Development Level

Tbio 661 | 11,178
Tchem 121 | 1,885
Tdark 116 | 6,569
Tclin 40 | 612

Collection

Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 58 | 979
preweaning lethality, incomple... 27 | 499
embryonic lethality prior to t... 22 | 278
abnormal embryo size 17 | 220
abnormal bone structure 16 | 187
increased total body fat amoun... 15 | 134
embryonic lethality prior to o... 14 | 239
decreased body weight 12 | 161
decreased total body fat amoun... 12 | 207
abnormal behavior 11 | 298
abnormal heart morphology 11 | 162
decreased bone mineral content 11 | 151
decreased circulating HDL chol... 11 | 68
decreased circulating glucose ... 11 | 126
embryonic growth retardation 11 | 106
enlarged heart 11 | 210
decreased grip strength 10 | 116
decreased lean body mass 10 | 135
decreased vertical activity 10 | 208
increased circulating alkaline... 10 | 122
increased lean body mass 10 | 172
decreased circulating choleste... 9 | 93
hypoactivity 9 | 132
abnormal seminal vesicle morph... 8 | 114
decreased circulating triglyce... 8 | 79
increased fasted circulating g... 8 | 76
decreased circulating alanine ... 7 | 47
increased leukocyte cell numbe... 7 | 47
abnormal neural tube closure 6 | 46
decreased bone mineral density 6 | 126
decreased circulating alkaline... 6 | 46
decreased circulating aspartat... 6 | 34
hyperactivity 6 | 148
increased mean corpuscular vol... 6 | 92
increased startle reflex 6 | 112
abnormal eye morphology 5 | 68
decreased circulating phosphat... 5 | 27
decreased fasted circulating g... 5 | 65
decreased lymphocyte cell numb... 5 | 83
hydrometra 5 | 53
impaired glucose tolerance 5 | 75
increased bone mineral density 5 | 72
increased heart weight 5 | 62
increased mean corpuscular hem... 5 | 36
male infertility 5 | 123
tremors 5 | 39
abnormal locomotor behavior 4 | 24
abnormal tail morphology 4 | 25
decreased blood urea nitrogen ... 4 | 51
decreased circulating creatini... 4 | 39
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased erythrocyte cell num... 4 | 62
decreased leukocyte cell numbe... 4 | 73
decreased red blood cell distr... 4 | 41
decreased startle reflex 4 | 75
edema 4 | 59
increased bone mineral content 4 | 108
increased circulating amylase ... 4 | 25
increased circulating bilirubi... 4 | 16
increased circulating chloride... 4 | 41
increased circulating choleste... 4 | 66
increased circulating phosphat... 4 | 26
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 32
increased red blood cell distr... 4 | 34
pale yolk sac 4 | 25
pallor 4 | 34
thrombocytopenia 4 | 56
abnormal bone mineralization 3 | 38
abnormal forebrain development 3 | 20
abnormal gait 3 | 69
abnormal hindbrain development 3 | 16
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal limb bud morphology 3 | 17
abnormal midbrain development 3 | 20
abnormal pericardium morpholog... 3 | 26
abnormal skin morphology 3 | 50
anophthalmia 3 | 33
decreased T cell number 3 | 15
decreased circulating amylase ... 3 | 28
decreased circulating insulin ... 3 | 76
decreased circulating sodium l... 3 | 22
decreased hemoglobin content 3 | 68
decreased prepulse inhibition 3 | 82
decreased threshold for audito... 3 | 26
increased circulating serum al... 3 | 22
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
limb grasping 3 | 41
mammalian phenotype 3 | 17
short tibia 3 | 97
small adrenal glands 3 | 16
small superior vagus ganglion 3 | 74
small testis 3 | 58
thrombocytosis 3 | 27
increased circulating calcium ... 2 | 34

Disease

Carcinoma 555 | 11,192
ovarian cancer 476 | 8,297
osteosarcoma 403 | 7,766
psoriasis 383 | 6,514
glioblastoma 331 | 5,635
medulloblastoma, large-cell 325 | 6,086
atypical teratoid / rhabdoid tumor 259 | 4,971
lung cancer 255 | 4,607
ependymoma 229 | 4,559
Cancer 202 | 2,388
intraductal papillary-mucinous neoplasm (IPMN) 202 | 3,204
Breast cancer 200 | 3,469
Astrocytoma, Pilocytic 192 | 3,006
group 3 medulloblastoma 188 | 4,002
invasive ductal carcinoma 185 | 2,867
adult high grade glioma 176 | 3,701
intraductal papillary-mucinous adenoma (IPMA) 169 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 168 | 2,902
malignant mesothelioma 168 | 3,135
lung adenocarcinoma 166 | 2,627
non-small cell lung cancer 166 | 2,799
diabetes mellitus 165 | 1,683
pancreatic cancer 156 | 2,322
lung carcinoma 152 | 2,755
pancreatic ductal adenocarcinoma liver metastasis 152 | 1,911
oligodendroglioma 149 | 2,768
tuberculosis 146 | 1,963
subependymal giant cell astrocytoma 142 | 2,230
primitive neuroectodermal tumor 138 | 2,957
interstitial cystitis 129 | 2,237
astrocytic glioma 126 | 2,530
pituitary cancer 119 | 1,915
ulcerative colitis 119 | 1,765
Multiple myeloma 116 | 1,296
Pick disease 116 | 1,856
Autosomal recessive predisposition 115 | 1,407
breast carcinoma 110 | 1,589
ductal carcinoma in situ 109 | 1,686
Kidney cancer 108 | 2,548
Rheumatoid arthritis 101 | 1,156
group 4 medulloblastoma 100 | 1,806
dermatomyositis 91 | 941
active Crohn's disease 90 | 882
cystic fibrosis 86 | 1,629
astrocytoma 85 | 1,113
adrenocortical carcinoma 83 | 1,385
juvenile dermatomyositis 83 | 1,147
acute quadriplegic myopathy 79 | 1,133
Ankylosing spondylitis 74 | 134
colon cancer 73 | 1,428
Behcet's disease 71 | 87
pediatric high grade glioma 71 | 1,035
Arthritis 70 | 276
Alzheimer's disease 66 | 640
Intellectual disability 65 | 998
Schizophrenia 65 | 1,136
Hypersensitivity reaction type II disease 64 | 245
primary pancreatic ductal adenocarcinoma 64 | 1,071
Acquired immunodeficiency syndrome 62 | 192
Epilepsy 61 | 775
esophageal adenocarcinoma 61 | 696
Juvenile rheumatoid arthritis 59 | 110
Neurodegenerative disease 59 | 402
Uveitis 59 | 102
Herpes zoster 57 | 68
non primary Sjogren syndrome sicca 56 | 861
Human immunodeficiency virus infectious disease 55 | 136
Multiple Sclerosis 55 | 527
Stevens-Johnson syndrome 55 | 92
cutaneous lupus erythematosus 55 | 1,016
Liver Cirrhosis, Experimental 53 | 733
nasopharyngeal carcinoma 53 | 1,024
Atopic dermatitis 50 | 915
Psoriatic arthritis 50 | 84
Obesity 49 | 655
Seizures 49 | 584
active ulcerative colitis 49 | 736
progressive supranuclear palsy 49 | 656
Anemia 48 | 353
spina bifida 48 | 1,053
Duchenne muscular dystrophy 47 | 587
Kidney disease 47 | 411
gastric carcinoma 47 | 781
Prostatic Neoplasms 46 | 472
Waldenstrons macroglobulinemia 46 | 742
Dermatitis 44 | 154
Dull intelligence 44 | 634
Low intelligence 44 | 634
Mental Retardation 44 | 634
Mental deficiency 44 | 634
Poor school performance 44 | 634
autosomal dominant Emery-Dreifuss muscular dystrophy 43 | 492
Muscle hypotonia 42 | 562
pancreatic carcinoma 42 | 555
primary Sjogren syndrome 42 | 710
Bipolar Disorder 39 | 646
Congenital adrenal hyperplasia 39 | 71
acute myeloid leukemia 39 | 760
fibroadenoma 39 | 538
Liver disease 38 | 227

Tissue

Endocrine System 833 | 18,159
Digestive Tract 832 | 17,369
Female tissues 827 | 17,400
Skin and soft tissues 823 | 17,230
Liver and Pancreas 822 | 16,750
Urinary Tract 817 | 16,678
Nervous System 815 | 16,725
Male tissues 814 | 17,142
Blood and immune system 813 | 16,909
Respiratory system 801 | 16,393
Cardiovascular System 765 | 15,192

Target Family

Non-IDG 524 | 12,091
Enzyme 305 | 4,145
Ion Channel 28 | 344
Transporter 28 | 473
Kinase 21 | 634
Transcription Factor 20 | 1,400
GPCR 11 | 408
Epigenetic 1 | 242

GO Component

endoplasmic reticulum 938 | 938
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Alkaline ceramidase 1 ACER1 Tbio Enzyme -0.89946 7.07 114
Copper-transporting ATPase 1 ATP7A Tbio Enzyme -3.08069 1155.0 263
Probable palmitoyltransferase ZDHHC12 ZDHHC12 Tdark Enzyme -0.20713 1.21 38
Probable phospholipid-transporting ATPase VA ATP10A Tbio Transporter -1.17971 17.2 12
Long-chain fatty acid transport protein 1 SLC27A1 Tchem Transporter -2.18464 151.5 79
Transient receptor potential cation channel subfamily M member 4 TRPM4 Tchem Ion Channel -2.19653 160.9 186
Synaptic vesicle glycoprotein 2A SV2A Tclin Non-IDG -2.60937 395.1 107