Development Level

Tbio 2,014 | 11,445
Tchem 364 | 1,598
Tdark 268 | 6,588
Tclin 121 | 613

Collection

RFA-RM-18-021 25 | 328
Ion Channel: IDG Consortium (T... 13 | 99
GPCR: IDG Consortium (Targets) 5 | 126
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 169 | 979
preweaning lethality, incomple... 78 | 499
embryonic lethality prior to t... 55 | 278
abnormal behavior 50 | 298
embryonic lethality prior to o... 49 | 239
decreased vertical activity 40 | 208
abnormal embryo size 38 | 220
enlarged heart 36 | 210
decreased total body fat amoun... 32 | 207
abnormal bone structure 30 | 187
increased circulating alkaline... 26 | 122
abnormal heart morphology 25 | 162
decreased bone mineral content 25 | 151
decreased bone mineral density 25 | 126
abnormal seminal vesicle morph... 24 | 114
decreased lean body mass 24 | 135
hyperactivity 23 | 148
hypoactivity 23 | 132
increased lean body mass 23 | 172
decreased body weight 22 | 161
decreased grip strength 22 | 116
short tibia 20 | 97
abnormal retina morphology 18 | 71
decreased body length 18 | 101
embryonic growth retardation 18 | 106
cataract 17 | 92
decreased mean corpuscular vol... 17 | 79
increased mean corpuscular vol... 17 | 92
increased total body fat amoun... 17 | 134
impaired glucose tolerance 16 | 75
increased bone mineral content 16 | 108
increased mean corpuscular hem... 16 | 96
increased or absent threshold ... 16 | 101
increased startle reflex 16 | 112
prenatal lethality prior to he... 16 | 87
abnormal kidney morphology 15 | 65
abnormal lens morphology 15 | 81
decreased circulating glucose ... 15 | 126
decreased circulating insulin ... 15 | 76
decreased hemoglobin content 15 | 68
increased heart weight 15 | 62
improved glucose tolerance 14 | 79
male infertility 14 | 123
increased fasted circulating g... 13 | 76
abnormal neural tube closure 12 | 46
abnormal skin morphology 12 | 50
decreased circulating choleste... 12 | 93
decreased circulating serum al... 12 | 82
decreased leukocyte cell numbe... 12 | 73
decreased lymphocyte cell numb... 12 | 83
decreased mean corpuscular hem... 12 | 50
decreased prepulse inhibition 12 | 82
decreased startle reflex 12 | 75
increased blood urea nitrogen ... 12 | 48
small superior vagus ganglion 12 | 74
decreased circulating triglyce... 11 | 79
decreased erythrocyte cell num... 11 | 62
increased bone mineral density 11 | 72
small testis 11 | 58
decreased circulating HDL chol... 10 | 68
decreased circulating total pr... 10 | 49
edema 10 | 59
enlarged spleen 10 | 41
hydrometra 10 | 53
increased erythrocyte cell num... 10 | 39
abnormal eye morphology 9 | 68
cardiovascular system phenotyp... 9 | 36
corneal opacity 9 | 32
decreased circulating alkaline... 9 | 46
increased monocyte cell number 9 | 63
abnormal bone mineralization 8 | 38
abnormal coat appearance 8 | 31
abnormal cornea morphology 8 | 31
abnormal cranium morphology 8 | 36
abnormal epididymis morphology 8 | 42
abnormal sleep behavior 8 | 70
decreased circulating phosphat... 8 | 27
decreased fasted circulating g... 8 | 65
decreased red blood cell distr... 8 | 41
increased circulating HDL chol... 8 | 80
increased circulating choleste... 8 | 66
increased hematocrit 8 | 46
increased leukocyte cell numbe... 8 | 47
pallor 8 | 34
thrombocytopenia 8 | 56
abnormal behavioral response t... 7 | 66
abnormal gait 7 | 69
abnormal lung morphology 7 | 26
abnormal spleen morphology 7 | 55
abnormal testis morphology 7 | 43
decreased neutrophil cell numb... 7 | 42
enlarged epididymis 7 | 31
enlarged lymph nodes 7 | 37
increased circulating sodium l... 7 | 71
increased grip strength 7 | 41
increased mean corpuscular hem... 7 | 36
increased neutrophil cell numb... 7 | 46
increased prepulse inhibition 7 | 32
tremors 7 | 39
prolonged ST segment 6 | 36

Disease

Carcinoma 1,619 | 11,493
ovarian cancer 1,568 | 8,520
osteosarcoma 1,208 | 7,950
psoriasis 1,189 | 6,694
glioblastoma 997 | 5,792
lung cancer 976 | 4,740
medulloblastoma, large-cell 958 | 6,241
atypical teratoid / rhabdoid tumor 793 | 5,112
ependymoma 732 | 4,679
Breast cancer 711 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 695 | 3,291
Cancer 647 | 2,499
malignant mesothelioma 634 | 3,232
pancreatic cancer 628 | 2,398
invasive ductal carcinoma 626 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 622 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 612 | 2,989
non-small cell lung cancer 608 | 2,890
lung adenocarcinoma 602 | 2,716
adult high grade glioma 583 | 3,801
lung carcinoma 582 | 2,843
group 3 medulloblastoma 574 | 4,104
Astrocytoma, Pilocytic 557 | 3,081
pancreatic ductal adenocarcinoma liver metastasis 506 | 1,962
interstitial cystitis 482 | 2,312
oligodendroglioma 453 | 2,850
primitive neuroectodermal tumor 448 | 3,035
subependymal giant cell astrocytoma 432 | 2,287
Multiple myeloma 423 | 1,332
diabetes mellitus 421 | 1,728
tuberculosis 414 | 2,010
astrocytic glioma 403 | 2,597
ulcerative colitis 398 | 1,819
Autosomal recessive predisposition 396 | 1,442
breast carcinoma 389 | 1,638
cystic fibrosis 383 | 1,696
Kidney cancer 381 | 2,613
ductal carcinoma in situ 380 | 1,745
colon cancer 336 | 1,478
pituitary cancer 333 | 1,972
Pick disease 325 | 1,894
primary pancreatic ductal adenocarcinoma 317 | 1,109
group 4 medulloblastoma 294 | 1,855
astrocytoma 271 | 1,146
acute quadriplegic myopathy 269 | 1,158
juvenile dermatomyositis 269 | 1,187
adrenocortical carcinoma 256 | 1,428
Waldenstrons macroglobulinemia 253 | 765
Liver Cirrhosis, Experimental 252 | 769
esophageal adenocarcinoma 247 | 737
Schizophrenia 243 | 1,160
dermatomyositis 239 | 966
Duchenne muscular dystrophy 233 | 601
Rheumatoid arthritis 231 | 1,191
nasopharyngeal carcinoma 231 | 1,058
cutaneous lupus erythematosus 225 | 1,057
Atopic dermatitis 216 | 952
gastric carcinoma 203 | 807
active ulcerative colitis 200 | 764
pediatric high grade glioma 199 | 1,064
spina bifida 195 | 1,074
active Crohn's disease 187 | 922
Intellectual disability 175 | 1,016
autosomal dominant Emery-Dreifuss muscular dystrophy 174 | 510
Epilepsy 173 | 792
non primary Sjogren syndrome sicca 157 | 891
Kidney disease 155 | 430
Prostatic Neoplasms 154 | 495
acute myeloid leukemia 150 | 783
Obesity 148 | 678
Alzheimer's disease 145 | 658
Muscle hypotonia 145 | 571
Seizures 142 | 596
Down syndrome 138 | 499
primary Sjogren syndrome 137 | 735
Cognitive delay 132 | 608
Global developmental delay 132 | 608
Hypertension 132 | 396
Mental and motor retardation 132 | 608
Melanoma 130 | 711
Bipolar Disorder 128 | 666
fibroadenoma 128 | 559
aldosterone-producing adenoma 127 | 665
mucosa-associated lymphoid tissue lymphoma 127 | 484
Dull intelligence 122 | 645
Low intelligence 122 | 645
Mental Retardation 122 | 645
Mental deficiency 122 | 645
Poor school performance 122 | 645
medulloblastoma 121 | 720
nephrosclerosis 120 | 333
progressive supranuclear palsy 117 | 676
Liver cancer 113 | 604
pancreatic carcinoma 113 | 562
Anemia 111 | 365
Short stature 111 | 531
Multiple Sclerosis 109 | 540
Neurodegenerative disease 105 | 414
Breast Neoplasms 104 | 445
Endometriosis 104 | 540

Tissue

Endocrine System 2,644 | 18,159
Female tissues 2,643 | 17,400
Digestive Tract 2,639 | 17,369
Skin and soft tissues 2,624 | 17,230
Blood and immune system 2,602 | 16,909
Liver and Pancreas 2,595 | 16,750
Urinary Tract 2,592 | 16,678
Male tissues 2,591 | 17,142
Respiratory system 2,541 | 16,393
Nervous System 2,532 | 16,725
Cardiovascular System 2,402 | 15,192

Target Family

Non-IDG 1,618 | 12,091
Enzyme 900 | 4,145
Kinase 88 | 634
Transporter 77 | 473
Ion Channel 36 | 344
Transcription Factor 19 | 1,400
GPCR 14 | 408
Epigenetic 13 | 242
Nuclear Receptor 1 | 48
oGPCR 1 | 421

GO Component

extracellular exosome 2,767 | 2,767
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90