 8 | 35
decreased caudal vertebrae num... 8 | 49
decreased erythrocyte cell num... 8 | 43
increased bone mineral density 8 | 52
increased prepulse inhibition 8 | 21
abnormal behavioral response t... 7 | 52
abnormal heart morphology 7 | 51
abnormal testis morphology 7 | 30
abnormal vocalization 7 | 21
decreased NK T cell number 7 | 28
decreased circulating alanine ... 7 | 53
decreased circulating chloride... 7 | 32
decreased circulating total pr... 7 | 41
decreased mean corpuscular hem... 7 | 34
female infertility 7 | 34
impaired glucose tolerance 7 | 52
increased circulating serum al... 7 | 25
increased circulating triglyce... 7 | 24
limb grasping 7 | 35
prenatal lethality prior to he... 7 | 64
tremors 7 | 34
abnormal QRS complex 6 | 25
abnormal coat appearance 6 | 25
abnormal locomotor activation 6 | 26
decreased B cell number 6 | 30
decreased circulating calcium ... 6 | 33
decreased monocyte cell number 6 | 28
increased circulating HDL chol... 6 | 63
increased circulating choleste... 6 | 53
increased circulating phosphat... 6 | 24
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 37
increased mean corpuscular hem... 6 | 25
small testis 6 | 37
thrombocytopenia 6 | 46
increased heart weight 5 | 37

Disease

ovarian cancer 1,371 | 8,484
osteosarcoma 1,331 | 7,933
psoriasis 1,149 | 6,685
medulloblastoma, large-cell 1,126 | 6,234
glioblastoma 1,000 | 5,572
atypical teratoid / rhabdoid tumor 825 | 4,369
pilocytic astrocytoma 657 | 3,086
lung cancer 656 | 4,466
lung carcinoma 618 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 595 | 3,289
invasive ductal carcinoma 559 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 558 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 536 | 2,988
Breast cancer 534 | 3,094
primitive neuroectodermal tumor 527 | 3,031
pediatric high grade glioma 522 | 2,712
interstitial cystitis 521 | 2,299
lung adenocarcinoma 494 | 2,713
non-small cell lung cancer 494 | 2,798
oligodendroglioma 480 | 2,849
malignant mesothelioma 471 | 3,162
ependymoma 456 | 2,514
pancreatic cancer 429 | 2,300
subependymal giant cell astrocytoma 425 | 2,287
ulcerative colitis 421 | 2,087
adult high grade glioma 389 | 2,148
astrocytic glioma 384 | 2,241
Carcinoma 381 | 2,147
pituitary cancer 381 | 1,972
ductal carcinoma in situ 352 | 1,745
Pick disease 340 | 1,893
group 4 medulloblastoma 339 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 333 | 1,795
cystic fibrosis 319 | 1,665
group 3 medulloblastoma 318 | 2,254
posterior fossa group A ependymoma 318 | 1,511
breast carcinoma 296 | 1,614
tuberculosis 290 | 1,557
diabetes mellitus 271 | 1,663
sonic hedgehog group medulloblastoma 267 | 1,482
medulloblastoma 257 | 1,524
posterior fossa group B ependymoma 255 | 1,530
adrenocortical carcinoma 246 | 1,427
astrocytoma 240 | 1,493
primary pancreatic ductal adenocarcinoma 238 | 1,271
Cancer 234 | 2,346
active Crohn's disease 218 | 918
atypical teratoid/rhabdoid tumor 218 | 1,095
colon cancer 202 | 1,475
cutaneous lupus erythematosus 202 | 1,056
Multiple myeloma 196 | 1,327
Rheumatoid Arthritis 183 | 1,160
juvenile dermatomyositis 174 | 1,189
acute quadriplegic myopathy 167 | 1,157
spina bifida 163 | 1,064
nasopharyngeal carcinoma 161 | 1,056
Atopic dermatitis 160 | 944
non primary Sjogren syndrome sicca 156 | 840
gastric carcinoma 151 | 832
primary Sjogren syndrome 148 | 789
esophageal adenocarcinoma 136 | 737
active ulcerative colitis 128 | 477
aldosterone-producing adenoma 125 | 664
Alzheimer's disease 118 | 644
fibroadenoma 116 | 557
Obesity 115 | 616
dermatomyositis 115 | 933
acute myeloid leukemia 113 | 780
tuberculosis and treatment for 6 months 110 | 686
Down syndrome 108 | 548
progressive supranuclear palsy 106 | 674
mucosa-associated lymphoid tissue lymphoma 105 | 480
Duchenne muscular dystrophy 104 | 602
Multiple Sclerosis 103 | 498
pancreatic carcinoma 102 | 567
Endometriosis 85 | 535
Schizophrenia 85 | 501
non-small cell lung carcinoma 83 | 413
IGA Glomerulonephritis 82 | 454
Intellectual disability 82 | 573
Neurodegenerative disease 78 | 383
Waldenstrons macroglobulinemia 78 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 75 | 499
Epilepsy 73 | 346
urothelial carcinoma 70 | 318
Prostatic Neoplasms 69 | 471
hepatocellular carcinoma 69 | 532
sarcoidosis 67 | 358
chronic rhinosinusitis 66 | 512
glioblastoma multiforme 66 | 347
tuberculosis and treatment for 3 months 65 | 327
Autistic Disorder 63 | 320
gastric cancer 61 | 430
inflammatory breast cancer 60 | 404
periodontitis 60 | 269
Amyotrophic Lateral Sclerosis 56 | 431
head and neck cancer and chronic obstructive pulmonary disease 56 | 237
facioscapulohumeral dystrophy 54 | 286
nephrosclerosis 53 | 329
Asthma 51 | 349

Tissue

Female tissues 3,412 | 18,647
Urinary Tract 3,378 | 18,444
Nervous System 3,347 | 18,561
Endocrine System 3,341 | 18,512
Digestive Tract 3,315 | 18,473
Skin and soft tissues 3,241 | 18,115
Liver and Pancreas 3,196 | 18,136
Blood and immune system 3,160 | 17,995
Cardiovascular System 3,150 | 17,958
Male tissues 3,128 | 17,969
Respiratory system 3,059 | 17,484

Target Family

Non-IDG 1,982 | 11,971
Enzyme 736 | 4,146
oGPCR 385 | 421
Transporter 244 | 473
GPCR 184 | 406
Ion Channel 96 | 341
Kinase 28 | 634
Transcription Factor 19 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 2 | 48

GO Component

integral component of membrane 3,679 | 3,679
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Transmembrane protein 229B TMEM229B Tdark Non-IDG 1.34 0.03 3
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34
Transmembrane protein 62 TMEM62 Tdark Non-IDG 0.30 0.75 11