Development Level

Tbio 13 | 11,651
Tdark 1 | 6,593

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
embryonic lethality prior to t... 2 | 278
abnormal heart morphology 1 | 162
decreased circulating insulin ... 1 | 76
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87

Disease

osteosarcoma 13 | 7,950
ovarian cancer 9 | 8,520
group 3 medulloblastoma 6 | 4,104
Carcinoma 5 | 11,493
psoriasis 5 | 6,694
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
medulloblastoma, large-cell 3 | 6,241
Autosomal recessive predisposition 2 | 1,442
Cerebral atrophy 2 | 178
Cognitive delay 2 | 608
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Kidney cancer 2 | 2,613
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Myositis 2 | 30
Neurodegenerative disease 2 | 414
Perlman syndrome 2 | 9
Polyhydramnios 2 | 108
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
Systemic scleroderma 2 | 60
X-linked cerebral adrenoleukodystrophy 2 | 116
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
Absent speech 1 | 43
Acquired metabolic disease 1 | 336
Arthritis, Juvenile 1 | 126
Atrophy of cerebellum 1 | 103
Axial hypotonia 1 | 46
Brachydactyly 1 | 156
Cerebellar degeneration 1 | 103
Charcot-Marie-Tooth disease type 1C 1 | 5
Congenital deafness 1 | 185
Contracture 1 | 96
Contracture of joint 1 | 93
Deafness 1 | 198
Degenerative brain disorder 1 | 100
Disease Progression 1 | 136
Failure to gain weight 1 | 365
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Foot Deformities 1 | 30
Gastric antral vascular ectasia 1 | 10
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hearing Loss, Partial 1 | 185
Highly variable severity 1 | 157
Hyperreflexia 1 | 209
Hypoplasia of corpus callosum 1 | 90
Infratentorial atrophy 1 | 103
Juvenile arthritis 1 | 126
Leukemia 1 | 104
Liver neoplasms 1 | 130
Low Vision 1 | 174
Malaria 1 | 160
Muscle Spasticity 1 | 195
Muscle Weakness 1 | 170
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Pediatric failure to thrive 1 | 365
Pick disease 1 | 1,894
Poor growth 1 | 114
Prenatal onset 1 | 139
Respiratory Failure 1 | 104
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Skeletal muscle atrophy 1 | 139
Spinal muscular atrophy 1 | 34
Stomach Neoplasms 1 | 300
Strabismus 1 | 270
Supratentorial atrophy 1 | 94
Systemic lupus erythematosus 1 | 194
Telangiectasis 1 | 36
Type 2 diabetes mellitus 1 | 272
Variable expressivity 1 | 157
Very poor growth 1 | 114
Visual Impairment 1 | 174
Waldenstrons macroglobulinemia 1 | 765
dermatomyositis 1 | 966
glioblastoma multiforme 1 | 142
hearing impairment 1 | 199
interstitial lung disease 1 | 298
muscle degeneration 1 | 139
nonverbal 1 | 43
pancreatic carcinoma 1 | 562
spina bifida 1 | 1,074
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 5 | 12,091

GO Component

exosome (RNase complex) 14 | 14
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129
Exosome complex component RRP42 EXOSC7 Tbio Enzyme -0.83091 5.93 161
Exosome complex component RRP43 EXOSC8 Tbio Enzyme -1.44056 25.6 87
DIS3-like exonuclease 2 DIS3L2 Tbio Enzyme -1.32394 21.5 118
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
Exosome component 10 EXOSC10 Tbio Non-IDG -2.45249 279.1 123
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113