Development Level

Tbio 309 | 11,651
Tchem 49 | 1,388
Tclin 19 | 612
Tdark 10 | 6,593

Collection

GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 29 | 979
preweaning lethality, incomple... 15 | 499
embryonic lethality prior to t... 14 | 278
embryonic lethality prior to o... 10 | 239
abnormal embryo size 9 | 220
decreased total body fat amoun... 9 | 207
decreased body weight 7 | 161
embryonic growth retardation 7 | 106
increased lean body mass 6 | 172
abnormal behavior 5 | 298
increased startle reflex 5 | 112
abnormal retina morphology 4 | 71
decreased circulating glucose ... 4 | 126
decreased circulating insulin ... 4 | 76
decreased circulating serum al... 4 | 82
decreased leukocyte cell numbe... 4 | 73
decreased vertical activity 4 | 208
hypoactivity 4 | 132
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased circulating triglyce... 4 | 42
short tibia 4 | 97
abnormal bone structure 3 | 187
abnormal pericardium morpholog... 3 | 26
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
decreased bone mineral content 3 | 151
decreased eosinophil cell numb... 3 | 24
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
decreased startle reflex 3 | 75
edema 3 | 59
increased body weight 3 | 25
increased bone mineral density 3 | 72
increased circulating choleste... 3 | 66
increased mean corpuscular vol... 3 | 92
increased neutrophil cell numb... 3 | 46
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal eye morphology 2 | 68
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased neutrophil cell numb... 2 | 42
enlarged heart 2 | 210
enlarged kidney 2 | 14
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased heart rate 2 | 23
increased heart weight 2 | 62
increased leukocyte cell numbe... 2 | 47
increased total body fat amoun... 2 | 134
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prolonged PR interval 2 | 15
thrombocytosis 2 | 27
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
long tibia 1 | 25
small thymus 1 | 16
tremors 1 | 39
vertebral fusion 1 | 23

Disease

ovarian cancer 263 | 8,520
Carcinoma 251 | 11,493
osteosarcoma 216 | 7,950
glioblastoma 202 | 5,792
medulloblastoma, large-cell 166 | 6,241
atypical teratoid / rhabdoid tumor 158 | 5,112
psoriasis 153 | 6,694
lung cancer 149 | 4,740
Cancer 144 | 2,499
ependymoma 141 | 4,679
pancreatic cancer 124 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 121 | 3,291
Breast cancer 115 | 3,578
invasive ductal carcinoma 113 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 109 | 2,955
Astrocytoma, Pilocytic 108 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 108 | 2,989
non-small cell lung cancer 103 | 2,890
lung adenocarcinoma 101 | 2,716
malignant mesothelioma 99 | 3,232
lung carcinoma 97 | 2,843
oligodendroglioma 96 | 2,850
adult high grade glioma 95 | 3,801
group 3 medulloblastoma 90 | 4,104
Kidney cancer 87 | 2,613
primitive neuroectodermal tumor 85 | 3,035
astrocytic glioma 75 | 2,597
diabetes mellitus 71 | 1,728
juvenile dermatomyositis 71 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 71 | 1,962
tuberculosis 71 | 2,010
acute quadriplegic myopathy 70 | 1,158
interstitial cystitis 70 | 2,312
primary pancreatic ductal adenocarcinoma 69 | 1,109
subependymal giant cell astrocytoma 69 | 2,287
ulcerative colitis 65 | 1,819
astrocytoma 64 | 1,146
group 4 medulloblastoma 64 | 1,855
breast carcinoma 63 | 1,638
Multiple myeloma 62 | 1,332
cystic fibrosis 61 | 1,696
dermatomyositis 60 | 966
colon cancer 58 | 1,478
pediatric high grade glioma 57 | 1,064
Pick disease 56 | 1,894
ductal carcinoma in situ 53 | 1,745
pituitary cancer 53 | 1,972
Duchenne muscular dystrophy 51 | 601
Rheumatoid arthritis 51 | 1,191
Waldenstrons macroglobulinemia 48 | 765
adrenocortical carcinoma 46 | 1,428
Liver Cirrhosis, Experimental 45 | 769
autosomal dominant Emery-Dreifuss muscular dystrophy 45 | 510
gastric carcinoma 42 | 807
spina bifida 37 | 1,074
Autosomal recessive predisposition 36 | 1,442
Schizophrenia 36 | 1,160
Down syndrome 34 | 499
Prostatic Neoplasms 34 | 495
esophageal adenocarcinoma 34 | 737
Breast Neoplasms 30 | 445
cutaneous lupus erythematosus 29 | 1,057
Intellectual disability 28 | 1,016
Mammary Neoplasms 27 | 425
Melanoma 26 | 711
active Crohn's disease 26 | 922
fibroadenoma 26 | 559
pancreatic carcinoma 26 | 562
medulloblastoma 25 | 720
Alzheimer's disease 24 | 658
Kidney disease 24 | 430
Neoplasm Invasiveness 24 | 161
Vascular disease 24 | 319
active ulcerative colitis 24 | 764
Liver cancer 23 | 604
Neoplasm Metastasis 23 | 168
nasopharyngeal carcinoma 23 | 1,058
Anemia 22 | 365
Hypertension 22 | 396
Stomach Neoplasms 22 | 300
mucosa-associated lymphoid tissue lymphoma 22 | 484
primary Sjogren syndrome 22 | 735
sonic hedgehog group medulloblastoma 22 | 467
acute myeloid leukemia 21 | 783
aldosterone-producing adenoma 21 | 665
Becker muscular dystrophy 20 | 191
Dull intelligence 20 | 645
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
Short stature 20 | 531
gastric cancer 20 | 459
interstitial lung disease 20 | 298
Atopic dermatitis 19 | 952
progressive supranuclear palsy 19 | 676
Mammary Neoplasms, Experimental 18 | 154
hereditary spastic paraplegia 18 | 318
Orbital separation excessive 17 | 244
non primary Sjogren syndrome sicca 17 | 891

Tissue

Digestive Tract 386 | 17,369
Endocrine System 386 | 18,159
Liver and Pancreas 386 | 16,750
Male tissues 386 | 17,142
Skin and soft tissues 386 | 17,230
Blood and immune system 385 | 16,909
Female tissues 385 | 17,400
Respiratory system 384 | 16,393
Urinary Tract 384 | 16,678
Nervous System 383 | 16,725
Cardiovascular System 379 | 15,192

Target Family

Non-IDG 275 | 12,091
Enzyme 69 | 4,145
Kinase 29 | 634
GPCR 5 | 408
Transporter 4 | 473
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344

GO Component

focal adhesion 387 | 387
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Actin filament-associated protein 1 AFAP1 Tbio Non-IDG -1.89567 70.0 314
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
CD166 antigen ALCAM Tbio Non-IDG -2.49297 326.4 492
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088