Development Level

Tbio 597 | 10,625
Tdark 112 | 7,003
Tchem 110 | 1,890
Tclin 40 | 602

Collection

Eligible Ion Channel Proteins 3 | 117
Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 40 | 633
embryonic lethality prior to t... 14 | 187
decreased body weight 12 | 174
decreased bone mineral content 12 | 157
preweaning lethality, incomple... 12 | 260
abnormal bone structure 10 | 131
decreased total body fat amoun... 10 | 186
increased circulating alkaline... 9 | 119
increased lean body mass 9 | 107
decreased bone mineral density 8 | 126
decreased circulating glucose ... 8 | 121
decreased lean body mass 8 | 195
abnormal behavior 7 | 226
decreased circulating HDL chol... 7 | 77
decreased circulating alanine ... 7 | 53
decreased circulating choleste... 7 | 85
decreased grip strength 7 | 123
embryonic lethality prior to o... 7 | 148
abnormal embryo size 6 | 112
decreased circulating triglyce... 6 | 83
decreased startle reflex 6 | 48
hypoactivity 6 | 89
increased grip strength 6 | 83
abnormal bone mineralization 5 | 55
abnormal retina morphology 5 | 100
decreased T cell number 5 | 31
decreased circulating aspartat... 5 | 27
decreased circulating insulin ... 5 | 75
enlarged heart 5 | 111
increased bone mineral content 5 | 92
increased circulating HDL chol... 5 | 63
increased circulating choleste... 5 | 53
increased hemoglobin content 5 | 45
increased total body fat amoun... 5 | 57
thrombocytopenia 5 | 46
abnormal heart morphology 4 | 51
abnormal neural tube closure 4 | 37
abnormal seminal vesicle morph... 4 | 47
abnormal tail morphology 4 | 17
decreased fasted circulating g... 4 | 49
decreased leukocyte cell numbe... 4 | 54
impaired glucose tolerance 4 | 52
increased bone mineral density 4 | 52
increased circulating phosphat... 4 | 24
increased circulating serum al... 4 | 25
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular hem... 4 | 93
increased mean corpuscular hem... 4 | 25
increased mean corpuscular vol... 4 | 91
short tibia 4 | 82
tremors 4 | 34
abnormal heart left ventricle ... 3 | 20
abnormal lens morphology 3 | 73
abnormal locomotor activation 3 | 26
decreased B cell number 3 | 30
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased NK cell number 3 | 16
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating calcium ... 3 | 33
decreased circulating phosphat... 3 | 15
decreased circulating serum al... 3 | 79
hydrometra 3 | 13
increased T cell number 3 | 15
increased body length 3 | 20
increased circulating bilirubi... 3 | 16
increased circulating calcium ... 3 | 32
increased circulating free fat... 3 | 17
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 24
increased heart weight 3 | 37
increased or absent threshold ... 3 | 128
male infertility 3 | 62
small adrenal glands 3 | 15
abnormal gait 2 | 51
abnormal hair growth 2 | 8
abnormal lung morphology 2 | 15
decreased IgG1 level 2 | 4
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating sodium l... 2 | 18
decreased effector memory CD8-... 2 | 24
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 34
decreased neutrophil cell numb... 2 | 37
decreased pulmonary respirator... 2 | 4
decreased rib number 2 | 59
embryonic growth retardation 2 | 28
enlarged stomach 2 | 2
increased NK T cell number 2 | 11
increased circulating fructosa... 2 | 11
increased sacral vertebrae num... 2 | 62
lethargy 2 | 5
small testis 2 | 37
small thymus 2 | 11
straub tail 2 | 26
thrombocytosis 2 | 23
vertebral fusion 2 | 23

Disease

ovarian cancer 442 | 8,484
osteosarcoma 373 | 7,933
psoriasis 367 | 6,685
medulloblastoma, large-cell 297 | 6,234
glioblastoma 295 | 5,572
lung cancer 239 | 4,466
atypical teratoid / rhabdoid tumor 201 | 4,369
Cancer 194 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 192 | 3,289
pilocytic astrocytoma 177 | 3,086
invasive ductal carcinoma 175 | 2,950
Breast cancer 170 | 3,094
malignant mesothelioma 162 | 3,162
lung adenocarcinoma 161 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 160 | 2,956
diabetes mellitus 158 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 158 | 2,988
non-small cell lung cancer 153 | 2,798
lung carcinoma 152 | 2,844
pediatric high grade glioma 151 | 2,712
pancreatic cancer 147 | 2,300
oligodendroglioma 139 | 2,849
ulcerative colitis 137 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 136 | 1,795
subependymal giant cell astrocytoma 131 | 2,287
primitive neuroectodermal tumor 130 | 3,031
interstitial cystitis 123 | 2,299
ependymoma 117 | 2,514
Multiple myeloma 113 | 1,327
pituitary cancer 110 | 1,972
Pick disease 109 | 1,893
group 4 medulloblastoma 108 | 1,875
ductal carcinoma in situ 103 | 1,745
breast carcinoma 100 | 1,614
astrocytoma 97 | 1,493
Rheumatoid Arthritis 96 | 1,160
astrocytic glioma 92 | 2,241
tuberculosis 85 | 1,557
active Crohn's disease 83 | 918
adrenocortical carcinoma 82 | 1,427
adult high grade glioma 82 | 2,148
posterior fossa group A ependymoma 82 | 1,511
group 3 medulloblastoma 81 | 2,254
Carcinoma 80 | 2,147
cystic fibrosis 79 | 1,665
juvenile dermatomyositis 77 | 1,189
Ankylosing spondylitis 75 | 138
primary pancreatic ductal adenocarcinoma 75 | 1,271
acute quadriplegic myopathy 71 | 1,157
colon cancer 69 | 1,475
Arthritis 66 | 248
medulloblastoma 64 | 1,524
Hypersensitivity reaction type II disease 63 | 235
Alzheimer's disease 61 | 644
Acquired immunodeficiency syndrome 60 | 164
posterior fossa group B ependymoma 59 | 1,530
Behcet's disease 58 | 74
Uveitis 58 | 103
esophageal adenocarcinoma 58 | 737
Juvenile rheumatoid arthritis 57 | 104
dermatomyositis 57 | 933
Neurodegenerative disease 56 | 383
sonic hedgehog group medulloblastoma 54 | 1,482
non primary Sjogren syndrome sicca 53 | 840
atypical teratoid/rhabdoid tumor 52 | 1,095
nasopharyngeal carcinoma 52 | 1,056
Psoriatic arthritis 51 | 83
cutaneous lupus erythematosus 51 | 1,056
Multiple Sclerosis 49 | 498
Kidney disease 48 | 396
progressive supranuclear palsy 48 | 674
Down syndrome 47 | 548
Prostatic Neoplasms 45 | 471
Waldenstrons macroglobulinemia 45 | 765
gastric carcinoma 45 | 832
spina bifida 45 | 1,064
Atopic dermatitis 44 | 944
Duchenne muscular dystrophy 44 | 602
Stevens-Johnson syndrome 42 | 78
autosomal dominant Emery-Dreifuss muscular dystrophy 42 | 499
Anemia 41 | 252
Obesity 41 | 616
fibroadenoma 40 | 557
pancreatic carcinoma 40 | 567
Congenital adrenal hyperplasia 39 | 74
IGA Glomerulonephritis 38 | 454
acute myeloid leukemia 38 | 780
primary Sjogren syndrome 37 | 789
Liver disease 36 | 219
aldosterone-producing adenoma 36 | 664
tuberculosis and treatment for 6 months 36 | 686
Intellectual disability 35 | 573
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
Parkinson's disease 33 | 364
Schizophrenia 33 | 501
hepatocellular carcinoma 33 | 532
Atherosclerosis 31 | 275
Epilepsy 31 | 346
Hepatitis B 31 | 103

Tissue

Nervous System 786 | 18,561
Female tissues 785 | 18,647
Blood and immune system 780 | 17,995
Urinary Tract 777 | 18,444
Digestive Tract 775 | 18,473
Liver and Pancreas 775 | 18,136
Endocrine System 771 | 18,512
Male tissues 765 | 17,969
Cardiovascular System 763 | 17,958
Skin and soft tissues 763 | 18,115
Respiratory system 757 | 17,484

Target Family

Non-IDG 469 | 11,971
Enzyme 284 | 4,146
Transporter 29 | 473
Ion Channel 26 | 341
Kinase 20 | 634
Transcription Factor 19 | 1,400
GPCR 11 | 406
Epigenetic 1 | 242

GO Component

endoplasmic reticulum 859 | 859
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Seizure protein 6 homolog SEZ6 Tdark Non-IDG -0.87986 8.64 27
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 USP17L1 Tdark Enzyme 10.9 3