Development Level

Tbio 23 | 10,625
Tdark 6 | 7,003
Tchem 1 | 1,890

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal spleen morphology 1 | 36
decreased bone mineral content 1 | 157
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
hyperactivity 1 | 108
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased heart weight 1 | 37
increased total body fat amoun... 1 | 57
preweaning lethality, incomple... 1 | 260
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

medulloblastoma, large-cell 17 | 6,234
glioblastoma 15 | 5,572
osteosarcoma 12 | 7,933
atypical teratoid / rhabdoid tumor 11 | 4,369
lung carcinoma 11 | 2,844
primitive neuroectodermal tumor 11 | 3,031
psoriasis 11 | 6,685
ovarian cancer 10 | 8,484
pilocytic astrocytoma 10 | 3,086
Pick disease 8 | 1,893
oligodendroglioma 8 | 2,849
posterior fossa group A ependymoma 8 | 1,511
subependymal giant cell astrocytoma 8 | 2,287
astrocytic glioma 7 | 2,241
ependymoma 7 | 2,514
group 3 medulloblastoma 7 | 2,254
pediatric high grade glioma 7 | 2,712
Breast cancer 6 | 3,094
breast carcinoma 6 | 1,614
group 4 medulloblastoma 6 | 1,875
invasive ductal carcinoma 6 | 2,950
lung cancer 6 | 4,466
active Crohn's disease 5 | 918
lung adenocarcinoma 5 | 2,713
malignant mesothelioma 5 | 3,162
non-small cell lung cancer 5 | 2,798
pancreatic cancer 5 | 2,300
pituitary cancer 5 | 1,972
adult high grade glioma 4 | 2,148
astrocytoma 4 | 1,493
colon cancer 4 | 1,475
ductal carcinoma in situ 4 | 1,745
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
juvenile dermatomyositis 4 | 1,189
ulcerative colitis 4 | 2,087
Duchenne muscular dystrophy 3 | 602
Night Blindness 3 | 39
active ulcerative colitis 3 | 477
acute quadriplegic myopathy 3 | 1,157
atypical teratoid/rhabdoid tumor 3 | 1,095
cystic fibrosis 3 | 1,665
non primary Sjogren syndrome sicca 3 | 840
tuberculosis 3 | 1,557
Amnesia 2 | 17
Cancer 2 | 2,346
Cholera 2 | 33
Fibrous dysplasia 2 | 15
Intellectual disability 2 | 573
McCune Albright syndrome 2 | 19
Multiple myeloma 2 | 1,327
Obesity 2 | 616
Pseudohypoparathyroidism 2 | 17
Rheumatoid Arthritis 2 | 1,160
Schizophrenia 2 | 501
Substance Withdrawal Syndrome 2 | 52
diabetes mellitus 2 | 1,663
gastric cancer 2 | 430
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
non-inflammatory breast cancer 2 | 208
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
sarcoidosis 2 | 358
sonic hedgehog group medulloblastoma 2 | 1,482
Acquired metabolic disease 1 | 267
Acromegaly 1 | 40
Adenoma 1 | 165
Animal Mammary Neoplasms 1 | 136
Blindness 1 | 84
Brachydactyly 1 | 52
Congenital stationary night blindness 1 | 27
Cushing's syndrome 1 | 47
Depressive disorder 1 | 48
Disease of anatomical entity 1 | 25
Dyskinesia, Drug-Induced 1 | 15
Early infantile epileptic encephalopathy with suppression bursts 1 | 18
Epilepsy 1 | 346
Gaucher disease type 3 1 | 76
Hyperphosphatemia 1 | 32
Hypothyroidism 1 | 89
Kidney disease 1 | 396
Liver diseases 1 | 66
Lymphoma 1 | 56
Major Depressive Disorder 1 | 106
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 150
Mental depression 1 | 58
Myopia 1 | 99
Ocular albinism 1 | 29
Parkinson's disease 1 | 364
Pituitary adenoma 1 | 35
Retinal Degeneration 1 | 49
Retinitis pigmentosa 1 | 153
Venous Thromboembolism 1 | 34
facioscapulohumeral dystrophy 1 | 286
glioblastoma multiforme 1 | 347
head and neck cancer 1 | 270
non-small cell lung carcinoma 1 | 413
severe Alzheimer's disease 1 | 49

Tissue

Blood and immune system 29 | 17,995
Digestive Tract 29 | 18,473
Endocrine System 29 | 18,512
Female tissues 29 | 18,647
Liver and Pancreas 29 | 18,136
Male tissues 29 | 17,969
Nervous System 29 | 18,561
Skin and soft tissues 29 | 18,115
Urinary Tract 29 | 18,444
Cardiovascular System 28 | 17,958
Respiratory system 27 | 17,484

Target Family

Non-IDG 30 | 11,971

GO Component

heterotrimeric G-protein compl... 30 | 30
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

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