Development Level

Tbio 30 | 11,445
Tdark 5 | 6,588

IMPC Phenotype

increased startle reflex 3 | 112
preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
increased heart weight 2 | 62
abnormal spleen morphology 1 | 55
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
hyperactivity 1 | 148
impaired righting response 1 | 26
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small kidney 1 | 16
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

medulloblastoma, large-cell 20 | 6,241
glioblastoma 18 | 5,792
Carcinoma 17 | 11,493
ependymoma 17 | 4,679
atypical teratoid / rhabdoid tumor 16 | 5,112
osteosarcoma 15 | 7,950
ovarian cancer 15 | 8,520
psoriasis 14 | 6,694
group 3 medulloblastoma 12 | 4,104
primitive neuroectodermal tumor 12 | 3,035
adult high grade glioma 11 | 3,801
lung carcinoma 11 | 2,843
Astrocytoma, Pilocytic 10 | 3,081
Breast cancer 10 | 3,578
Pick disease 10 | 1,894
astrocytic glioma 9 | 2,597
lung cancer 9 | 4,740
oligodendroglioma 9 | 2,850
subependymal giant cell astrocytoma 9 | 2,287
breast carcinoma 7 | 1,638
colon cancer 7 | 1,478
invasive ductal carcinoma 7 | 2,951
pancreatic cancer 7 | 2,398
pituitary cancer 7 | 1,972
group 4 medulloblastoma 6 | 1,855
lung adenocarcinoma 6 | 2,716
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
ulcerative colitis 6 | 1,819
Cancer 5 | 2,499
active Crohn's disease 5 | 922
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
juvenile dermatomyositis 5 | 1,187
Fibrous dysplasia 4 | 15
McCune Albright syndrome 4 | 19
Pseudohypoparathyroidism 4 | 18
Substance Withdrawal Syndrome 4 | 55
astrocytoma 4 | 1,146
interstitial cystitis 4 | 2,312
tuberculosis 4 | 2,010
ACTH-secreting pituitary adenoma 3 | 9
Cholera 3 | 34
Duchenne muscular dystrophy 3 | 601
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Melanoma 3 | 711
Night Blindness 3 | 101
Obesity 3 | 678
Polycystic ovary syndrome 3 | 360
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Skin cancer 3 | 469
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
non primary Sjogren syndrome sicca 3 | 891
pediatric high grade glioma 3 | 1,064
Abnormal vision 2 | 52
Acromegaly 2 | 51
Adenoma 2 | 167
Big calvaria 2 | 147
Brachydactyly 2 | 156
Cerebral atrophy 2 | 178
Charcot-Marie-Tooth disease dominant intermediate F 2 | 3
Cone dystrophy 2 | 71
Congenital Heart Defects 2 | 58
Cushing's syndrome 2 | 48
DOID:2415 2 | 5
Depressive disorder 2 | 409
Disease of anatomical entity 2 | 32
Epilepsy 2 | 792
Heart Defects, Congenital 2 | 37
Hyperphosphatemia 2 | 32
Hypoparathyroidism 2 | 41
Hypothyroidism 2 | 122
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Kidney disease 2 | 430
Liver cancer 2 | 604
Low Vision 2 | 174
Malignant melanoma of iris 2 | 4
Ocular cancer 2 | 7
Pertussis 2 | 20
Photodysphoria 2 | 121
Photophobia 2 | 121
Pituitary adenoma 2 | 38
Retinal Detachment 2 | 51
Thyroid cancer 2 | 36
Uveal melanoma 2 | 20
Visual Impairment 2 | 174
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
sarcoidosis 2 | 370
substance-related disorder 2 | 162
urothelial carcinoma 2 | 318

Tissue

Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Blood and immune system 31 | 16,909
Nervous System 31 | 16,725
Skin and soft tissues 31 | 17,230
Female tissues 30 | 17,400
Male tissues 30 | 17,142
Liver and Pancreas 29 | 16,750
Respiratory system 29 | 16,393
Urinary Tract 28 | 16,678
Cardiovascular System 27 | 15,192

Target Family

Non-IDG 35 | 12,091

GO Component

heterotrimeric G-protein compl... 35 | 35
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

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