Development Level

Tbio 24 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
vertebral fusion 2 | 23
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
decreased B cell number 1 | 5
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating total pr... 1 | 49
decreased granulocyte number 1 | 6
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
increased T cell number 1 | 6
increased circulating total pr... 1 | 28
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 17 | 8,520
Carcinoma 15 | 11,493
osteosarcoma 12 | 7,950
glioblastoma 10 | 5,792
medulloblastoma, large-cell 9 | 6,241
atypical teratoid / rhabdoid tumor 8 | 5,112
Kidney cancer 7 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Rheumatoid arthritis 6 | 1,191
lung cancer 6 | 4,740
psoriasis 6 | 6,694
Astrocytoma, Pilocytic 5 | 3,081
Pick disease 5 | 1,894
ependymoma 5 | 4,679
pancreatic cancer 5 | 2,398
Breast cancer 4 | 3,578
malignant mesothelioma 4 | 3,232
medulloblastoma 4 | 720
primitive neuroectodermal tumor 4 | 3,035
progressive supranuclear palsy 4 | 676
tuberculosis 4 | 2,010
Alzheimer's disease 3 | 658
Multiple myeloma 3 | 1,332
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
cystic fibrosis 3 | 1,696
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
non primary Sjogren syndrome sicca 3 | 891
oligodendroglioma 3 | 2,850
pancreatic carcinoma 3 | 562
subependymal giant cell astrocytoma 3 | 2,287
Acquired metabolic disease 2 | 336
Anemia 2 | 365
Cancer 2 | 2,499
Chemical and Drug Induced Liver Injury 2 | 195
Epilepsy 2 | 792
Familial encephalopathy with neuroserpin inclusion bodies 2 | 10
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Pick's disease 2 | 15
Seizures 2 | 596
Syringomyelia 2 | 15
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
non-small cell lung cancer 2 | 2,890
spina bifida 2 | 1,074
Aggressive behavior 1 | 75
Aggressive reaction 1 | 75
Alpha 1-antitrypsin deficiency 1 | 11
Alzheimer Disease 1 | 83
Bladder Neoplasm 1 | 112
Broad eyebrows 1 | 4
Cardiovascular system disease 1 | 246
Cholestasis 1 | 155
Congenital disorder of glycosylation 1 | 54
Disease Progression 1 | 136
Downward slant of palpebral fissure 1 | 158
Gaucher disease type 1 1 | 180
Hypertrophy of nose 1 | 23
Infertility 1 | 188
Isolated cases 1 | 72
Large nose 1 | 23
Liver cancer 1 | 604
Long narrow head 1 | 75
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15 1 | 1
Major Depressive Disorder 1 | 301
Malar flattening 1 | 129
Mediastinitis 1 | 7
Melancholia 1 | 10
Moderate mental retardation (I.Q. 35-49) 1 | 28
Myopathy 1 | 185
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Neuroblastoma 1 | 80
Nevoid basal cell carcinoma syndrome 1 | 16
Pain agnosia 1 | 104
Physical aggression 1 | 76
Pointed chin 1 | 33
Profound Mental Retardation 1 | 31
Profound intellectual disabilities 1 | 31
Short philtrum 1 | 53
Thin upper lip vermilion 1 | 67
Turridolichocephaly 1 | 75
Unipolar Depression 1 | 250
Urinary Bladder Neoplasms 1 | 114
active ulcerative colitis 1 | 764
permanent atrial fibrillation 1 | 45
sarcoidosis 1 | 370
severe Alzheimer's disease 1 | 47
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 25 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Enzyme 16 | 4,145
Non-IDG 9 | 12,091

GO Component

endoplasmic reticulum quality ... 25 | 25
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 Tchem Enzyme -1.80418 63.8 91
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.17169 16.6 133
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
UDP-glucose:glycoprotein glucosyltransferase 1 UGGT1 Tbio Enzyme -1.60583 43.0 80
ER degradation-enhancing alpha-mannosidase-like protein 3 EDEM3 Tbio Enzyme -0.60839 3.23 88
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
E3 ubiquitin-protein ligase RNF103 RNF103 Tbio Enzyme -1.95102 35.6 76