Development Level

Tbio 141 | 10,625
Tchem 36 | 1,890
Tdark 28 | 7,003
Tclin 12 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 10 | 633
decreased grip strength 6 | 123
increased circulating HDL chol... 4 | 63
increased circulating alkaline... 4 | 119
increased circulating choleste... 4 | 53
preweaning lethality, incomple... 4 | 260
decreased body weight 3 | 174
decreased lean body mass 3 | 195
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular vol... 3 | 50
increased sacral vertebrae num... 3 | 62
abnormal kidney morphology 2 | 30
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular hem... 2 | 19
decreased prepulse inhibition 2 | 52
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased B cell number 2 | 23
increased T cell number 2 | 15
increased circulating LDL chol... 2 | 15
increased circulating serum al... 2 | 25
increased fasted circulating g... 2 | 68
increased leukocyte cell numbe... 2 | 37
increased neutrophil cell numb... 2 | 15
short tibia 2 | 82
abnormal QRS complex 1 | 25
abnormal body wall morphology 1 | 7
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal motor capabilities/co... 1 | 4
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal tooth morphology 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased NK T cell number 1 | 28
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased follicular B cell nu... 1 | 4
decreased mean platelet volume 1 | 12
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
hydrometra 1 | 13
impaired glucose tolerance 1 | 52
increased Ly6C low monocyte nu... 1 | 8
increased NK T cell number 1 | 11
increased alpha-beta T cell nu... 1 | 9
increased bone mineral density 1 | 52
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
increased rib number 1 | 41
oligodactyly 1 | 14
polydactyly 1 | 22
shortened ST segment 1 | 9
thrombocytosis 1 | 23
vertebral transformation 1 | 12

Disease

ovarian cancer 125 | 8,492
osteosarcoma 108 | 7,933
psoriasis 93 | 6,685
medulloblastoma, large-cell 79 | 6,234
glioblastoma 73 | 5,572
lung cancer 57 | 4,473
atypical teratoid / rhabdoid tumor 48 | 4,369
invasive ductal carcinoma 45 | 2,950
malignant mesothelioma 44 | 3,163
Cancer 42 | 2,346
Breast cancer 37 | 3,099
lung adenocarcinoma 37 | 2,714
lung carcinoma 37 | 2,844
diabetes mellitus 36 | 1,663
non-small cell lung cancer 36 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,988
oligodendroglioma 35 | 2,849
pilocytic astrocytoma 35 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,289
pediatric high grade glioma 34 | 2,712
subependymal giant cell astrocytoma 34 | 2,287
Carcinoma 33 | 2,147
primitive neuroectodermal tumor 33 | 3,031
ulcerative colitis 31 | 2,087
astrocytoma 30 | 1,493
ependymoma 30 | 2,514
interstitial cystitis 29 | 2,299
juvenile dermatomyositis 28 | 1,189
Multiple myeloma 27 | 1,328
pancreatic cancer 26 | 2,300
Pick disease 24 | 1,893
breast carcinoma 24 | 1,614
cystic fibrosis 24 | 1,670
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,795
pituitary cancer 24 | 1,972
ductal carcinoma in situ 23 | 1,745
group 4 medulloblastoma 22 | 1,875
adult high grade glioma 21 | 2,148
astrocytic glioma 21 | 2,241
Atherosclerosis 20 | 275
Obesity 20 | 616
Rheumatoid Arthritis 20 | 1,171
tuberculosis 20 | 1,563
posterior fossa group A ependymoma 19 | 1,511
primary pancreatic ductal adenocarcinoma 18 | 1,271
Coronary artery disease 17 | 240
gastric carcinoma 17 | 832
group 3 medulloblastoma 17 | 2,254
medulloblastoma 16 | 1,524
sonic hedgehog group medulloblastoma 16 | 1,482
atypical teratoid/rhabdoid tumor 15 | 1,095
dermatomyositis 15 | 967
acute quadriplegic myopathy 14 | 1,157
adrenocortical carcinoma 14 | 1,427
Alzheimer's disease 13 | 644
aldosterone-producing adenoma 13 | 664
cutaneous lupus erythematosus 13 | 1,056
esophageal adenocarcinoma 13 | 737
posterior fossa group B ependymoma 13 | 1,530
primary Sjogren syndrome 13 | 789
Cerebrovascular disease 12 | 231
Heart disease 12 | 279
Hypertension 12 | 293
Neurodegenerative disease 12 | 383
colon cancer 12 | 1,475
hereditary spastic paraplegia 12 | 313
nasopharyngeal carcinoma 12 | 1,056
Duchenne muscular dystrophy 11 | 602
Kidney disease 11 | 397
Stomach Neoplasms 11 | 282
active Crohn's disease 11 | 918
tuberculosis and treatment for 6 months 11 | 686
Lipid metabolism disorder 10 | 102
Multiple Sclerosis 10 | 498
Parkinson's disease 10 | 364
Intellectual disability 9 | 573
Paraplegia 9 | 71
Waldenstrons macroglobulinemia 9 | 765
acute myeloid leukemia 9 | 785
non primary Sjogren syndrome sicca 9 | 840
pancreatic carcinoma 9 | 567
spina bifida 9 | 1,064
Autistic Disorder 8 | 320
Cardiovascular Diseases 8 | 50
Cardiovascular system disease 8 | 194
Hypertensive disease 8 | 193
IGA Glomerulonephritis 8 | 454
Liver disease 8 | 219
Metabolic syndrome X 8 | 155
Schizophrenia 8 | 503
chronic rhinosinusitis 8 | 512
glioblastoma multiforme 8 | 347
hepatocellular carcinoma 8 | 550
mucosa-associated lymphoid tissue lymphoma 8 | 480
Arthritis 7 | 248
Asthma 7 | 349
Down syndrome 7 | 548
periodontitis 7 | 269
progressive supranuclear palsy 7 | 674

Tissue

Cardiovascular System 212 | 17,958
Digestive Tract 212 | 18,473
Endocrine System 212 | 18,512
Female tissues 212 | 18,647
Liver and Pancreas 212 | 18,136
Male tissues 212 | 17,969
Nervous System 212 | 18,561
Respiratory system 212 | 17,484
Urinary Tract 212 | 18,444
Blood and immune system 211 | 17,995
Skin and soft tissues 211 | 18,115

Target Family

Non-IDG 138 | 11,969
Enzyme 46 | 4,146
GPCR 12 | 408
Kinase 12 | 634
Transporter 5 | 473
Ion Channel 4 | 341

GO Component

early endosome 217 | 217
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.44656 282.1 289
Ras-GEF domain-containing family member 1B RASGEF1B Tdark Non-IDG -0.68847 5.25 36
WAS protein family homolog 1 WASHC1 Tbio Non-IDG -0.16688 1.80 3
Nucleobindin-1 NUCB1 Tbio Non-IDG -2.69747 485.4 129
Ankyrin repeat domain-containing protein 27 ANKRD27 Tbio Non-IDG -1.12081 13.6 61
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.04744 808.6 1868
WASH complex subunit CCDC53 WASHC3 Tdark Non-IDG 0.18 0.42 14
V-type proton ATPase subunit d 2 ATP6V0D2 Tbio Enzyme -1.12579 10.3 58
Contactin-associated protein-like 2 CNTNAP2 Tbio Non-IDG -2.30539 192.4 187
Transforming growth factor-beta receptor-associated protein 1 TGFBRAP1 Tbio Non-IDG -0.98693 8.90 158