Development Level

Tbio 27 | 10,625
Tchem 25 | 1,890
Tclin 13 | 602
Tdark 1 | 7,003

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

abnormal behavior 2 | 226
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased total body fat amoun... 2 | 186
hypoactivity 2 | 89
increased circulating phosphat... 2 | 24
preweaning lethality, complete... 2 | 633
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities/... 1 | 3
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
embryonic lethality prior to t... 1 | 187
enlarged seminal vesicle 1 | 1
enlarged spleen 1 | 26
increased CD4-positive, alpha ... 1 | 15
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating chloride... 1 | 43
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
tremors 1 | 34

Disease

osteosarcoma 48 | 7,933
ovarian cancer 44 | 8,484
medulloblastoma, large-cell 35 | 6,234
Cancer 34 | 2,346
glioblastoma 29 | 5,572
psoriasis 27 | 6,685
atypical teratoid / rhabdoid tumor 23 | 4,369
oligodendroglioma 22 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
invasive ductal carcinoma 21 | 2,950
pilocytic astrocytoma 21 | 3,086
pancreatic cancer 20 | 2,300
lung cancer 19 | 4,466
non-small cell lung cancer 19 | 2,798
Blastic phase chronic myeloid leukemia 18 | 58
Breast cancer 18 | 3,094
Chronic Myelocytic Leukemia Accelerated Phase 18 | 59
interstitial cystitis 18 | 2,299
subependymal giant cell astrocytoma 18 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung carcinoma 17 | 2,844
primitive neuroectodermal tumor 17 | 3,031
Chronic phase chronic myeloid leukemia 16 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 16 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 16 | 47
ependymoma 16 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
adult high grade glioma 15 | 2,148
juvenile dermatomyositis 15 | 1,189
ulcerative colitis 14 | 2,087
Carcinoma 13 | 2,147
ductal carcinoma in situ 13 | 1,745
lung adenocarcinoma 13 | 2,713
malignant mesothelioma 13 | 3,162
pediatric high grade glioma 13 | 2,712
Pick disease 12 | 1,893
astrocytoma 12 | 1,493
primary Sjogren syndrome 12 | 789
tuberculosis 12 | 1,557
Rheumatoid Arthritis 11 | 1,160
group 4 medulloblastoma 10 | 1,875
medulloblastoma 10 | 1,524
pituitary cancer 10 | 1,972
astrocytic glioma 9 | 2,241
cutaneous lupus erythematosus 9 | 1,056
group 3 medulloblastoma 9 | 2,254
Atopic dermatitis 8 | 944
cystic fibrosis 8 | 1,665
dermatomyositis 8 | 933
diabetes mellitus 8 | 1,663
posterior fossa group A ependymoma 8 | 1,511
primary pancreatic ductal adenocarcinoma 8 | 1,271
Alzheimer's disease 7 | 644
Down syndrome 7 | 548
acute quadriplegic myopathy 7 | 1,157
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
breast carcinoma 7 | 1,614
colon cancer 7 | 1,475
pancreatic carcinoma 7 | 567
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group B ependymoma 7 | 1,530
IGA Glomerulonephritis 6 | 454
Multiple myeloma 6 | 1,327
adrenocortical carcinoma 6 | 1,427
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 832
mucosa-associated lymphoid tissue lymphoma 6 | 480
spina bifida 6 | 1,064
Agammaglobulinemia 5 | 24
Amyotrophic Lateral Sclerosis 5 | 431
Chronic Lymphocytic Leukemia 5 | 242
Duchenne muscular dystrophy 5 | 602
Epilepsy 5 | 346
Polycythemia Vera 5 | 24
Waldenstrons macroglobulinemia 5 | 765
urothelial carcinoma 5 | 318
Asthma 4 | 349
Bladder Neoplasm 4 | 109
Crohn's disease 4 | 304
Endometriosis 4 | 535
Immune system cancer 4 | 38
Liver carcinoma 4 | 217
Liver neoplasms 4 | 109
Mammary Neoplasms 4 | 410
Obesity 4 | 616
Polycystic Ovary Syndrome 4 | 332
Stomach Neoplasms 4 | 282
non-small cell lung carcinoma 4 | 413
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686
Arthritis 3 | 248
Multiple Sclerosis 3 | 498
Schizophrenia 3 | 501
acute myeloid leukemia 3 | 780
chronic lymphosyte leukemia 3 | 232
fibroadenoma 3 | 557
hepatocellular carcinoma 3 | 532
nasopharyngeal carcinoma 3 | 1,056
nephrosclerosis 3 | 329
periodontitis 3 | 269

Tissue

Blood and immune system 66 | 17,995
Cardiovascular System 66 | 17,958
Digestive Tract 66 | 18,473
Endocrine System 66 | 18,512
Female tissues 66 | 18,647
Liver and Pancreas 66 | 18,136
Nervous System 66 | 18,561
Skin and soft tissues 66 | 18,115
Urinary Tract 66 | 18,444
Male tissues 65 | 17,969
Respiratory system 65 | 17,484

Target Family

Kinase 34 | 634
Non-IDG 20 | 11,971
Enzyme 7 | 4,146
Ion Channel 3 | 341
GPCR 1 | 406
Transporter 1 | 473

GO Component

extrinsic component of cytopla... 66 | 66
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Guanine nucleotide exchange factor DBS MCF2L Tbio Non-IDG -0.93602 11.4 104
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Tyrosine-protein kinase ABL1 ABL1 Tclin Kinase -3.47805 3222.2 1533
Rac GTPase-activating protein 1 RACGAP1 Tbio Enzyme -1.64660 53.0 346
Tyrosine-protein kinase BTK BTK Tclin Kinase -2.98909 1061.8 721
Cytoplasmic tyrosine-protein kinase BMX BMX Tchem Kinase -2.22889 191.5 429
Cyclin-dependent kinase 16 CDK16 Tchem Kinase -1.39897 32.3 122
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.57530 419.2 260