Development Level

Tbio 74 | 10,625
Tchem 16 | 1,890
Tdark 11 | 7,003

IMPC Term

preweaning lethality, complete... 11 | 633
decreased lean body mass 4 | 195
decreased circulating alanine ... 3 | 53
embryonic lethality prior to t... 3 | 187
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased T cell number 2 | 31
decreased circulating insulin ... 2 | 75
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
increased circulating alkaline... 2 | 119
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal seminal vesicle morph... 1 | 47
abnormal testis morphology 1 | 30
absent vibrissae 1 | 14
convulsive seizures 1 | 11
decreased B cell number 1 | 30
decreased CD8-positive, alpha-... 1 | 26
decreased IgG1 level 1 | 4
decreased NK T cell number 1 | 28
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased granulocyte number 1 | 8
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
enlarged epididymis 1 | 27
hydroencephaly 1 | 6
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased KLRG1-positive NK ce... 1 | 9
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased effector memory CD8-... 1 | 14
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
male infertility 1 | 62
microphthalmia 1 | 15
prenatal lethality prior to he... 1 | 64
small adrenal glands 1 | 15
small testis 1 | 37
thrombocytopenia 1 | 46
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 55 | 8,484
osteosarcoma 47 | 7,933
psoriasis 34 | 6,685
medulloblastoma, large-cell 33 | 6,234
glioblastoma 31 | 5,572
lung cancer 25 | 4,466
atypical teratoid / rhabdoid tumor 21 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
pilocytic astrocytoma 20 | 3,086
Breast cancer 19 | 3,094
invasive ductal carcinoma 18 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
non-small cell lung cancer 16 | 2,798
interstitial cystitis 15 | 2,299
lung carcinoma 15 | 2,844
astrocytoma 14 | 1,493
malignant mesothelioma 14 | 3,162
oligodendroglioma 14 | 2,849
pituitary cancer 14 | 1,972
tuberculosis 14 | 1,557
Multiple myeloma 13 | 1,327
diabetes mellitus 12 | 1,663
ependymoma 12 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
pancreatic cancer 12 | 2,300
Neurodegenerative disease 11 | 383
active Crohn's disease 11 | 918
astrocytic glioma 11 | 2,241
group 3 medulloblastoma 11 | 2,254
group 4 medulloblastoma 11 | 1,875
lung adenocarcinoma 11 | 2,713
primitive neuroectodermal tumor 11 | 3,031
Pick disease 10 | 1,893
Rheumatoid Arthritis 10 | 1,160
adult high grade glioma 10 | 2,148
subependymal giant cell astrocytoma 10 | 2,287
Atopic dermatitis 9 | 944
Cancer 9 | 2,346
juvenile dermatomyositis 9 | 1,189
ulcerative colitis 9 | 2,087
aldosterone-producing adenoma 8 | 664
cystic fibrosis 8 | 1,665
ductal carcinoma in situ 8 | 1,745
esophageal adenocarcinoma 8 | 737
pediatric high grade glioma 8 | 2,712
adrenocortical carcinoma 7 | 1,427
breast carcinoma 7 | 1,614
colon cancer 7 | 1,475
non primary Sjogren syndrome sicca 7 | 840
primary Sjogren syndrome 7 | 789
progressive supranuclear palsy 7 | 674
spina bifida 7 | 1,064
tuberculosis and treatment for 6 months 7 | 686
acute quadriplegic myopathy 6 | 1,157
dermatomyositis 6 | 933
medulloblastoma 6 | 1,524
Carcinoma 5 | 2,147
Glycogen storage disease 5 | 37
Intellectual disability 5 | 573
Obesity 5 | 616
hereditary spastic paraplegia 5 | 313
nasopharyngeal carcinoma 5 | 1,056
posterior fossa group A ependymoma 5 | 1,511
posterior fossa group B ependymoma 5 | 1,530
primary pancreatic ductal adenocarcinoma 5 | 1,271
sonic hedgehog group medulloblastoma 5 | 1,482
Congenital disorder of glycosylation 4 | 53
Epilepsy 4 | 346
Gaucher disease type 1 4 | 171
Multiple Sclerosis 4 | 498
Vascular disease 4 | 281
Waldenstrons macroglobulinemia 4 | 765
atypical teratoid/rhabdoid tumor 4 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
cutaneous lupus erythematosus 4 | 1,056
hepatocellular carcinoma 4 | 532
Alzheimer's disease 3 | 644
Autistic Disorder 3 | 320
Disease Progression 3 | 125
Down syndrome 3 | 548
Duchenne muscular dystrophy 3 | 602
Fatty liver disease 3 | 84
Myocardial Ischemia 3 | 169
Neuropathy 3 | 210
Paraplegia 3 | 71
Peripheral Neuropathy 3 | 303
Type 2 diabetes mellitus 3 | 189
active ulcerative colitis 3 | 477
acute myeloid leukemia 3 | 780
cystic fibrosis and chronic rhinosinusitis 3 | 213
gastric cancer 3 | 430
gastric carcinoma 3 | 832
non diabetic and post-ischemic heart failure 3 | 200
pancreatic carcinoma 3 | 567
periodontitis 3 | 269
sarcoidosis 3 | 358
Endometriosis 2 | 535
mucosa-associated lymphoid tissue lymphoma 2 | 480
nephrosclerosis 2 | 329

Tissue

Blood and immune system 100 | 17,995
Cardiovascular System 100 | 17,958
Digestive Tract 100 | 18,473
Endocrine System 100 | 18,512
Female tissues 100 | 18,647
Liver and Pancreas 100 | 18,136
Nervous System 100 | 18,561
Urinary Tract 100 | 18,444
Male tissues 99 | 17,969
Respiratory system 99 | 17,484
Skin and soft tissues 99 | 18,115

Target Family

Non-IDG 45 | 11,971
Enzyme 38 | 4,146
Transporter 11 | 473
Transcription Factor 5 | 1,400
Kinase 2 | 634

GO Component

integral component of endoplas... 101 | 101
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Glucose-6-phosphate exchanger SLC37A4 SLC37A4 Tchem Transporter 0.00000 0
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 HACD1 Tbio Enzyme -1.46870 28.7 59
Very-long-chain enoyl-CoA reductase TECR Tbio Enzyme -2.58601 380.5 85
Dolichyldiphosphatase 1 DOLPP1 Tdark Enzyme 0.30 0.50 48
Elongation of very long chain fatty acids protein 5 ELOVL5 Tchem Non-IDG -1.81279 72.3 189
Protein transport protein Sec61 subunit alpha isoform 1 SEC61A1 Tbio Non-IDG -2.43916 280.2 94
78 kDa glucose-regulated protein HSPA5 Tchem Non-IDG -3.28487 2003.3 918
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 HACD2 Tbio Enzyme -0.27875 0.96 54
Phosphatidylcholine:ceramide cholinephosphotransferase 2 SGMS2 Tbio Enzyme -1.33759 24.8 175