Development Level

Tbio 823 | 10,625
Tdark 395 | 7,003
Tchem 210 | 1,890
Tclin 65 | 602

Collection

Eligible non-olfactory GPCR Proteins 3 | 143
Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 32 | 633
enlarged heart 18 | 111
decreased total body fat amoun... 15 | 186
preweaning lethality, incomple... 15 | 260
decreased bone mineral content 13 | 157
decreased circulating glucose ... 12 | 121
decreased lean body mass 12 | 195
short tibia 11 | 82
increased circulating HDL chol... 9 | 63
increased or absent threshold ... 9 | 128
hypoactivity 8 | 89
improved glucose tolerance 8 | 56
abnormal behavior 7 | 226
abnormal heart morphology 7 | 51
abnormal seminal vesicle morph... 7 | 47
decreased body weight 7 | 174
decreased bone mineral density 7 | 126
decreased circulating serum al... 7 | 79
decreased grip strength 7 | 123
impaired glucose tolerance 7 | 52
increased fasted circulating g... 7 | 68
increased lean body mass 7 | 107
abnormal bone structure 6 | 131
abnormal coat/hair pigmentatio... 6 | 54
abnormal embryo size 6 | 112
abnormal kidney morphology 6 | 30
abnormal lens morphology 6 | 73
decreased body length 6 | 108
decreased circulating HDL chol... 6 | 77
decreased circulating insulin ... 6 | 75
decreased circulating triglyce... 6 | 83
decreased heart weight 6 | 44
embryonic lethality prior to t... 6 | 187
increased grip strength 6 | 83
increased hemoglobin content 6 | 45
increased mean corpuscular hem... 6 | 93
increased mean corpuscular vol... 6 | 91
abnormal tooth morphology 5 | 24
decreased circulating alanine ... 5 | 53
decreased circulating choleste... 5 | 85
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
increased total body fat amoun... 5 | 57
thrombocytopenia 5 | 46
abnormal cranium morphology 4 | 32
abnormal gait 4 | 51
abnormal tail morphology 4 | 17
decreased circulating free fat... 4 | 39
decreased fasted circulating g... 4 | 49
decreased hemoglobin content 4 | 53
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
increased blood urea nitrogen ... 4 | 44
increased circulating choleste... 4 | 53
increased hematocrit 4 | 36
limb grasping 4 | 35
small testis 4 | 37
abnormal QRS complex 3 | 25
abnormal coat appearance 3 | 25
abnormal femur morphology 3 | 14
abnormal humerus morphology 3 | 11
abnormal retina morphology 3 | 100
abnormal sleep behavior 3 | 63
abnormal snout morphology 3 | 18
abnormal spleen morphology 3 | 36
abnormal testis morphology 3 | 30
abnormal tibia morphology 3 | 14
abnormal vibrissa morphology 3 | 17
abnormal vocalization 3 | 21
cataract 3 | 26
decreased caudal vertebrae num... 3 | 49
decreased circulating iron lev... 3 | 25
decreased circulating total pr... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased hematocrit 3 | 25
decreased kidney weight 3 | 7
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 19
decreased monocyte cell number 3 | 28
decreased rib number 3 | 59
decreased startle reflex 3 | 48
enlarged epididymis 3 | 27
female infertility 3 | 34
hydrometra 3 | 13
hyperactivity 3 | 108
impaired righting response 3 | 19
increased NK T cell number 3 | 11
increased body weight 3 | 42
increased circulating aspartat... 3 | 17
increased circulating serum al... 3 | 25
increased circulating total pr... 3 | 20
increased exploration in new e... 3 | 56
increased sacral vertebrae num... 3 | 62
increased startle reflex 3 | 38
male infertility 3 | 62
persistence of hyaloid vascula... 3 | 22
tremors 3 | 34
abnormal lung morphology 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating fructosa... 2 | 11

Disease

psoriasis 642 | 6,685
ovarian cancer 507 | 8,484
osteosarcoma 435 | 7,933
lung cancer 400 | 4,466
glioblastoma 395 | 5,572
medulloblastoma, large-cell 366 | 6,234
Cancer 362 | 2,346
lung adenocarcinoma 317 | 2,713
lung carcinoma 315 | 2,844
pilocytic astrocytoma 305 | 3,086
non-small cell lung cancer 292 | 2,798
invasive ductal carcinoma 291 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 289 | 2,956
pancreatic cancer 286 | 2,300
interstitial cystitis 285 | 2,299
atypical teratoid / rhabdoid tumor 279 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 278 | 3,289
malignant mesothelioma 273 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 269 | 2,988
Breast cancer 262 | 3,094
ulcerative colitis 258 | 2,087
cystic fibrosis 241 | 1,665
diabetes mellitus 239 | 1,663
pituitary cancer 212 | 1,972
pediatric high grade glioma 199 | 2,712
oligodendroglioma 195 | 2,849
breast carcinoma 193 | 1,614
ductal carcinoma in situ 186 | 1,745
posterior fossa group A ependymoma 186 | 1,511
Carcinoma 178 | 2,147
tuberculosis 175 | 1,557
primitive neuroectodermal tumor 169 | 3,031
adult high grade glioma 162 | 2,148
cutaneous lupus erythematosus 161 | 1,056
primary pancreatic ductal adenocarcinoma 161 | 1,271
subependymal giant cell astrocytoma 151 | 2,287
colon cancer 150 | 1,475
Atopic dermatitis 147 | 944
pancreatic ductal adenocarcinoma liver metastasis 136 | 1,795
sonic hedgehog group medulloblastoma 133 | 1,482
Kidney disease 132 | 396
adrenocortical carcinoma 132 | 1,427
gastric carcinoma 126 | 832
ependymoma 122 | 2,514
astrocytic glioma 120 | 2,241
group 3 medulloblastoma 119 | 2,254
Atherosclerosis 115 | 275
astrocytoma 114 | 1,493
Duchenne muscular dystrophy 113 | 602
juvenile dermatomyositis 112 | 1,189
Obesity 110 | 616
nasopharyngeal carcinoma 105 | 1,056
group 4 medulloblastoma 104 | 1,875
esophageal adenocarcinoma 100 | 737
Rheumatoid Arthritis 99 | 1,160
Hypertension 98 | 287
active Crohn's disease 96 | 918
Coronary artery disease 92 | 240
Asthma 90 | 349
Pick disease 90 | 1,893
fibroadenoma 89 | 557
Arthritis 86 | 248
primary Sjogren syndrome 85 | 789
medulloblastoma 84 | 1,524
posterior fossa group B ependymoma 84 | 1,530
autosomal dominant Emery-Dreifuss muscular dystrophy 83 | 499
Mammary Neoplasms 81 | 410
Heart disease 80 | 279
Multiple Sclerosis 80 | 498
Prostatic Neoplasms 79 | 471
Vascular disease 79 | 281
Alzheimer's disease 78 | 644
Cerebrovascular disease 78 | 231
Endometriosis 77 | 535
acute quadriplegic myopathy 76 | 1,157
mucosa-associated lymphoid tissue lymphoma 74 | 480
Lung disease 69 | 132
Osteoporosis 69 | 257
atypical teratoid/rhabdoid tumor 66 | 1,095
Down syndrome 65 | 548
Liver disease 64 | 219
Hypersensitivity reaction type II disease 62 | 235
periodontitis 62 | 269
non-small cell lung carcinoma 61 | 413
Hypertensive disease 60 | 193
dermatomyositis 60 | 933
Spontaneous abortion 59 | 108
Multiple myeloma 58 | 1,327
non primary Sjogren syndrome sicca 58 | 840
Schizophrenia 57 | 501
spina bifida 57 | 1,064
chronic rhinosinusitis 55 | 512
interstitial lung disease 55 | 291
Inflammatory bowel disease 54 | 142
Autistic Disorder 53 | 320
Inflammation 53 | 109
Becker muscular dystrophy 52 | 187
inflammatory breast cancer 52 | 404
Pneumonia 51 | 133
urothelial carcinoma 51 | 318

Tissue

Nervous System 1,375 | 18,561
Female tissues 1,367 | 18,647
Digestive Tract 1,365 | 18,473
Endocrine System 1,362 | 18,512
Urinary Tract 1,347 | 18,444
Skin and soft tissues 1,329 | 18,115
Liver and Pancreas 1,317 | 18,136
Cardiovascular System 1,300 | 17,958
Blood and immune system 1,287 | 17,995
Male tissues 1,272 | 17,969
Respiratory system 1,255 | 17,484

Target Family

Non-IDG 1,180 | 11,971
Enzyme 271 | 4,146
Kinase 22 | 634
GPCR 9 | 406
Transcription Factor 7 | 1,400
Ion Channel 2 | 341
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

GO Component

extracellular region 1,493 | 1,493
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748