Development Level

Tbio 79 | 11,651
Tchem 13 | 1,388
Tdark 11 | 6,593

IMPC Phenotype

preweaning lethality, complete... 13 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 5 | 499
increased lean body mass 4 | 172
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
decreased blood urea nitrogen ... 2 | 51
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased startle reflex 2 | 75
increased circulating triglyce... 2 | 42
increased grip strength 2 | 41
increased prepulse inhibition 2 | 32
limb grasping 2 | 41
abnormal behavior 1 | 298
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
bleb 1 | 2
brachydactyly 1 | 19
decreased B cell number 1 | 5
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased granulocyte number 1 | 6
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
enlarged epididymis 1 | 31
hydroencephaly 1 | 14
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased circulating total pr... 1 | 28
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23
thrombocytopenia 1 | 56
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 67 | 11,493
ovarian cancer 57 | 8,520
osteosarcoma 49 | 7,950
psoriasis 34 | 6,694
medulloblastoma, large-cell 33 | 6,241
glioblastoma 31 | 5,792
lung cancer 26 | 4,740
atypical teratoid / rhabdoid tumor 24 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
Autosomal recessive predisposition 22 | 1,442
Astrocytoma, Pilocytic 20 | 3,081
Breast cancer 19 | 3,578
group 3 medulloblastoma 19 | 4,104
ependymoma 18 | 4,679
invasive ductal carcinoma 18 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
adult high grade glioma 16 | 3,801
non-small cell lung cancer 16 | 2,890
tuberculosis 16 | 2,010
lung carcinoma 15 | 2,843
pituitary cancer 15 | 1,972
Multiple myeloma 14 | 1,332
astrocytoma 14 | 1,146
interstitial cystitis 14 | 2,312
malignant mesothelioma 14 | 3,232
oligodendroglioma 14 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
Intellectual disability 12 | 1,016
pancreatic cancer 12 | 2,398
Epilepsy 11 | 792
Neurodegenerative disease 11 | 414
active Crohn's disease 11 | 922
astrocytic glioma 11 | 2,597
diabetes mellitus 11 | 1,728
lung adenocarcinoma 11 | 2,716
primitive neuroectodermal tumor 11 | 3,035
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Pick disease 10 | 1,894
Poor school performance 10 | 645
Rheumatoid arthritis 10 | 1,191
Short stature 10 | 531
subependymal giant cell astrocytoma 10 | 2,287
Atopic dermatitis 9 | 952
Cancer 9 | 2,499
Seizures 9 | 596
aldosterone-producing adenoma 9 | 665
cystic fibrosis 9 | 1,696
group 4 medulloblastoma 9 | 1,855
juvenile dermatomyositis 9 | 1,187
Muscle hypotonia 8 | 571
adrenocortical carcinoma 8 | 1,428
ductal carcinoma in situ 8 | 1,745
esophageal adenocarcinoma 8 | 737
non primary Sjogren syndrome sicca 8 | 891
Obesity 7 | 678
active ulcerative colitis 7 | 764
acute quadriplegic myopathy 7 | 1,158
breast carcinoma 7 | 1,638
colon cancer 7 | 1,478
progressive supranuclear palsy 7 | 676
spina bifida 7 | 1,074
Bipolar Disorder 6 | 666
Cerebral atrophy 6 | 178
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Mental and motor retardation 6 | 608
Micrognathism 6 | 275
Schizophrenia 6 | 1,160
dermatomyositis 6 | 966
primary Sjogren syndrome 6 | 735
Acquired scoliosis 5 | 281
Curvature of spine 5 | 282
Fatty liver disease 5 | 103
Glycogen storage disease 5 | 39
Hepatomegaly 5 | 285
Hyperreflexia 5 | 209
Liver Cirrhosis, Experimental 5 | 769
Nystagmus 5 | 317
Osteoporosis 5 | 363
Small head 5 | 374
Strabismus 5 | 270
Tooth Abnormalities 5 | 69
Type 2 diabetes mellitus 5 | 272
Waldenstrons macroglobulinemia 5 | 765
hereditary spastic paraplegia 5 | 318
nasopharyngeal carcinoma 5 | 1,058
primary pancreatic ductal adenocarcinoma 5 | 1,109
ulcerative colitis 5 | 1,819
Attention deficit hyperactivity disorder 4 | 278
Glaucoma 4 | 239
Kidney cancer 4 | 2,613
Vascular disease 4 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
cutaneous lupus erythematosus 4 | 1,057

Tissue

Endocrine System 101 | 18,159
Digestive Tract 100 | 17,369
Liver and Pancreas 100 | 16,750
Blood and immune system 99 | 16,909
Female tissues 99 | 17,400
Nervous System 99 | 16,725
Urinary Tract 99 | 16,678
Male tissues 98 | 17,142
Respiratory system 98 | 16,393
Skin and soft tissues 98 | 17,230
Cardiovascular System 96 | 15,192

Target Family

Non-IDG 46 | 12,091
Enzyme 39 | 4,145
Transporter 11 | 473
Transcription Factor 5 | 1,400
Kinase 2 | 634

GO Component

integral component of endoplas... 103 | 103
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Endoplasmic reticulum junction formation protein lunapark LNPK Tbio Non-IDG -1.07127 11.1 9
Fat storage-inducing transmembrane protein 2 FITM2 Tdark Non-IDG -1.27967 17.3 2
Ankyrin repeat and LEM domain-containing protein 2 ANKLE2 Tbio Non-IDG -1.07238 11.8 76
Ancient ubiquitous protein 1 AUP1 Tbio Non-IDG -1.00442 12.6 142
Cyclic AMP-dependent transcription factor ATF-6 beta ATF6B Tbio Transcription Factor -1.03459 8.22 6
Dolichol phosphate-mannose biosynthesis regulatory protein DPM2 Tdark Non-IDG -0.95378 9.57 34
Extended synaptotagmin-1 ESYT1 Tbio Non-IDG -1.29290 19.3 161
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 HACD1 Tbio Enzyme -1.49278 29.5 68
Aspartyl/asparaginyl beta-hydroxylase ASPH Tbio Enzyme -2.70558 505.4 235