Development Level

Tbio 291 | 10,625
Tchem 64 | 1,890
Tclin 18 | 602
Tdark 10 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 18 | 633
preweaning lethality, incomple... 10 | 260
decreased body weight 8 | 174
decreased total body fat amoun... 8 | 186
abnormal behavior 6 | 226
abnormal retina morphology 6 | 100
decreased lean body mass 6 | 195
embryonic lethality prior to t... 5 | 187
increased lean body mass 5 | 107
abnormal embryo size 4 | 112
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
decreased eosinophil cell numb... 4 | 41
improved glucose tolerance 4 | 56
increased mean corpuscular vol... 4 | 91
abnormal retinal pigmentation 3 | 61
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating iron lev... 3 | 25
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
increased bone mineral content 3 | 92
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased circulating triglyce... 3 | 24
increased leukocyte cell numbe... 3 | 37
increased or absent threshold ... 3 | 128
abnormal bone mineralization 2 | 55
abnormal head morphology 2 | 10
abnormal pericardium morpholog... 2 | 11
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased NK cell number 2 | 16
decreased basophil cell number 2 | 11
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased startle reflex 2 | 48
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
hyperactivity 2 | 108
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased heart rate 2 | 17
increased mean corpuscular hem... 2 | 93
increased vertical activity 2 | 18
shortened ST segment 2 | 9
thrombocytosis 2 | 23
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal neural tube closure 1 | 37
abnormal response to new envir... 1 | 8
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
decreased Ly6C high monocyte n... 1 | 18
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased neutrophil cell numb... 1 | 37
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired righting response 1 | 19
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased total body fat amoun... 1 | 57
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
short tibia 1 | 82
small thymus 1 | 11
stereotypic behavior 1 | 3
straub tail 1 | 26
tremors 1 | 34
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 261 | 8,484
osteosarcoma 218 | 7,933
glioblastoma 196 | 5,572
medulloblastoma, large-cell 168 | 6,234
psoriasis 154 | 6,685
lung cancer 147 | 4,466
atypical teratoid / rhabdoid tumor 144 | 4,369
Cancer 141 | 2,346
pancreatic cancer 124 | 2,300
intraductal papillary-mucinous neoplasm (IPMN) 121 | 3,289
invasive ductal carcinoma 116 | 2,950
pediatric high grade glioma 113 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 112 | 2,956
pilocytic astrocytoma 112 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 109 | 2,988
non-small cell lung cancer 106 | 2,798
lung adenocarcinoma 104 | 2,713
Breast cancer 102 | 3,094
lung carcinoma 100 | 2,844
malignant mesothelioma 96 | 3,162
oligodendroglioma 95 | 2,849
primary pancreatic ductal adenocarcinoma 90 | 1,271
primitive neuroectodermal tumor 87 | 3,031
ependymoma 83 | 2,514
astrocytoma 78 | 1,493
ulcerative colitis 74 | 2,087
interstitial cystitis 73 | 2,299
juvenile dermatomyositis 72 | 1,189
acute quadriplegic myopathy 70 | 1,157
diabetes mellitus 70 | 1,663
subependymal giant cell astrocytoma 69 | 2,287
Carcinoma 67 | 2,147
group 4 medulloblastoma 67 | 1,875
tuberculosis 64 | 1,557
breast carcinoma 63 | 1,614
Multiple myeloma 62 | 1,327
astrocytic glioma 62 | 2,241
cystic fibrosis 60 | 1,665
dermatomyositis 60 | 933
colon cancer 58 | 1,475
ductal carcinoma in situ 56 | 1,745
sonic hedgehog group medulloblastoma 56 | 1,482
pituitary cancer 55 | 1,972
Pick disease 54 | 1,893
Duchenne muscular dystrophy 51 | 602
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
Rheumatoid Arthritis 49 | 1,160
posterior fossa group A ependymoma 48 | 1,511
adrenocortical carcinoma 47 | 1,427
Waldenstrons macroglobulinemia 46 | 765
gastric carcinoma 45 | 832
autosomal dominant Emery-Dreifuss muscular dystrophy 42 | 499
medulloblastoma 42 | 1,524
adult high grade glioma 41 | 2,148
spina bifida 38 | 1,064
group 3 medulloblastoma 37 | 2,254
esophageal adenocarcinoma 35 | 737
Down syndrome 34 | 548
Prostatic Neoplasms 34 | 471
posterior fossa group B ependymoma 32 | 1,530
Alzheimer's disease 29 | 644
cutaneous lupus erythematosus 28 | 1,056
Mammary Neoplasms 27 | 410
active Crohn's disease 27 | 918
fibroadenoma 27 | 557
pancreatic carcinoma 26 | 567
atypical teratoid/rhabdoid tumor 25 | 1,095
Vascular disease 24 | 281
IGA Glomerulonephritis 23 | 454
Kidney disease 23 | 396
nasopharyngeal carcinoma 23 | 1,056
Neoplasm Metastasis 22 | 138
Stomach Neoplasms 22 | 282
mucosa-associated lymphoid tissue lymphoma 22 | 480
tuberculosis and treatment for 6 months 22 | 686
acute myeloid leukemia 21 | 780
aldosterone-producing adenoma 21 | 664
primary Sjogren syndrome 21 | 789
Becker muscular dystrophy 20 | 187
Neoplasm Invasiveness 20 | 127
interstitial lung disease 20 | 291
Atopic dermatitis 19 | 944
progressive supranuclear palsy 19 | 674
Hypertension 18 | 287
Mammary Neoplasms, Experimental 18 | 150
gastric cancer 18 | 430
non-small cell lung carcinoma 18 | 413
Animal Mammary Neoplasms 17 | 136
hereditary spastic paraplegia 17 | 313
Amyotrophic Lateral Sclerosis 16 | 431
Leukemia, Myelocytic, Acute 16 | 113
non primary Sjogren syndrome sicca 16 | 840
Barrett's esophagus 15 | 183
COPD 15 | 113
Endometriosis 15 | 535
Intellectual disability 15 | 573
Liver carcinoma 15 | 217
Renal Cell Carcinoma 15 | 199
active ulcerative colitis 15 | 477
urothelial carcinoma 14 | 318

Tissue

Digestive Tract 383 | 18,473
Endocrine System 383 | 18,512
Female tissues 383 | 18,647
Liver and Pancreas 383 | 18,136
Male tissues 383 | 17,969
Nervous System 383 | 18,561
Blood and immune system 382 | 17,995
Cardiovascular System 382 | 17,958
Urinary Tract 382 | 18,444
Respiratory system 381 | 17,484
Skin and soft tissues 380 | 18,115

Target Family

Non-IDG 276 | 11,971
Enzyme 67 | 4,146
Kinase 29 | 634
GPCR 4 | 406
Transporter 3 | 473
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 341

GO Component

focal adhesion 383 | 383
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
Neuroblast differentiation-associated protein AHNAK AHNAK Tbio Non-IDG -1.61845 51.3 82
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.73537 50.7 134
Lipoma-preferred partner LPP Tbio Non-IDG -2.68601 520.6 153
Beta-1-syntrophin SNTB1 Tbio Non-IDG -1.02258 8.71 102