Development Level

Tbio 603 | 11,445
Tchem 125 | 1,598
Tdark 116 | 6,588
Tclin 35 | 613

Collection

Kinase: IDG Consortium (Target... 4 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 67 | 979
preweaning lethality, incomple... 31 | 499
embryonic lethality prior to t... 24 | 278
abnormal embryo size 20 | 220
embryonic lethality prior to o... 20 | 239
decreased lean body mass 14 | 135
increased total body fat amoun... 14 | 134
decreased bone mineral content 13 | 151
decreased total body fat amoun... 13 | 207
increased lean body mass 13 | 172
abnormal behavior 11 | 298
embryonic growth retardation 11 | 106
increased startle reflex 11 | 112
abnormal bone structure 10 | 187
decreased circulating glucose ... 8 | 126
hyperactivity 8 | 148
hypoactivity 8 | 132
increased mean corpuscular vol... 8 | 92
decreased blood urea nitrogen ... 7 | 51
decreased body weight 7 | 161
decreased circulating HDL chol... 7 | 68
decreased circulating triglyce... 7 | 79
decreased vertical activity 7 | 208
enlarged heart 7 | 210
increased mean corpuscular hem... 7 | 96
abnormal gait 6 | 69
abnormal testis morphology 6 | 43
decreased bone mineral density 6 | 126
decreased circulating choleste... 6 | 93
decreased circulating insulin ... 6 | 76
decreased fasted circulating g... 6 | 65
decreased prepulse inhibition 6 | 82
increased circulating alkaline... 6 | 122
increased or absent threshold ... 6 | 101
abnormal lens morphology 5 | 81
abnormal neural tube closure 5 | 46
abnormal pericardium morpholog... 5 | 26
abnormal retina morphology 5 | 71
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased circulating alkaline... 5 | 46
decreased circulating serum al... 5 | 82
decreased grip strength 5 | 116
decreased hemoglobin content 5 | 68
decreased mean corpuscular vol... 5 | 79
improved glucose tolerance 5 | 79
increased bone mineral content 5 | 108
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 76
increased prepulse inhibition 5 | 32
increased red blood cell distr... 5 | 34
limb grasping 5 | 41
pallor 5 | 34
small testis 5 | 58
abnormal epididymis morphology 4 | 42
abnormal heart morphology 4 | 162
abnormal joint morphology 4 | 23
abnormal kidney morphology 4 | 65
abnormal limb bud morphology 4 | 17
decreased circulating LDL chol... 4 | 38
decreased circulating alanine ... 4 | 47
decreased circulating phosphat... 4 | 27
decreased erythrocyte cell num... 4 | 62
decreased lymphocyte cell numb... 4 | 83
edema 4 | 59
enlarged epididymis 4 | 31
increased blood urea nitrogen ... 4 | 48
increased bone mineral density 4 | 72
increased circulating HDL chol... 4 | 80
increased circulating choleste... 4 | 66
increased circulating creatini... 4 | 38
increased leukocyte cell numbe... 4 | 47
increased monocyte cell number 4 | 63
pale yolk sac 4 | 25
prenatal lethality prior to he... 4 | 87
syndactyly 4 | 23
thrombocytopenia 4 | 56
vertebral fusion 4 | 23
abnormal bone mineralization 3 | 38
abnormal cranium morphology 3 | 36
abnormal embryo turning 3 | 31
abnormal hair growth 3 | 10
abnormal sleep behavior 3 | 70
abnormal vibrissa morphology 3 | 25
brachydactyly 3 | 19
decreased body length 3 | 101
decreased circulating amylase ... 3 | 28
decreased circulating aspartat... 3 | 34
decreased eosinophil cell numb... 3 | 24
decreased hematocrit 3 | 46
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
impaired glucose tolerance 3 | 75
impaired pupillary reflex 3 | 26
increased anti-nuclear antigen... 3 | 19
increased circulating calcium ... 3 | 34
increased circulating triglyce... 3 | 42
increased mean platelet volume 3 | 45
male infertility 3 | 123
persistence of hyaloid vascula... 3 | 33

Disease

Carcinoma 550 | 11,493
ovarian cancer 489 | 8,520
osteosarcoma 421 | 7,950
glioblastoma 323 | 5,792
medulloblastoma, large-cell 322 | 6,241
psoriasis 321 | 6,694
atypical teratoid / rhabdoid tumor 264 | 5,112
lung cancer 245 | 4,740
ependymoma 232 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 212 | 3,291
adult high grade glioma 188 | 3,801
Breast cancer 186 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 183 | 1,962
group 3 medulloblastoma 180 | 4,104
invasive ductal carcinoma 180 | 2,951
Astrocytoma, Pilocytic 178 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 166 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 164 | 2,955
malignant mesothelioma 158 | 3,232
non-small cell lung cancer 149 | 2,890
pancreatic cancer 148 | 2,398
lung carcinoma 147 | 2,843
lung adenocarcinoma 140 | 2,716
oligodendroglioma 137 | 2,850
interstitial cystitis 132 | 2,312
tuberculosis 131 | 2,010
subependymal giant cell astrocytoma 124 | 2,287
primitive neuroectodermal tumor 123 | 3,035
Autosomal recessive predisposition 119 | 1,442
astrocytic glioma 116 | 2,597
group 4 medulloblastoma 115 | 1,855
pituitary cancer 115 | 1,972
Pick disease 114 | 1,894
Multiple myeloma 108 | 1,332
ductal carcinoma in situ 106 | 1,745
Cancer 104 | 2,499
cystic fibrosis 101 | 1,696
Kidney cancer 99 | 2,613
diabetes mellitus 98 | 1,728
active Crohn's disease 97 | 922
ulcerative colitis 94 | 1,819
breast carcinoma 93 | 1,638
astrocytoma 81 | 1,146
adrenocortical carcinoma 75 | 1,428
Rheumatoid arthritis 67 | 1,191
acute quadriplegic myopathy 67 | 1,158
juvenile dermatomyositis 67 | 1,187
pediatric high grade glioma 66 | 1,064
Intellectual disability 65 | 1,016
Schizophrenia 64 | 1,160
Epilepsy 62 | 792
primary pancreatic ductal adenocarcinoma 62 | 1,109
colon cancer 58 | 1,478
cutaneous lupus erythematosus 58 | 1,057
active ulcerative colitis 56 | 764
non primary Sjogren syndrome sicca 55 | 891
esophageal adenocarcinoma 54 | 737
spina bifida 54 | 1,074
Alzheimer's disease 51 | 658
Prostatic Neoplasms 51 | 495
Obesity 50 | 678
Liver Cirrhosis, Experimental 49 | 769
Atopic dermatitis 46 | 952
Muscle hypotonia 45 | 571
Seizures 45 | 596
acute myeloid leukemia 43 | 783
aldosterone-producing adenoma 43 | 665
dermatomyositis 43 | 966
nasopharyngeal carcinoma 43 | 1,058
pancreatic carcinoma 43 | 562
progressive supranuclear palsy 43 | 676
Cognitive delay 42 | 608
Global developmental delay 42 | 608
Mental and motor retardation 42 | 608
Neurodegenerative disease 42 | 414
gastric carcinoma 42 | 807
Dull intelligence 41 | 645
Low intelligence 41 | 645
Mental Retardation 41 | 645
Mental deficiency 41 | 645
Poor school performance 41 | 645
Waldenstrons macroglobulinemia 38 | 765
Down syndrome 36 | 499
Hypertension 36 | 396
primary Sjogren syndrome 36 | 735
Bipolar Disorder 34 | 666
Failure to gain weight 33 | 365
Melanoma 33 | 711
Pediatric failure to thrive 33 | 365
Endometriosis 32 | 540
Short stature 32 | 531
medulloblastoma 32 | 720
hepatocellular carcinoma 31 | 547
hereditary spastic paraplegia 31 | 318
chronic rhinosinusitis 30 | 512
Duchenne muscular dystrophy 29 | 601
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 510
Cryptorchidism 28 | 296
fibroadenoma 27 | 559
gastric cancer 27 | 459

Tissue

Digestive Tract 854 | 17,369
Endocrine System 853 | 18,159
Female tissues 849 | 17,400
Skin and soft tissues 846 | 17,230
Liver and Pancreas 843 | 16,750
Male tissues 843 | 17,142
Urinary Tract 833 | 16,678
Blood and immune system 831 | 16,909
Nervous System 820 | 16,725
Respiratory system 815 | 16,393
Cardiovascular System 769 | 15,192

Target Family

Non-IDG 396 | 12,091
Enzyme 389 | 4,145
Transporter 34 | 473
Transcription Factor 19 | 1,400
Ion Channel 17 | 344
Kinase 17 | 634
GPCR 5 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

GO Component

endoplasmic reticulum membrane 879 | 879
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Ceroid-lipofuscinosis neuronal protein 6 CLN6 Tbio Non-IDG -1.87357 0.00000 103
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 Tchem Enzyme -1.80418 63.8 91
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase ALG10 Tbio Enzyme -1.32430 19.1 70