Development Level

Tbio 537 | 10,625
Tchem 146 | 1,890
Tdark 130 | 7,003
Tclin 35 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 48 | 633
decreased lean body mass 18 | 195
preweaning lethality, incomple... 16 | 260
embryonic lethality prior to t... 15 | 187
decreased bone mineral content 12 | 157
decreased total body fat amoun... 12 | 186
decreased body weight 10 | 174
decreased circulating choleste... 10 | 85
embryonic lethality prior to o... 10 | 148
abnormal behavior 9 | 226
increased mean corpuscular hem... 9 | 93
increased or absent threshold ... 9 | 128
decreased bone mineral density 8 | 126
decreased circulating HDL chol... 8 | 77
decreased circulating insulin ... 8 | 75
decreased circulating triglyce... 8 | 83
increased total body fat amoun... 8 | 57
abnormal embryo size 7 | 112
decreased circulating alanine ... 7 | 53
decreased circulating glucose ... 7 | 121
abnormal bone structure 6 | 131
abnormal gait 6 | 51
abnormal retina morphology 6 | 100
increased bone mineral content 6 | 92
increased circulating alkaline... 6 | 119
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
abnormal retinal pigmentation 5 | 61
abnormal testis morphology 5 | 30
decreased circulating aspartat... 5 | 27
decreased fasted circulating g... 5 | 49
decreased mean corpuscular vol... 5 | 50
decreased prepulse inhibition 5 | 52
enlarged heart 5 | 111
hyperactivity 5 | 108
limb grasping 5 | 35
abnormal bone mineralization 4 | 55
abnormal lens morphology 4 | 73
abnormal neural tube closure 4 | 37
decreased body length 4 | 108
decreased circulating LDL chol... 4 | 37
decreased circulating calcium ... 4 | 33
decreased circulating phosphat... 4 | 15
decreased grip strength 4 | 123
hypoactivity 4 | 89
increased circulating choleste... 4 | 53
increased prepulse inhibition 4 | 21
prenatal lethality prior to he... 4 | 64
small testis 4 | 37
abnormal QRS complex 3 | 25
abnormal epididymis morphology 3 | 31
abnormal seminal vesicle morph... 3 | 47
abnormal sleep behavior 3 | 63
decreased NK T cell number 3 | 28
decreased NK cell number 3 | 16
decreased T cell number 3 | 31
decreased blood urea nitrogen ... 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating free fat... 3 | 39
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased startle reflex 3 | 48
enlarged epididymis 3 | 27
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased circulating sodium l... 3 | 71
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased heart weight 3 | 37
increased hemoglobin content 3 | 45
persistence of hyaloid vascula... 3 | 22
shortened RR interval 3 | 19
thrombocytopenia 3 | 46
vertebral fusion 3 | 23
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal cranium morphology 2 | 32
abnormal hair growth 2 | 8
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
cardiovascular system phenotyp... 2 | 35
decreased circulating glycerol... 2 | 19
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased vertical activity 2 | 22
embryonic growth retardation 2 | 28
impaired glucose tolerance 2 | 52
increased CD4-positive, CD25-p... 2 | 18
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating potassiu... 2 | 31
increased mean platelet volume 2 | 19
increased rib number 2 | 41
thrombocytosis 2 | 23

Disease

ovarian cancer 474 | 8,484
osteosarcoma 409 | 7,933
psoriasis 313 | 6,685
medulloblastoma, large-cell 310 | 6,234
glioblastoma 300 | 5,572
lung cancer 237 | 4,466
atypical teratoid / rhabdoid tumor 223 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 211 | 3,289
invasive ductal carcinoma 176 | 2,950
pilocytic astrocytoma 173 | 3,086
pancreatic ductal adenocarcinoma liver metastasis 169 | 1,795
Breast cancer 163 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 163 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 162 | 2,988
malignant mesothelioma 147 | 3,162
pancreatic cancer 145 | 2,300
non-small cell lung cancer 144 | 2,798
lung carcinoma 143 | 2,844
pediatric high grade glioma 140 | 2,712
lung adenocarcinoma 138 | 2,713
ependymoma 135 | 2,514
oligodendroglioma 134 | 2,849
interstitial cystitis 132 | 2,299
subependymal giant cell astrocytoma 123 | 2,287
primitive neuroectodermal tumor 117 | 3,031
Pick disease 114 | 1,893
pituitary cancer 113 | 1,972
ulcerative colitis 113 | 2,087
group 4 medulloblastoma 112 | 1,875
astrocytic glioma 107 | 2,241
adult high grade glioma 106 | 2,148
ductal carcinoma in situ 105 | 1,745
Multiple myeloma 101 | 1,327
tuberculosis 98 | 1,557
active Crohn's disease 96 | 918
group 3 medulloblastoma 96 | 2,254
Cancer 95 | 2,346
cystic fibrosis 95 | 1,665
diabetes mellitus 95 | 1,663
breast carcinoma 92 | 1,614
astrocytoma 82 | 1,493
posterior fossa group A ependymoma 80 | 1,511
adrenocortical carcinoma 72 | 1,427
primary pancreatic ductal adenocarcinoma 72 | 1,271
medulloblastoma 71 | 1,524
Rheumatoid Arthritis 70 | 1,160
acute quadriplegic myopathy 66 | 1,157
juvenile dermatomyositis 64 | 1,189
Carcinoma 61 | 2,147
cutaneous lupus erythematosus 56 | 1,056
posterior fossa group B ependymoma 56 | 1,530
colon cancer 55 | 1,475
esophageal adenocarcinoma 54 | 737
spina bifida 53 | 1,064
non primary Sjogren syndrome sicca 52 | 840
Prostatic Neoplasms 50 | 471
Obesity 49 | 616
sonic hedgehog group medulloblastoma 49 | 1,482
Alzheimer's disease 48 | 644
Atopic dermatitis 48 | 944
pancreatic carcinoma 45 | 567
atypical teratoid/rhabdoid tumor 44 | 1,095
dermatomyositis 44 | 933
gastric carcinoma 43 | 832
aldosterone-producing adenoma 42 | 664
Intellectual disability 41 | 573
nasopharyngeal carcinoma 41 | 1,056
acute myeloid leukemia 40 | 780
progressive supranuclear palsy 40 | 674
tuberculosis and treatment for 6 months 40 | 686
Neurodegenerative disease 39 | 383
Down syndrome 38 | 548
IGA Glomerulonephritis 38 | 454
Waldenstrons macroglobulinemia 37 | 765
primary Sjogren syndrome 36 | 789
Endometriosis 32 | 535
Peripheral Neuropathy 32 | 303
active ulcerative colitis 32 | 477
Duchenne muscular dystrophy 31 | 602
Schizophrenia 31 | 501
chronic rhinosinusitis 31 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 499
hepatocellular carcinoma 30 | 532
hereditary spastic paraplegia 28 | 313
Epilepsy 27 | 346
fibroadenoma 27 | 557
Congenital disorder of glycosylation 26 | 53
Hypertension 26 | 287
gastric cancer 26 | 430
Asthma 22 | 349
Mammary Neoplasms 22 | 410
Parkinson's disease 22 | 364
inflammatory breast cancer 22 | 404
mucosa-associated lymphoid tissue lymphoma 22 | 480
sarcoidosis 22 | 358
Cerebrovascular disease 21 | 231
Heart disease 21 | 279
Liver carcinoma 21 | 217
Multiple Sclerosis 21 | 498
glioblastoma multiforme 21 | 347

Tissue

Liver and Pancreas 839 | 18,136
Digestive Tract 837 | 18,473
Urinary Tract 837 | 18,444
Female tissues 835 | 18,647
Endocrine System 833 | 18,512
Blood and immune system 832 | 17,995
Nervous System 832 | 18,561
Skin and soft tissues 830 | 18,115
Male tissues 828 | 17,969
Cardiovascular System 824 | 17,958
Respiratory system 819 | 17,484

Target Family

Enzyme 382 | 4,146
Non-IDG 379 | 11,971
Transporter 32 | 473
Transcription Factor 19 | 1,400
Ion Channel 16 | 341
Kinase 14 | 634
GPCR 4 | 406
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

GO Component

endoplasmic reticulum membrane 848 | 848
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Protein FAM69C FAM69C Tdark Non-IDG 0.27 0.39 3
Vacuolar ATPase assembly integral membrane protein VMA21 VMA21 Tbio Enzyme 1.00 53
Lymphoid-restricted membrane protein LRMP Tbio Non-IDG -1.17754 15.9 54
Transmembrane 6 superfamily member 2 TM6SF2 Tbio Non-IDG -1.59935 44.0 21
Vesicular integral-membrane protein VIP36 LMAN2 Tbio Non-IDG -1.35463 24.9 101
Transmembrane channel-like protein 8 TMC8 Tbio Ion Channel -1.45295 32.2 147
Dimethylaniline monooxygenase [N-oxide-forming] 5 FMO5 Tbio Enzyme -0.93021 9.11 128
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Calumenin CALU Tbio Non-IDG -1.76431 61.4 157