Development Level

Tbio 681 | 11,445
Tdark 117 | 6,588
Tchem 100 | 1,598
Tclin 40 | 613

Collection

RFA-RM-18-021 7 | 328
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 58 | 979
preweaning lethality, incomple... 27 | 499
embryonic lethality prior to t... 22 | 278
abnormal embryo size 17 | 220
abnormal bone structure 16 | 187
increased total body fat amoun... 15 | 134
embryonic lethality prior to o... 14 | 239
decreased body weight 12 | 161
decreased total body fat amoun... 12 | 207
abnormal behavior 11 | 298
abnormal heart morphology 11 | 162
decreased bone mineral content 11 | 151
decreased circulating HDL chol... 11 | 68
decreased circulating glucose ... 11 | 126
embryonic growth retardation 11 | 106
enlarged heart 11 | 210
decreased grip strength 10 | 116
decreased lean body mass 10 | 135
decreased vertical activity 10 | 208
increased circulating alkaline... 10 | 122
increased lean body mass 10 | 172
decreased circulating choleste... 9 | 93
hypoactivity 9 | 132
abnormal seminal vesicle morph... 8 | 114
decreased circulating triglyce... 8 | 79
increased fasted circulating g... 8 | 76
decreased circulating alanine ... 7 | 47
increased leukocyte cell numbe... 7 | 47
abnormal neural tube closure 6 | 46
decreased bone mineral density 6 | 126
decreased circulating alkaline... 6 | 46
decreased circulating aspartat... 6 | 34
hyperactivity 6 | 148
increased mean corpuscular vol... 6 | 92
increased startle reflex 6 | 112
abnormal eye morphology 5 | 68
decreased circulating phosphat... 5 | 27
decreased fasted circulating g... 5 | 65
decreased lymphocyte cell numb... 5 | 83
hydrometra 5 | 53
impaired glucose tolerance 5 | 75
increased bone mineral density 5 | 72
increased heart weight 5 | 62
increased mean corpuscular hem... 5 | 36
male infertility 5 | 123
tremors 5 | 39
abnormal locomotor behavior 4 | 24
abnormal tail morphology 4 | 25
decreased blood urea nitrogen ... 4 | 51
decreased circulating creatini... 4 | 39
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased erythrocyte cell num... 4 | 62
decreased leukocyte cell numbe... 4 | 73
decreased red blood cell distr... 4 | 41
decreased startle reflex 4 | 75
edema 4 | 59
increased bone mineral content 4 | 108
increased circulating amylase ... 4 | 25
increased circulating bilirubi... 4 | 16
increased circulating chloride... 4 | 41
increased circulating choleste... 4 | 66
increased circulating phosphat... 4 | 26
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 32
increased red blood cell distr... 4 | 34
pale yolk sac 4 | 25
pallor 4 | 34
thrombocytopenia 4 | 56
abnormal bone mineralization 3 | 38
abnormal forebrain development 3 | 20
abnormal gait 3 | 69
abnormal hindbrain development 3 | 16
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal limb bud morphology 3 | 17
abnormal midbrain development 3 | 20
abnormal pericardium morpholog... 3 | 26
abnormal skin morphology 3 | 50
anophthalmia 3 | 33
decreased T cell number 3 | 15
decreased circulating amylase ... 3 | 28
decreased circulating insulin ... 3 | 76
decreased circulating sodium l... 3 | 22
decreased hemoglobin content 3 | 68
decreased prepulse inhibition 3 | 82
decreased threshold for audito... 3 | 26
increased circulating serum al... 3 | 22
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
limb grasping 3 | 41
mammalian phenotype 3 | 17
short tibia 3 | 97
small adrenal glands 3 | 16
small superior vagus ganglion 3 | 74
small testis 3 | 58
thrombocytosis 3 | 27
increased circulating calcium ... 2 | 34

Disease

Carcinoma 572 | 11,493
ovarian cancer 487 | 8,520
osteosarcoma 410 | 7,950
psoriasis 397 | 6,694
glioblastoma 336 | 5,792
medulloblastoma, large-cell 329 | 6,241
lung cancer 264 | 4,740
atypical teratoid / rhabdoid tumor 263 | 5,112
ependymoma 234 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 210 | 3,291
Breast cancer 208 | 3,578
Cancer 207 | 2,499
Astrocytoma, Pilocytic 196 | 3,081
group 3 medulloblastoma 193 | 4,104
invasive ductal carcinoma 189 | 2,951
adult high grade glioma 178 | 3,801
lung adenocarcinoma 173 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 172 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 172 | 2,989
malignant mesothelioma 172 | 3,232
non-small cell lung cancer 171 | 2,890
diabetes mellitus 170 | 1,728
pancreatic cancer 160 | 2,398
lung carcinoma 158 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 157 | 1,962
oligodendroglioma 152 | 2,850
tuberculosis 147 | 2,010
subependymal giant cell astrocytoma 145 | 2,287
primitive neuroectodermal tumor 140 | 3,035
interstitial cystitis 130 | 2,312
astrocytic glioma 127 | 2,597
pituitary cancer 122 | 1,972
ulcerative colitis 122 | 1,819
Multiple myeloma 120 | 1,332
Pick disease 119 | 1,894
Autosomal recessive predisposition 118 | 1,442
breast carcinoma 114 | 1,638
Kidney cancer 111 | 2,613
ductal carcinoma in situ 111 | 1,745
Rheumatoid arthritis 103 | 1,191
group 4 medulloblastoma 103 | 1,855
active Crohn's disease 93 | 922
dermatomyositis 93 | 966
cystic fibrosis 91 | 1,696
astrocytoma 88 | 1,146
adrenocortical carcinoma 86 | 1,428
juvenile dermatomyositis 84 | 1,187
acute quadriplegic myopathy 81 | 1,158
colon cancer 76 | 1,478
Ankylosing spondylitis 75 | 140
pediatric high grade glioma 74 | 1,064
Arthritis 72 | 290
Behcet's disease 72 | 89
Alzheimer's disease 68 | 658
Intellectual disability 67 | 1,016
Schizophrenia 67 | 1,160
Hypersensitivity reaction type II disease 65 | 253
Epilepsy 64 | 792
primary pancreatic ductal adenocarcinoma 64 | 1,109
esophageal adenocarcinoma 63 | 737
Acquired immunodeficiency syndrome 62 | 197
Neurodegenerative disease 60 | 414
non primary Sjogren syndrome sicca 60 | 891
Juvenile rheumatoid arthritis 59 | 111
Uveitis 59 | 103
Herpes zoster 57 | 68
Liver Cirrhosis, Experimental 56 | 769
cutaneous lupus erythematosus 56 | 1,057
Human immunodeficiency virus infectious disease 55 | 138
Multiple Sclerosis 55 | 540
Stevens-Johnson syndrome 55 | 92
nasopharyngeal carcinoma 54 | 1,058
active ulcerative colitis 53 | 764
Seizures 52 | 596
Obesity 51 | 678
Psoriatic arthritis 51 | 86
progressive supranuclear palsy 51 | 676
spina bifida 51 | 1,074
Atopic dermatitis 50 | 952
Anemia 49 | 365
Kidney disease 49 | 430
Waldenstrons macroglobulinemia 49 | 765
gastric carcinoma 48 | 807
Duchenne muscular dystrophy 47 | 601
Dull intelligence 46 | 645
Low intelligence 46 | 645
Mental Retardation 46 | 645
Mental deficiency 46 | 645
Poor school performance 46 | 645
Prostatic Neoplasms 46 | 495
Dermatitis 45 | 157
Muscle hypotonia 43 | 571
autosomal dominant Emery-Dreifuss muscular dystrophy 43 | 510
pancreatic carcinoma 43 | 562
primary Sjogren syndrome 42 | 735
fibroadenoma 41 | 559
Down syndrome 40 | 499
acute myeloid leukemia 40 | 783
Bipolar Disorder 39 | 666
hepatocellular carcinoma 39 | 547

Tissue

Endocrine System 833 | 18,159
Digestive Tract 832 | 17,369
Female tissues 827 | 17,400
Skin and soft tissues 823 | 17,230
Liver and Pancreas 822 | 16,750
Urinary Tract 817 | 16,678
Nervous System 815 | 16,725
Male tissues 814 | 17,142
Blood and immune system 813 | 16,909
Respiratory system 801 | 16,393
Cardiovascular System 765 | 15,192

Target Family

Non-IDG 524 | 12,091
Enzyme 305 | 4,145
Ion Channel 28 | 344
Transporter 28 | 473
Kinase 21 | 634
Transcription Factor 20 | 1,400
GPCR 11 | 408
Epigenetic 1 | 242

GO Component

endoplasmic reticulum 938 | 938
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 17-like protein 20 USP17L20 Tdark Enzyme 0.00000 3
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.74914 5601.8 1083
Prominin-1 PROM1 Tbio Non-IDG -3.30229 2035.0 351
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519
60S ribosomal protein L10 RPL10 Tbio Non-IDG -0.94919 8.10 191
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205
Sterol regulatory element-binding protein cleavage-activating protein SCAP Tbio Non-IDG -1.85010 73.9 172
Protein FAM57B FAM57B Tdark Non-IDG 0.48 0.62 20
WASH complex subunit 5 WASHC5 Tbio Non-IDG -1.43182 26.4 38
Ras-related protein R-Ras2 RRAS2 Tbio Enzyme -1.56623 42.9 157